WO2007016405A3 - Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility - Google Patents

Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility Download PDF

Info

Publication number
WO2007016405A3
WO2007016405A3 PCT/US2006/029555 US2006029555W WO2007016405A3 WO 2007016405 A3 WO2007016405 A3 WO 2007016405A3 US 2006029555 W US2006029555 W US 2006029555W WO 2007016405 A3 WO2007016405 A3 WO 2007016405A3
Authority
WO
WIPO (PCT)
Prior art keywords
active agent
copolymer
articles
devices
methods
Prior art date
Application number
PCT/US2006/029555
Other languages
French (fr)
Other versions
WO2007016405A2 (en
Inventor
Timothy M Kloke
Bob Hergenrother
Laurie R Lawin
Original Assignee
Surmodics Inc
Timothy M Kloke
Bob Hergenrother
Laurie R Lawin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Surmodics Inc, Timothy M Kloke, Bob Hergenrother, Laurie R Lawin filed Critical Surmodics Inc
Priority to EP06800498.5A priority Critical patent/EP1912684B1/en
Priority to JP2008524219A priority patent/JP2009502355A/en
Priority to CA002616959A priority patent/CA2616959A1/en
Publication of WO2007016405A2 publication Critical patent/WO2007016405A2/en
Publication of WO2007016405A3 publication Critical patent/WO2007016405A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D133/00—Coating compositions based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Coating compositions based on derivatives of such polymers
    • C09D133/04—Homopolymers or copolymers of esters
    • C09D133/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/064—Use of macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form

Abstract

The present invention relates to devices, articles, coatings, and methods for controlled active agent release and/or for providing a hemocompatible surface. More specifically, the present invention relates to copolymer compositions and devices, articles, and methods regarding the same for controlled active agent release. In an embodiment, the present invention includes a copolymer composition. The copolymer composition can include a copolymer and an active agent. In an embodiment, the copolymer includes an effective portion of a monomelic unit including a polar moiety. The active agent can be polar. The active agent can be charged. The active agent can be non-polar. In an embodiment, the copolymer composition includes a random copolymer. In an embodiment, the random copolymer includes butyl methacrylate-co-acrylamido-methyl-propane sulfonate copolymer, which can provide reduced platelet adhesion.
PCT/US2006/029555 2005-07-29 2006-07-27 Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility WO2007016405A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06800498.5A EP1912684B1 (en) 2005-07-29 2006-07-27 Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
JP2008524219A JP2009502355A (en) 2005-07-29 2006-07-27 Devices, products, coatings and methods for controlled active agent release or blood compatibility
CA002616959A CA2616959A1 (en) 2005-07-29 2006-07-27 Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70355505P 2005-07-29 2005-07-29
US60/703,555 2005-07-29
US73342305P 2005-11-03 2005-11-03
US60/733,423 2005-11-03

Publications (2)

Publication Number Publication Date
WO2007016405A2 WO2007016405A2 (en) 2007-02-08
WO2007016405A3 true WO2007016405A3 (en) 2007-07-12

Family

ID=37709234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/029555 WO2007016405A2 (en) 2005-07-29 2006-07-27 Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility

Country Status (5)

Country Link
US (1) US8663673B2 (en)
EP (1) EP1912684B1 (en)
JP (1) JP2009502355A (en)
CA (1) CA2616959A1 (en)
WO (1) WO2007016405A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155671B2 (en) 2012-10-16 2015-10-13 Surmodics, Inc. Wound packing device and methods

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7611533B2 (en) * 1995-06-07 2009-11-03 Cook Incorporated Coated implantable medical device
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US20070212397A1 (en) * 2005-09-15 2007-09-13 Roth Daniel B Pharmaceutical delivery device and method for providing ocular treatment
US8968782B2 (en) * 2006-06-28 2015-03-03 Surmodics, Inc. Combination degradable and non-degradable matrices for active agent delivery
US8685421B2 (en) * 2006-07-07 2014-04-01 Surmodics, Inc. Beaded wound spacer device
US20080171087A1 (en) * 2006-08-16 2008-07-17 Chappa Ralph A Methods and materials for increasing the adhesion of elution control matrices to substrates
WO2008039749A2 (en) * 2006-09-25 2008-04-03 Surmodics, Inc. Multi-layered coatings and methods for controlling elution of active agents
WO2008088593A2 (en) * 2006-09-27 2008-07-24 Surmodics, Inc. Additives and methods for enhancing active agent elution kinetics
JP2010512225A (en) * 2006-12-12 2010-04-22 ボーシュ アンド ローム インコーポレイティド Regular polymer systems and intraocular lenses
US8182829B2 (en) * 2007-07-27 2012-05-22 Abbott Cardiovascular Systems Inc. Drug eluting implantable medical device with hemocompatible and/or prohealing topcoat
TR201820076T4 (en) * 2007-08-16 2019-01-21 Biocompatibles Uk Ltd Release of drug combinations.
US20090214601A1 (en) * 2007-09-28 2009-08-27 Chappa Ralph A Porous Drug Delivery Devices and Related Methods
US20090202609A1 (en) * 2008-01-06 2009-08-13 Keough Steven J Medical device with coating composition
US20090186059A1 (en) * 2008-01-14 2009-07-23 Johnson Elizabeth E Devices and methods for elution of nucleic acid delivery complexes
WO2009126830A2 (en) * 2008-04-09 2009-10-15 Surmodics, Inc. Delivery of nucleic acid complexes from materials including negatively charged groups
US8936811B2 (en) * 2008-05-07 2015-01-20 Surmodics, Inc. Device coated with glycogen particles comprising nucleic acid complexes
EP2306929A1 (en) * 2008-07-14 2011-04-13 SurModics, Inc. Medical devices and methods for delivery of nucleic acids
DE102008038368A1 (en) * 2008-08-19 2010-02-25 Biotronik Vi Patent Ag Use of organic gold complexes as bioactive and radioopaque stent coating for permanent and degradable vascular implants
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CA2757037C (en) 2009-01-29 2019-08-06 Forsight Vision4, Inc. Posterior segment drug delivery
WO2010118238A2 (en) * 2009-04-08 2010-10-14 Surmodics, Inc. Controlled release devices and methods for delivery of nucleic acids
US8883208B2 (en) * 2009-04-08 2014-11-11 Surmodics, Inc. Particles for delivery of nucleic acids and related devices and methods
US8246576B2 (en) 2009-05-18 2012-08-21 Surmodics, Inc. Method and apparatus for delivery of a therapeutic agent with an expandable medical device
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US10166142B2 (en) 2010-01-29 2019-01-01 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
EP3375446B1 (en) 2010-04-13 2020-04-08 KCI Licensing, Inc. Compositions with reactive ingredients, and wound dressings, apparatuses, and methods
US20110319473A1 (en) 2010-06-29 2011-12-29 Surmodics, Inc. Compositions and methods for enhancement of nucleic acid delivery
RS62540B1 (en) 2010-08-05 2021-12-31 Forsight Vision4 Inc Apparatus to treat an eye
RS61601B1 (en) 2010-08-05 2021-04-29 Forsight Vision4 Inc Injector apparatus for drug delivery
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
AU2011329656B2 (en) 2010-11-19 2017-01-05 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
US20130041203A1 (en) * 2011-02-18 2013-02-14 Marlin Stephen Heilman Blood flow assist devices, systems and methods
US10213529B2 (en) 2011-05-20 2019-02-26 Surmodics, Inc. Delivery of coated hydrophobic active agent particles
US9861727B2 (en) 2011-05-20 2018-01-09 Surmodics, Inc. Delivery of hydrophobic active agent particles
US9120040B2 (en) * 2011-05-26 2015-09-01 The University Of Akron Anti-fouling materials based on poly(β-peptoid)s
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP2726016B1 (en) 2011-06-28 2023-07-19 ForSight Vision4, Inc. An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye
WO2013040247A2 (en) 2011-09-16 2013-03-21 Forsight Vision4, Inc. Fluid exchange apparatus and methods
WO2013116061A1 (en) 2012-02-03 2013-08-08 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
WO2014071387A1 (en) 2012-11-05 2014-05-08 Surmodics, Inc. Composition and method for delivery of hydrophobic active agents
US11246963B2 (en) 2012-11-05 2022-02-15 Surmodics, Inc. Compositions and methods for delivery of hydrophobic active agents
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
AU2014241163B2 (en) 2013-03-28 2018-09-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
WO2015184173A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
WO2016011191A1 (en) 2014-07-15 2016-01-21 Forsight Vision4, Inc. Ocular implant delivery device and method
US10201457B2 (en) 2014-08-01 2019-02-12 Surmodics, Inc. Wound packing device with nanotextured surface
SG11201700943TA (en) 2014-08-08 2017-03-30 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
CA2967330A1 (en) 2014-11-10 2016-05-19 Forsight Vision4, Inc. Expandable drug delivery devices and methods of use
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
JP6823875B2 (en) 2015-09-15 2021-02-03 サベージ メディカル， インコーポレイテッド Devices and methods for mooring sheaths in tissue cavities
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
CN113069681B (en) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 Method of manufacturing a therapeutic device for sustained drug delivery
ES2837524T3 (en) 2016-04-05 2021-06-30 Forsight Vision4 Inc Implantable ocular drug delivery devices
WO2017184881A1 (en) 2016-04-20 2017-10-26 Harold Alexander Heitzmann Bioresorbable ocular drug delivery device
US10898446B2 (en) 2016-12-20 2021-01-26 Surmodics, Inc. Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
CN111655206B (en) 2017-11-21 2022-10-14 弗赛特影像4股份有限公司 Fluid exchange device for expandable port delivery system and method of use

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0942003A1 (en) * 1998-03-09 1999-09-15 National Starch and Chemical Investment Holding Corporation Pressure sensitive adhesive with allyl amine moiety
WO2000040628A1 (en) * 1998-12-30 2000-07-13 The B.F. Goodrich Company Branched/block copolymers for treatment of keratinous substrates
EP1026219A1 (en) * 1999-02-02 2000-08-09 First Water Limited Bioadhesive compositions
WO2001083866A2 (en) * 2000-05-04 2001-11-08 Kimberly-Clark Worldwide, Inc. Salt-sensitive, water-dispersible polymer composition
WO2006116348A2 (en) * 2005-04-26 2006-11-02 Advanced Cardiovascular Systems, Inc. Compositions for medical devices containing agent combinations in controlled volumes
WO2006121669A2 (en) * 2005-05-05 2006-11-16 Boston Scientific Limited Coating of medical devices with solids

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4638045A (en) 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
DE69231073T2 (en) * 1991-10-24 2001-02-15 Insutech Inc INFUSION SYSTEM DRIVEN BY GAS PRESSURE GENERATED BY HYDROGEL BY ELECTROLYSIS
JP3455217B2 (en) 1992-02-13 2003-10-14 バイオ−メトリック システムズ インコーポレイテッド Immobilization of chemical species in crosslinked matrix
US5344455A (en) 1992-10-30 1994-09-06 Medtronic, Inc. Graft polymer articles having bioactive surfaces
US5788687A (en) 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
US5466233A (en) 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
US5840387A (en) 1995-07-28 1998-11-24 Aegis Biosciences L.L.C. Sulfonated multiblock copolymer and uses therefor
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
WO1999055396A1 (en) 1998-04-27 1999-11-04 Surmodics, Inc. Bioactive agent release coating
US20020188037A1 (en) 1999-04-15 2002-12-12 Chudzik Stephen J. Method and system for providing bioactive agent release coating
US6306419B1 (en) 2000-02-23 2001-10-23 Aegis Biosciences, Llc Medical uses of styrene sulfonate polymers
MXPA03001406A (en) 2000-08-15 2004-05-04 Surmodics Inc Medicament incorporation matrix.
DE60135352D1 (en) 2000-08-30 2008-09-25 Univ Johns Hopkins DEVICE FOR INTRA-OCCULAR ACTIVE AGGREGATION
ATE506929T1 (en) 2001-06-12 2011-05-15 Univ Johns Hopkins Med RESERVOIR DEVICE FOR INTRAOCULAR MEDICINAL DELIVERY
WO2003030879A1 (en) 2001-10-05 2003-04-17 Surmodics, Inc. Particle immobilized coatings and uses thereof
CA2498489C (en) 2002-09-29 2010-02-23 Surmodics, Inc. Method for subretinal administration of therapeutics including steroids;method for localizing pharmacodynamic action at the choroid and the retina; and related methods for treatment and/or prevention of retinal diseases
US20040142910A1 (en) 2002-10-21 2004-07-22 Aegis Biosciences Llc Sulfonated styrene copolymers for medical uses
ATE476960T1 (en) 2003-05-02 2010-08-15 Surmodics Inc SYSTEM FOR THE CONTROLLED RELEASE OF A BIOACTIVE INGREDIENT IN THE BACK OF THE EYE
US20060110428A1 (en) 2004-07-02 2006-05-25 Eugene Dejuan Methods and devices for the treatment of ocular conditions
US7771740B2 (en) * 2004-07-19 2010-08-10 Boston Scientific Scimed, Inc. Medical devices containing copolymers with graft copolymer endblocks for drug delivery

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0942003A1 (en) * 1998-03-09 1999-09-15 National Starch and Chemical Investment Holding Corporation Pressure sensitive adhesive with allyl amine moiety
WO2000040628A1 (en) * 1998-12-30 2000-07-13 The B.F. Goodrich Company Branched/block copolymers for treatment of keratinous substrates
EP1026219A1 (en) * 1999-02-02 2000-08-09 First Water Limited Bioadhesive compositions
WO2001083866A2 (en) * 2000-05-04 2001-11-08 Kimberly-Clark Worldwide, Inc. Salt-sensitive, water-dispersible polymer composition
WO2006116348A2 (en) * 2005-04-26 2006-11-02 Advanced Cardiovascular Systems, Inc. Compositions for medical devices containing agent combinations in controlled volumes
WO2006121669A2 (en) * 2005-05-05 2006-11-16 Boston Scientific Limited Coating of medical devices with solids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9155671B2 (en) 2012-10-16 2015-10-13 Surmodics, Inc. Wound packing device and methods

Also Published As

Publication number Publication date
EP1912684B1 (en) 2014-03-05
WO2007016405A2 (en) 2007-02-08
US20070026037A1 (en) 2007-02-01
CA2616959A1 (en) 2007-02-08
US8663673B2 (en) 2014-03-04
EP1912684A2 (en) 2008-04-23
JP2009502355A (en) 2009-01-29

Similar Documents

Publication Publication Date Title
WO2007016405A3 (en) Devices, articles, coatings, and methods for controlled active agent release or hemocompatibility
WO2009064879A3 (en) Antimicrobial coatings for medical devices and methods for making and using them
WO2009047269A3 (en) Use of highly functional, highly branched polyetheramine polyols for coating surfaces
WO2007130734A3 (en) Antimicrobial coating
SI1709125T1 (en) Coating composition having surface depolluting properties
WO2009125222A3 (en) Antimicrobial system
WO2006042116A3 (en) Aluminum phosphate compositions, coatings and related composites
WO2007077560A3 (en) Cryoprotective compositions and methods of using same
WO2008022803A3 (en) Extrusion coated substrate
WO2007140375A3 (en) Methods and systems for selectively depositing si-containing films using chloropolysilanes
WO2007130838A3 (en) Coating compositions exhibiting corrosion resistance properties, related coated articles and methods
WO2009048645A3 (en) Lipid coatings for implantable medical devices
WO2007070649A3 (en) Antimicrobial coating system
WO2006124365A3 (en) Endothelial cell binding coatings for rapid encapsulation of bioerodable stents
WO2006031965A3 (en) Controlled release antimicrobial polymer compositions
WO2006074391A3 (en) Biodegradable coating compositions comprising blends
WO2007019439A3 (en) Block copolymer compositions and uses thereof
EP1803754A3 (en) Biologically active block copolymers, coating compositions and coated articles thereof
WO2008128028A3 (en) Solifenacin compositions
WO2008024509A3 (en) Cationic latex as a carrier for bioactive ingredients and methods for making and using the same
EP1939935A3 (en) Indium Compositions
WO2007095258A3 (en) Rhamnolipid compositions and related methods of use
MXPA03001299A (en) Coating compositions for adhesion to olefinic substrates.
WO2006060468A3 (en) Rubber formulation and methods for manufacturing same
JP2009529356A5 (en)

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2616959

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2008524219

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006800498

Country of ref document: EP