WO2007109709A3 - Apparatus and methods for leak detection in bioprocessing bags - Google Patents

Apparatus and methods for leak detection in bioprocessing bags Download PDF

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Publication number
WO2007109709A3
WO2007109709A3 PCT/US2007/064492 US2007064492W WO2007109709A3 WO 2007109709 A3 WO2007109709 A3 WO 2007109709A3 US 2007064492 W US2007064492 W US 2007064492W WO 2007109709 A3 WO2007109709 A3 WO 2007109709A3
Authority
WO
WIPO (PCT)
Prior art keywords
leak
methods
leak detection
bag
sensor
Prior art date
Application number
PCT/US2007/064492
Other languages
French (fr)
Other versions
WO2007109709A2 (en
Inventor
Alexandre N Terentiev
Original Assignee
Levtech Inc
Alexandre N Terentiev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Levtech Inc, Alexandre N Terentiev filed Critical Levtech Inc
Priority to CN2007800144538A priority Critical patent/CN101427119B/en
Priority to EP07758988A priority patent/EP1999446A4/en
Priority to US11/689,761 priority patent/US7516648B2/en
Publication of WO2007109709A2 publication Critical patent/WO2007109709A2/en
Publication of WO2007109709A3 publication Critical patent/WO2007109709A3/en
Priority to US12/412,737 priority patent/US8104328B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/04—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point
    • G01M3/16—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means
    • G01M3/18—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators
    • G01M3/186—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators
    • G01M3/187—Investigating fluid-tightness of structures by using fluid or vacuum by detecting the presence of fluid at the leakage point using electric detection means for pipes, cables or tubes; for pipe joints or seals; for valves; for welds; for containers, e.g. radiators for containers, e.g. radiators for flexible or elastic containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/10—Bag-type containers

Abstract

An apparatus detects a leak of an electrically conductive fluid from a disposable plastic bag used in mixing applications, such as during bioprocessing in a sterile environment. In one embodiment, the bag is associated with a sensor for detecting a leak from an interior compartment. The sensor may be arranged to detect either a leak internal to the at least two material layers of the bag or external to the outer layer, or both. Related methods are also disclosed.
PCT/US2007/064492 2006-03-22 2007-03-21 Apparatus and methods for leak detection in bioprocessing bags WO2007109709A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN2007800144538A CN101427119B (en) 2006-03-22 2007-03-21 Apparatus and methods for leak detection in bioprocessing bags
EP07758988A EP1999446A4 (en) 2006-03-22 2007-03-21 Apparatus and methods for leak detection in bioprocessing bags
US11/689,761 US7516648B2 (en) 2006-03-22 2007-03-22 Apparatus and methods for leak detection in bioprocessing bags
US12/412,737 US8104328B2 (en) 2006-03-22 2009-03-27 Apparatus and methods for leak detection in bioprocessing bags

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78461506P 2006-03-22 2006-03-22
US60/784,615 2006-03-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/689,761 Continuation US7516648B2 (en) 2006-03-22 2007-03-22 Apparatus and methods for leak detection in bioprocessing bags

Publications (2)

Publication Number Publication Date
WO2007109709A2 WO2007109709A2 (en) 2007-09-27
WO2007109709A3 true WO2007109709A3 (en) 2008-08-28

Family

ID=38523276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/064492 WO2007109709A2 (en) 2006-03-22 2007-03-21 Apparatus and methods for leak detection in bioprocessing bags

Country Status (4)

Country Link
US (1) US7516648B2 (en)
EP (1) EP1999446A4 (en)
CN (1) CN101427119B (en)
WO (1) WO2007109709A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101430297B (en) * 2008-12-18 2012-01-11 中国大冢制药有限公司 Electrical conductance type plastic infusion bottle leak detection machine

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7086778B2 (en) * 2000-10-09 2006-08-08 Levtech, Inc. System using a levitating, rotating pumping or mixing element and related methods
US8182137B2 (en) 2000-10-09 2012-05-22 Atmi Packaging, Inc. Mixing bag or vessel with a fluid-agitating element
CA2462309C (en) * 2001-10-03 2010-12-14 Levtech, Inc. Mixing bag or vessel having a receiver for a fluid-agitating element
JP2007522801A (en) * 2004-01-07 2007-08-16 リーブテック，インコーポレイテッド Mixing bag with integral sparger and sensor receptacle
WO2008040567A1 (en) * 2006-10-03 2008-04-10 Artelis Flexible mixing bag, mixing device and mixing system
WO2007050971A1 (en) * 2005-10-26 2007-05-03 Levtech, Inc. Bioreactor with mixer and sparger
US10632433B2 (en) 2006-05-13 2020-04-28 Pall Life Sciences Belgium Bvba Disposable bioreactor
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
WO2009093995A1 (en) * 2008-01-25 2009-07-30 Xcellerex, Inc. Bag wrinkel remover, leak detection systems, and electromagnetic agitation for liquid containment systems
FR2946868B1 (en) 2009-06-18 2011-07-22 Sartorius Stedim Biotech Sa DETECTION OF LOSS OF INTEGRITY OF A FLEXIBLE POCKET, OF NON-POROUS PLASTIC MATERIAL, CLOSED.
BR112012016123A2 (en) * 2009-12-29 2016-05-31 Nestec Sa sealing integrity assessment device and method of use
FR2965556B1 (en) * 2010-09-30 2013-08-02 Sartorius Stedim Biotech Sa DETECTION OF THE INTEGRITY OF A FLEXIBLE, CLOSED, PLASTIC-LOCKED POCKET FOR RECEIVING AND PROTECTING A BIOPHARMACEUTICAL PRODUCT OR DEVICE
DE102011106162B3 (en) * 2011-06-30 2012-09-13 Sartorius Stedim Biotech Gmbh Bioreactor containers and bioreactor container integrity testing methods
DE102011106165B4 (en) * 2011-06-30 2015-07-02 Sartorius Stedim Biotech Gmbh Bioreactor container test method and apparatus and use
CN104024818A (en) * 2012-01-03 2014-09-03 雅培制药有限公司 Device for detecting leaks in packages
US9339026B2 (en) 2012-06-14 2016-05-17 Therapeutic Proteins International, LLC Pneumatically agitated and aerated single-use bioreactor
US8534120B1 (en) 2012-09-14 2013-09-17 Advanced Scientifics, Inc. Test system and method for flexible containers
CA2872886A1 (en) * 2012-10-24 2014-05-01 Pall Technology Uk Limited Integrity testing apparatus and related methods
FR3012980B1 (en) * 2013-11-13 2015-11-13 Interscience LABORATORY MIXER
US8979357B1 (en) 2014-03-17 2015-03-17 Advanced Scientifics, Inc. Transportable mixing system for biological and pharmaceutical materials
US9101893B1 (en) 2014-03-17 2015-08-11 Advanced Scientifics, Inc. Mixing assembly and mixing method
US9643142B2 (en) 2014-07-01 2017-05-09 Advanced Scientifics, Inc. Plunge-mixing bag arrangement and plunge-mixing system
DE102015000314B8 (en) * 2014-07-17 2015-12-17 Sartorius Stedim Biotech Gmbh Apparatus and method for performing an integrity test
DE102015116617B4 (en) 2015-09-30 2020-09-10 Sartorius Stedim Biotech Gmbh Sterile packaging unit and process for its manufacture
CA3033195A1 (en) * 2018-02-09 2019-08-09 Ecolab Usa Inc. Flowability testing systems and methods
IT201900014271A1 (en) * 2019-08-07 2021-02-07 Saipem Spa UNDERWATER STORAGE TANK
CN110828862B (en) * 2019-10-29 2020-09-22 中国科学院武汉岩土力学研究所 Electric energy storage device of salt cavern flow battery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225812A (en) * 1991-05-30 1993-07-06 Wright State University Protective composite liner
US20060081036A1 (en) * 1997-03-26 2006-04-20 Martin Lehmann Method for leak testing and leak testing apparatus

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2636799C3 (en) * 1976-08-16 1979-01-25 Hoechst Ag, 6000 Frankfurt Plastic container and method for non-destructive testing of the tightness of the closed plastic container
ES2005914A6 (en) * 1987-10-30 1989-04-01 Distrex Iberica Sa Method for determining the reliability of male contraceptives.
FR2650391B1 (en) * 1989-07-27 1993-07-16 Durand Alain PROCESS FOR THE MANUFACTURE OR REHABILITATION OF A STORAGE TANK, RESERVOIRS OBTAINED
US5191785A (en) * 1991-04-16 1993-03-09 Cpf Chemical Equipment Ltd. Method and apparatus for identifying and locating a leak in the inner liner of a vessel having a laminated wall structure
US5477155A (en) 1993-08-11 1995-12-19 Millipore Corporation Current flow integrity test
SE501693C2 (en) * 1993-11-26 1995-04-24 Aaf Industriteknik Ab Method and apparatus for checking leakage from a closed container
DE4426225B4 (en) 1994-07-23 2005-08-04 Robert Griebel Device for checking the porosity of thin rubber products
EP0803728A1 (en) * 1996-04-24 1997-10-29 Celsis International Plc Method for measuring the conductivity of fluids
US6057689A (en) * 1997-08-04 2000-05-02 Gynecare, Inc. Apparatus and method for leak detection in a fluid-filled balloon useful to treat body tissue
US6112579A (en) * 1997-08-25 2000-09-05 Tryba; Stephen A. Fluid leakage sensors
JP3494585B2 (en) * 1999-03-10 2004-02-09 ジョーベン電機株式会社 Inspection method of sealed package
FR2810733A1 (en) * 2000-06-23 2001-12-28 Bonduelle Sa Ets Method and equipment for testing watertightness of a container, comprises application of electric potential to conductor in contact with contents while container is immersed in conducting medium
US7176030B2 (en) * 2002-06-17 2007-02-13 O.R. Solutions, Inc. Method and apparatus for ensuring sterility of disposable medical items used with medical equipment
JP2003194663A (en) 2001-12-28 2003-07-09 Nihon Tetra Pak Kk Sealing state inspection device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225812A (en) * 1991-05-30 1993-07-06 Wright State University Protective composite liner
US20060081036A1 (en) * 1997-03-26 2006-04-20 Martin Lehmann Method for leak testing and leak testing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101430297B (en) * 2008-12-18 2012-01-11 中国大冢制药有限公司 Electrical conductance type plastic infusion bottle leak detection machine

Also Published As

Publication number Publication date
US7516648B2 (en) 2009-04-14
CN101427119A (en) 2009-05-06
EP1999446A4 (en) 2011-12-14
US20070220956A1 (en) 2007-09-27
CN101427119B (en) 2011-11-02
WO2007109709A2 (en) 2007-09-27
EP1999446A2 (en) 2008-12-10

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