WO2007019582A3 - Methods and systems for monitoring multiple optical signals from a single source - Google Patents

Methods and systems for monitoring multiple optical signals from a single source Download PDF

Info

Publication number
WO2007019582A3
WO2007019582A3 PCT/US2006/031387 US2006031387W WO2007019582A3 WO 2007019582 A3 WO2007019582 A3 WO 2007019582A3 US 2006031387 W US2006031387 W US 2006031387W WO 2007019582 A3 WO2007019582 A3 WO 2007019582A3
Authority
WO
WIPO (PCT)
Prior art keywords
systems
methods
single source
optical signals
multiple optical
Prior art date
Application number
PCT/US2006/031387
Other languages
French (fr)
Other versions
WO2007019582A2 (en
Inventor
Paul Lundquist
Stephen Turner
Denis Zaccarin
Original Assignee
Pacific Biosciences California
Paul Lundquist
Stephen Turner
Denis Zaccarin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pacific Biosciences California, Paul Lundquist, Stephen Turner, Denis Zaccarin filed Critical Pacific Biosciences California
Priority to JP2008526232A priority Critical patent/JP2009505076A/en
Priority to CA2616439A priority patent/CA2616439C/en
Priority to AU2006278236A priority patent/AU2006278236B2/en
Priority to EP06813384A priority patent/EP1920277A4/en
Publication of WO2007019582A2 publication Critical patent/WO2007019582A2/en
Priority to US11/981,740 priority patent/US20080226307A1/en
Publication of WO2007019582A3 publication Critical patent/WO2007019582A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/2803—Investigating the spectrum using photoelectric array detector
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/30—Measuring the intensity of spectral lines directly on the spectrum itself
    • G01J3/36—Investigating two or more bands of a spectrum by separate detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Abstract

Methods and systems for monitoring a plurality of different optical signals from a single source of such signals, where each such different optical signal is spatially separated from other such signals and directed to different detectors or locations upon a single detector, which direction is generally accomplished through the use of a small number of optical components and/or manipulations.
PCT/US2006/031387 2005-08-11 2006-08-10 Methods and systems for monitoring multiple optical signals from a single source WO2007019582A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008526232A JP2009505076A (en) 2005-08-11 2006-08-10 Method and system for monitoring multiple optical signals from a single signal source
CA2616439A CA2616439C (en) 2005-08-11 2006-08-10 Methods and systems for monitoring multiple optical signals from a single source
AU2006278236A AU2006278236B2 (en) 2005-08-11 2006-08-10 Methods and systems for monitoring multiple optical signals from a single source
EP06813384A EP1920277A4 (en) 2005-08-11 2006-08-10 Methods and systems for monitoring multiple optical signals from a single source
US11/981,740 US20080226307A1 (en) 2005-08-11 2007-10-31 Methods and systems for monitoring multiple optical signals from a single source

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/201,768 2005-08-11
US11/201,768 US7805081B2 (en) 2005-08-11 2005-08-11 Methods and systems for monitoring multiple optical signals from a single source

Publications (2)

Publication Number Publication Date
WO2007019582A2 WO2007019582A2 (en) 2007-02-15
WO2007019582A3 true WO2007019582A3 (en) 2009-04-23

Family

ID=37728043

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031387 WO2007019582A2 (en) 2005-08-11 2006-08-10 Methods and systems for monitoring multiple optical signals from a single source

Country Status (7)

Country Link
US (3) US7805081B2 (en)
EP (1) EP1920277A4 (en)
JP (1) JP2009505076A (en)
CN (1) CN101536368A (en)
AU (1) AU2006278236B2 (en)
CA (1) CA2616439C (en)
WO (1) WO2007019582A2 (en)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
US7763423B2 (en) * 2005-09-30 2010-07-27 Pacific Biosciences Of California, Inc. Substrates having low density reactive groups for monitoring enzyme activity
US8247026B2 (en) * 2006-03-20 2012-08-21 Mitsui Chemicals, Inc. Optical film and method for producing same
US8975216B2 (en) * 2006-03-30 2015-03-10 Pacific Biosciences Of California Articles having localized molecules disposed thereon and methods of producing same
US20080050747A1 (en) * 2006-03-30 2008-02-28 Pacific Biosciences Of California, Inc. Articles having localized molecules disposed thereon and methods of producing and using same
EP3936857B1 (en) * 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US8703422B2 (en) 2007-06-06 2014-04-22 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
CA2689626C (en) * 2007-06-06 2016-10-25 Pacific Biosciences Of California, Inc. Methods and processes for calling bases in sequence by incorporation methods
US9026370B2 (en) 2007-12-18 2015-05-05 Hospira, Inc. User interface improvements for medical devices
WO2009089056A1 (en) * 2008-01-10 2009-07-16 Pacific Biosciences Of California, Inc. Methods and systems for analysis of fluorescent reactions with modulated excitation
WO2009100382A1 (en) 2008-02-07 2009-08-13 Pacific Biosciences Of California, Inc. Cis reactive oxygen quenchers integrated into linkers
US8530164B2 (en) * 2008-09-05 2013-09-10 Pacific Biosciences Of California, Inc. Method for sequencing using branching fraction of incorporatable nucleotides
EP2255014A4 (en) * 2008-02-12 2011-05-18 Pacific Biosciences California Compositions and methods for use in analytical reactions
US8652781B2 (en) 2008-02-12 2014-02-18 Pacific Biosciences Of California, Inc. Cognate sampling kinetics
CA2718404C (en) 2008-03-13 2018-04-10 Pacific Biosciences Of California, Inc. Labeled reactants and their uses
US20090229651A1 (en) * 2008-03-14 2009-09-17 Fay Jr Theodore Denis Solar energy production system
US7973146B2 (en) 2008-03-26 2011-07-05 Pacific Biosciences Of California, Inc. Engineered fluorescent dye labeled nucleotide analogs for DNA sequencing
US8257954B2 (en) * 2008-03-31 2012-09-04 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
US8999676B2 (en) 2008-03-31 2015-04-07 Pacific Biosciences Of California, Inc. Recombinant polymerases for improved single molecule sequencing
WO2009145828A2 (en) * 2008-03-31 2009-12-03 Pacific Biosciences Of California, Inc. Two slow-step polymerase enzyme systems and methods
US8420366B2 (en) * 2008-03-31 2013-04-16 Pacific Biosciences Of California, Inc. Generation of modified polymerases for improved accuracy in single molecule sequencing
EP2279268A4 (en) 2008-04-04 2011-12-07 Life Technologies Corp Scanning system and method for imaging and sequencing
AU2009292629B2 (en) 2008-09-16 2014-03-20 Pacific Biosciences Of California, Inc. Substrates and optical systems and methods of use thereof
WO2010036287A1 (en) 2008-09-24 2010-04-01 Pacific Biosciences Of California, Inc. Intermittent detection during analytical reactions
CN102317473A (en) 2008-12-11 2012-01-11 加利福尼亚太平洋生物科学股份有限公司 Shenzhen tcl new technology co. , ltd
WO2010096890A1 (en) * 2009-02-25 2010-09-02 Synergx Technologies Inc. Optical structure and optical system for providing concurrent optical images of an object
US9778188B2 (en) 2009-03-11 2017-10-03 Industrial Technology Research Institute Apparatus and method for detection and discrimination molecular object
WO2010117420A2 (en) 2009-03-30 2010-10-14 Pacific Biosciences Of California, Inc. Fret-labeled compounds and uses therefor
US8501406B1 (en) 2009-07-14 2013-08-06 Pacific Biosciences Of California, Inc. Selectively functionalized arrays
EP2524260A4 (en) * 2009-08-11 2013-07-24 Chromx Llc Ultra dark field microscope
US8772016B2 (en) 2009-11-13 2014-07-08 Pacific Biosciences Of California, Inc. Sealed chip package
AU2011217862B9 (en) 2010-02-19 2014-07-10 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8994946B2 (en) 2010-02-19 2015-03-31 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US9482615B2 (en) * 2010-03-15 2016-11-01 Industrial Technology Research Institute Single-molecule detection system and methods
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9670243B2 (en) 2010-06-02 2017-06-06 Industrial Technology Research Institute Compositions and methods for sequencing nucleic acids
US8865077B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8865078B2 (en) 2010-06-11 2014-10-21 Industrial Technology Research Institute Apparatus for single-molecule detection
US8986930B2 (en) 2010-07-12 2015-03-24 Pacific Biosciences Of California, Inc. Sequencing reactions with alkali metal cations for pulse width control
WO2012027623A2 (en) 2010-08-25 2012-03-01 Pacific Biosciences Of California, Inc. Cyanine dyes
EP2658988B1 (en) 2010-12-27 2018-01-24 Ibis Biosciences, Inc. Nucleic acid sample preparation methods and compositions
US20120258871A1 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
US9670538B2 (en) 2011-08-05 2017-06-06 Ibis Biosciences, Inc. Nucleic acid sequencing by electrochemical detection
AU2012299169B2 (en) 2011-08-19 2017-08-24 Icu Medical, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
US9267917B2 (en) 2011-11-04 2016-02-23 Pacific Biosciences Of California, Inc. Nanopores in zero mode waveguides
WO2013090709A1 (en) 2011-12-16 2013-06-20 Hospira, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9222115B2 (en) 2011-12-30 2015-12-29 Abbott Molecular, Inc. Channels with cross-sectional thermal gradients
CN104334739A (en) 2012-01-13 2015-02-04 Data生物有限公司 Genotyping by next-generation sequencing
EP3222627B1 (en) 2012-02-15 2019-08-07 Pacific Biosciences of California, Inc. Polymerase enzyme substrates with protein shield
EP2831283A4 (en) 2012-03-30 2015-11-04 Pacific Biosciences California Methods and composition for sequencing modified nucleic acids
WO2013148798A1 (en) 2012-03-30 2013-10-03 Hospira, Inc. Air detection system and method for detecting air in a pump of an infusion system
WO2013166304A1 (en) 2012-05-02 2013-11-07 Ibis Biosciences, Inc. Dna sequencing
ES2840456T3 (en) 2012-05-02 2021-07-06 Ibis Biosciences Inc DNA sequencing
ES2683707T3 (en) 2012-05-02 2018-09-27 Ibis Biosciences, Inc. DNA sequencing
WO2013173844A1 (en) 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
GB2517875A (en) 2012-06-08 2015-03-04 Pacific Biosciences California Modified base detection with nanopore sequencing
US9551030B2 (en) 2012-06-17 2017-01-24 Pacific Biosciences Of California, Inc. Filter architecture for analytical devices
US9372308B1 (en) 2012-06-17 2016-06-21 Pacific Biosciences Of California, Inc. Arrays of integrated analytical devices and methods for production
DE102012221356A1 (en) * 2012-06-20 2013-12-24 Robert Bosch Gmbh Sensor and method for detecting light and method and device for determining color information
CA3089257C (en) 2012-07-31 2023-07-25 Icu Medical, Inc. Patient care system for critical medications
US9399766B2 (en) 2012-10-01 2016-07-26 Pacific Biosciences Of California, Inc. Recombinant polymerases for incorporation of protein shield nucleotide analogs
WO2014062835A1 (en) 2012-10-16 2014-04-24 Abbott Molecular Inc. Methods and apparatus to sequence a nucleic acid
EP4123294A1 (en) 2012-12-18 2023-01-25 Pacific Biosciences Of California, Inc. An optical analytical device
US9624540B2 (en) 2013-02-22 2017-04-18 Pacific Biosciences Of California, Inc. Integrated illumination of optical analytical devices
AU2014268355B2 (en) 2013-05-24 2018-06-14 Icu Medical, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
ES2838450T3 (en) 2013-05-29 2021-07-02 Icu Medical Inc Infusion set that uses one or more sensors and additional information to make an air determination relative to the infusion set
AU2014274122A1 (en) 2013-05-29 2016-01-21 Icu Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
US9581550B2 (en) 2013-05-31 2017-02-28 Pacific Biosciences Of California Analytical devices having compact lens train arrays
WO2014210225A1 (en) 2013-06-25 2014-12-31 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
ES2873850T3 (en) 2013-08-19 2021-11-04 Abbott Molecular Inc Next Generation Sequencing Libraries
EP3049539B1 (en) 2013-09-25 2018-09-05 Bio-Id Diagnostic Inc. Methods for detecting nucleic acid fragments
CN104518835B (en) * 2013-10-08 2019-07-23 中兴通讯股份有限公司 A kind of reception device of visible light communication mimo system
US9349260B2 (en) * 2013-11-13 2016-05-24 Rockwell Automation Technologies, Inc. Sensor device with enhanced light guide visualization and related methods
WO2015095355A2 (en) 2013-12-17 2015-06-25 The Brigham And Women's Hospital, Inc. Detection of an antibody against a pathogen
US10342917B2 (en) * 2014-02-28 2019-07-09 Icu Medical, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
US9723386B1 (en) * 2014-05-05 2017-08-01 Google Inc. Communication device
JP2017517302A (en) 2014-05-29 2017-06-29 ホスピーラ インコーポレイテッド Infusion system and pump with configurable closed loop delivery rate catchup
US11155809B2 (en) 2014-06-24 2021-10-26 Bio-Rad Laboratories, Inc. Digital PCR barcoding
CN107209188A (en) 2014-06-27 2017-09-26 雅培制药有限公司 Composition and method for detecting people Pegivirus 2 (HPgV 2)
JP6415893B2 (en) * 2014-08-05 2018-10-31 キヤノンメディカルシステムズ株式会社 Sample measuring apparatus and sample measuring method
CN114280023A (en) 2014-08-27 2022-04-05 加利福尼亚太平洋生物科学股份有限公司 Integrated analytical device array
CN107002293B (en) 2014-09-17 2020-12-08 艾比斯生物科学公司 Sequencing by synthesis using pulsed readout optics
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
US10302972B2 (en) 2015-01-23 2019-05-28 Pacific Biosciences Of California, Inc. Waveguide transmission
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
EP3271762B1 (en) 2015-03-16 2023-01-04 Pacific Biosciences of California, Inc. Analytical system comprising integrated devices and systems for free-space optical coupling
US10300452B2 (en) 2015-03-24 2019-05-28 Pacific Biosciences Of California, Inc. Methods and compositions for single molecule composition loading
EP3530752B1 (en) 2015-04-10 2021-03-24 Spatial Transcriptomics AB Spatially distinguished, multiplex nucleic acid analysis of biological specimens
SG11201707511UA (en) * 2015-04-22 2017-10-30 Shenzhen Genorivision Tech Co Ltd A biosensor
CN107615283B (en) 2015-05-26 2022-07-05 加利福尼亚太平洋生物科学股份有限公司 Methods, software and systems for diploid genome assembly and haplotype sequence reconstruction
CN107924027B (en) 2015-06-12 2024-01-23 加利福尼亚太平洋生物科学股份有限公司 Integrated target waveguide device and system for optical coupling
WO2017087696A1 (en) 2015-11-18 2017-05-26 Pacific Biosciences Of California, Inc. Methods and compositions for loading of polymerase complexes
US10435741B2 (en) 2015-11-19 2019-10-08 Pacific Biosciences Of California, Inc. Compounds and systems for improving signal detection
EP3400298B1 (en) 2016-01-08 2024-03-06 Bio-Rad Laboratories, Inc. Multiple beads per droplet resolution
CA3023658C (en) 2016-05-13 2023-03-07 Icu Medical, Inc. Infusion pump system and method with common line auto flush
AU2017277804B2 (en) 2016-06-10 2022-05-26 Icu Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
US10544457B2 (en) 2016-06-14 2020-01-28 Pacific Biosciences Of California, Inc. Methods and compositions for enriching compositions for polymerase enzyme complexes
US10711300B2 (en) 2016-07-22 2020-07-14 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US11543417B2 (en) 2016-08-29 2023-01-03 Oslo Universitetssykehus Hf ChIP-seq assays
WO2018118971A1 (en) 2016-12-19 2018-06-28 Bio-Rad Laboratories, Inc. Droplet tagging contiguity preserved tagmented dna
US11186862B2 (en) 2017-06-20 2021-11-30 Bio-Rad Laboratories, Inc. MDA using bead oligonucleotide
US11162138B2 (en) 2017-10-30 2021-11-02 Pacific Biosciences Of California, Inc. Multi-amplitude modular labeled compounds
CN111295443B (en) 2017-11-02 2024-04-16 生物辐射实验室股份有限公司 Transposase-based genomic analysis
US10655168B2 (en) 2017-12-22 2020-05-19 Pacific Biosciences Of California, Inc. Modified biotin-binding proteins for immobilization
US10089055B1 (en) 2017-12-27 2018-10-02 Icu Medical, Inc. Synchronized display of screen content on networked devices
EP3746552B1 (en) 2018-01-31 2023-12-27 Bio-Rad Laboratories, Inc. Methods and compositions for deconvoluting partition barcodes
AU2019235867A1 (en) 2018-03-13 2020-10-29 Sarmal, Inc. Methods for single molecule sequencing
US11512002B2 (en) 2018-04-18 2022-11-29 University Of Virginia Patent Foundation Silica materials and methods of making thereof
US11332787B2 (en) 2018-06-29 2022-05-17 Pacific Biosciences Of California, Inc. Methods and compositions for delivery of molecules and complexes to reaction sites
US11479816B2 (en) 2018-08-20 2022-10-25 Bio-Rad Laboratories, Inc. Nucleotide sequence generation by barcode bead-colocalization in partitions
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
WO2021152586A1 (en) 2020-01-30 2021-08-05 Yeda Research And Development Co. Ltd. Methods of analyzing microbiome, immunoglobulin profile and physiological state
WO2021214766A1 (en) 2020-04-21 2021-10-28 Yeda Research And Development Co. Ltd. Methods of diagnosing viral infections and vaccines thereto
WO2021236929A1 (en) 2020-05-22 2021-11-25 10X Genomics, Inc. Simultaneous spatio-temporal measurement of gene expression and cellular activity
WO2022020184A1 (en) 2020-07-21 2022-01-27 Icu Medical, Inc. Fluid transfer devices and methods of use
US11476933B1 (en) * 2020-09-24 2022-10-18 SA Photonics, Inc. Free space optical communication terminal with rotatable dispersive optical component
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030077610A1 (en) * 2001-08-29 2003-04-24 John Nelson Terminal-phosphate-labeled nucleotides and methods of use
US20030174992A1 (en) * 2001-09-27 2003-09-18 Levene Michael J. Zero-mode metal clad waveguides for performing spectroscopy with confined effective observation volumes
US6690002B2 (en) * 2000-08-02 2004-02-10 Nippon Sheet Glass, Co., Ltd. Photodetector array and optical communication monitor module using the same
WO2004100068A2 (en) * 2003-05-05 2004-11-18 D3D, L.P. Optical coherence tomography imaging

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4626684A (en) * 1983-07-13 1986-12-02 Landa Isaac J Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples
US5821058A (en) 1984-01-16 1998-10-13 California Institute Of Technology Automated DNA sequencing technique
US4648712A (en) * 1985-02-04 1987-03-10 Champion International Corporation Apparatus and method for analyzing parameters of a fibrous substrate
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6919211B1 (en) * 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5239178A (en) * 1990-11-10 1993-08-24 Carl Zeiss Optical device with an illuminating grid and detector grid arranged confocally to an object
US5677196A (en) * 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5470710A (en) * 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
US5491344A (en) * 1993-12-01 1996-02-13 Tufts University Method and system for examining the composition of a fluid or solid sample using fluorescence and/or absorption spectroscopy
US5578832A (en) * 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) * 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5695934A (en) * 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
WO1996027025A1 (en) 1995-02-27 1996-09-06 Ely Michael Rabani Device, compounds, algorithms, and methods of molecular characterization and manipulation with molecular parallelism
US6017434A (en) * 1995-05-09 2000-01-25 Curagen Corporation Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments
US5545531A (en) * 1995-06-07 1996-08-13 Affymax Technologies N.V. Methods for making a device for concurrently processing multiple biological chip assays
JP2935661B2 (en) * 1996-04-09 1999-08-16 株式会社日立製作所 Fluorescence detection method in fluorescence detection type electrophoresis apparatus
US5776785A (en) * 1996-12-30 1998-07-07 Diagnostic Products Corporation Method and apparatus for immunoassay using fluorescent induced surface plasma emission
US5828452A (en) * 1996-12-31 1998-10-27 Dakota Technologies, Inc. Spectroscopic system with a single converter and method for removing overlap in time of detected emissions
AU756945B2 (en) * 1997-05-23 2003-01-30 Bioarray Solutions Ltd Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US6071748A (en) * 1997-07-16 2000-06-06 Ljl Biosystems, Inc. Light detection device
PT1017848E (en) 1997-07-28 2003-02-28 Medical Biosystems Ltd ANALYSIS OF NUCLEIC ACID SEQUENCES
GB9727355D0 (en) * 1997-12-24 1998-02-25 Kalibrant Limited A composition for use in fluorescence assay systems
US6388788B1 (en) * 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US6571118B1 (en) * 1998-05-04 2003-05-27 Board Of Regents, The University Of Texas System Combined fluorescence and reflectance spectroscopy
CA2339121A1 (en) 1998-07-30 2000-02-10 Shankar Balasubramanian Arrayed biomolecules and their use in sequencing
US6263286B1 (en) * 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US6210896B1 (en) * 1998-08-13 2001-04-03 Us Genomics Molecular motors
AU749690B2 (en) * 1998-08-21 2002-07-04 Surromed, Inc. Novel optical architectures for microvolume laser-scanning cytometers
JP3335314B2 (en) * 1998-10-29 2002-10-15 インターナショナル・ビジネス・マシーンズ・コーポレーション Data recording apparatus and control method thereof
CA2355816C (en) 1998-12-14 2007-10-30 Li-Cor, Inc. A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
AU3372800A (en) 1999-02-23 2000-09-14 Caliper Technologies Corporation Manipulation of microparticles in microfluidic systems
GB9906929D0 (en) * 1999-03-26 1999-05-19 Univ Glasgow Assay system
US7056661B2 (en) * 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6287774B1 (en) * 1999-05-21 2001-09-11 Caliper Technologies Corp. Assay methods and system
EP1055925B1 (en) * 1999-05-28 2010-09-08 Yokogawa Electric Corporation Biochip reader
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7209836B1 (en) * 1999-07-16 2007-04-24 Perkinelmer Las, Inc. Method and system for automatically creating crosstalk-corrected data of a microarray
AU7086800A (en) 1999-08-30 2001-03-26 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The High speed parallel molecular nucleic acid sequencing
US6982146B1 (en) 1999-08-30 2006-01-03 The United States Of America As Represented By The Department Of Health And Human Services High speed parallel molecular nucleic acid sequencing
US6867851B2 (en) * 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US6784982B1 (en) * 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
JP2001311690A (en) * 2000-04-28 2001-11-09 Yokogawa Electric Corp Biochip reader and electrophoretic apparatus
US6690467B1 (en) 2000-05-05 2004-02-10 Pe Corporation Optical system and method for optically analyzing light from a sample
US20060008799A1 (en) * 2000-05-22 2006-01-12 Hong Cai Rapid haplotyping by single molecule detection
US6869764B2 (en) 2000-06-07 2005-03-22 L--Cor, Inc. Nucleic acid sequencing using charge-switch nucleotides
GB0016473D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method
GB0016472D0 (en) 2000-07-05 2000-08-23 Amersham Pharm Biotech Uk Ltd Sequencing method and apparatus
US20070196815A1 (en) * 2000-08-02 2007-08-23 Jason Lappe Positive Selection Procedure for Optically Directed Selection of Cells
US6545758B1 (en) * 2000-08-17 2003-04-08 Perry Sandstrom Microarray detector and synthesizer
US6718395B1 (en) * 2000-10-10 2004-04-06 Computer Access Technology Corporation Apparatus and method using an inquiry response for synchronizing to a communication network
FR2824139B1 (en) * 2001-04-27 2003-05-30 Commissariat Energie Atomique LUMINESCENCE MEASURING DEVICE WITH PREFILTRE EFFECT ELIMINATION
US7244566B2 (en) 2001-08-29 2007-07-17 Ge Healthcare Bio-Sciences Corp. Analyte detection
US7033762B2 (en) 2001-08-29 2006-04-25 Amersham Biosciences Corp Single nucleotide amplification and detection by polymerase
US7560254B2 (en) 2001-08-29 2009-07-14 Ge Healthcare Bio-Sciences Corp. Allele specific primer extension
US7189361B2 (en) 2001-12-19 2007-03-13 3M Innovative Properties Company Analytical device with lightguide Illumination of capillary and microgrooves arrays
DE10200499A1 (en) * 2002-01-03 2003-07-10 Zeiss Carl Jena Gmbh Method and / or arrangement for the identification of fluorescent, luminescent and / or absorbent substances on and / or in sample carriers
JP4209623B2 (en) * 2002-03-19 2009-01-14 株式会社日立ハイテクノロジーズ Nucleotide sequencing method
WO2003080981A2 (en) * 2002-03-20 2003-10-02 Rollease Inc A roller shade clutch with internal gearing
AU2003244122A1 (en) * 2002-06-21 2004-01-06 Olympus Corporation Biomolecule analyzer
US6970240B2 (en) * 2003-03-10 2005-11-29 Applera Corporation Combination reader
FI20030867A (en) 2003-06-10 2004-12-11 Wallac Oy Optical measuring method and laboratory measuring apparatus
JP4331521B2 (en) * 2003-06-25 2009-09-16 富士フイルム株式会社 Target detection apparatus, target detection method, and target detection reagent
US7075059B2 (en) 2003-09-11 2006-07-11 Applera Corporation Image enhancement by sub-pixel imaging
US7323681B1 (en) 2003-09-11 2008-01-29 Applera Corporation Image enhancement by sub-pixel imaging
US7233393B2 (en) 2004-08-05 2007-06-19 Applera Corporation Signal noise reduction for imaging in biological analysis
US20050135974A1 (en) 2003-12-18 2005-06-23 Harvey Michael A. Device for preparing multiple assay samples using multiple array surfaces
US7302348B2 (en) * 2004-06-02 2007-11-27 Agilent Technologies, Inc. Method and system for quantifying and removing spatial-intensity trends in microarray data
US20070048748A1 (en) * 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
US7130041B2 (en) 2005-03-02 2006-10-31 Li-Cor, Inc. On-chip spectral filtering using CCD array for imaging and spectroscopy
US20060252070A1 (en) 2005-04-28 2006-11-09 Applera Corporation Multi-Color Light Detection With Imaging Detectors
EP1922419A4 (en) 2005-06-10 2010-11-17 Life Technologies Corp Method and system for multiplex genetic analysis
US20060291706A1 (en) 2005-06-23 2006-12-28 Applera Corporation Method of extracting intensity data from digitized image
WO2007011549A1 (en) 2005-06-30 2007-01-25 Applera Corporation Two-dimensional spectral imaging system
US7227128B2 (en) 2005-06-30 2007-06-05 Applera Corporation System and methods for improving signal/noise ratio for signal detectors
EP1907591A2 (en) * 2005-07-28 2008-04-09 Helicos Biosciences Corporation Consecutive base single molecule sequencing
US7805081B2 (en) * 2005-08-11 2010-09-28 Pacific Biosciences Of California, Inc. Methods and systems for monitoring multiple optical signals from a single source
EP2027442A2 (en) * 2006-05-16 2009-02-25 Applied Biosystems, Inc. Systems, methods, and apparatus for single molecule sequencing
WO2008002765A2 (en) 2006-06-27 2008-01-03 Applera Corporation Method and system for compensating for spatial cross-talk
US7803609B2 (en) 2006-07-21 2010-09-28 Affymetrix, Inc. System, method, and product for generating patterned illumination
EP3936857B1 (en) * 2006-09-01 2023-06-21 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6690002B2 (en) * 2000-08-02 2004-02-10 Nippon Sheet Glass, Co., Ltd. Photodetector array and optical communication monitor module using the same
US20030077610A1 (en) * 2001-08-29 2003-04-24 John Nelson Terminal-phosphate-labeled nucleotides and methods of use
US20030174992A1 (en) * 2001-09-27 2003-09-18 Levene Michael J. Zero-mode metal clad waveguides for performing spectroscopy with confined effective observation volumes
WO2004100068A2 (en) * 2003-05-05 2004-11-18 D3D, L.P. Optical coherence tomography imaging

Also Published As

Publication number Publication date
EP1920277A2 (en) 2008-05-14
CA2616439C (en) 2012-03-20
WO2007019582A2 (en) 2007-02-15
US20100331212A1 (en) 2010-12-30
EP1920277A4 (en) 2013-01-16
US20070036511A1 (en) 2007-02-15
US7805081B2 (en) 2010-09-28
AU2006278236A1 (en) 2007-02-15
AU2006278236B2 (en) 2012-01-12
JP2009505076A (en) 2009-02-05
CN101536368A (en) 2009-09-16
CA2616439A1 (en) 2007-02-15
US20080226307A1 (en) 2008-09-18

Similar Documents

Publication Publication Date Title
WO2007019582A3 (en) Methods and systems for monitoring multiple optical signals from a single source
WO2011103032A3 (en) Optical detection systems and methods of using the same
WO2009052444A3 (en) Microphone array processor based on spatial analysis
WO2008126516A1 (en) Transmitting method, transmitting device, receiving method, and receiving device
ATE417286T1 (en) DETECTION OF AN ELECTROMAGNETIC SIGNAL
WO2007095119A3 (en) Methods and systems for simultaneous real-time monitoring of optical signals from multiple sources
WO2011103271A3 (en) Fiber optic personnel safety systems and methods of using the same
WO2007002016A3 (en) Systems and methods for product authentication
WO2007052185A3 (en) Hearing aid comprising sound tracking means
WO2009044509A1 (en) Sounnd source direction detector
WO2006102295A3 (en) Child-oriented computing facilities
WO2006081294A3 (en) Coordinated shared storage architecture
EP1804573A4 (en) Methods and apparatus for identifying and diagnosing live eggs using heart rate and embryo motion
WO2007089863A3 (en) Methods and systems for avoiding transmission-channel disruptions
MY170009A (en) Optical demultiplexing system
WO2005010935A3 (en) Method and system for electronic spatial filtering of spectral reflectometer optical signals
WO2006110262A3 (en) Positioning system with a sparse antenna array
WO2008122938A3 (en) Line-of-sight optical detection system, and communication system
WO2008105841A3 (en) Robotic sentry with low dispersion acoustic projector
EP3913340A4 (en) Light detection device, light detection system, and filter array
WO2007018745A3 (en) Tomography system
WO2008064064A3 (en) Signal identifying apparatus for an optical fiber
WO2005070054A3 (en) Optical switch assembly
ATE356337T1 (en) FIBER OPTICAL MONITORING SYSTEM
WO2005001520A3 (en) Serial routing of optical signals

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680029426.3

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006278236

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2616439

Country of ref document: CA

ENP Entry into the national phase

Ref document number: 2006278236

Country of ref document: AU

Date of ref document: 20060810

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008526232

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2006813384

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1212/CHENP/2008

Country of ref document: IN