WO2007067502A3 - Cardiac targeted delivery of cells - Google Patents

Cardiac targeted delivery of cells Download PDF

Info

Publication number
WO2007067502A3
WO2007067502A3 PCT/US2006/046292 US2006046292W WO2007067502A3 WO 2007067502 A3 WO2007067502 A3 WO 2007067502A3 US 2006046292 W US2006046292 W US 2006046292W WO 2007067502 A3 WO2007067502 A3 WO 2007067502A3
Authority
WO
WIPO (PCT)
Prior art keywords
cardiac
cells
targeted delivery
subject
circulation
Prior art date
Application number
PCT/US2006/046292
Other languages
French (fr)
Other versions
WO2007067502A2 (en
Inventor
Charles R Bridges
Original Assignee
Univ Pennsylvania
Charles R Bridges
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Charles R Bridges filed Critical Univ Pennsylvania
Priority to US12/086,024 priority Critical patent/US8158119B2/en
Publication of WO2007067502A2 publication Critical patent/WO2007067502A2/en
Publication of WO2007067502A3 publication Critical patent/WO2007067502A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
    • A61M1/3604—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in opposite directions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3613—Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A61M2202/0429—Red blood cells; Erythrocytes
    • A61M2202/0437—Blood stem cells

Abstract

A method of delivering cardiac stem cell and treating damaged cardiac tissue is provided. The method involves isolation of subject's cardiac circulation from the subject's systemic circulation and perfusing a solution comprising stem cells into the cardiac circuit.
PCT/US2006/046292 2005-12-05 2006-12-04 Cardiac targeted delivery of cells WO2007067502A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/086,024 US8158119B2 (en) 2005-12-05 2006-12-04 Cardiac targeted delivery of cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74224405P 2005-12-05 2005-12-05
US60/742,244 2005-12-05

Publications (2)

Publication Number Publication Date
WO2007067502A2 WO2007067502A2 (en) 2007-06-14
WO2007067502A3 true WO2007067502A3 (en) 2008-12-11

Family

ID=38123409

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046292 WO2007067502A2 (en) 2005-12-05 2006-12-04 Cardiac targeted delivery of cells

Country Status (2)

Country Link
US (1) US8158119B2 (en)
WO (1) WO2007067502A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030292A2 (en) 2003-09-26 2005-04-07 The Trustees Of The University Of Pennsylvania Methods, compositions and apparatus for delivering heterologous molecules to cells
WO2006039218A2 (en) 2004-09-30 2006-04-13 The Trustees Of The University Of Pennsylvania Perfusion circuit and use therein in targeted delivery of macromolecules
EP2091587B1 (en) * 2006-11-03 2016-12-21 University of Utah Research Foundation Ventricular assist device capable of implantation of stem cells
US9655666B2 (en) 2010-10-29 2017-05-23 Medtronic Ablatio Frontiers LLC Catheter with coronary sinus ostium anchor
US20150272999A1 (en) * 2014-03-31 2015-10-01 Banner Health Retrograde coronary vein delivery of stem cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040665A1 (en) * 1999-05-28 2003-02-27 E-Monitors, Inc. Systems and methods of pH tissue monitoring
US20040126879A1 (en) * 2002-08-29 2004-07-01 Baylor College Of Medicine Heart derived cells for cardiac repair
WO2005030292A2 (en) * 2003-09-26 2005-04-07 The Trustees Of The University Of Pennsylvania Methods, compositions and apparatus for delivering heterologous molecules to cells

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5813842A (en) * 1989-09-22 1998-09-29 Tamari; Yehuda Pressure sensitive valves for extracorporeal pumping-3
US5451207A (en) * 1994-04-25 1995-09-19 The Regents Of The University Of California Method of coronary plaque removal with bypass and perfusion
US6071258A (en) * 1994-09-12 2000-06-06 Cobe Cardiovascular, Inc. Perfusion control assembly with improved component visibility and accessibility
CA2314905A1 (en) 1997-12-19 1999-07-01 The Trustees Of The University Of Pennsylvania Transvascular delivery of a composition to an extravascular tissue of a mammal
US6699231B1 (en) * 1997-12-31 2004-03-02 Heartport, Inc. Methods and apparatus for perfusion of isolated tissue structure
US6508777B1 (en) * 1998-05-08 2003-01-21 Cardeon Corporation Circulatory support system and method of use for isolated segmental perfusion
US6267747B1 (en) * 1998-05-11 2001-07-31 Cardeon Corporation Aortic catheter with porous aortic root balloon and methods for inducing cardioplegic arrest
US6726651B1 (en) * 1999-08-04 2004-04-27 Cardeon Corporation Method and apparatus for differentially perfusing a patient during cardiopulmonary bypass
US7214369B2 (en) * 2003-05-05 2007-05-08 Mirus Bio Corporation Devices and processes for distribution of genetic material to mammalian limb
WO2005027995A2 (en) 2003-09-19 2005-03-31 The Trustees Of The University Of Pennsylvania Global myocardial perfusion catheter
US7722596B2 (en) * 2004-02-26 2010-05-25 Osprey Medical, Inc. Regional cardiac tissue treatment
WO2006039218A2 (en) 2004-09-30 2006-04-13 The Trustees Of The University Of Pennsylvania Perfusion circuit and use therein in targeted delivery of macromolecules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030040665A1 (en) * 1999-05-28 2003-02-27 E-Monitors, Inc. Systems and methods of pH tissue monitoring
US20040126879A1 (en) * 2002-08-29 2004-07-01 Baylor College Of Medicine Heart derived cells for cardiac repair
WO2005030292A2 (en) * 2003-09-26 2005-04-07 The Trustees Of The University Of Pennsylvania Methods, compositions and apparatus for delivering heterologous molecules to cells

Also Published As

Publication number Publication date
US8158119B2 (en) 2012-04-17
US20090287185A1 (en) 2009-11-19
WO2007067502A2 (en) 2007-06-14

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