WO2007090147A3 - Method and apparatus for measurement of optical properties in tissue - Google Patents

Method and apparatus for measurement of optical properties in tissue Download PDF

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Publication number
WO2007090147A3
WO2007090147A3 PCT/US2007/061364 US2007061364W WO2007090147A3 WO 2007090147 A3 WO2007090147 A3 WO 2007090147A3 US 2007061364 W US2007061364 W US 2007061364W WO 2007090147 A3 WO2007090147 A3 WO 2007090147A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
measurement
optical properties
radiation
sample signal
Prior art date
Application number
PCT/US2007/061364
Other languages
French (fr)
Other versions
WO2007090147A2 (en
Inventor
Adam M Zysk
Steven G Adie
Matthew S Leigh
Julian J Armstrong
David D Sampson
Stephen A Boppart
Original Assignee
Univ Illinois
Adam M Zysk
Steven G Adie
Matthew S Leigh
Julian J Armstrong
David D Sampson
Stephen A Boppart
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois, Adam M Zysk, Steven G Adie, Matthew S Leigh, Julian J Armstrong, David D Sampson, Stephen A Boppart filed Critical Univ Illinois
Priority to AU2007211061A priority Critical patent/AU2007211061B2/en
Publication of WO2007090147A2 publication Critical patent/WO2007090147A2/en
Publication of WO2007090147A3 publication Critical patent/WO2007090147A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography

Abstract

A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.
PCT/US2007/061364 2006-01-31 2007-01-31 Method and apparatus for measurement of optical properties in tissue WO2007090147A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2007211061A AU2007211061B2 (en) 2006-01-31 2007-01-31 Method and apparatus for measurement of optical properties in tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76417806P 2006-01-31 2006-01-31
US60/764,178 2006-01-31

Publications (2)

Publication Number Publication Date
WO2007090147A2 WO2007090147A2 (en) 2007-08-09
WO2007090147A3 true WO2007090147A3 (en) 2008-08-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061364 WO2007090147A2 (en) 2006-01-31 2007-01-31 Method and apparatus for measurement of optical properties in tissue

Country Status (3)

Country Link
US (1) US7787129B2 (en)
AU (1) AU2007211061B2 (en)
WO (1) WO2007090147A2 (en)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002230842A1 (en) 2000-10-30 2002-05-15 The General Hospital Corporation Optical methods and systems for tissue analysis
US7623908B2 (en) * 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
US7567349B2 (en) 2003-03-31 2009-07-28 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
US20080235055A1 (en) * 2003-07-17 2008-09-25 Scott Mattingly Laboratory instrumentation information management and control network
US7447408B2 (en) 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
EP2272421A1 (en) 2004-08-24 2011-01-12 The General Hospital Corporation Method and apparatus for imaging of vessel segments
US8922781B2 (en) 2004-11-29 2014-12-30 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US7586618B2 (en) 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7725169B2 (en) * 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
KR101410867B1 (en) 2005-04-28 2014-06-23 더 제너럴 하스피탈 코포레이션 Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique
EP1889037A2 (en) 2005-06-01 2008-02-20 The General Hospital Corporation Apparatus, method and system for performing phase-resolved optical frequency domain imaging
DE602006017558D1 (en) 2005-08-09 2010-11-25 Gen Hospital Corp DEVICE AND METHOD FOR CARRYING OUT POLARIZATION-BASED QUADRATURE DEMODULATION IN OPTICAL COHERENCE TOMOGRAPHY
EP1937137B1 (en) 2005-09-29 2022-06-15 General Hospital Corporation Method and apparatus for optical imaging via spectral encoding
US7603161B2 (en) * 2005-12-30 2009-10-13 Medtronic, Inc. Position detection in a magnetic field
US9087368B2 (en) 2006-01-19 2015-07-21 The General Hospital Corporation Methods and systems for optical imaging or epithelial luminal organs by beam scanning thereof
US8145018B2 (en) 2006-01-19 2012-03-27 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and methods for producing one or more optical arrangements
WO2007090147A2 (en) 2006-01-31 2007-08-09 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
US10426548B2 (en) 2006-02-01 2019-10-01 The General Hosppital Corporation Methods and systems for providing electromagnetic radiation to at least one portion of a sample using conformal laser therapy procedures
EP2659852A3 (en) 2006-02-01 2014-01-15 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
WO2007101026A2 (en) 2006-02-24 2007-09-07 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
WO2007133961A2 (en) 2006-05-10 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
US8115934B2 (en) 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography
US8983580B2 (en) 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US7751057B2 (en) 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
WO2009137701A2 (en) 2008-05-07 2009-11-12 The General Hospital Corporation System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
CN102046071B (en) * 2008-06-02 2013-11-06 光学实验室成像公司 Quantitative methods for obtaining tissue characteristics from optical coherence tomography images
EP2309923B1 (en) 2008-07-14 2020-11-25 The General Hospital Corporation Apparatus and methods for color endoscopy
WO2010090837A2 (en) 2009-01-20 2010-08-12 The General Hospital Corporation Endoscopic biopsy apparatus, system and method
RU2526929C2 (en) * 2009-01-23 2014-08-27 Конинклейке Филипс Электроникс Н.В. Optical research device, made with possibility of, at least, partial placement into turbid medium
JP6053284B2 (en) 2009-02-04 2016-12-27 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for use of a high speed optical wavelength tuning source
JP5819823B2 (en) 2009-07-14 2015-11-24 ザ ジェネラル ホスピタル コーポレイション Device for measuring the flow and pressure inside a blood vessel and method of operating the device
US9089331B2 (en) 2009-07-31 2015-07-28 Case Western Reserve University Characterizing ablation lesions using optical coherence tomography (OCT)
EP2542145B1 (en) 2010-03-05 2020-08-12 The General Hospital Corporation Systems which provide microscopic images of at least one anatomical structure at a particular resolution
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
WO2011150069A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
WO2011149972A2 (en) 2010-05-25 2011-12-01 The General Hospital Corporation Systems, devices, methods, apparatus and computer-accessible media for providing optical imaging of structures and compositions
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US20120265062A1 (en) * 2011-04-13 2012-10-18 St. Jude Medical, Inc. Optical coherence tomography catheter for elastographic property mapping of lumens utilizing micropalpation
WO2012149175A1 (en) * 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
JP2013004903A (en) * 2011-06-21 2013-01-07 Canon Inc Semiconductor optical integrated element and optical tomograph equipped with the same
WO2013013049A1 (en) 2011-07-19 2013-01-24 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
WO2013066631A1 (en) 2011-10-18 2013-05-10 The General Hospital Corporation Apparatus and methods for producing and/or providing recirculating optical delay(s)
EP2775903B1 (en) * 2011-11-10 2020-04-29 OncoRes Medical Pty Ltd. Device for characterising a mechanical property of a material
WO2013148306A1 (en) 2012-03-30 2013-10-03 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
US11490797B2 (en) 2012-05-21 2022-11-08 The General Hospital Corporation Apparatus, device and method for capsule microscopy
JP5861000B2 (en) 2012-06-26 2016-02-16 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． Biopsy needle with large fiber spacing at the tip
US20140034829A1 (en) * 2012-08-06 2014-02-06 Peter Crozier System and method for irradiating an etem-sample with light
JP6227652B2 (en) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション System, method, and computer-accessible medium for fabricating a miniature endoscope using soft lithography
EP2929327B1 (en) 2012-12-05 2019-08-14 Perimeter Medical Imaging, Inc. System and method for wide field oct imaging
EP2741110A1 (en) * 2012-12-06 2014-06-11 Services Pétroliers Schlumberger Downhole gas-filled radiation detector with optical fiber
US20140200446A1 (en) * 2013-01-16 2014-07-17 Thomas Haider Method and apparatus for the infusion of a catheter into an artery/vein and for suspected tissue removal
JP6560126B2 (en) 2013-01-28 2019-08-14 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for providing diffusion spectroscopy superimposed on optical frequency domain imaging
US10893806B2 (en) 2013-01-29 2021-01-19 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
JP6378311B2 (en) 2013-03-15 2018-08-22 ザ ジェネラル ホスピタル コーポレイション Methods and systems for characterizing objects
WO2014186353A1 (en) 2013-05-13 2014-11-20 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
EP4349242A2 (en) 2013-07-19 2024-04-10 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
WO2015013651A2 (en) 2013-07-26 2015-01-29 The General Hospital Corporation System, apparatus and method utilizing optical dispersion for fourier-domain optical coherence tomography
US9867528B1 (en) 2013-08-26 2018-01-16 The Board Of Trustees Of The University Of Illinois Quantitative pneumatic otoscopy using coherent light ranging techniques
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
US10736494B2 (en) 2014-01-31 2020-08-11 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
US9301691B2 (en) 2014-02-21 2016-04-05 Covidien Lp Instrument for optically detecting tissue attributes
US10228556B2 (en) 2014-04-04 2019-03-12 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
US20160007840A1 (en) 2014-07-10 2016-01-14 The Board Of Trustees Of The University Of Illinois Handheld Device for Identification of Microbiological Constituents in the Middle Ear
KR102513779B1 (en) 2014-07-25 2023-03-24 더 제너럴 하스피탈 코포레이션 Apparatus, devices and methods for in vivo imaging and diagnosis
KR20160014470A (en) * 2014-07-29 2016-02-11 삼성전자주식회사 Apparatus and method for supporting computer aided diagnosis based on providing non-visual information, and computer aided diagnosis system
CN112634267A (en) 2014-12-12 2021-04-09 光学实验室成像公司 System and method for detecting and displaying intravascular features
WO2016127065A1 (en) * 2015-02-05 2016-08-11 The General Hospital Corporation Dba Massachusetts General Hospital Non-invasive visualization and quantification of natural pigments
US10571390B2 (en) * 2015-12-21 2020-02-25 The Boeing Company Composite inspection
US10401141B2 (en) 2016-12-01 2019-09-03 The Board Of Trustees Of The University Of Illinois Method and apparatus for obtaining a three-dimensional map of tympanic membrane thickness
US11445915B2 (en) 2016-12-01 2022-09-20 The Board Of Trustees Of The University Of Illinois Compact briefcase OCT system for point-of-care imaging
US10258238B2 (en) 2017-02-17 2019-04-16 The Board Of Trustees Of The University Of Illinois Method and apparatus for OCT-based viscometry
WO2018156984A1 (en) * 2017-02-23 2018-08-30 Beth Israel Deaconess Medical Center, Inc. Method and apparatus to determine the malignant potential of pancreatic cysts using light scattering spectroscopy
EP3655748B1 (en) 2017-07-18 2023-08-09 Perimeter Medical Imaging, Inc. Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis
WO2019147908A1 (en) * 2018-01-26 2019-08-01 Diagnostic Photonics, Inc. Method and apparatus for classifying core biopsy specimens with optical coherence tomography
US11446055B1 (en) 2018-10-18 2022-09-20 Lumoptik, Inc. Light assisted needle placement system and method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990001697A1 (en) * 1988-08-05 1990-02-22 Red Kite Technology Limited Blood glucose monitoring
WO2000042912A1 (en) * 1999-01-25 2000-07-27 Massachusetts Institute Of Technology Polarized light scattering spectroscopy of tissue
WO2002088705A2 (en) * 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US20040186359A1 (en) * 2001-07-09 2004-09-23 Beaudoin Stephen P. Afinity biosensor for monitoring biological process

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US5199431A (en) * 1985-03-22 1993-04-06 Massachusetts Institute Of Technology Optical needle for spectroscopic diagnosis
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5095487A (en) 1990-12-14 1992-03-10 The University Of Rochester System for generating pluralities of optical pulses with predetermined frequencies in a temporally and spatially overlapped relationship
US6246892B1 (en) 1991-01-24 2001-06-12 Non-Invasive Technology Phase modulation spectroscopy
US5280788A (en) * 1991-02-26 1994-01-25 Massachusetts Institute Of Technology Devices and methods for optical diagnosis of tissue
CA2104960C (en) * 1991-02-26 2005-04-05 Richard P. Rava Systems and methods of molecular spectroscopy to provide for the diagnosis of tissue
US6485413B1 (en) * 1991-04-29 2002-11-26 The General Hospital Corporation Methods and apparatus for forward-directed optical scanning instruments
US6564087B1 (en) 1991-04-29 2003-05-13 Massachusetts Institute Of Technology Fiber optic needle probes for optical coherence tomography imaging
DE69227902T3 (en) 1991-04-29 2010-04-22 Massachusetts Institute Of Technology, Cambridge DEVICE FOR OPTICAL IMAGING AND MEASUREMENT
US6111645A (en) * 1991-04-29 2000-08-29 Massachusetts Institute Of Technology Grating based phase control optical delay line
US6134003A (en) * 1991-04-29 2000-10-17 Massachusetts Institute Of Technology Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope
MX9205298A (en) 1991-09-17 1993-05-01 Steven Carl Quay GASEOUS ULTRASOUND CONTRASTING MEDIA AND METHOD FOR SELECTING GASES TO BE USED AS ULTRASOUND CONTRASTING MEDIA
US5247343A (en) 1991-11-01 1993-09-21 Nicolet Instrument Corporation Raman spectrometer having interferometer with optical substraction filters
WO1993024476A1 (en) 1992-06-04 1993-12-09 Clover Consolidated, Limited Water-soluble polymeric carriers for drug delivery
US5303710A (en) 1992-11-03 1994-04-19 The United States Of America As Represented By The Secretary Of The Navy Apparatus for imaging an object in or through a scattering medium using coherent anti-Stokes Raman scattering
US5665383A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of immunostimulating agents for in vivo delivery
US5650156A (en) 1993-02-22 1997-07-22 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of nutriceuticals and compositions useful therefor
US5439686A (en) 1993-02-22 1995-08-08 Vivorx Pharmaceuticals, Inc. Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor
US5665382A (en) 1993-02-22 1997-09-09 Vivorx Pharmaceuticals, Inc. Methods for the preparation of pharmaceutically active agents for in vivo delivery
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
BR9405798A (en) 1993-02-22 1995-12-12 Vivorx Pharmaceuticals Inc Methods for in vivo release of biological material and useful compositions thereof
EP0711179B2 (en) 1993-07-30 2010-09-01 IMCOR Pharmaceutical Co. Stabilized microbubble compositions for ultrasound
US5995645A (en) * 1993-08-18 1999-11-30 Applied Spectral Imaging Ltd. Method of cancer cell detection
US5451785A (en) * 1994-03-18 1995-09-19 Sri International Upconverting and time-gated two-dimensional infrared transillumination imaging
US6159445A (en) 1994-07-20 2000-12-12 Nycomed Imaging As Light imaging contrast agents
GB2292119B (en) 1994-08-10 1998-12-30 Chemitech Inc A process for producing a magnetic display sheet using microcapsules
US5491524A (en) * 1994-10-05 1996-02-13 Carl Zeiss, Inc. Optical coherence tomography corneal mapping apparatus
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6262706B1 (en) 1995-07-20 2001-07-17 E Ink Corporation Retroreflective electrophoretic displays and materials for making the same
US7106296B1 (en) 1995-07-20 2006-09-12 E Ink Corporation Electronic book with multiple page displays
US5799055A (en) * 1996-05-15 1998-08-25 Northwestern University Apparatus and method for planning a stereotactic surgical procedure using coordinated fluoroscopy
GB9610830D0 (en) 1996-05-23 1996-07-31 Andaris Ltd Use of hollow microcapsules
US5930026A (en) 1996-10-25 1999-07-27 Massachusetts Institute Of Technology Nonemissive displays and piezoelectric power supplies therefor
US5752518A (en) * 1996-10-28 1998-05-19 Ep Technologies, Inc. Systems and methods for visualizing interior regions of the body
US6264917B1 (en) 1996-10-28 2001-07-24 Nycomed Imaging As Targeted ultrasound contrast agents
US6068600A (en) 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
US5891619A (en) * 1997-01-14 1999-04-06 Inphocyte, Inc. System and method for mapping the distribution of normal and abnormal cells in sections of tissue
US5760901A (en) * 1997-01-28 1998-06-02 Zetetic Institute Method and apparatus for confocal interference microscopy with background amplitude reduction and compensation
US5836877A (en) * 1997-02-24 1998-11-17 Lucid Inc System for facilitating pathological examination of a lesion in tissue
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US5994690A (en) * 1997-03-17 1999-11-30 Kulkarni; Manish D. Image enhancement in optical coherence tomography using deconvolution
US6208886B1 (en) 1997-04-04 2001-03-27 The Research Foundation Of City College Of New York Non-linear optical tomography of turbid media
US6002480A (en) 1997-06-02 1999-12-14 Izatt; Joseph A. Depth-resolved spectroscopic optical coherence tomography
US5921926A (en) * 1997-07-28 1999-07-13 University Of Central Florida Three dimensional optical imaging colposcopy
ATE278352T1 (en) 1997-08-09 2004-10-15 Roche Diagnostics Gmbh ANALYZING DEVICE FOR IN-VIVO ANALYSIS IN A PATIENT'S BODY
US6300932B1 (en) 1997-08-28 2001-10-09 E Ink Corporation Electrophoretic displays with luminescent particles and materials for making the same
US6091984A (en) * 1997-10-10 2000-07-18 Massachusetts Institute Of Technology Measuring tissue morphology
AU1047399A (en) 1997-11-12 1999-05-31 Nycomed Imaging As Para-hydrogen labelled agents and their use in magnetic resonance imaging
US6037579A (en) * 1997-11-13 2000-03-14 Biophotonics Information Laboratories, Ltd. Optical interferometer employing multiple detectors to detect spatially distorted wavefront in imaging of scattering media
JP2001513205A (en) 1997-12-19 2001-08-28 シュウ，バーナード System and method for evaluating bond integrity by laser ultrasound
US5914806A (en) 1998-02-11 1999-06-22 International Business Machines Corporation Stable electrophoretic particles for displays
US6363163B1 (en) 1998-02-23 2002-03-26 Arch Development Corporation Method and system for the automated temporal subtraction of medical images
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US6201608B1 (en) 1998-03-13 2001-03-13 Optical Biopsy Technologies, Inc. Method and apparatus for measuring optical reflectivity and imaging through a scattering medium
US6560478B1 (en) * 1998-03-16 2003-05-06 The Research Foundation Of City University Of New York Method and system for examining biological materials using low power CW excitation Raman spectroscopy
US6151522A (en) * 1998-03-16 2000-11-21 The Research Foundation Of Cuny Method and system for examining biological materials using low power CW excitation raman spectroscopy
US6002476A (en) * 1998-04-22 1999-12-14 Chemicon Inc. Chemical imaging system
US6137585A (en) 1998-05-15 2000-10-24 Laser Diagnostic Technologies, Inc. Method and apparatus for recording three-dimensional distribution of light backscattering potential in transparent and semi-transparent structures
US6108081A (en) 1998-07-20 2000-08-22 Battelle Memorial Institute Nonlinear vibrational microscopy
WO2000020921A1 (en) 1998-10-07 2000-04-13 E Ink Corporation Capsules for electrophoretic displays and methods for making the same
US6219137B1 (en) 1998-12-03 2001-04-17 Lockheed Martin Energy Research Corporation Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening
US6312304B1 (en) 1998-12-15 2001-11-06 E Ink Corporation Assembly of microencapsulated electronic displays
US6538805B1 (en) 1999-02-19 2003-03-25 Photon-X, Inc. Codopant polymers for efficient optical amplification
US6574401B2 (en) 1999-03-30 2003-06-03 Ceramoptec Industries, Inc. Optical fiber-handpiece combination for medical laser treatments
US6167297A (en) 1999-05-05 2000-12-26 Benaron; David A. Detecting, localizing, and targeting internal sites in vivo using optical contrast agents
JP2003500861A (en) 1999-05-21 2003-01-07 ギガオプティクス・ゲーエムベーハー Passive mode-locked femtosecond laser
PT1226422E (en) 1999-10-06 2008-03-04 Oxonica Inc Surface enhanced spectroscopy-active composite nanoparticles
US6539156B1 (en) 1999-11-02 2003-03-25 Georgia Tech Research Corporation Apparatus and method of optical transfer and control in plasmon supporting metal nanostructures
JP2004500197A (en) 2000-02-08 2004-01-08 コーネル　リサーチ　ファンデーション　インコーポレーテッド Multiphoton excitation for fluorescence spectroscopy through optical fibers
US6530944B2 (en) 2000-02-08 2003-03-11 Rice University Optically-active nanoparticles for use in therapeutic and diagnostic methods
EP1154224A1 (en) 2000-05-09 2001-11-14 Fuji Photo Film Co., Ltd. Optical coherence tomography apparatus using optical-waveguide structure which reduces pulse width of low-coherence light
US6529277B1 (en) 2000-07-07 2003-03-04 California Institute Of Technology Optical devices based on resonant configurational effects
US6534039B2 (en) 2000-07-21 2003-03-18 James F. Hainfeld Extended organic cobalt and nickel magnetic complexes
EP1312912A4 (en) 2000-07-27 2005-09-21 Hamamatsu Photonics Kk Light track observing device
KR100867392B1 (en) 2000-08-15 2008-11-06 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 Microparticles
US6690962B2 (en) 2000-09-15 2004-02-10 Institut fur Diagnostikforshung GmbH Process for graphic visualization and diagnosis of thrombi by means of nuclear spin tomography with use of particulate contrast media
US6615063B1 (en) * 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
US7383076B2 (en) * 2000-11-27 2008-06-03 The General Hospital Corporation Fluorescence-mediated molecular tomography
WO2002084821A2 (en) 2001-04-11 2002-10-24 University Of Southampton Sources of, and methods for generating, optical pulses
US6899947B2 (en) 2001-08-14 2005-05-31 Purdue Research Foundation Nanoparticle arrays and sensors using same
US20030045798A1 (en) 2001-09-04 2003-03-06 Richard Hular Multisensor probe for tissue identification
DE10151670A1 (en) 2001-10-19 2003-05-08 Siemens Ag Imaging method and imaging device, in particular for small animal imaging
US6689067B2 (en) * 2001-11-28 2004-02-10 Siemens Corporate Research, Inc. Method and apparatus for ultrasound guidance of needle biopsies
US6825928B2 (en) 2001-12-19 2004-11-30 Wisconsin Alumni Research Foundation Depth-resolved fluorescence instrument
US6795777B1 (en) 2002-03-04 2004-09-21 The Texas A&M University System Identifying molecules of a sample
EP1487343B1 (en) 2002-03-05 2008-12-31 Board of Regents, The University of Texas System Biospecific contrast agents
US6824516B2 (en) * 2002-03-11 2004-11-30 Medsci Technologies, Inc. System for examining, mapping, diagnosing, and treating diseases of the prostate
US20040058458A1 (en) 2002-04-18 2004-03-25 The Regents Of The University Of Michigan Modulated chemical sensors
US7075658B2 (en) * 2003-01-24 2006-07-11 Duke University Method for optical coherence tomography imaging with molecular contrast
US7623908B2 (en) * 2003-01-24 2009-11-24 The Board Of Trustees Of The University Of Illinois Nonlinear interferometric vibrational imaging
JP2006516739A (en) 2003-01-24 2006-07-06 ザ・ジェネラル・ホスピタル・コーポレイション System and method for identifying tissue using a low coherence interferometer
DE10305599A1 (en) 2003-02-11 2004-08-26 Richard Wolf Gmbh Tissue diagnostic imaging device
US7181266B2 (en) * 2003-03-04 2007-02-20 Massachusetts Institute Of Technology Materials and methods for near-infrared and infrared lymph node mapping
EP1610684A2 (en) 2003-03-17 2006-01-04 Da Silva, Luiz B. Optical biopsy system with single use needle probe
US20050149002A1 (en) 2003-04-08 2005-07-07 Xingwu Wang Markers for visualizing interventional medical devices
KR100554155B1 (en) 2003-06-09 2006-02-22 학교법인 포항공과대학교 Contacts fabric using heterostructure of metal/semiconductor nanorods and fabrication method thereof
US7198777B2 (en) * 2003-06-17 2007-04-03 The Board Of Trustees Of The University Of Illinois Optical contrast agents for optically modifying incident radiation
US7217410B2 (en) * 2003-06-17 2007-05-15 The Board Of Trustees Of The Universtiy Of Illinois Surface modified protein microparticles
DE10347712A1 (en) 2003-10-14 2005-05-12 Leica Microsystems scanning microscope
US7610074B2 (en) * 2004-01-08 2009-10-27 The Board Of Trustees Of The University Of Illinois Multi-functional plasmon-resonant contrast agents for optical coherence tomography
JP4602993B2 (en) * 2004-01-16 2010-12-22 ボストン サイエンティフィック リミテッド Method and apparatus for medical imaging
US20060281068A1 (en) * 2005-06-09 2006-12-14 Chemimage Corp. Cytological methods for detecting a disease condition such as malignancy by Raman spectroscopic imaging
US7184148B2 (en) * 2004-05-14 2007-02-27 Medeikon Corporation Low coherence interferometry utilizing phase
AU2005266943C1 (en) * 2004-07-23 2011-01-06 Citrix Systems, Inc. Systems and methods for optimizing communications between network nodes
KR101332222B1 (en) 2004-08-06 2013-11-22 더 제너럴 하스피탈 코포레이션 Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
US7289203B2 (en) 2004-09-30 2007-10-30 Chromaplex, Inc. Method and system for spectral analysis of biological materials using stimulated cars
EP2278266A3 (en) * 2004-11-24 2011-06-29 The General Hospital Corporation Common-Path Interferometer for Endoscopic OCT
US7586618B2 (en) 2005-02-28 2009-09-08 The Board Of Trustees Of The University Of Illinois Distinguishing non-resonant four-wave-mixing noise in coherent stokes and anti-stokes Raman scattering
US7725169B2 (en) 2005-04-15 2010-05-25 The Board Of Trustees Of The University Of Illinois Contrast enhanced spectroscopic optical coherence tomography
WO2007090147A2 (en) 2006-01-31 2007-08-09 The Board Of Trustees Of The University Of Illinois Method and apparatus for measurement of optical properties in tissue
WO2008008774A2 (en) * 2006-07-10 2008-01-17 The Board Of Trustees Of The University Of Illinois Interferometric synthetic aperture microscopy
US8983580B2 (en) * 2008-01-18 2015-03-17 The Board Of Trustees Of The University Of Illinois Low-coherence interferometry and optical coherence tomography for image-guided surgical treatment of solid tumors
US7751057B2 (en) * 2008-01-18 2010-07-06 The Board Of Trustees Of The University Of Illinois Magnetomotive optical coherence tomography
US8115934B2 (en) * 2008-01-18 2012-02-14 The Board Of Trustees Of The University Of Illinois Device and method for imaging the ear using optical coherence tomography

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990001697A1 (en) * 1988-08-05 1990-02-22 Red Kite Technology Limited Blood glucose monitoring
WO2000042912A1 (en) * 1999-01-25 2000-07-27 Massachusetts Institute Of Technology Polarized light scattering spectroscopy of tissue
WO2002088705A2 (en) * 2001-05-01 2002-11-07 The General Hospital Corporation Method and apparatus for determination of atherosclerotic plaque type by measurement of tissue optical properties
US20040186359A1 (en) * 2001-07-09 2004-09-23 Beaudoin Stephen P. Afinity biosensor for monitoring biological process

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