WO2006127692A3 - Optical microscopy with phototransformable optical labels - Google Patents
Optical microscopy with phototransformable optical labels Download PDFInfo
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- WO2006127692A3 WO2006127692A3 PCT/US2006/019887 US2006019887W WO2006127692A3 WO 2006127692 A3 WO2006127692 A3 WO 2006127692A3 US 2006019887 W US2006019887 W US 2006019887W WO 2006127692 A3 WO2006127692 A3 WO 2006127692A3
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- ptols
- optical
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- 230000003287 optical effect Effects 0.000 title abstract 2
- 238000000399 optical microscopy Methods 0.000 title 1
- 230000005855 radiation Effects 0.000 abstract 4
- 230000004913 activation Effects 0.000 abstract 2
- 238000003384 imaging method Methods 0.000 abstract 2
- 230000005284 excitation Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
- G02B21/365—Control or image processing arrangements for digital or video microscopes
- G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
- G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6419—Excitation at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G01N2021/6421—Measuring at two or more wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
Abstract
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008513618A JP4709278B2 (en) | 2005-05-23 | 2006-05-23 | Optical microscopy using optically convertible optical labels |
EP06784461.3A EP1894010B2 (en) | 2005-05-23 | 2006-05-23 | Optical microscopy with phototransformable optical labels |
CA2609653A CA2609653C (en) | 2005-05-23 | 2006-05-23 | Optical microscopy with phototransformable optical labels |
US11/944,289 US7626703B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,280 US7626694B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,321 US7626695B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,285 US7710563B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,312 US7535012B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,274 US7782457B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US12/645,019 US7864314B2 (en) | 2005-05-23 | 2009-12-22 | Optical microscopy with phototransformable optical labels |
US12/956,946 US8462336B2 (en) | 2005-05-23 | 2010-11-30 | Optical microscopy with phototransformable optical labels |
US13/655,102 US8599376B2 (en) | 2005-05-23 | 2012-10-18 | Optical microscopy with phototransformable optical labels |
US14/064,582 US9360426B2 (en) | 2005-05-23 | 2013-10-28 | Optical microscopy with phototransformable optical labels |
US15/170,521 US10107753B2 (en) | 2005-05-23 | 2016-06-01 | Optical microscopy with phototransformable optical labels |
US16/166,485 US11009460B2 (en) | 2005-05-23 | 2018-10-22 | Optical microscopy with phototransformable optical labels |
US17/302,829 US20220091038A1 (en) | 2005-05-23 | 2021-05-13 | Optical microscopy with phototransformable optical labels |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68333705P | 2005-05-23 | 2005-05-23 | |
US60/683,337 | 2005-05-23 | ||
US78096806P | 2006-03-10 | 2006-03-10 | |
US60/780,968 | 2006-03-10 |
Related Child Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/944,312 Continuation US7535012B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,321 Continuation US7626695B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,274 Continuation US7782457B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,289 Continuation US7626703B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,280 Continuation US7626694B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
US11/944,285 Continuation US7710563B2 (en) | 2005-05-23 | 2007-11-21 | Optical microscopy with phototransformable optical labels |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006127692A2 WO2006127692A2 (en) | 2006-11-30 |
WO2006127692A3 true WO2006127692A3 (en) | 2007-04-26 |
Family
ID=37452733
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/019887 WO2006127692A2 (en) | 2005-05-23 | 2006-05-23 | Optical microscopy with phototransformable optical labels |
Country Status (5)
Country | Link |
---|---|
US (13) | US7626695B2 (en) |
EP (7) | EP3203235A1 (en) |
JP (3) | JP4709278B2 (en) |
CA (1) | CA2609653C (en) |
WO (1) | WO2006127692A2 (en) |
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