WO2007053447A3 - Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions - Google Patents

Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions Download PDF

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Publication number
WO2007053447A3
WO2007053447A3 PCT/US2006/042027 US2006042027W WO2007053447A3 WO 2007053447 A3 WO2007053447 A3 WO 2007053447A3 US 2006042027 W US2006042027 W US 2006042027W WO 2007053447 A3 WO2007053447 A3 WO 2007053447A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
treatment
conditions
fibrotic
Prior art date
Application number
PCT/US2006/042027
Other languages
French (fr)
Other versions
WO2007053447A2 (en
Inventor
Roger A Sabbadini
William A Garland
Glenn L Stoller
Original Assignee
Lpath Therapeutics Inc
Roger A Sabbadini
William A Garland
Glenn L Stoller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2008538001A priority Critical patent/JP5739089B2/en
Application filed by Lpath Therapeutics Inc, Roger A Sabbadini, William A Garland, Glenn L Stoller filed Critical Lpath Therapeutics Inc
Priority to EP06844226A priority patent/EP1948234B1/en
Priority to EA200801197A priority patent/EA017945B1/en
Priority to PL06844226T priority patent/PL1948234T3/en
Priority to DK06844226.8T priority patent/DK1948234T3/en
Priority to SI200631487T priority patent/SI1948234T1/en
Priority to AU2006309008A priority patent/AU2006309008B2/en
Priority to ES06844226T priority patent/ES2398919T3/en
Priority to CA002627427A priority patent/CA2627427A1/en
Priority to US12/091,890 priority patent/US20090220523A1/en
Publication of WO2007053447A2 publication Critical patent/WO2007053447A2/en
Publication of WO2007053447A3 publication Critical patent/WO2007053447A3/en
Priority to HK09100789.6A priority patent/HK1123000A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

The present invention relates to compositions and methods for the treatment of diseases and conditions, including ocular diseases and conditions, characterized by aberrant fibrogenesis or scarring, inflammation and/or aberrant neovascularization or angiogenesis. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against bioactive lipids and which are capable of decreasing the effective concentration of the bioactive lipids. In some embodiments, the immune-derived moiety is a monoclonal antibody that is reactive against sphinxine- 1 -phosphate (SlP) or lysophosphophatidic acid (LPA).
PCT/US2006/042027 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions WO2007053447A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SI200631487T SI1948234T1 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
EP06844226A EP1948234B1 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
EA200801197A EA017945B1 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions of the eye of an animal
PL06844226T PL1948234T3 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
DK06844226.8T DK1948234T3 (en) 2005-10-28 2006-10-27 COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF FIBROTIC, INFLAMMATORY AND NEOVASCULAR CONDITIONS
JP2008538001A JP5739089B2 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrosis, inflammatory and neovascular conditions
AU2006309008A AU2006309008B2 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
US12/091,890 US20090220523A1 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
CA002627427A CA2627427A1 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
ES06844226T ES2398919T3 (en) 2005-10-28 2006-10-27 Compositions and procedures for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions
HK09100789.6A HK1123000A1 (en) 2005-10-28 2009-01-23 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/261,935 2005-10-28
US11/261,935 US7794713B2 (en) 2004-04-07 2005-10-28 Compositions and methods for the treatment and prevention of hyperproliferative diseases

Publications (2)

Publication Number Publication Date
WO2007053447A2 WO2007053447A2 (en) 2007-05-10
WO2007053447A3 true WO2007053447A3 (en) 2007-07-05

Family

ID=38006397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/042027 WO2007053447A2 (en) 2005-10-28 2006-10-27 Compositions and methods for the treatment and prevention of fibrotic, inflammatory and neovascularization conditions

Country Status (14)

Country Link
US (3) US7794713B2 (en)
EP (1) EP1948234B1 (en)
JP (2) JP5739089B2 (en)
CN (1) CN101340929A (en)
AU (1) AU2006309008B2 (en)
CA (1) CA2627427A1 (en)
DK (1) DK1948234T3 (en)
EA (1) EA017945B1 (en)
ES (1) ES2398919T3 (en)
HK (1) HK1123000A1 (en)
PL (1) PL1948234T3 (en)
PT (1) PT1948234E (en)
SI (1) SI1948234T1 (en)
WO (1) WO2007053447A2 (en)

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