WO2007090068A3 - Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif) - Google Patents

Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif) Download PDF

Info

Publication number
WO2007090068A3
WO2007090068A3 PCT/US2007/061171 US2007061171W WO2007090068A3 WO 2007090068 A3 WO2007090068 A3 WO 2007090068A3 US 2007061171 W US2007061171 W US 2007061171W WO 2007090068 A3 WO2007090068 A3 WO 2007090068A3
Authority
WO
WIPO (PCT)
Prior art keywords
hif
inducible factor
hypoxia inducible
cyanoisoquinoline
cyanoisoquinoline compounds
Prior art date
Application number
PCT/US2007/061171
Other languages
French (fr)
Other versions
WO2007090068A2 (en
Inventor
Michael P Arend
Lee A Flippin
Min Wu
Eric D Turtle
Wen-Bin Ho
Shaojiang Deng
Original Assignee
Fibrogen Inc
Michael P Arend
Lee A Flippin
Min Wu
Eric D Turtle
Wen-Bin Ho
Shaojiang Deng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0707302A priority Critical patent/BRPI0707302B8/en
Priority to CA2640435A priority patent/CA2640435C/en
Priority to JP2008552602A priority patent/JP5161793B2/en
Priority to KR1020087020971A priority patent/KR101446499B1/en
Application filed by Fibrogen Inc, Michael P Arend, Lee A Flippin, Min Wu, Eric D Turtle, Wen-Bin Ho, Shaojiang Deng filed Critical Fibrogen Inc
Priority to EP07717454A priority patent/EP2044028B1/en
Priority to MX2008009581A priority patent/MX2008009581A/en
Priority to CN2007800035992A priority patent/CN101374815B/en
Priority to AU2007211077A priority patent/AU2007211077B2/en
Priority to DK07717454.8T priority patent/DK2044028T3/en
Priority to KR1020147017534A priority patent/KR20140089446A/en
Publication of WO2007090068A2 publication Critical patent/WO2007090068A2/en
Priority to IL193047A priority patent/IL193047A/en
Priority to NO20083658A priority patent/NO342678B1/en
Publication of WO2007090068A3 publication Critical patent/WO2007090068A3/en
Priority to HK09109169.7A priority patent/HK1129114A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present invention relates to cyanoisoquinoline compounds suitable for use in treating hypoxia inducible factor-mediated and/or erythropoietin-associated conditions. The cyanoisoquinoline compounds of the invention have the following structure: Formula (I).
PCT/US2007/061171 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif) WO2007090068A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
MX2008009581A MX2008009581A (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds and methods of use thereof.
JP2008552602A JP5161793B2 (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia-inducing factor (HIF)
KR1020087020971A KR101446499B1 (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor(ｈｉｆ)
AU2007211077A AU2007211077B2 (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF)
EP07717454A EP2044028B1 (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
CA2640435A CA2640435C (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
CN2007800035992A CN101374815B (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (HIF)
BRPI0707302A BRPI0707302B8 (en) 2006-01-27 2007-01-26 cyanoisoquinoline compounds that act on tissue damage associated with ischemia, hypoxia and anemia, as well as pharmaceutical composition comprising them
DK07717454.8T DK2044028T3 (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds to stabilize the hypoxia-inducing factor (HIF)
KR1020147017534A KR20140089446A (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor(hif)
IL193047A IL193047A (en) 2006-01-27 2008-07-24 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
NO20083658A NO342678B1 (en) 2006-01-27 2008-08-25 Cyanoisoquinoline compounds, pharmaceutical compositions containing them and their use
HK09109169.7A HK1129114A1 (en) 2006-01-27 2009-10-05 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76278006P 2006-01-27 2006-01-27
US60/762,780 2006-01-27

Publications (2)

Publication Number Publication Date
WO2007090068A2 WO2007090068A2 (en) 2007-08-09
WO2007090068A3 true WO2007090068A3 (en) 2008-09-18

Family

ID=38042727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061171 WO2007090068A2 (en) 2006-01-27 2007-01-26 Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)

Country Status (16)

Country Link
US (5) US7928120B2 (en)
EP (2) EP2044028B1 (en)
JP (1) JP5161793B2 (en)
KR (2) KR20140089446A (en)
CN (3) CN101374815B (en)
AU (1) AU2007211077B2 (en)
BR (1) BRPI0707302B8 (en)
CA (1) CA2640435C (en)
DK (1) DK2044028T3 (en)
HK (1) HK1129114A1 (en)
IL (1) IL193047A (en)
MX (1) MX2008009581A (en)
NO (1) NO342678B1 (en)
RU (1) RU2457204C2 (en)
WO (1) WO2007090068A2 (en)
ZA (1) ZA200806752B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927591B2 (en) 2008-11-14 2015-01-06 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7323475B2 (en) 2003-06-06 2008-01-29 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and methods of use thereof
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
BRPI0707302B8 (en) * 2006-01-27 2021-05-25 Fibrogen Inc cyanoisoquinoline compounds that act on tissue damage associated with ischemia, hypoxia and anemia, as well as pharmaceutical composition comprising them
EP1991269A1 (en) * 2006-02-16 2008-11-19 Fibrogen, Inc. Compounds and methods for treatment of stroke
CA2647596C (en) * 2006-04-04 2012-06-12 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators
US8962530B2 (en) * 2007-06-27 2015-02-24 Regents Of The University Of Colorado Inflammatory bowel disease therapies
AU2008319229A1 (en) * 2007-11-02 2009-05-07 Fibrogen, Inc. Methods for reducing blood pressure
US8269008B2 (en) * 2007-12-03 2012-09-18 Fibrogen, Inc. Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions
EP2231157A1 (en) * 2007-12-06 2010-09-29 Fibrogen, Inc. Methods for increasing endothelial progentior cells
US20110039879A1 (en) * 2007-12-07 2011-02-17 FibroGen ,Inc. Methods for increasing white blood cells
WO2009089547A1 (en) * 2008-01-11 2009-07-16 Fibrogen, Inc. Isothiazole-pyridine derivatives as modulators of hif (hypoxia inducible factor) activity
US8324405B2 (en) 2008-02-05 2012-12-04 Fibrogen, Inc. Chromene derivatives and use thereof as HIF hydroxylase activity inhibitors
WO2009117269A1 (en) * 2008-03-18 2009-09-24 Merck & Co., Inc. Substituted 4-hydroxypyrimidine-5-carboxamides
CA2722772C (en) 2008-04-28 2020-12-22 Janssen Pharmaceutica N.V. Benzoimidazoles as prolyl hydroxylase inhibitors
CN102264740B (en) 2008-08-20 2014-10-15 菲布罗根有限公司 Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators
WO2010024911A1 (en) * 2008-08-26 2010-03-04 Fibrogen, Inc. Methods for increasing neurogenesis
CN102639700A (en) 2009-09-30 2012-08-15 哈佛大学校长及研究员协会 Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
CN103608346B (en) * 2011-02-02 2016-06-15 菲布罗根有限公司 As the 7-naphthyridine derivatives of hypoxia inducible factor (HIF) hydroxylase inhibitors
GB201102659D0 (en) 2011-02-15 2011-03-30 Isis Innovation Assay
WO2012150221A2 (en) 2011-05-04 2012-11-08 Bayer Cropscience Ag Novel halogenated benzyl alcohol esters of cyclopropane carboxylic acid as pest control agents
WO2012150208A1 (en) 2011-05-04 2012-11-08 Bayer Cropscience Ag Use of substituted benzyl alcohol esters of cyclopropanecarboxylic acid for controlling insecticide-resistant insects
KR102029951B1 (en) * 2011-07-22 2019-11-08 베이징 베타 파머수티컬 컴퍼니 리미티드 Polymorphic forms of compounds as prolyl hydroxylase inhibitor, and uses thereof
GB201113101D0 (en) 2011-07-28 2011-09-14 Isis Innovation Assay
ES2574262T3 (en) 2011-10-25 2016-06-16 Janssen Pharmaceutica, N.V. Formulations of 1- (5,6-dichloro-1h-benzo [d] imidazol-2-yl) -1h-pyrazol-4-carboxylic acid meglumine salt
EP2834220B1 (en) 2012-03-09 2016-11-09 Fibrogen, Inc. 4-hydroxy-isoquinoline compounds as hif hydroxylase inhibitors
KR20220164068A (en) 2012-07-16 2022-12-12 피브로겐, 인크. Crystalline forms of the prolyl hydroxylase inhibitor [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
CN103435546B (en) 2012-07-16 2016-08-10 菲布罗根有限公司 The method preparing isoquinoline compound
WO2014018881A1 (en) * 2012-07-27 2014-01-30 Biogen Idec Ma Inc. Atx modulating agents
CA2899024C (en) 2013-01-24 2022-01-04 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
IL296484A (en) 2013-06-06 2022-11-01 Fibrogen Inc Pharmaceutical formulations of a hif hydroxylase inhibitor
EP2915878A1 (en) 2014-03-07 2015-09-09 Institut Pasteur Method and device for conserving viable and functional human polymorphonuclear neutrophils
WO2016034108A1 (en) 2014-09-02 2016-03-10 广东东阳光药业有限公司 Quinolinone compound and use thereof
TWI699355B (en) 2014-12-24 2020-07-21 美商基利科學股份有限公司 Quinazoline compounds
CN107207498B (en) 2014-12-24 2020-03-24 吉利德科学公司 Fused pyrimidine compounds for the treatment of HIV
JP6356919B2 (en) * 2014-12-24 2018-07-11 ギリアード サイエンシーズ， インコーポレイテッド Isoquinoline compounds for the treatment of HIV
CN106146395B (en) 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3- hydroxypyridine compound, preparation method and its pharmaceutical applications
CN104892509B (en) * 2015-06-04 2018-03-09 苏州明锐医药科技有限公司 Nuo get Si Ta preparation method
KR102333180B1 (en) * 2015-08-05 2021-11-30 삼성전자주식회사 Electronic apparatus having a flexible display
CN106083720B (en) 2016-02-28 2018-09-11 深圳市塔吉瑞生物医药有限公司 A kind of substituted heteroaryl compound and the composition and application thereof comprising the compound
CN106478503A (en) * 2016-09-29 2017-03-08 上海勋和医药科技有限公司 The preparation method of Roxadustat intermediate
CN107954931B (en) * 2016-10-17 2021-06-22 上海医药集团青岛国风药业股份有限公司 Preparation method of nodispat
CN108017583B (en) * 2016-11-01 2021-04-06 徐州万邦金桥制药有限公司 Preparation method of kebomei
CN110878096A (en) * 2018-09-05 2020-03-13 石药集团中奇制药技术（石家庄）有限公司 1, 7-naphthyridine derivative and preparation method and application thereof
IT201800009318A1 (en) * 2018-10-10 2020-04-10 Luigi Frati Antioxidant compositions
AU2019375983A1 (en) 2018-11-09 2021-06-10 Vivace Therapeutics, Inc. Bicyclic compounds
CN113727983A (en) 2019-02-26 2021-11-30 拜耳公司 Fused bicyclic heterocyclic derivatives as pest control agents
AU2020229979A1 (en) 2019-02-26 2021-09-02 Bayer Aktiengesellschaft Fused bicyclic heterocycle derivatives as pesticides
KR20220016456A (en) 2019-04-16 2022-02-09 비바체 테라퓨틱스, 인크. bicyclic compounds
TW202120490A (en) 2019-07-30 2021-06-01 德商拜耳動物保健有限公司 New isoquinoline derivatives
WO2023111985A1 (en) * 2021-12-17 2023-06-22 Akebia Therapeutics, Inc. Picolinamide compounds as selective phd1 inhibitors, compositions, and methods of use

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108681A1 (en) * 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4036964A (en) * 1973-10-11 1977-07-19 Beecham Group Limited Isocarbostyril-3-carboxylic acid derivatives for the prophylaxis of asthma, hayfever and rhinitis
US3989704A (en) * 1973-10-30 1976-11-02 Sandoz, Inc. 3-Substituted-4-aryl isoquinolines
DE2818423A1 (en) * 1978-04-27 1979-11-08 Hoechst Ag NEW ISOCHINOLINE DERIVATIVES AND THE PROCESS FOR THEIR PRODUCTION
DE3233424A1 (en) * 1982-09-09 1984-03-15 Hoechst Ag, 6230 Frankfurt ISOCHINOL DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS AND THEIR USE
US4559403A (en) * 1983-05-19 1985-12-17 Hoffmann-La Roche Inc. Substituted isoquinolines
US4584379A (en) * 1985-01-22 1986-04-22 Merrell Dow Pharmaceuticals Inc. Isoquinoline thromboxane synthetase inhibitors
US4822800A (en) * 1986-06-09 1989-04-18 Ortho Pharmaceutical Corporation Isoquinolinol compounds having cardiotonic and phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties
US4966906A (en) * 1987-11-27 1990-10-30 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-isoquinolinecarboxamides
US4952588A (en) * 1987-11-27 1990-08-28 Hoechst-Roussel Pharmaceuticals Inc. 1-aryl-3-quinoline-and 1-aryl-3-isoquinoline-carboxamides
EP0532466A3 (en) 1991-09-12 1993-06-16 Ciba-Geigy Ag Derivatives of 5-amino-4-hydroxy-hexanoic acid and their therapeutical use
EP0626178A1 (en) 1993-05-17 1994-11-30 Ciba-Geigy Ag Use of inhibitors of HIV-protease for the treatment of tumorous diseases
DE59401924D1 (en) 1993-11-02 1997-04-10 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as medicines
DK0650960T3 (en) 1993-11-02 1997-09-01 Hoechst Ag Substituted heterocyclic carboxylic acid amide esters, their preparation and their use as drugs.
TW406076B (en) * 1993-12-30 2000-09-21 Hoechst Ag Substituted heterocyclic carboxamides, their preparation and their use as pharmaceuticals
US5563143A (en) 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
AU4515696A (en) 1994-12-12 1996-07-03 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
AP9600817A0 (en) * 1995-06-06 1996-07-31 Pfizer Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt.
IL135495A (en) * 1995-09-28 2002-12-01 Hoechst Ag Intermediate compounds for the preparation of substituted quinoline-2-carboxylic acid amides
AU5362998A (en) * 1996-11-27 1998-06-22 Du Pont Pharmaceuticals Company Novel integrin receptor antagonists
GB9707830D0 (en) 1997-04-18 1997-06-04 Smithkline Beecham Plc Novel compounds
WO1998050346A2 (en) 1997-04-18 1998-11-12 Smithkline Beecham Plc Acetamide and urea derivatives, process for their preparation and their use in the treatment of cns disorders
DE19746287A1 (en) 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituted isoquinoline-2-carboxylic acid amides, their preparation and their use as medicaments
FR2779963A1 (en) * 1998-06-22 1999-12-24 Centre Nat Rech Scient New composition useful for treat cancer, comprises compound with affinity for mitochondrial benzodiazepine receptors and agent to induce apoptosis
IT1302677B1 (en) * 1998-10-15 2000-09-29 Zambon Spa BENZAZINIC DERIVATIVES INHIBITORS OF PHOSPHODIESTERASE 4
AU4802500A (en) * 1999-04-26 2000-11-10 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
IT1320162B1 (en) 2000-02-09 2003-11-18 Rotta Research Lab DERIVATIVES OF THYROSIN WITH ANTI LEUKOTRIENIC ACTIVITY, PROCEDURES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE.
US7622503B2 (en) * 2000-08-24 2009-11-24 University Of Tennessee Research Foundation Selective androgen receptor modulators and methods of use thereof
FI20002044A0 (en) * 2000-09-15 2000-09-15 Orion Yhtymae Oyj Naphthalene derivatives which inhibit Comt enzymes
DE10110750A1 (en) 2001-03-07 2002-09-12 Bayer Ag Novel aminodicarboxylic acid derivatives with pharmaceutical properties
WO2002074981A2 (en) 2001-03-21 2002-09-26 Isis Innovation Ltd. Assays, methods and means relating to hypoxia inducible factor (hif) hydroxylase
WO2002101073A2 (en) 2001-06-13 2002-12-19 Genesoft Pharmaceuticals, Inc. Aryl-benzimidazole compounds having antiinfective activity
JP2005505507A (en) * 2001-06-13 2005-02-24 ジーンソフト ファーマシューティカルズ インコーポレイテッド Isoquinoline compounds having anti-infective activity
US7105544B2 (en) * 2001-07-05 2006-09-12 Synaptic Pharmaceutical Corporation Substituted alkyl amido piperidines
US6841566B2 (en) 2001-07-20 2005-01-11 Boehringer Ingelheim, Ltd. Viral polymerase inhibitors
EP2335700A1 (en) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C virus polymerase inhibitors with a heterobicylic structure
US7294457B2 (en) * 2001-08-07 2007-11-13 Boehringer Ingelheim (Canada) Ltd. Direct binding assay for identifying inhibitors of HCV polymerase
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
US6762318B2 (en) * 2001-12-03 2004-07-13 Novo Nordisk A/S Glucagon antagonists
CN102526044A (en) * 2001-12-06 2012-07-04 法布罗根股份有限公司 Methods of increasing endogenous erythropoietin EPO
GB0206711D0 (en) 2002-03-21 2002-05-01 Isis Innovation HIF Inhibitor
US7618940B2 (en) * 2002-12-06 2009-11-17 Fibrogen, Inc. Fat regulation
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
US8614204B2 (en) * 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
US20060251638A1 (en) * 2003-06-06 2006-11-09 Volkmar Guenzler-Pukall Cytoprotection through the use of hif hydroxylase inhibitors
CA2532064A1 (en) 2003-07-15 2005-02-03 Merck & Co., Inc. Hydroxypyridine cgrp receptor antagonists
US7208601B2 (en) * 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
CA2531796A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
EP1766047B1 (en) 2004-05-28 2009-09-23 Fibrogen, Inc. Hif prolyl hydroxylase activity assay
JP2008507097A (en) * 2004-07-15 2008-03-06 パワープリサイス・ソリューションズ・インコーポレーテッド One-time operating state detection method and apparatus
EP1676834A1 (en) 2004-12-30 2006-07-05 Sanofi-Aventis Deutschland GmbH Fused bicyclic carboxamide derivates for use as CXCR2 inhibitors in the treatment of inflammation
US8703795B2 (en) * 2005-03-02 2014-04-22 Fibrogen, Inc. Thienopyridine compounds, and methods of use thereof
CN101394843A (en) * 2005-06-06 2009-03-25 菲布罗根公司 Improved treatment for anemia using a HIF-alpha stabilising agent
CA2611785A1 (en) * 2005-06-15 2006-12-28 Fibrogen, Inc. Use of hif 1alfa modulators for treatment of cancer
BRPI0707302B8 (en) * 2006-01-27 2021-05-25 Fibrogen Inc cyanoisoquinoline compounds that act on tissue damage associated with ischemia, hypoxia and anemia, as well as pharmaceutical composition comprising them
CA2647596C (en) * 2006-04-04 2012-06-12 Fibrogen, Inc. Pyrrolo- and thiazolo-pyridine compounds as hif modulators
US20070293575A1 (en) * 2006-06-15 2007-12-20 Fibrogen, Inc. Compounds and methods for treatment of cancer-related anemia
US7713986B2 (en) * 2006-06-15 2010-05-11 Fibrogen, Inc. Compounds and methods for treatment of chemotherapy-induced anemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108681A1 (en) * 2003-06-06 2004-12-16 Fibrogen, Inc. Nitrogen-containing heteroaryl compounds and their use in increasing endogenous erythropoietin

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927591B2 (en) 2008-11-14 2015-01-06 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
US9149476B2 (en) 2008-11-14 2015-10-06 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors

Also Published As

Publication number Publication date
AU2007211077A8 (en) 2008-09-04
EP2476669A1 (en) 2012-07-18
US20160009653A1 (en) 2016-01-14
EP2044028A2 (en) 2009-04-08
KR101446499B1 (en) 2014-10-06
US20110212959A1 (en) 2011-09-01
ZA200806752B (en) 2009-10-28
US7928120B2 (en) 2011-04-19
KR20140089446A (en) 2014-07-14
CA2640435C (en) 2011-11-01
NO20083658L (en) 2008-10-27
CN101374815A (en) 2009-02-25
HK1129114A1 (en) 2009-11-20
IL193047A0 (en) 2009-02-11
BRPI0707302B8 (en) 2021-05-25
RU2457204C2 (en) 2012-07-27
RU2008134664A (en) 2010-03-10
NO342678B1 (en) 2018-06-25
US20070298104A1 (en) 2007-12-27
WO2007090068A2 (en) 2007-08-09
CN103382216B (en) 2016-04-20
US20120178755A1 (en) 2012-07-12
EP2044028B1 (en) 2012-05-16
AU2007211077B2 (en) 2012-09-20
BRPI0707302A2 (en) 2011-05-03
CN103382216A (en) 2013-11-06
US8759373B2 (en) 2014-06-24
IL193047A (en) 2014-01-30
CA2640435A1 (en) 2007-08-09
KR20080101938A (en) 2008-11-21
CN102351791B (en) 2014-10-29
CN101374815B (en) 2013-07-17
AU2007211077A1 (en) 2007-08-09
JP2009524694A (en) 2009-07-02
DK2044028T3 (en) 2012-08-20
US9174976B2 (en) 2015-11-03
BRPI0707302B1 (en) 2020-03-10
MX2008009581A (en) 2009-01-07
JP5161793B2 (en) 2013-03-13
US20150031696A1 (en) 2015-01-29
CN102351791A (en) 2012-02-15

Similar Documents

Publication Publication Date Title
WO2007090068A3 (en) Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
IL257622B (en) Methods and compositions for the treatment of persistent infections
WO2007115821A3 (en) Organic compounds
WO2007115315A3 (en) Pyrrolo- and thiazolo-pyridine compounds as hif modulators
WO2008002571A3 (en) Human protein tyrosine phosphatase inhibitors and methods of use
WO2009155001A3 (en) Wnt protein signalling inhibitors
MX2009006535A (en) Indol-4-yl-pyrimidinyl-2-yl-amine derivatives and use thereof as cyclin dependant kinase inhibitors.
WO2007001851A3 (en) Compositions and methods for the diagnosis and treatment of tumor
WO2007101864A3 (en) Compounds that modulate ppar activity, their preparation and use
WO2009026179A3 (en) Antiinfective proanthocyanidin compounds and methods of use thereof
WO2007137066A3 (en) HETEROCYCLIC INHIBITORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE I AND METHODS OF USING THE SAME
WO2008033562A3 (en) Kinase inhibitor compounds
WO2008067219A3 (en) Quinazolinone modulators of tgr5
WO2007088123A3 (en) Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
WO2010056767A8 (en) Thiochromene derivatives as hif hydroxylase inhibitors
WO2010068794A3 (en) Hif inhibitors and use thereof
MX2009010960A (en) Heterocyclic compounds and their methods of use.
WO2008086462A3 (en) AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS
WO2008132021A3 (en) Fungicide mixtures
EP1907013A4 (en) Compositions and methods for the treatment or prevention of chemoresistant neoplasia
PL1922128T3 (en) Element for reducing the particulate matter content of air by the use of mosses and/or lichens
SG158091A1 (en) Imidazoazepinone compounds
WO2009062576A3 (en) Benzimidazoledihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, and pharmaceutical compositions comprising same
WO2008061108A3 (en) Phthalazine derivatives
WO2007109088A3 (en) Combinationtherapies of thiazolidinedione analogues and glucocorticoid agonists

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 193047

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 200780003599.2

Country of ref document: CN

Ref document number: 2008552602

Country of ref document: JP

Ref document number: 2640435

Country of ref document: CA

Ref document number: MX/A/2008/009581

Country of ref document: MX

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007211077

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 3367/KOLNP/2008

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2007717454

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008134664

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020087020971

Country of ref document: KR

ENP Entry into the national phase

Ref document number: PI0707302

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20080728