WO2007103372A3 - Plga/hydroxyapatite composite biomaterial and method of making the same - Google Patents

Plga/hydroxyapatite composite biomaterial and method of making the same Download PDF

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Publication number
WO2007103372A3
WO2007103372A3 PCT/US2007/005693 US2007005693W WO2007103372A3 WO 2007103372 A3 WO2007103372 A3 WO 2007103372A3 US 2007005693 W US2007005693 W US 2007005693W WO 2007103372 A3 WO2007103372 A3 WO 2007103372A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
plga
composite
new
graft material
Prior art date
Application number
PCT/US2007/005693
Other languages
French (fr)
Other versions
WO2007103372A8 (en
WO2007103372A2 (en
Inventor
Byung-Soo Kim
Original Assignee
Nano Orthopedics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nano Orthopedics Llc filed Critical Nano Orthopedics Llc
Priority to EP07752397A priority Critical patent/EP1996114A4/en
Priority to US12/279,172 priority patent/US20090048358A1/en
Publication of WO2007103372A2 publication Critical patent/WO2007103372A2/en
Publication of WO2007103372A8 publication Critical patent/WO2007103372A8/en
Publication of WO2007103372A3 publication Critical patent/WO2007103372A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone 1 ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.
PCT/US2007/005693 2006-03-06 2007-03-06 Plga/hydroxyapatite composite biomaterial and method of making the same WO2007103372A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07752397A EP1996114A4 (en) 2006-03-06 2007-03-06 Plga/hydroxyapatite composite biomaterial and method of making the same
US12/279,172 US20090048358A1 (en) 2006-03-06 2007-03-06 PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76713706P 2006-03-06 2006-03-06
US60/767,137 2006-03-06

Publications (3)

Publication Number Publication Date
WO2007103372A2 WO2007103372A2 (en) 2007-09-13
WO2007103372A8 WO2007103372A8 (en) 2008-08-28
WO2007103372A3 true WO2007103372A3 (en) 2008-10-23

Family

ID=38475500

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005693 WO2007103372A2 (en) 2006-03-06 2007-03-06 Plga/hydroxyapatite composite biomaterial and method of making the same

Country Status (4)

Country Link
US (3) US20090048358A1 (en)
EP (1) EP1996114A4 (en)
KR (1) KR20090008208A (en)
WO (1) WO2007103372A2 (en)

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WO2008039530A2 (en) * 2006-09-27 2008-04-03 Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Cell-nanofiber composite and cell-nanofiber-hydrogel composite amalgam based engineered intervertebral disc
WO2008157594A2 (en) 2007-06-18 2008-12-24 New Jersey Institute Of Technology Electrospun ceramic-polymer composite as a scaffold for tissue repair
US7567129B2 (en) * 2007-06-29 2009-07-28 Intel Corporation Monolithic flexible power amplifier using integrated tunable matching networks
US20090325296A1 (en) 2008-03-25 2009-12-31 New Jersey Institute Of Technology Electrospun electroactive polymers for regenerative medicine applications
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
EP2127689A1 (en) * 2008-05-27 2009-12-02 RevisiOs B.V. i.o. Novel homogenous osteoinductive nanocomposites
US7897164B2 (en) * 2008-10-30 2011-03-01 Warsaw Orthopedic, Inc Compositions and methods for nucleus pulposus regeneration
JP4815496B2 (en) * 2009-01-26 2011-11-16 エンパイア テクノロジー ディベロップメント エルエルシー Method for producing a three-dimensional product having a nanoporous surface
IT1393814B1 (en) * 2009-02-26 2012-05-11 Univ Degli Studi Genova COMPOSITE BIOMATERIAL AND PROCESS FOR ITS PREPARATION
US9334476B2 (en) 2009-03-12 2016-05-10 New Jersey Institute Of Technology Method for nerve growth and repair using a piezoelectric scaffold
US9192655B2 (en) 2009-03-12 2015-11-24 New Jersey Institute Of Technology System and method for a hydrogel and hydrogel composite for cartilage repair applications
US9771557B2 (en) 2009-03-12 2017-09-26 New Jersey Institute Of Technology Piezoelectric scaffold for nerve growth and repair
US9476026B2 (en) 2009-03-12 2016-10-25 New Jersey Institute Of Technology Method of tissue repair using a piezoelectric scaffold
US20100267143A1 (en) * 2009-04-16 2010-10-21 Snu R&Db Foundation Method for Surface Modification of Polymeric Scaffold for Stem Cell Transplantation Using Decellularized Extracellular Matrix
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US8567162B2 (en) * 2009-10-29 2013-10-29 Prosidyan, Inc. Dynamic bioactive bone graft material and methods for handling
US20110104265A1 (en) * 2009-10-29 2011-05-05 Mousa Shaker A Compositions and methods of targeted nanoformulations in the management of osteoporosis
US9707318B2 (en) * 2009-10-29 2017-07-18 Shaker A. Mousa Compositions of novel bone patch in bone and vascular regeneration
US8758791B2 (en) 2010-01-26 2014-06-24 Warsaw Orthopedic, Inc. Highly compression resistant matrix with porous skeleton
GB201003761D0 (en) * 2010-03-05 2010-04-21 Invibio Ltd Polymeric materials
US9180166B2 (en) 2010-03-12 2015-11-10 New Jersey Institute Of Technology Cartilage repair systems and applications utilizing a glycosaminoglycan mimic
US10081794B2 (en) 2011-04-13 2018-09-25 New Jersey Institute Of Technology System and method for electrospun biodegradable scaffold for bone repair
US20160000974A1 (en) * 2011-08-09 2016-01-07 New Jersey Institute Of Technoloty Composite Matrix for Bone Repair Applications
CN102429745B (en) * 2011-09-26 2014-12-10 中国人民解放军第二军医大学 Nanometer artificial bone framework with transverse gradient hole structure and preparation method thereof
WO2013126562A1 (en) * 2012-02-21 2013-08-29 Thierry Giorno Plga/ha hydroxyapatite composite bone grafts and method of making
KR101309218B1 (en) * 2012-02-22 2013-09-17 재단법인 포항산업과학연구원 Method for manufacturing biocompatible implant
CN102552984B (en) * 2012-02-29 2014-08-06 中国科学院长春应用化学研究所 Bone tissue engineering bracket material and preparation method thereof
CA2870188A1 (en) 2012-04-12 2013-10-17 Howard University Polylactide and calcium phosphate compositions and methods of making the same
US10918588B2 (en) 2012-11-09 2021-02-16 Colgate-Palmolive Company Block copolymers for tooth enamel protection
WO2014123978A2 (en) 2013-02-05 2014-08-14 University Of Utah Research Foundation Implantable devices for bone or joint defects
WO2015142631A1 (en) * 2014-03-17 2015-09-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Magnesium composite-containing scaffolds to enhance tissue regeneration
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
JP6860474B2 (en) * 2015-03-18 2021-04-14 公益財団法人神戸医療産業都市推進機構 A drug for treating and / or preventing an ischemic disease, a method for improving cell angiogenesis-promoting activity, or a method for producing a drug.
KR101902198B1 (en) * 2016-12-28 2018-09-28 전북대학교산학협력단 PLGA/Hydroxyapatite hybrid bone graft containing duck's feet-derived collagen and a fabrication method of it
US20180326123A1 (en) * 2017-05-10 2018-11-15 Board Of Trustees Of The University Of Arkansas Biocompatible structure for tissue regeneration and methods of making and using same
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CN112972773B (en) * 2021-02-04 2022-03-08 深圳先进技术研究院 Bioactive bone composite material and preparation method and application thereof
CN113769167B (en) * 2021-09-14 2023-07-25 深圳先进技术研究院 Preparation method of orthopedic implant material capable of sequentially releasing bioactive factors, product and application thereof
CN114456434B (en) * 2022-03-17 2023-03-28 昆明理工大学 Preparation method of polylactic acid-based bone repair composite aerogel material
CN114870074B (en) * 2022-06-10 2023-05-09 重庆医药高等专科学校 Icariin-based functionalized polylactic acid bionic bone material and preparation method thereof
CN115554471B (en) * 2022-07-18 2023-08-01 北京大学口腔医学院 Charged composite membrane material with high osteogenesis activity and tissue adhesion prevention and preparation method thereof

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Also Published As

Publication number Publication date
US20120259426A1 (en) 2012-10-11
US20080065228A1 (en) 2008-03-13
KR20090008208A (en) 2009-01-21
WO2007103372A8 (en) 2008-08-28
US20090048358A1 (en) 2009-02-19
WO2007103372A2 (en) 2007-09-13
EP1996114A2 (en) 2008-12-03
US8178013B2 (en) 2012-05-15
EP1996114A4 (en) 2011-08-31

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