WO2007016605A3 - An apparatus and a method for processing a sample using acoustic energy - Google Patents

An apparatus and a method for processing a sample using acoustic energy Download PDF

Info

Publication number
WO2007016605A3
WO2007016605A3 PCT/US2006/030019 US2006030019W WO2007016605A3 WO 2007016605 A3 WO2007016605 A3 WO 2007016605A3 US 2006030019 W US2006030019 W US 2006030019W WO 2007016605 A3 WO2007016605 A3 WO 2007016605A3
Authority
WO
WIPO (PCT)
Prior art keywords
sample
acoustic energy
sensor
processing sequence
desired condition
Prior art date
Application number
PCT/US2006/030019
Other languages
French (fr)
Other versions
WO2007016605A2 (en
Inventor
James A Laugharn Jr
Brevard S Garrison
Douglas A Yates
Original Assignee
Covaris Inc
James A Laugharn Jr
Brevard S Garrison
Douglas A Yates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covaris Inc, James A Laugharn Jr, Brevard S Garrison, Douglas A Yates filed Critical Covaris Inc
Publication of WO2007016605A2 publication Critical patent/WO2007016605A2/en
Publication of WO2007016605A3 publication Critical patent/WO2007016605A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/87—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations transmitting the vibratory energy by means of a fluid, e.g. by means of air shock waves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/44—Sample treatment involving radiation, e.g. heat
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02—Analysing fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00554—Mixing by a special element, e.g. stirrer using ultrasound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/024—Mixtures
    • G01N2291/02408—Solids in gases, e.g. particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02872—Pressure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2291/00—Indexing codes associated with group G01N29/00
    • G01N2291/02—Indexing codes associated with the analysed material
    • G01N2291/028—Material parameters
    • G01N2291/02881—Temperature
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom

Abstract

The apparatus includes an acoustic energy source for emitting acoustic energy substantially converging in a focal zone proximate to the sample, a liquid, semi- solid or solid medium for coupling the converged acoustic energy to the sample, a sensor for sensing a physical parameter of the sample, and a controller for controlling delivery of the acoustic energy to the sample base on a signal sensed by the sensor. In the method, a processing sequence appropriate to the sensed parameters of the sample is executed in order to deliver acoustic energy to the sample, periodically or continuously interrogating the at least one sample to detect the presence or absence of a desired condition of the at last one sample, and adjusting or terminating the processing sequence when the desired condition is detected.
PCT/US2006/030019 2005-08-01 2006-08-01 An apparatus and a method for processing a sample using acoustic energy WO2007016605A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70479405P 2005-08-01 2005-08-01
US60/704,794 2005-08-01
US71566005P 2005-09-09 2005-09-09
US60/715,660 2005-09-09

Publications (2)

Publication Number Publication Date
WO2007016605A2 WO2007016605A2 (en) 2007-02-08
WO2007016605A3 true WO2007016605A3 (en) 2007-05-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/030019 WO2007016605A2 (en) 2005-08-01 2006-08-01 An apparatus and a method for processing a sample using acoustic energy

Country Status (2)

Country Link
US (1) US7757561B2 (en)
WO (1) WO2007016605A2 (en)

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