WO2007098297A3 - Method for diagnosing and treating kidney cancer - Google Patents

Method for diagnosing and treating kidney cancer Download PDF

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Publication number
WO2007098297A3
WO2007098297A3 PCT/US2007/005378 US2007005378W WO2007098297A3 WO 2007098297 A3 WO2007098297 A3 WO 2007098297A3 US 2007005378 W US2007005378 W US 2007005378W WO 2007098297 A3 WO2007098297 A3 WO 2007098297A3
Authority
WO
WIPO (PCT)
Prior art keywords
kidney cancer
diagnosing
treating kidney
normal tissue
compared
Prior art date
Application number
PCT/US2007/005378
Other languages
French (fr)
Other versions
WO2007098297A2 (en
Inventor
Bruce Wang
Matthias Wabl
Original Assignee
Picobella Llc
Bruce Wang
Matthias Wabl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Picobella Llc, Bruce Wang, Matthias Wabl filed Critical Picobella Llc
Publication of WO2007098297A2 publication Critical patent/WO2007098297A2/en
Publication of WO2007098297A3 publication Critical patent/WO2007098297A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038—Kidney, bladder
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

Methods, reagents and kits for diagnosing and treating kidney cancer are disclosed. An immunoassay for detecting kidney cancer is based on the relative change of the CELSR1 protein in urine or blood compared with normal tissue. An immunohistochemical assay for detecting kidney cancer is based on the relative absence of labeled antibody binding to cancerous tissue, compared with normal tissue.
PCT/US2007/005378 2006-02-27 2007-02-27 Method for diagnosing and treating kidney cancer WO2007098297A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/363,596 US7459280B2 (en) 2006-02-27 2006-02-27 Methods for diagnosing and treating kidney cancer
US11/363,596 2006-02-27

Publications (2)

Publication Number Publication Date
WO2007098297A2 WO2007098297A2 (en) 2007-08-30
WO2007098297A3 true WO2007098297A3 (en) 2009-04-09

Family

ID=38438035

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005378 WO2007098297A2 (en) 2006-02-27 2007-02-27 Method for diagnosing and treating kidney cancer

Country Status (2)

Country Link
US (2) US7459280B2 (en)
WO (1) WO2007098297A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3779444A1 (en) 2008-01-18 2021-02-17 President and Fellows of Harvard College Methods of detecting signatures of disease or conditions in bodily fluids
CZ303555B6 (en) * 2009-08-04 2012-12-05 Masarykova Univerzita Method of determining severity and prognosis of B-cell chronic lymphocytic leukemia
CA2806293A1 (en) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methods of detecting autoimmune or immune-related diseases or conditions
AU2011281007A1 (en) 2010-07-23 2013-02-28 President And Fellows Of Harvard College Methods of detecting kidney-associated diseases or conditions
EA201390149A1 (en) 2010-07-23 2013-08-30 Президент Энд Феллоуз Оф Гарвард Колледж METHODS FOR DETECTING DISEASES OR PATHOLOGICAL CONDITIONS USING PHAGOCYTARY CELLS
CN103119179A (en) 2010-07-23 2013-05-22 哈佛大学校长及研究员协会 Methods for detecting signatures of disease or conditions in bodily fluids
EP2596353A4 (en) 2010-07-23 2014-01-15 Harvard College Methods of detecting prenatal or pregnancy-related diseases or conditions
WO2014164362A1 (en) 2013-03-09 2014-10-09 Harry Stylli Methods of detecting prostate cancer
NZ771629A (en) 2013-03-09 2022-12-23 Harry Stylli Methods of detecting cancer
US10626464B2 (en) 2014-09-11 2020-04-21 Cell Mdx, Llc Methods of detecting prostate cancer
RU2616531C1 (en) * 2015-12-24 2017-04-17 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации Method for treatment of primary patients with locally advanced cervical cancer

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Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US20020077466A1 (en) * 1999-12-14 2002-06-20 Spaderna Steven K. Polypeptides and nucleic acids encoding same
US20040058340A1 (en) * 2001-06-18 2004-03-25 Hongyue Dai Diagnosis and prognosis of breast cancer patients
US20050259483A1 (en) * 2002-09-30 2005-11-24 Oncotherapy Science, Inc. Genes and polypeptides relating to prostate cancers
EP1517146A2 (en) * 2003-09-22 2005-03-23 Bernd Dr. Hinzmann Flamingo (ant)agonists for the diagnosis and treatment of cancer

Also Published As

Publication number Publication date
US20070202510A1 (en) 2007-08-30
US20090123484A1 (en) 2009-05-14
WO2007098297A2 (en) 2007-08-30
US7459280B2 (en) 2008-12-02
US8071324B2 (en) 2011-12-06

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