WO2007120811A3 - Hemangio-colony forming cells - Google Patents

Hemangio-colony forming cells Download PDF

Info

Publication number
WO2007120811A3
WO2007120811A3 PCT/US2007/009106 US2007009106W WO2007120811A3 WO 2007120811 A3 WO2007120811 A3 WO 2007120811A3 US 2007009106 W US2007009106 W US 2007009106W WO 2007120811 A3 WO2007120811 A3 WO 2007120811A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
hemangio
colony forming
methods
forming cells
Prior art date
Application number
PCT/US2007/009106
Other languages
French (fr)
Other versions
WO2007120811A2 (en
Inventor
Robert Lanza
Shi-Jiang Lu
Original Assignee
Advanced Cell Tech Inc
Robert Lanza
Shi-Jiang Lu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Cell Tech Inc, Robert Lanza, Shi-Jiang Lu filed Critical Advanced Cell Tech Inc
Priority to AU2007238660A priority Critical patent/AU2007238660C1/en
Priority to KR1020237033022A priority patent/KR20230145494A/en
Priority to KR1020197035159A priority patent/KR102230288B1/en
Priority to KR1020177023744A priority patent/KR20170102040A/en
Priority to NZ572842A priority patent/NZ572842A/en
Priority to KR1020217007639A priority patent/KR102510368B1/en
Priority to KR1020227014323A priority patent/KR102651433B1/en
Priority to KR1020147033315A priority patent/KR20140146224A/en
Priority to JP2009505494A priority patent/JP5630781B2/en
Priority to CNA2007800218226A priority patent/CN101528915A/en
Priority to EP07755391A priority patent/EP2013331A2/en
Priority to EP20169139.1A priority patent/EP3712258A1/en
Publication of WO2007120811A2 publication Critical patent/WO2007120811A2/en
Publication of WO2007120811A3 publication Critical patent/WO2007120811A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/165—Vascular endothelial growth factor [VEGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998—Proteins not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Abstract

Methods of generating and expanding human hemangio-colony forming cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications.
PCT/US2007/009106 2006-04-14 2007-04-13 Hemangio-colony forming cells WO2007120811A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
AU2007238660A AU2007238660C1 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
KR1020237033022A KR20230145494A (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
KR1020197035159A KR102230288B1 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
KR1020177023744A KR20170102040A (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
NZ572842A NZ572842A (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
KR1020217007639A KR102510368B1 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
KR1020227014323A KR102651433B1 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
KR1020147033315A KR20140146224A (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
JP2009505494A JP5630781B2 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
CNA2007800218226A CN101528915A (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
EP07755391A EP2013331A2 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells
EP20169139.1A EP3712258A1 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US79222406P 2006-04-14 2006-04-14
US60/792,224 2006-04-14
US80199306P 2006-05-19 2006-05-19
US60/801,993 2006-05-19
US84616306P 2006-09-20 2006-09-20
US60/846,163 2006-09-20
US85214206P 2006-10-16 2006-10-16
US60/852,142 2006-10-16
US86067606P 2006-11-22 2006-11-22
US60/860,676 2006-11-22
US91883207P 2007-03-19 2007-03-19
US60/918,832 2007-03-19

Publications (2)

Publication Number Publication Date
WO2007120811A2 WO2007120811A2 (en) 2007-10-25
WO2007120811A3 true WO2007120811A3 (en) 2008-03-06

Family

ID=38461853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009106 WO2007120811A2 (en) 2006-04-14 2007-04-13 Hemangio-colony forming cells

Country Status (7)

Country Link
US (5) US8017393B2 (en)
EP (6) EP2377924A1 (en)
JP (5) JP5630781B2 (en)
KR (7) KR20230145494A (en)
CN (3) CN101528915A (en)
AU (1) AU2007238660C1 (en)
WO (1) WO2007120811A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007238660C1 (en) 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
US20080108044A1 (en) * 2006-11-08 2008-05-08 Deepika Rajesh In vitro differentiation of hematopoietic cells from primate embryonic stem cells
EP2129775A1 (en) 2007-02-12 2009-12-09 Anthrogenesis Corporation Hepatocytes and chondrocytes from adherent placental stem cells; and cd34+, cd45- placental stem cell-enriched cell populations
US9200253B1 (en) * 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
US8222206B2 (en) * 2008-03-04 2012-07-17 Taiwan Advance Bio-Pharm Inc. Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H
KR101923290B1 (en) 2008-05-06 2018-11-28 아스텔라스 인스티튜트 포 리제너러티브 메디슨 Hemangio colony forming cells and non-engrafting hemangio cells
CN112280739A (en) * 2008-05-06 2021-01-29 安斯泰来再生医药协会 Methods for preparing enucleated erythroid cells derived from pluripotent stem cells
US9730749B2 (en) * 2009-04-17 2017-08-15 Domain Surgical, Inc. Surgical scalpel with inductively heated regions
GB0911060D0 (en) * 2009-06-26 2009-08-12 Ge Healthcare Uk Ltd Methods for predicting the toxicity of a chemical
WO2011002727A1 (en) * 2009-06-29 2011-01-06 Qingfeng Chen Methods of producing humanized non-human mammals
CA2767014C (en) * 2009-07-02 2022-01-25 Anthrogenesis Corporation Method of producing erythrocytes without feeder cells
JP2013512676A (en) * 2009-12-04 2013-04-18 ステム セル アンド リジェネレイティブ メディスン インターナショナル， インコーポレイテッド Large-scale generation of functional megakaryocytes and platelets from human embryonic stem cells under non-stromal conditions
EP2507365A4 (en) 2009-12-04 2014-01-01 Stem Cell & Regenerative Medicine International Inc Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts
AU2011217171B2 (en) * 2010-02-22 2016-07-07 Assistance Publique - Hopitaux De Paris Cell culture medium for the growth and differentiation of cells of the hematopoietic lineage
WO2011115308A1 (en) * 2010-03-18 2011-09-22 Kyoto University Method for inducing differentiation of pluripotent stem cells into mesodermal cells
WO2012103098A2 (en) * 2011-01-24 2012-08-02 Immunepath, Inc. Compositions and methods for treating hematological cytopenias
CN102239821B (en) * 2011-05-10 2013-08-14 郑家伟 Human hemangioma animal model and constructing method and application thereof
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
KR102246369B1 (en) 2011-11-30 2021-04-29 아스텔라스 인스티튜트 포 리제너러티브 메디슨 Mesenchymal stromal cells and uses related thereto
ES2896354T3 (en) 2012-12-21 2022-02-24 Astellas Inst For Regenerative Medicine Methods for the production of platelets from pluripotent stem cells
WO2014120714A1 (en) * 2013-01-30 2014-08-07 Cornell University Compositions and methods for the expansion of stem cells
DE102013105217A1 (en) * 2013-05-22 2014-11-27 Illinois Tool Works Inc. Compressor for generating a pressure medium
KR20180053646A (en) * 2015-07-20 2018-05-23 앤지오크린 바이오사이언스 인코포레이티드 Engineered endothelial cells expressing ETS transcription factors
EA037915B1 (en) 2015-08-18 2021-06-07 Астеллас Инститьют Фор Ридженерэйтив Медсин Clinical formulations
WO2018093797A1 (en) 2016-11-15 2018-05-24 The Schepens Eye Research Institute, Inc. Compositions and methods for the treatment of aberrant angiogenesis
CN109402047A (en) * 2017-09-18 2019-03-01 武汉原生原代生物医药科技有限公司 Promote tissue adhension and growth bioadhesive and its preparation method and application
CA3082643A1 (en) * 2017-11-14 2019-05-23 The Schepens Eye Research Institute, Inc. Runx1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition
KR102167641B1 (en) * 2018-08-27 2020-10-19 주식회사 사이루스 Composition for growth-promoting cell containing erythropoietin-derived peptide
WO2020223145A1 (en) * 2019-04-27 2020-11-05 Figene, Llc Selection of fibroblast donors for optimization of allogeneic fibroblast-mediated regeneration
MX2022002418A (en) 2019-08-28 2022-03-22 Astellas Inst For Regenerative Medicine Compositions and methods of treating vascular diseases.
KR20220054359A (en) 2019-08-28 2022-05-02 아스텔라스 인스티튜트 포 리제너러티브 메디슨 How to treat vascular disease
US20210192477A1 (en) * 2019-12-24 2021-06-24 Up N' Go App-less restaurant processing system using mobile devices and offering check splitting
CN112940097A (en) * 2021-02-08 2021-06-11 华东理工大学 Survivin multi-point mutant recombinant protein and application thereof
WO2024019962A1 (en) 2022-07-18 2024-01-25 Astellas Institute For Regenerative Medicine Methods of treating brain injury

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003050251A2 (en) * 2001-12-07 2003-06-19 Geron Corporation Hematopoietic cells from human embryonic stem cells
WO2004029231A1 (en) * 2002-09-26 2004-04-08 Institut National De La Sante Et De La Recherche Medicale Compositions and methods for amplification of human stem cells
WO2006130651A2 (en) * 2005-06-01 2006-12-07 Wisconsin Alumni Research Foundation Method of forming dendritic cells from embryonic stem cells
WO2007095064A2 (en) * 2006-02-09 2007-08-23 Wisconsin Alumni Research Foundation ERYTHROID CELLS PRODUCING ADULT-TYPE β-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5128259A (en) * 1989-10-27 1992-07-07 Hahnemann University Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation
US5635387A (en) 1990-04-23 1997-06-03 Cellpro, Inc. Methods and device for culturing human hematopoietic cells and their precursors
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
EP1179350A3 (en) 1993-08-12 2003-01-02 Cytotherapeutics, Inc. Encapsulated cell system for implantation into the human CNS
US5599705A (en) * 1993-11-16 1997-02-04 Cameron; Robert B. In vitro method for producing differentiated universally compatible mature human blood cells
WO1995017500A1 (en) 1993-12-23 1995-06-29 Abs Global, Inc. Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals
US5914268A (en) * 1994-11-21 1999-06-22 National Jewish Center For Immunology & Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5874301A (en) * 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US6063593A (en) 1996-11-12 2000-05-16 University Of Southern California University Park Campus TGFβ1 responsive bone marrow derived cells to express a recombinant protein
WO1998033891A1 (en) 1997-01-31 1998-08-06 Hemosol Inc. Method for the production of selected lymphocytes
WO1998053048A1 (en) 1997-05-21 1998-11-26 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells
US6429012B1 (en) 1997-10-06 2002-08-06 Viacell, Inc. Cell population containing non-fetal hemangioblasts and method for producing same
WO1999067360A2 (en) 1998-06-25 1999-12-29 Hemosol Inc. Media and methods for expansion of erythroid stem cells for the production of hemoglobin
JP2002523039A (en) 1998-08-24 2002-07-30 ティー．ブリーダーズ，インコーポレイテッド Cell population containing non-fetal hemangioblasts and method for producing the same
IL129966A (en) 1999-05-14 2009-12-24 Technion Res & Dev Foundation ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS
AU782385B2 (en) 1999-10-15 2005-07-21 Advanced Cell Technology, Inc. Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells
JP2003530826A (en) 1999-11-17 2003-10-21 ユニバーシティー オブ ロチェスター Human ex vivo immune system
US20020035735A1 (en) * 2000-01-07 2002-03-21 Gerald Schatten Clonal propagation of primate offspring by embryo splitting
US7795026B2 (en) * 2000-01-21 2010-09-14 The Johns Hopkins University School Of Medicine Methods for obtaining human embryoid body-derived cells
US6602711B1 (en) * 2000-02-21 2003-08-05 Wisconsin Alumni Research Foundation Method of making embryoid bodies from primate embryonic stem cells
CA2417356A1 (en) * 2000-08-01 2002-02-07 Yissum Research Development Company Directed differentiation of embryonic cells
EP1364197B1 (en) 2001-01-29 2010-04-14 Ivan N. Rich ATP-based assay for the determination of the proliferation status of hematopoietic stem and progenitor cells
JP3660601B2 (en) 2001-03-30 2005-06-15 独立行政法人科学技術振興機構 Method for producing neural stem cells, motor neurons and GABAergic neurons from embryonic stem cells
WO2002078449A2 (en) 2001-04-02 2002-10-10 Advanced Cell Technology, Inc. Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells
KR20020083634A (en) 2001-04-27 2002-11-04 크레아젠 주식회사 Pharmaceutical Compositions Comprising Dendritic Cells for Immunotherapy of Autoimmune Disease and Treatment Method Using the Same
US6861504B2 (en) 2001-05-03 2005-03-01 Cbr, Inc. Compounds and methods for the modulation of CD154
WO2002092756A2 (en) * 2001-05-15 2002-11-21 Rappaport Family Institute For Research In The Medical Sciences Insulin producing cells derived from human embryonic stem cells
WO2003038072A1 (en) 2001-10-31 2003-05-08 Universite Libre De Bruxelles Generation and use of new types of dendritic cells
CA2465173C (en) 2001-11-02 2010-04-20 Wisconsin Alumni Research Foundation Endothelial cells derived from primate embryonic stem cells
US20030232430A1 (en) 2001-11-26 2003-12-18 Advanced Cell Technology Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
CA2473909A1 (en) 2002-01-15 2003-07-24 Advanced Cell Technology, Inc. Cloning b and t lymphocytes
US20040091936A1 (en) 2002-05-24 2004-05-13 Michael West Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank
US20040052771A1 (en) 2002-07-12 2004-03-18 Lim Sai Kiang Hemangioblast progenitor cells
AU2003248609A1 (en) 2002-07-12 2004-02-02 Agency For Science, Technology And Research Hemangioblast progenitor cells
EP1536688B1 (en) 2002-09-13 2011-12-28 The Board Of Trustees Of The Leland Stanford Junior University Mammalian megakaryocyte progenitor cell
US7427603B2 (en) * 2002-09-26 2008-09-23 The Children's Medical Center Corporation Method of enhancing proliferation and/or hematopoietic differentiation of stem cells
AU2003269379A1 (en) 2002-10-31 2004-05-25 Pfizer Products Inc. Suspension method for producing embryoid bodies, and compositions and methods related thereto
US20050054096A1 (en) 2002-11-06 2005-03-10 Piniella Carlos J. Pluripotent cells from monocytes, and methods of making and using pluripotent cells
AU2003302701A1 (en) 2002-11-29 2004-06-23 Technion Research And Development Foundation Ltd. Method of dynamically culturing embryonic stem cells
US20050032210A1 (en) 2003-03-18 2005-02-10 Kirin Beer Kabushiki Kaisha Method of preparing immuno-regulatory dendritic cells and the use thereof
US20040229350A1 (en) * 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
EP1627913A4 (en) 2003-05-28 2007-08-22 Riken Mesenchymal stem cell
US8148152B2 (en) 2003-07-08 2012-04-03 Axiogenesis Ag Method for the preparation of embryoid bodies (EBs) and uses thereof
US20050054100A1 (en) 2003-09-08 2005-03-10 Rennard Stephen I. Methods for fibroblast differentiation
WO2005040391A1 (en) 2003-10-27 2005-05-06 Murdoch Childrens Research Institute Compositions and methods for differentiating stem cells
WO2005049812A1 (en) 2003-11-19 2005-06-02 Australian Stem Cell Centre Limited Methods for producing blood products from pluripotent cells in cell culture
US20080026460A1 (en) 2006-06-20 2008-01-31 Palecek Sean P Method for culturing stem cells
CN1286970C (en) 2003-12-30 2006-11-29 上海伯瑞生物技术发展有限公司 Method of prodcing megacaryocyle using umbilical blood CD 344+cell in vitro induction method
KR100535326B1 (en) 2004-01-20 2005-12-09 한국생명공학연구원 Differentiation regulating agent containing gene which regulating differentiation from stem cell to natural killer cell as effective ingradient
US20050266556A1 (en) * 2004-02-09 2005-12-01 Yoder Mervin C Isolation, expansion and use of clonogenic endothelial progenitor cells
EP1735429A4 (en) 2004-03-31 2008-06-11 Newlink Genetics Corp Methods and compositions for obtaining hematopoietic stem cells derived from embryonic stem cells and uses thereof
AU2005243158B2 (en) 2004-05-07 2010-03-25 Wisconsin Alumni Research Foundation Method of forming mesenchymal stem cells from embryonic stem cells
WO2006001954A2 (en) 2004-05-20 2006-01-05 Puget Sound Blood Center And Program Methods for promoting the formation of platelets and for treating blood and bone marrow disorders
JP5139799B2 (en) 2004-06-04 2013-02-06 ユニベルシテ ピエール エ マリー キュリー（パリ シズエム） Red blood cell production method
WO2006001122A1 (en) 2004-06-24 2006-01-05 Dnavec Research Inc. Anticancer agent containing dendritic cell having rna virus transferred thereinto
EP1784481A1 (en) 2004-08-25 2007-05-16 Technion Research And Development Foundation, Ltd. Methods of generating embryoid bodies using three dimensional scaffolds
WO2006040763A2 (en) 2004-10-12 2006-04-20 Technion Research & Development Foundation Ltd. Isolated primate embryonic cells and methods of generating and using same
MX2007005200A (en) 2004-11-01 2007-05-11 Wisconsin Alumni Res Found Platelets from stem cells.
CN101052710A (en) 2004-11-01 2007-10-10 威斯康星校友研究基金会 Platelets from stem cells
US7893315B2 (en) * 2004-11-04 2011-02-22 Advanced Cell Technology, Inc. Derivation of embryonic stem cells and embryo-derived cells
US7558394B2 (en) 2005-02-14 2009-07-07 Insound Medical, Inc. Systems and methods for in situ cerumen removal from hearing devices
WO2006090882A1 (en) 2005-02-23 2006-08-31 Foundation For Biomedical Research And Innovation Method for amplification of endothelial progenitor cell in vitro
US20080166751A1 (en) 2005-02-23 2008-07-10 Takayuki Asahara Method of Analyzing Dynamics in the Differentiation of Vascular Endothelial Progenitor Cells
DK1863905T3 (en) 2005-03-17 2016-04-04 Ucl Business Plc PROCEDURE FOR ACTIVATING NATURAL KILLER CELLS USING VITRO TUMOR CELL PREPARATIONS
KR20200072566A (en) 2005-04-08 2020-06-22 코이뮨, 인크. Dendritic cell compositions and methods
WO2007005595A1 (en) 2005-07-05 2007-01-11 The New England Medical Center Hospitals, Inc. Pregnancy-associated progenitor cells
US9121008B2 (en) 2005-08-31 2015-09-01 University Of Utah Research Foundation Development of natural killer cells and functional natural killer cell lines
AU2006285467A1 (en) 2005-09-02 2007-03-08 Agency For Science, Technology And Research Method of deriving mesenchymal stem cells
WO2008020815A1 (en) 2006-08-15 2008-02-21 Agency For Science, Technology And Research Mesenchymal stem cell conditioned medium
EP1789435B1 (en) 2005-09-12 2010-02-24 Industry Foundation of Chonnam National University A method for production of mature natural killer cell
JP2007089432A (en) 2005-09-27 2007-04-12 Reprocell Inc Method for increasing production of blood platelet derived from stem cell
PT1941027E (en) 2005-09-28 2014-10-09 Ipd Therapeutics B V Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics.
US20070128727A1 (en) 2005-11-08 2007-06-07 Kraemer Fredric B Methods for differentiation of embryonic stem cells
US8241902B2 (en) 2006-01-11 2012-08-14 Technion Research & Development Foundation Ltd. Preparation of adult stem cell-derived connective tissue progenitors
CN101045915A (en) 2006-03-29 2007-10-03 旭日干 Oocyte germinal vecicle transplanting technology
CN101045914A (en) 2006-03-29 2007-10-03 中国人民解放军军事医学科学院野战输血研究所 Extracorporeal induction process for differentiating hemopoietic stem/ancestral cell into mature red blood cell and its application
NZ572842A (en) 2006-04-14 2012-01-12 Advanced Cell Tech Inc Hemangio-colony forming cells
AU2013201444B2 (en) 2006-04-14 2015-01-22 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
AU2007238660C1 (en) 2006-04-14 2013-11-07 Astellas Institute For Regenerative Medicine Hemangio-colony forming cells
WO2007122233A1 (en) 2006-04-25 2007-11-01 Vrije Universiteit Brussel Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells
US20070298496A1 (en) * 2006-06-23 2007-12-27 Hung-Chih Kuo Method of deriving pluripotent stem cells from a single blastomere
US20100233135A1 (en) 2006-08-16 2010-09-16 The General Hospital Corporation Compositions and methods for hematopoietic stem cell expansion or for modulating angiogenesis
US20080081370A1 (en) 2006-09-28 2008-04-03 Peiman Hematti Directed differentiation of human embryonic stem cells into mesenchymal/stromal cells
US20080108044A1 (en) * 2006-11-08 2008-05-08 Deepika Rajesh In vitro differentiation of hematopoietic cells from primate embryonic stem cells
WO2008056779A1 (en) 2006-11-09 2008-05-15 Japan As Represented By The President Of International Medical Center Of Japan Method for culture and passage of primate embryonic stem cell, and method for induction of differentiation of the embryonic stem cell
DE102006054041B3 (en) 2006-11-16 2008-05-08 Pierburg Gmbh Regulating device for an internal combustion engine
US20100184212A1 (en) 2007-05-30 2010-07-22 Steven Stice Human embryonic stem cell derived mesoderm-like epithelium transitions to mesenchymal progenitor cells
WO2008151390A1 (en) 2007-06-15 2008-12-18 Australian Stem Cell Centre Ltd Differentiation of human embryonic stem cells
WO2008151386A1 (en) 2007-06-15 2008-12-18 Australian Stem Cell Centre Ltd Megakaryocyte differentiation
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
US7615374B2 (en) 2007-09-25 2009-11-10 Wisconsin Alumni Research Foundation Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions
KR20210022148A (en) 2007-09-28 2021-03-02 안트로제네시스 코포레이션 Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells
US20120003738A1 (en) 2007-10-04 2012-01-05 University Hospitals Of Cleveland Method For Amplification And Functional Enhancment Of Blood Derived Progenitor Cells Using A Closed Culture System
WO2009050694A1 (en) 2007-10-15 2009-04-23 Technion Research & Development Foundation Ltd. Methods of generating embryoid bodies and uses of same
WO2009052389A1 (en) 2007-10-19 2009-04-23 Baylor College Of Medicine Hematopoietic fingerprints: methods of use
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
WO2009104825A1 (en) 2008-02-18 2009-08-27 Kaist Method for inducing the defferentiation of embryonic stem cells into hemangioblast
WO2009119105A1 (en) 2008-03-28 2009-10-01 国立大学法人東京大学 METHOD FOR IN VITRO PREPARATION OF GPIbα+GPV+GPVI+ PLATELET
JP5617631B2 (en) 2008-04-01 2014-11-05 国立大学法人東京大学 Method for preparing platelets from iPS cells
KR101923290B1 (en) 2008-05-06 2018-11-28 아스텔라스 인스티튜트 포 리제너러티브 메디슨 Hemangio colony forming cells and non-engrafting hemangio cells
CN112280739A (en) 2008-05-06 2021-01-29 安斯泰来再生医药协会 Methods for preparing enucleated erythroid cells derived from pluripotent stem cells
GB2467982A (en) 2008-05-08 2010-08-25 Coretherapix Slu Pluripotent adult stem cells
JP5639058B2 (en) 2008-09-03 2014-12-10 メソブラスト，インコーポレーテッド Hematopoietic progenitor cell proliferation
US8956867B2 (en) 2008-11-07 2015-02-17 Wisconsin Alumni Research Foundation Method for culturing stem cells
WO2010099539A1 (en) 2009-02-27 2010-09-02 Cellular Dynamics International, Inc. Differentiation of pluripotent cells
EP2467470A2 (en) 2009-08-17 2012-06-27 Technion Research & Development Foundation Ltd. Pericyte progenitor cells and methods of generating and using same
KR101193541B1 (en) 2009-08-24 2012-10-22 한국과학기술원 Method of inducing differentiation of human embryonic stem cells into mesenchymal stem cells
WO2011026221A1 (en) 2009-09-01 2011-03-10 Mcmaster University Methods of culturing embryoid bodies
KR101135636B1 (en) 2009-10-27 2012-04-17 서울대학교산학협력단 Method for producing mesenchymal stem cells from human pluripotent stem cells and mesenchymal stem cells produced by thereof
JP2013512676A (en) 2009-12-04 2013-04-18 ステム セル アンド リジェネレイティブ メディスン インターナショナル， インコーポレイテッド Large-scale generation of functional megakaryocytes and platelets from human embryonic stem cells under non-stromal conditions
EP2507365A4 (en) 2009-12-04 2014-01-01 Stem Cell & Regenerative Medicine International Inc Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts
WO2011091475A1 (en) 2010-01-28 2011-08-04 Australian Stem Cell Centre Limited Method for stem cell differentiation
KR101330327B1 (en) 2010-05-07 2013-11-14 한국생명공학연구원 A method for the large scale propagation and maintenance of embryoid bodies generated from stem cells
US10214722B2 (en) 2010-09-07 2019-02-26 Technion Research & Development Foundation Limited Methods for expanding and maintaining human pluripotent stem cells (PSCs) in an undifferentiated state in a single cell suspension culture
AU2012231207B2 (en) 2011-03-18 2016-06-23 New York Blood Center, Inc. Megakaryocyte and platelet production from stem cells
US9598675B2 (en) 2011-10-13 2017-03-21 Singapore Health Services Pte Ltd Method for preparing mesenchymal stem cell-like cells and cardiomyocyte-like cells
KR102246369B1 (en) * 2011-11-30 2021-04-29 아스텔라스 인스티튜트 포 리제너러티브 메디슨 Mesenchymal stromal cells and uses related thereto
KR101477016B1 (en) 2012-01-19 2014-12-29 (주)차바이오텍 Method for producing human embryonic stem cell-derived perivascular progenitor cell and composition for cell therapy comprising the same
CA2876512C (en) 2012-07-11 2022-12-13 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
CA2876499C (en) 2012-07-12 2021-10-26 Imstem Biotechnology, Inc. Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
WO2014138485A1 (en) 2013-03-08 2014-09-12 Irm Llc Ex vivo production of platelets from hematopoietic stem cells and the product thereof
PL2970912T3 (en) 2013-03-13 2019-08-30 Wisconsin Alumni Research Foundation Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
WO2014146057A2 (en) 2013-03-15 2014-09-18 Cmr Technologies, Llc Mesenchymal stem cells
US20140271616A1 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Compositions And Methods For Mesenchymal And/Or Chondrogenic Differentiation Of Stem Cells
KR101669124B1 (en) 2013-07-11 2016-10-25 서울대학교병원 Composition for prevention and treatment of liver fibrosis or liver cirrhosis comprising of mesenchymal stem cells derived from human embryonic stem cells as an active ingredient
WO2015179301A1 (en) 2014-05-19 2015-11-26 Eleftherios Papoutsakis Megakaryocytic particles and microparticles for cell therapy & fate modification of stem and progenitor cells
WO2015191632A1 (en) 2014-06-10 2015-12-17 Biomatrica, Inc. Stabilization of thrombocytes at ambient temperatures
JP6459257B2 (en) 2014-07-08 2019-01-30 富士ゼロックス株式会社 Image forming apparatus
AU2016242823A1 (en) 2015-03-30 2017-09-21 Jeffrey Thomas Loh Methods for producing modified red blood cell compositions, compositions and uses thereof
CN108884441B (en) 2016-03-16 2022-05-06 洋蓟治疗有限公司 Colony forming medium and use thereof
WO2018021566A1 (en) 2016-07-29 2018-02-01 ダイキン工業株式会社 Differentiated cell production method and culture bag used therefor
CN109666630A (en) 2017-10-17 2019-04-23 澳门大学 Pluripotent stem cell differentiation is the method and its culture medium of mescenchymal stem cell and application
WO2019213366A1 (en) 2018-05-02 2019-11-07 The Trustees Of Columbia University In The City Of New York Methods to induce terminal differentiation in stem cells by interfering with dna replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof
US20200080059A1 (en) 2018-09-07 2020-03-12 Wisconsin Alumni Research Foundation Generation of hematopoietic progenitor cells from human pluripotent stem cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003050251A2 (en) * 2001-12-07 2003-06-19 Geron Corporation Hematopoietic cells from human embryonic stem cells
WO2004029231A1 (en) * 2002-09-26 2004-04-08 Institut National De La Sante Et De La Recherche Medicale Compositions and methods for amplification of human stem cells
WO2006130651A2 (en) * 2005-06-01 2006-12-07 Wisconsin Alumni Research Foundation Method of forming dendritic cells from embryonic stem cells
WO2007095064A2 (en) * 2006-02-09 2007-08-23 Wisconsin Alumni Research Foundation ERYTHROID CELLS PRODUCING ADULT-TYPE β-HEMOGLOBIN GENERATED FROM HUMAN EMBRYONIC STEM CELLS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BOWLES KRISTIAN M ET AL: "HOXB4 overexpression promotes hematopoietic development by human embryonic stem cells.", STEM CELLS (DAYTON, OHIO) MAY 2006, vol. 24, no. 5, 12 January 2006 (2006-01-12), pages 1359 - 1369, XP002450482, ISSN: 1066-5099 *
TIAN X ET AL: "Cytokine requirements differ for stroma and embryoid body-mediated hematopoiesis from human embryonic stem cells", EXPERIMENTAL HEMATOLOGY 2004 UNITED STATES, vol. 32, no. 10, 2004, pages 1000 - 1009, XP002450481, ISSN: 0301-472X *

Also Published As

Publication number Publication date
EP2377925A1 (en) 2011-10-19
CN102660495A (en) 2012-09-12
EP2426197A1 (en) 2012-03-07
KR102230288B1 (en) 2021-03-22
AU2007238660B2 (en) 2013-05-02
JP6525899B2 (en) 2019-06-05
KR102651433B1 (en) 2024-03-25
US11566228B2 (en) 2023-01-31
KR102510368B1 (en) 2023-03-14
EP2377923A1 (en) 2011-10-19
CN106434527A (en) 2017-02-22
US20120027731A1 (en) 2012-02-02
JP5630781B2 (en) 2014-11-26
KR20170102040A (en) 2017-09-06
US20160115450A1 (en) 2016-04-28
AU2007238660C1 (en) 2013-11-07
KR20230145494A (en) 2023-10-17
EP2377924A1 (en) 2011-10-19
WO2007120811A2 (en) 2007-10-25
CN101528915A (en) 2009-09-09
KR20210031786A (en) 2021-03-22
US9938500B2 (en) 2018-04-10
KR20140146224A (en) 2014-12-24
JP2022141641A (en) 2022-09-29
JP2016063838A (en) 2016-04-28
JP2013126423A (en) 2013-06-27
JP2009533059A (en) 2009-09-17
US20080014180A1 (en) 2008-01-17
EP2013331A2 (en) 2009-01-14
KR20190134847A (en) 2019-12-04
KR20090045886A (en) 2009-05-08
EP3712258A1 (en) 2020-09-23
JP2019165732A (en) 2019-10-03
US8017393B2 (en) 2011-09-13
KR20220057664A (en) 2022-05-09
US20190017027A1 (en) 2019-01-17
AU2007238660A1 (en) 2007-10-25
US20230313141A1 (en) 2023-10-05

Similar Documents

Publication Publication Date Title
WO2007120811A3 (en) Hemangio-colony forming cells
EP3539380A3 (en) Improved cell composition and methods of making the same
WO2009137629A3 (en) Methods for producing enucleated erythroid cells derived from pluripotent stem cells
WO2007117765A3 (en) Ex vivo generated tissue system
WO2005007073A3 (en) Ex vivo progenitor and stem cell expansion for use in the treatment of disease of endodermally-derived organs
EP1483281A4 (en) Methods for producing interfering rna molecules in mammalian cells and therapeutic uses for such molecules
WO2008028117A3 (en) Glp-2 mimetibodies, polypeptides, compositions, methods and uses
WO2008119082A3 (en) Enhanced production of fatty acid derivatives
EP1854788B8 (en) Method for producing 1-substituted-3-fluoroalkyl pyrazole-4-carboxylate
WO2008066558A3 (en) Process for the preparation of 2-substituted-5-(1-alkylthio)alkylpyridines
WO2013040078A3 (en) Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
WO2007121131A3 (en) Medical devices including shape memory materials
HUE040654T2 (en) Methods and organisms for the growth-coupled production of 1,4-butanediol
PL2234947T3 (en) Glycerol-based product, process for obtaining same and use thereof in the manufacture of dichloropropanol
WO2005123736A8 (en) Novel 2-benzylaminodihydropteridinones, method for producing them and use thereof as drugs
PT1941027E (en) Methods and means for stem cell proliferation and subsequent generation and expansion of progenitor cells, as well as production of effector cells as clinical therapeutics.
MX356086B (en) Production of fatty acids and derivatives thereof.
IL207449A0 (en) Genetically modified cyanobacteria, methods of producing the same and methods of producing ethanol utilizing the same
WO2009137624A3 (en) Hemangio colony forming cells and non-engrafting hemangio cells
EP2840131A3 (en) Production of fatty acids and derivatives thereof
EP3257943A3 (en) Methods and vectors for cell immortalisation
WO2008017079A3 (en) Dyes and precursors and conjugates thereof
WO2007067828A3 (en) Glp-2 mimetibodies, polypeptides, compositions, methods and uses
WO2008083950A8 (en) Spirocyclic tetronic acid derivatives
HK1143404A1 (en) Cell for use in the production of exogenous protein, and production process using the cell

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780021822.6

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07755391

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009505494

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007238660

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 572842

Country of ref document: NZ

Ref document number: 2007755391

Country of ref document: EP

Ref document number: 1020087027950

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2007238660

Country of ref document: AU

Date of ref document: 20070413

Kind code of ref document: A