WO2007133509A2 - Water-dispersible patch containing an active agent for dermal delivery - Google Patents
Water-dispersible patch containing an active agent for dermal delivery Download PDFInfo
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- WO2007133509A2 WO2007133509A2 PCT/US2007/011036 US2007011036W WO2007133509A2 WO 2007133509 A2 WO2007133509 A2 WO 2007133509A2 US 2007011036 W US2007011036 W US 2007011036W WO 2007133509 A2 WO2007133509 A2 WO 2007133509A2
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- layer
- dermal patch
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- water
- agents
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Definitions
- the present invention relates to a device for delivering an active agent to the epidermis or skin of a wearer. More particularly, the invention relates to a dermal patch having at least two layers wherein at least one of the layers includes an active agent.
- Most skin or mucosal membrane diseases or disorders such as eczema, psoriasis, dermatitis, as well as infections from bacteria, fungal, parasitic, allergic, hormonal and other environment agents produce a inflammatory response.
- One important route for the administration of one or more drugs, or other active agents for treating a skin or mucosal membrane is by topical application of the active agent onto the skin.
- the localized treatment of body tissues, diseases and wounds requires that the particular active ingredient or agent be maintained at the treatment site for an effective period of time.
- Transdermal patches which permit the controlled release of the active ingredients onto the skin, are well known. Two types of patches for skin applications are described in the literature. The first type of patches has a multi-layer structure where the active ingredients are dissolved or dispersed in the various layers. Multi-layer patches have a structure comprising several successive layers.
- patches have a support layer, which is typically occlusive and can be composed of a material impermeable to the active compound to prevent its evaporation and to facilitate transdermal migration; a storage layer containing the active compound and capable of placement directly in contact with the skin; an adhesive layer applied to the surface of the storage layer and permeable to the active compound for attaching the patch to the skin; and a detachable protective layer to protect the laminated structure from any external contamination during storage prior to use of the patch.
- a support layer which is typically occlusive and can be composed of a material impermeable to the active compound to prevent its evaporation and to facilitate transdermal migration
- a storage layer containing the active compound and capable of placement directly in contact with the skin
- an adhesive layer applied to the surface of the storage layer and permeable to the active compound for attaching the patch to the skin
- a detachable protective layer to protect the laminated structure from any external contamination during storage prior to use of the patch.
- the active such as a transdermal drug
- a pressure sensitive adhesive layer which serves not only to carry the bioactive substance but to also attach the patch to the skin.
- the bioactive substances are mixed with and formulated into a pressure sensitive adhesive matrix which may be subsequently coated as a single pressure sensitive adhesive layer which serves not only to carry the bioactive substance but to also to attach the patch to the skin.
- the adhesive matrix type dermal or transdermal patch is typically of a simple design having an impermeable, generally occlusive, backing layer, a single pressure sensitive adhesive, i.e., the adhesive matrix, and attached to the adhesive layer a removable release liner.
- Prior art examples of patches for transdermal delivery of cosmetically active substances include U.S. Pat. No. 3,577,516 to Gould et al. discloses a spray-on bandage for protecting a wound to the skin comprising a gelling plastisol mixture of a polymer powder selected from polymers of hydroxy lower alkyl acrylates, methacrylates and copolymers of the same; and a high boiling polar plasticizer solvent.
- the plastisol can include a medically active ingredient which will diffuse from the film to the wound area over an extended period of time.
- the medically active ingredient can be incorporated into the film by impregnating the polymer with the agent; mixing the active agent with the polymer powder; or dissolving or dispersing the active ingredient in the high boiling plasticizer-solvent.
- U.S. Pat. No. 5,626,866 to Ebert et al. discloses a transdermal or transmucosal drug delivery device having a drug-containing adhesive composite layer.
- the adhesive composite layer has first and second drug permeable adhesive layers containing a drug in gel form.
- the drug-containing adhesive composite layer is formed by extruding the drug, in gel form, onto at least one exposed surface of either the first or second adhesive layers and then joining the first and second adhesive layers together.
- U.S. Pat. No. 5,965,154 to Haralambopoulos discloses an improved method for making an adhesive matrix type transdermal patch wherein ordinary, prefabricated, commercially available, pressure-sensitive adhesive tapes, with skin compatible adhesives, as the structural part of the patch is then loaded with the desirable bioactive substances and adjuvants.
- the bioactive substance can be a powder, liquid, or semi-liquid, e.g., a gel or an emulsion.
- a thin layer of the bioactive substance is placed between the adhesive surface of a tape and its release liner (or its backing layer, for a transfer tape), and subjecting the assembly to moderate heat and/or pressure to laminate the assembly. As a result, the bioactive substance becomes incorporated into the adhesive matrix of the tape while the tape remains adhesive over its entire delivery surface.
- U.S. Pat. No. 6,010,716 to Saunal et al. discloses a pharmaceutical composition for the transdermal administration of oestradiol, or of other medicinal substances, from a film formed on the skin.
- the pharmaceutical composition for transdermal administration comprises: 1) a polymeric release matrix capable of forming a flexible film after drying, chosen from cellulose polymers or copolymers or from vinylpyrrolidone/vinyl acetate copolymers; 2) an active principle, in particular oestradiol; 3) a promoter of transcutaneous absorption of the active principle; and 4) a physiologically acceptable nonaqueous solvent capable of dissolving the release matrix, the active principle and the transcutaneous absorption promoter and also capable of being rapidly removed by evaporation on contact with the skin.
- U.S. Pat. No. 6,143,319 to Meco ⁇ i et al. discloses a transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable derivative alone consisting of a backing layer, an active-substance-containing reservoir which is produced by using pressure sensitive adhesives, and a removable protective layer.
- the pressure sensitive adhesive includes esters of colophony and inactive ingredients.
- the estradiol-containing pressure sensitive adhesive may additionally include polymers selected from the group consisting of styrene-butadiene-styrene block copolymers, styrene-isoprene-styrene block copolymers, styrene- ethylene-butylene-styrene block copolymers, ethylene-vinyl acetate copolymers, polyvinyl pyrrolidone, cellulose derivatives, and polymers based on acrylic acid and methacrylic acid derivatives.
- polymers selected from the group consisting of styrene-butadiene-styrene block copolymers, styrene-isoprene-styrene block copolymers, styrene- ethylene-butylene-styrene block copolymers, ethylene-vinyl acetate copolymers, polyvinyl pyrrolidone, cellulose derivatives,
- U.S. Pat. No. 6,685,682 to Heinecke et al. discloses pressure sensitive adhesive composite dressing having a conformable backing with a pressure sensitive adhesive coated on a bottom face and an optional low adhesion coating on a top face, and which is supported by a removable carrier attached to the top face of the backing.
- the carrier is nonpermanently heat-sealed to the backing and a cut in the carrier substantially defining a window proximate a center of the carrier, the carrier further being formed of material substantially more rigid than the backing to provide rigidity to the adhesive composite.
- U.S. Patent Application Publication No. 2003/0152612 to Pugliese et al. discloses a multi-layered, transdermal patch.
- the patch must have at least two layers: the first layer comprises a pressure-sensitive, adhesive layer containing an adequate amount of a selected xanthine, uniformly distributed therein, for delivery to the skin over the duration of the patch application; the second layer consists of a backing film or a fabric, which provides protection to the xanthine containing adhesive first layer when applied to skin.
- the patch can be applied to the desired skin site by means of the adhesive first layer, which tightly adheres to the skin. Then, xanthine from the patch continuously diffuses through the skin into the underlying tissues including the fatty tissues.
- the xanthine-containing, adhesive may be selected from an acrylate copolymer, a vinyl ether polymer, or a silicone adhesive polymer.
- U.S. Patent Application Publication No. 2003/0157138 to Eini et al. discloses a pharmaceutical or cosmetic carrier comprising 1-25 weight % of a solidifying agent and 75-99 weight % of a hydrophobic solvent, and the solvent is typically liquid at ambient temperature.
- the solidifying agent includes at least one long chain fatty alcohol having at least 15 carbon atoms in its carbon backbone and/or at least one fatty acid, having at least 18 carbon atoms in its carbon backbone.
- the hydrophobic solvent includes at least one marine animal derived oil, at least one terrestrial animal derived oil, at least one mineral oil, at least one silicone oil and/or at least one plant-derived oil.
- U.S. Patent Application Publication No. 2003/0175333 to Shefer et al. discloses an invisible patch for the controlled delivery of cosmetic, dermatological, and pharmaceutical active ingredients onto the skin formed of a single matrix layer.
- the patch is a single layer water soluble matrix comprising one or more water sensitive bioadhesive polymers, a water soluble oligomer, and a surfactant.
- the patch dissolves or disintegrates and provides a substantive therapeutic layer to the treatment site over an extended period of time.
- U.S. Patent Application Publication No. 2004/0033254 to Song et al. discloses an active agent containing adhesive composition for the transdermal delivery of hydrophilic drugs.
- the matrix layer is made up of outer adhesive layers comprising an active ingredient, a hydrophobic acrylic adhesive polymer, a mixture of high and low molecular weight water soluble polyvinylpyrrolidone (PVP) polymers and colloidal silica.
- Sandwiched between the adhesive layers is an absorption enhancing layer comprising ingredients selected from the group consisting of non-ionic surfactants, terpenes and dissolution assisting agents.
- a pharmaceutical composition having a flexible backing sheet with opposing surfaces that are distal and proximal to the skin when applied and a coating on the proximal surface of the backing sheet.
- the coating comprises (a) an adhesive and (b) an active agent comprising valdecoxib or a prodrug thereof being in a therapeutically effective total amount and dispersed in a matrix that comprises zero to less than an active agent solubilizing effective amount in total of one or more solvents other than the adhesive.
- hydrophobic carrier such as petrolatum, liquid paraffin, lanolin, beeswax, vegetable oil, glycerin monostearate, polyethylene glycol and some emulsifying agents have limited use due to their consistency and greasy feeling following topical application.
- a patch having a hydrophobic carrier is used over an extended period of time without removal the hydrophobic carriers may interfere with moisture evaporation from the skin leading to skin maceration.
- hydrophobic liquids such as mono- and polyunsaturated oils from vegetable and marine sources, silicone oils, mineral oils, and liquid hydrophobic plant-derived oils are known for their therapeutic effects when applied topically.
- the oils may also contain essential nutritional constituents, such as oil soluble vitamins, minerals and other therapeutically effective constituents.
- administration of such therapeutic oils in a liquid form does not exert sufficient amounts of the therapeutic oils due to their flow-spread properties.
- a problem with incorporating such hydrophobic carriers and/or liquids is that they may interfere with the tackiness of the adhesive, resulting in a patch that does not stick to the intended site or the patch is easily dislodged.
- a further disadvantage of the patches of the prior art is that they are typically multiple layer devices that are thick, readily visible to others, and have a backing layer that although flexible is not sufficiently stretchable to allow for freedom of movement.
- a topically applied, layered composition or patch having a pharmaceutical, cosmetic or dermatological agent included there is a further need for such type of patch that is relatively thin, having a substantially non-tacky exposed surface and that would be flexible, stretchable and substantially non-perceptible during use.
- the present invention is a dermal patch having at least two layers, wherein at least one of the layers is a polymer matrix system having an active agent admixed therein, wherein at least one of the layers is water dispersible and wherein the dermal patch has an elongation factor of at least 50 %.
- One aspect of the invention pertains to a dermal patch having a first and a second layer, wherein at least one of said layers is a polymer matrix system having an active agent admixed therein, wherein at least one layer comprises a water-dispersible or water-dissipatable film-forming polymer, and wherein the dermal patch has an elongation factor of at least 50 %.
- Another aspect of the invention pertains to a dermal patch having a first layer and a second layer, wherein at least one layer comprises from 25 to 99.8 weight % of a water-dispersible or water-dissipatable film-forming polymer and at least one layer comprises from 0.1 to 50 weight % of an active agent, wherein the sum of the ingredients in each layer equals 100 weight %.
- Yet another aspect of the present invention is a method for making the dermal patch of the present invention.
- the method comprises the steps of combining a predetermined amount of the active agent with a predetermined amount of an acceptable water-dispersible or water-dissipatable polymer in an aqueous phase to form a blend, coating the blend on a suitable releasable substrate to form a first layer, drying the first layer, joining a second layer over the first layer and covering the second layer with a suitable releasable substrate.
- FlG. 1 is a cross-sectional view of one embodiment of the dermal patch of the present invention.
- FIG. 2 is a cross-sectional view of the dermal patch of the present invention shown as applied during use.
- FIG. 3 is a cross-sectional view of another embodiment of the dermal patch of the present invention having illustrating the top layer as an intermittent layer.
- FIG. 4 is a cross-sectional view of another embodiment of the dermal patch of the present invention having illustrating the bottom layer as an intermittent layer.
- FIG. 5 is a perspective view of the embodiment of FIG. 3 shown as applied during use.
- Ranges may be expressed herein as from one particular value, and/or to another particular value. When such a range is expressed, it is to be understood that another embodiment is from the one particular value and/or to the other particular value.
- the dermal patch of the present invention provides an effective residence time with minimal discomfort and ease of use, and is an appropriate vehicle for local as well as systemic delivery of cosmetic, derrnatological, and pharmaceutical active ingredients to the surface of skin or to the surrounding tissues.
- the patch of the present invention can have any dimension that would be convenient to the user or for delivery of any cosmetic, dermatological, and pharmaceutical active ingredient.
- the term "matrix”, “polymer matrix” and “adhesive matrix” are used interchangeably depending upon their context to mean a cosmetic, dermatological, or pharmaceutical active ingredient intimately admixed, dissolved or suspended in a biocompatible polymeric phase.
- the term “adhesive matrix” is more specific and means a cosmetic, dermatological, or pharmaceutical active ingredient intimately admixed, dissolved or suspended in a biocompatible polymeric phase wherein the polymeric matrix is adapted to have pressure sensitive adhesive characteristics.
- the matrix can also contain other ingredients. This definition is meant to include embodiments wherein such polymeric phase is laminated to a pressure sensitive adhesive or used with an overlay adhesive.
- a dermal patch having at least two layers. At least one of the layers contains an active ingredient that may be fixed within the layer or that may be fugitive from the layer. At least one of the layers comprises a water-dispersible or water- dissipatable polymer.
- the dermal patch of the present invention also has an elongation factor of at least 50%.
- the term "patch” is a generic term which is to be understood as covering any type of known devices, such as swatches, tapes poultices, pads, plasters, cataplasms, and dressings that are adhesive to the skin.
- the dermal patch 10 shall be described with reference to the various components as would be applied to a user's skin.
- the dermal patch 10 has a first protective covering 15 and a second protective covering 20, overlaying the first and second layers 25 and 30, respectively.
- First and second layers 25 and 30 are positioned between, but not coextensive with, the first and second protective coverings 15 and 20 to prevent contamination of the surfaces and to retain the hydrophilic nature of at least one of the layers.
- the protective coverings 15 and 20, or release substrates, are desirably flexible, and easily separated from the respective layers 25 and 30.
- the protective covering 15 can be relatively more rigid than, as flexible as, or more flexible than the polymeric layer 25.
- the only criteria for the protective covering 15 is that it be readily removable for exposing the first layer 25, and that the protective covering 20 should be flexible enough to readily conform to the wear's skin.
- the protective coverings 15 and 20 are a siliconized polymer film, such as polyethylene, polypropylene, polyvinyl chloride, ethyl vinyl acetate, polyurethane, polyester, oriented polyester, oriented polypropylene, silicone or wax treated paper, a woven or non-woven fabric which may optionally have one or more of the aforementioned polymers laminated onto a surface of the fabric.
- the fabric may also be siliconized, or treated with silicone release agent as is known to those skilled in the art.
- the protective coverings 15 and 20 may be impermeable to air and/or water.
- the protective coverings 15 and 20 are an elastic film that is water-resistant and skin- conformable.
- a preferred protective covering material is a release film (Polyester Liner L-25X available from Sil-Tech, 222 Mound Avenue, Miamisburg, OH 45342).
- a grasping means 35 for separating the protective covering 15 from layer 25.
- the grasping means 35 is illustrated as a separate member affixed to the inner surface of the protective covering 15. However, one skilled in the art will understand that the grasping means 35 could be attached to the outer surface of the protective covering 15 as well as being an integral part of the protective covering 15.
- the manner by which grasping means 35 is affixed, i.e., an integral or separate member, its configuration, or manner of manufacture may vary according to the present invention.
- the grasping means 35 provide a means by which the user can readily identify which side of the patch 10 is to placed adjacent to the wearer's skin and that the grasping means 35 facilitate removing the first protective covering 15 to expose the adhesive first layer 25 for dermal contact.
- the grasping means 35 is a separate piece of adhesive tape applied to the protective covering 15 so that its adhesive side of the tape bonds with the adhesive release substrate 15 and is typically applied on at least one edge of the patch.
- this tape can be many different types of adhesive tape, such as Scotch brand matte finish household or office tape available from 3M Company, Scotch Magic® Tape, Crystal Clear Duck tape available from Henkel Consumer Adnesives, Inc., electrical tape, or any other adhesive tapes which are thin films (0.5 to 5 mils in thickness) of plastics such as polyethylene terephthalate or cellulose acetate that contain a strong adhesive.
- a preferred width is from 0.5 to 1 inch.
- the adhesive or adhesive matrix i.e., adhesive containing one or more active agents or other ingredients, is illustrated as being positioned adjacent to the protective covering 15.
- the user separates the protective covering 15 from the adhesive layer 25.
- the adhesive layer 25 is then pressed onto the skin, typically using the hand to apply pressure on the release layer 20.
- the release layer 20 is grasped and peeled from the composite film.
- the adhesive layer 25 has a bonding strength to the second layer 30 and to the skin that is greater than the bonding strength of the protective layer 20 to the surface of the second layer 30.
- the second protective layer 20 is removed exposing the outer surface 40 of the second layer 30.
- a dermal patch 10 of the present invention is illustrated as applied to a wearer's skin 12.
- the dermal patch has at least two layers, wherein at least one of the layers is a polymer matrix system having an active agent admixed therein, and wherein at least one of the layers is water-dispersible, which may be the same or different from the matrix layer. It is also important aspect of the present invention that the dermal patch has an elongation factor of at least 50 % so that the patch will move in conjunction with the wear's movements. In the description that follows, all weight percentages are based on the total weight of the constituents comprising an individual layer, unless specifically designated as being directed to the total weight of the dermal patch.
- the adhesive layer 25 is adapted to be positioned adjacent to the user's skin and has a sufficiently low glass transition temperature, Tg, to substantially adhere to the skin when applied.
- the adhesive layer 25 is an adhesive matrix containing at least one active agent.
- the adhesive matrix 25 includes a film-forming, biocompatible polymer suitable for contact with the skin and an active ingredient.
- the adhesive matrix comprises: a) from 25 to 99.8 weight % of a film-forming, adhesive polymer; and b) from 0.1 to 50 weight % of an active ingredient.
- the adhesive matrix may include one or more of c) from 0.1 to 25 weight % of a surfactant; or d) less than 10 weight % of a skin permeation enhancing agent; or e) up to 20 weight % of a humectant; or f) up to 20 weight % of a plasticizer, wherein the sum of the ingredients equals 100 weight %.
- the adhesive matrix includes a film-forming, biocompatible polymer suitable for contact with the skin and an active ingredient.
- the adhesive matrix comprises: a) from 30 to 95 weight % of a film-forming, adhesive polymer; and b) from 1 to 40 weight % of an active ingredient.
- the adhesive matrix may further include one or more of c) from 0.1 to 25 weight % of a surfactant; or d) less than 10 weight % of a skin permeation enhancing agent; or e) up to 20 weight % of a humectant; or f) up to 20 weight % of a plasticizer, wherein the sum of the ingredients equals 100 weight %.
- the adhesive matrix of the present invention comprises: a) from 40 to 95 weight % of a film-forming, adhesive polymer; and b) from 1 to 40 weight % of an active ingredient.
- the adhesive matrix can further include c) from 0.1-25 weight % of a surfactant; and/or d) less than 10 weight % of a skin permeation enhancing agent; and/ore) up to 20 weight % of a humectant; and/or f) up to 20 weight % of a plasticizer, wherein the sum of the ingredients equals 100 weight %.
- the polymers suitable for use as an adhesive matrix include uncrosslinked or crosslinked , film-forming, water-dispersible polymers.
- the polymer should have some compatibility with the active agent such that the desired amount of active agent can be incorporated into the polymer matrix without substantially affecting the adhesive quality of the polymer. Desirably, the polymer should not be absorbable into the skin.
- Polymers which may be used include water-dispersible or water-dissipatable polyester or polyester amides such as sulfopolyesters or polyesteramides (collectively referred to as polyester(s) or sulfopolyester(s)) containing ether groups and sulfonate groups having a glycol residue and a dicarboxylic acid residue and at least one difunctional comonomer containing a sulfonate group attached to an aromatic nucleus and in the form of a metallic salt.
- Such polymers are well known to those skilled in the art and are available from Eastman Chemical Company under the trade name of Eastman AQ polyester polymers.
- Such sulfopolyesters can be dissolved, dispersed or otherwise dissipated in aqueous dispersions, preferably at temperatures of less than 80 0 C.
- aqueous dispersions preferably at temperatures of less than 80 0 C.
- Such polyesters are described in greater detail in U.S. Pat. No. 3,734,874, issued to Charles Kibler on May 22, 1973, the disclosure of which is incorporated herein by reference.
- the term "residue” or “component” as used in the specification and concluding claims refers to the moiety that is the resulting product of the chemical species in a particular reaction scheme or subsequent formulation or chemical product, regardless of whether the moiety is actually obtained from the chemical species.
- an ethylene glycol residue in a polyester refers to one or more -OCH2CH 2 O- repeat units in the polyester, regardless of whether ethylene glycol is used to prepare the polyester.
- acid in the above description and in the appended claims includes the various ester forming or condensable derivatives of the acid reactants such as the dimethyl esters thereof as employed in the preparations set out in these patents.
- sulfo-monomers those wherein the sulfonate group is attached to an aromatic nucleus such as benzene, naphthalene, diphenyl, or the like, or wherein the nucleus is cycloaliphatic such as in 1 ,4-cyclohexanedicarboxylic acid.
- Another a suitable polymer for use in the present invention can be a hybrid latex of a sulfopolyester and acrylic as described in US Patent No. 6,001,922.
- Other examples of such su If opoly ester-acrylic hybrid polymers, wherein the acrylic monomers are polymerized in the presence of the sulfopolyester dispersion are found in US Patent 4,946,932, the entire disclosures of which is incorporated herein by reference.
- polymers suitable for use in the current invention are sulfonated or sulfated acrylic copolymers prepared from acrylamide or acrylic type monomers such as 2-acrylamido-2-methyl propanesulphonic acid (AMPS®) available from Lubrizol or sulfoethyl methacrylate (SEM) available from Polysciences, Inc.
- AMPS or SEM may be polymerized with other monomers such as methyl methacrylate, butyl acrylate, styrene, and the like to form acrylic polymers.
- the AMPS or SEM may be present in the polymer as a salt with ammonia, an amine, or an alkali metal.
- miniemulsion refers to a polymerization of small
- the process is directed to forming hydrophobically modified emulsion polymers including a hydrophobic core and a hydrophilic shell.
- an organic hydrophobe is added to stabilize the miniemulsion pre- emulsion (before polymerization). This organic hydrophobe may be an active ingredient such as defined herein, or may be added in addition to the active ingredient.
- polymers are polymers known as sulfonate stabilized water dispersible acrylic polymers are available from ALCO Chemical Company, Chattanooga, Tennessee.
- sulfonated polystyrene polymers such as VERSA-TL Sulfonated Polymers are suitable.
- partially sulfonated polystyrene polymers neutralized as alkali metal salts are suitable. These may be used alone or in conjunction with other polymers.
- Other such water dispersible polymers are sulfonated polystyrene polymers such as those available from National Starch under the trade name FLEXAN® II.
- Suitable polymers include water dispersed polyurethane polymers. Suitable examples are polymers known as Avalure UR405 and Avalure UR450 available from Noveon Chemical Company.
- the polymer forming the adhesive matrix layer comprises a sulfonated or sulfated acrylic polymer or sulfonated polyester.
- the acrylic or polyester polymer comprises water dispersing or water dissipating polar moieties such as sulfate or sulfonate, carboxylate, or polyethylene oxide.
- the adhesive matrix layer may contain blends of polymers of low Tg (below zero degrees Centigrade), with polymers of high Tg (above zero degrees Centigrade), and optionally a humectant, a plasticizer, a surfactant, a skin permeation enhancing agent, or a tackifier.
- the polymer forming the adhesive matrix layer comprises an acrylic polymer having glass transition temperature (Tg) less than 0 0 C, such as, for example, less than -5°C, or even less than -10 0 C 1 whereupon the active ingredient is incorporated into the adhesive polymer layer.
- Tg glass transition temperature
- acrylic polymer is used interchangeably with "polyacrylate,” “polyacrylic polymer,” and "acrylic adhesive.”
- the acrylate polymers useful in practicing the invention are polymers of one or more monomers of acrylic acids and other copolymerizable monomers.
- the acrylate polymers also include copolymers of alkyl acrylates and/or methacrylates and/or copolymerizable secondary monomers or monomers with functional groups.
- the acrylic polymer is composed of at least 60 mole % of an acrylate or alkyl acrylate monomer and can contain up to 40 mole % of a functional monomer copolymerizable with the acrylate, wherein the above mole percentages are based on the total mole of polymer comprising the film- forming acrylic pressure sensitive adhesive.
- acrylic monomers include, but are not limited to, styrenic monomers such as styrene, alpha-methyl styrene, vinyl naphthalene, vinyl toluene, and chloromethyl styrene; ethylenically unsaturated species such as, (meth)acrylic acids and esters having carbon chain lengths of up to 30 carbon atoms, for example, methyl acrylate, acrylic acid, methacrylic acid, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, isob ⁇ tyl acrylate, isobutyl methacrylate, hexyl acrylate, hexyf methacrylate, ethylhexyl acrylate, ethylhexyl methacrylate, octyl acrylate, octyl methacrylate, fluor
- functional monomers such as hydroxyethyl acrylate, hydroxyethyl methacrylate, hydroxypropyl acrylate, glycidyl methacrylate, carbodiimide methacrylates such as cyclohexylcarbodiimidoethyl methacrylate; t- butylcarbodiimidoethyl methacrylate, and alkyl crotonates.
- the acrylic moiety also may include any pendant moiety which is capable of (i) surviving the polymerization process and/or (ii) participating in or promoting crosslinking of the resin.
- An acrylic moiety may have an ethylenic unsaturation such as, but not limited to, alfyl and vinyl groups. This group may also be an acetoacetoxy moiety or enamine moiety.
- acrylic monomers having latent oxidatively-functional groups include, but are not limited to, allyl methacrylate, vinyl methacrylate, acetoacetoxyethyl methacrylate, hydroxybutenyl methacrylate, the allyl or diallyl ester of maleic acid, and poly(allyl glycidyl ether).
- allyl means a three carbon-carbon chain which includes one ethylenically unsaturated moiety having from 2 to 24 carbon atoms.
- alkyl means branched, linear, and cyclic substitute carbon chain containing from one to 30 carbon atoms.
- the adhesive matrix layer may contain a high concentration of the active ingredient(s) contained therein which helps increase transdermal absorption efficiency and results in superior adhesion for long-term application onto the skin. Moreover, if the adhesive layer contains the active ingredient, the drying process of the adhesive layer can be achieved in a short period of time, which in turn significantly reduces the manufacturing time and cost.
- the total thickness of the patch of the present invention, excluding.the backing layers, is from 0.2 to 5 mils (5 to 125 micrometers), such as, for example, from 0.5 to 4 mils (12.5 to 100 micrometers), or from 0.7 to 3.5 mils.
- the water-dispersible or water dissipatable acrylic polymer matrix of the present invention may be prepared using a miniemulsion technique, whereby the active ingredient is present during polymer formation.
- miniemulsion refers to a polymerization of small (on average, generally ⁇ 1000 nanometers in diameter) droplets of acrylic monomers in contrast to a conventional acrylic monomer polymerization wherein monomer droplet sizes present are in the range of 1,000 to 10,000 nanometers.
- the process is directed to forming modified emulsion polymers including a hydrophobic core and a hydrophilic shell.
- an organic hydrophobe is added to stabilize the miniemulsion pre-emulsion (before polymerization).
- oils-acrylic hybrid emulsions may be prepared by incorporating hydrophobic, substantially saturated oils (such as coconut oil fatty acid or coconut oil) or unsaturated oils (such as natural oils such as avocado oil, Shea butter, and the like) in acrylic monomers.
- a water-based latex is prepared by polymerizing an acrylic monomer in the presence of hydrophobes.
- Tg glass transition temperature
- colloidal polymer dispersions of the present invention contain from 20 to 60% polymer particles dispersed in water.
- the average particle size of the modified acrylic latex may range from 25 to 500 nm. In another embodiment, particle sizes range from 50 to 300 nm, and in yet another embodiment particle sizes range from 70 to 250 nm.
- the latex particles generally have a spherical shape. Mini-emulsion polymerization can be accomplished by redox or thermal processes in batch, semi-continuous and continuous fashion.
- the second layer 30, may be the same as or different from the first layer 25. Although it is desirable that the second layer 30 include a water- dispersible or water-dissipatable polymer, it is not necessary if the first layer 25 is water-dispersible or water-dissipatable. In any manner, the second layer 30 should be compatible with and relatively strongly affixed to the first layer 25 and permit the patch 10 to have at least 50% elongation when used. Accordingly, the second layer 30 may be comprised of any polymer known to those skilled in the art, although a water-dispersible or water-dissipatable of the type described above is preferred.
- the second layer 30 should have a Tg such that it is substantially non-tacky or preferably tack-free in less than 3 minutes after the protective covering 20 is removed and the dermal patch is being used.
- substantially non-tacky means the film layer 30 no longer acquires fibers from a cotton ball (having a weight of 0.6 to 0.8 grams) being slowly rolled across the width of the film. This time corresponds approximately to the time at which the film, when pushed gently with a clean finger, no longer pulls on the finger as the finger was withdrawn.
- the glass transition temperature, Tg, of the polymer in the adhesive first layer 25 will be from -5°C to -45°C, and the Tg of the polymer in the second layer 30 will be greater than 5°C, wherein the delta or difference in Tg of the two polymers is at least 15°C. In another embodiment, the delta or difference in Tg of the two polymers is at least 25°C.
- plasticizers that are both compatible with the polymer used in one or both of the layers as well as being suitable for dermal contact.
- plasticizers are well known to those skilled in the dermal patch art.
- Such plasticizers may be included in the polymer in an amounts up to 20 weight % of the respective layer composition. In another embodiment the amount of plasticizer is from 0 to 25 weight % of the layer composition.
- Non-limiting examples of such plasticizers include diols, triols, polyols, alcohol ethers, alcohol esters, esters, ethers, carboxylic acids, hydroxy acids, amides, carbonates, and mixtures thereof.
- Suitable plasticizers include triacetin, triethyl citrate, glycerin, sorbitol, 1 ,2-propylene glycol, ethylene glycol, 1,3 propylene glycol, 2-methyl-1 ,3-propanediol, butylene glycol, hexylene glycol, isoprene glycol, xylitol, fructose, hexanediol, octanediol, and mixtures thereof.
- a particulate material may be included in layer 30 to reduce the gloss.
- the particulate material may be inorganic or organic and may be added to the upper surface 40 (FIG. 2) of the film.
- the particle diameter may be from 1 to 10 micrometers, preferably from 2 to 5 micrometers. From 1 to 10 percent by weight of the particulate material may be added, based on the total weight of the patch 10. Preferably from 2 to 7 percent of the particulate material is added to the film. Examples are glass spheres, hollow glass spheres, ceramic spheres, silica spheres, alumina particles, polymer particles produced by grinding, and the like.
- the upper film's surface may be embossed with a pattern to inhibit reflection.
- the active ingredient useful in the practice of the present invention is selected from one or more cosmetic, dermatological, and pharmaceutical active ingredients that may be fixed within the incorporating layer or fugitive, i.e., migrates onto the skin surface or is absorbed into the skin.
- the dermal patch of the present invention may have a fugitive active ingredient that transfers from 1 to 100 weight % of the active agent to the epidermis of the user, preferably from 10 to 100 weight % and more preferably greater than 80 weight % of the fugitive active ingredient is transferred to the epidermis of the user.
- fugitive active agents have a beneficial effect on the skin, including, but not limited to: anti-oxidants; free radical scavengers; skin moisturizers; de-pigmentation agents; reflectants; humectants; antimicrobial (e.g., antibacterial) agents; allergy inhibitors; anti-acne agents; anti-aging agents; anti-wrinkling agents, antiseptics; analgesics; antitussives; antipruritics; local anesthetics; hair growth promoting agents, antihistamines; keratolytic agents; anti-inflammatory agents; fresheners; healing agents; anti- infectives; inflammation inhibitors; anticholinergics; vasoconstrictors; vasodilators; wound healing promoters; peptides, polypeptides and proteins; deodorants and antiperspirants; skin emollients; tanning agents; skin lightening agents; antifungals such as antifungals for foot preparations; depilating agents;
- the polymer matrix of the present invention can also include as the active ingredient or as an additive one or more vegetable preparations, such as extracts or tinctures for the treatment of topical skin diseases.
- suitable extracts or tinctures include oak bark extract, walnut extract, tincture of arnica, hamamelis extract, ribwort extract, pansy extract, thyme or sage extract; for the treatment of damaged or injured skin, for example, St. John's wort tincture, cone flowers tincture, chamomile flowers extract, or calendula flowers tincture; and for the care of exhausted and damaged skin, for example, birch leaf extract, nettle extract, coldsfoot extract, comfrey tincture, horsetail extract, or aloe vera extract.
- Vegetable preparations can also be released from the film layer for the intradermal treatment of diseases, for example, extracts of horse chestnut and butcher's broom in case of vein diseases, or extracts and tinctures of arnica, calendula, and capsicum in case of contusions, distortions, or hemorrhages.
- Vegetable preparations in the system according to the present invention may also be used in transdermal therapy, for example, ginseng extract in case of geriatric complaints; valerian tincture, extracts of melissa and hop to cause a sedative effect in case of superexcitation, sleep disturbances, and stress; extracts of kola and tea for stimulating; or hawthorn extract to stabilize the circulatory system.
- Suitable amino acid agents that can be used in the present invention include amino acids derived from the hydrolysis of various proteins as well as the salts, esters, and acyl derivatives thereof.
- Non-limiting examples of such amino acid agents include amphoteric amino acids such as alkylamido alkylamines, stearyl acetyl glutamate, capryloyl silk amino acid, caprylol collagen amino acids; capryloyl kertain amino acids; capryloyl pea amino acids; cocodimonium hydroxypropyl silk amino acids; corn gluten amino acids; cysteine; glutamic acid; glycine; hair keratin amino acids; hair amino acids such as aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, half-cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, cysteic acid, lysine, his
- Suitable peptides, polypeptides, and proteins that can be used in the present invention include those polymers that have a long chain, such as at least 10 carbon atoms, and a high molecular weight, such as at least 1000, and are formed by self-condensation of amino acids.
- proteins include collagen, deoxyribonuclease, iodized corn protein; keratin; milk protein; protease; serum protein; silk; sweet almond protein; wheat germ protein; wheat protein; wheat protein, alpha and beta helix of keratin proteins; hair proteins, such as intermediate filament proteins, high-sulfur proteins, ultrahigh-sulfur proteins, intermediate filament-associated proteins, high- tyrosine proteins, high-glycine tyrosine proteins, tricohyalin, and mixtures thereof.
- hair proteins such as intermediate filament proteins, high-sulfur proteins, ultrahigh-sulfur proteins, intermediate filament-associated proteins, high- tyrosine proteins, high-glycine tyrosine proteins, tricohyalin, and mixtures thereof.
- vitamins examples include vitamin B complex; including thiamine, nicotinic acid, biotin, pantothenic acid, choline, riboflavin, vitamin B 6 , vitamin B 1 2, pyr ⁇ doxine, inositol, carnitine; vitamins A, C, D, E, K and their derivatives such as vitamin A palmitate and pro-vitamins, such as panthenol (pro vitamin B 5 ) and panthenol triacetate, and mixtures thereof.
- vitamin B complex including thiamine, nicotinic acid, biotin, pantothenic acid, choline, riboflavin, vitamin B 6 , vitamin B 1 2, pyr ⁇ doxine, inositol, carnitine; vitamins A, C, D, E, K and their derivatives such as vitamin A palmitate and pro-vitamins, such as panthenol (pro vitamin B 5 ) and panthenol triacetate, and mixtures thereof.
- Suitable antibacterial agents that can be used in the present invention include bacitracin, erythromycin, neomycin, tetracycline, chlortetracycline, benzethonium chloride, phenol, and mixtures thereof.
- Suitable skin emollients and skin moisturizers include mineral oil, lanolin, vegetable oils, isostearyl isostearate, glyceryl laurate, methyl gluceth 10, methyl gluceth 20 chitosan, and mixtures thereof.
- Suitable hair conditioners that can be used in the present invention include quaternized compounds such as behenamidopropyl PG- dimonium chloride, tricetylammonium chloride, dihydrogenated tallowamidoethyl hydroxyethylmonium methosulfate, and mixtures thereof as well as lipophilic compounds like cetyl alcohol, stearyl alcohol, hydrogenated polydecene, and mixtures thereof.
- sunscreen agents examples include butyl methoxydibenzoylmethane, octyl methoxycinnamate, oxybenzone, octocrylene, octyl salicylate, phenylbenzimidazole sulfonic acid, ethyl hydroxypropyl aminobenzoate, menthyl anthranilate, aminobenzoic acid, cinoxate, diethanolamine methoxycinnamate, glyceryl aminobenzoate, titanium dioxide, zinc oxide, padimate, red petrolatum, -benzoyl-4-hydroxy-2- methoxy benzene sulfonic acid, 3,3'-(1 ,4 phenylenedimethylidene)-bis(7,7- dimethyl-2-oxo-bicyclo[2.2.1] heptane-1 -methane sulfonic acid) sodium salt, mixtures of these compounds and others mentioned in Chapter 1 of "
- Suitable tanning agent is dihydroxyacetone.
- suitable skin lightening agents include hydroquinone, catechol and its derivatives, ascorbic acid and its derivatives, and mixtures thereof.
- UV absorbers admixed with the polymers of the invention it is often desirable to retain or fix the UV absorber within the dry film.
- a reason for retaining the UV absorber within the film is to protect skin tissue underneath the patch from ultraviolet light. The selection process may be done by one skilled in the art and through experimentation.
- depilating agents examples include calcium thioglycolate, magnesium thioglycolate, potassium thioglycolate, strontium thioglycolate, and mixtures thereof.
- Suitable external analgesics and local anesthetics include benzocaine, dibucaine, benzyl alcohol, camphor, capsaicin, capsicum, capsicum oleoresin, juniper tar, menthol, methyl nicotinate, methyl salicylate, phenol, resorcinol, turpentine oil, and mixtures thereof.
- suitable antiperspirants and deodorants include aluminium chlorohydrates, aluminium zirconium chlorohydrates, and mixtures thereof.
- Suitable counterirritants examples include camphor, menthol, methyl salicylate, peppermint and clove oils, ichtammol, and mixtures thereof.
- An example of a suitable inflammation inhibitor that can be used in the present invention includes hydrocortisone.
- hemorrhoidal products examples include anesthetics such as benzocaine, pramoxine hydrochloride, and mixtures thereof; antiseptics such as benzethonium chloride; astringents such as zinc oxide, bismuth subgallate, balsam Peru, and mixtures thereof; skin protectants such as cod liver oil, vegetable oil, and mixtures thereof.
- anesthetics such as benzocaine, pramoxine hydrochloride, and mixtures thereof
- antiseptics such as benzethonium chloride
- astringents such as zinc oxide, bismuth subgallate, balsam Peru, and mixtures thereof
- skin protectants such as cod liver oil, vegetable oil, and mixtures thereof.
- a type of active ingredient that can be used in the present invention includes those therapeutic agents that are effective in the treatment of seborrheic dermatitis, and psoriasis as well as the symptoms associated therewith.
- suitable therapeutic agents include zinc pyrithione, shale oil and derivatives thereof such as sulfonated shale oil, selenium sulfide, sulfur; salicylic acid; coal tar; povidone-iodine and imidazoles.
- Antimicrobials that can be used in the present invention for topical application are penicillins, cephalosporins, other beta-lactam compounds, aminoglycosides, tetracyclines, erythromycin, antifungal agents, and combinations thereof.
- Antiseptics that can be used in the present invention for topical application onto acneiform skin are triclosan (Irgasan DP 300), phenoxy isopropanol, resorcinol, chlorhexidine, povidone and iodine.
- Keratolytic agents that can be used in the present invention for topical application onto acneiform skin are salicylic acid, benzoyl peroxide, sulphur, retinoic acid and any of a number of fruit acids and alpha hydoxy acids.
- anti-irritants examples include alpha-bisabolol, famesol, chamomile extract and glycyrrhetinic acid.
- anti-cellulite agents examples include caffeine and carnitine.
- anti-inflammatory analgesic agents examples include acetaminophen, methyl salicylate, monoglycol salicylate, aspirin, mefenamic acid, flufenamic acid, indomethacin, diclofenac, alclofenac, diclofenac sodium, ibuprofen, ketoprofe ⁇ , naproxen, pranoprofe ⁇ , fenoprofen, sulindac, fenclofenac, clidanac, flurbiprofen, fentiazac, bufexarnac, piroxicam, phenylbutazone, oxyphenbutazone, clofezone, pentazocine, mepirizole, and tiaramide hydrochloride.
- steroidal anti-inflammatory agents include hydrocortisone, predonisolone, dexamethasone, triamcinolone acetonide, fluocinolone acetonide, hydrocortisone acetate, predonisolone acetate, methylpredonisolone, dexamethasone acetate, betamethasone, betamethasone valerate, flumetasone, fluorometholone, and beclomethasone diproprio ⁇ ate.
- antihistamines examples include diphenhydramine hydrochloride, diphenhydramine salicylate, diphenhydramine, chlorpheniramine hydrochloride, chlorpheniramine maleate isothipendyl hydrochloride, tripelennamine hydrochloride, promethazine hydrochloride, methdilazine hydrochloride, and the like.
- Examples of local anesthetics include dibucaine hydrochloride, dibucaine, lidocaine hydrochloride, lidocaine, benzocaine, p-buthylaminobenzoic acid 2-(die- ethylamino) ethyl ester hydrochloride, procaine hydrochloride, tetracaine, tetracaine hydrochloride, chloroprocaine hydrochloride, oxyprocaine hydrochloride, mepivacaine, cocaine hydrochloride, piperocaine hydrochloride, dyclonine, and dyclonine hydrochloride.
- bactericides and disinfectants examples include thimerosal, phenol, thymol, benzalkonium chloride, benzethonium chloride, chlorhexidine, povidone iode, cetylpyridinium chloride, eugenol, and trimethylammonium bromide.
- vasoconstrictors include naphazoline nitrate, tetrahydrozoline hydrochloride, oxymetazoline hydrochloride, phenylephrine hydrochloride, tramazoline hydrochloride, and the like.
- hemostatics examples include thrombin, phytonadione, protamine sulfate, aminocaproic acid, tranexamic acid, carbazochrome, carbaxochrome sodium sulfanate, rutin, and hesperidin.
- chemotherapeutic drugs examples include sulfamine, sulfathiazole, sulfadiazine, homosulfamine, sulfisoxazole, sulfisomidine, sulfamethizole, and nitrofurazone.
- antibiotics examples include penicillin, meticillin, oxacillin, cefalotin, cefalordin, erythromcycin, lincomycin, tetracycline, chlortetracycline, oxytetracycline, metacycline, chloramphenicol, kanamycin, streptomycin, gentamicin, bacitracin, and cycloserine.
- antiviral drugs examples include protease inhibitors, thymadine kinase inhibitors, sugar or glycoprotein synthesis inhibitors, structural protein synthesis inhibitors, attachment and adsorption inhibitors, and nucleoside analogues such as acyclovir, penciclovir, valacyclovir, and ganciclovir.
- cosmetic active ingredients that can be used in the present invention are D- ⁇ -tocopherol, DL- ⁇ -tocopherol, D- ⁇ -tocopheryl acetate, DL- ⁇ - tocopheryl acetate, ascorbyl palmitate, vitamin F and vitamin F glycerides, vitamin D, vitamin D 2 , vitamin D 3 , retinol, retinol esters, retinyl palmitate, retinyl propionate, ⁇ -carotene, D-panthenol, famesol, farnesyl acetate; jojoba oils and blackcurrant oils rich in essential fatty acids; 5-n-octanoylsalicylic acid and esters thereof, salicylic acid and esters thereof; alkyl esters of ⁇ -hydroxy acids such as citric acid, lactic acid, glycolic acid; asiatic acid, madecassic acid, asiaticoside, total extract of centella asiatica, ⁇ -glycyrrhet
- Alpha-hydroxy acids can be used in the present invention as exfoliants, moisturizers, and emollients.
- Lactic acid salts such as sodium lactate can be used in the present invention.
- AHAs and salicylic acid can be used in the present invention as a structurally similar ⁇ -hydroxy acid as peeling agents.
- the moisturizing activity of AHAs and their ability to exfoliate the skin and interfere with intercellular cohesion in the outer epidermis is well known. It has been suggested that AHAs interfere with cohesion in the stratum granulosum, unlike salicylic acid and other exfoliants.
- Vitamin C (ascorbic acid) can be used in the present invention. Vitamin C promotes collagen (connective tissue) synthesis, lipid (fat) and carbohydrate metabolism, and the synthesis of neurotransmitters. Vitamin C is also essential for optimum maintenance of the body's immune system. Vitamin C is toxic to a wide range of cancer cells, especially melanoma. The oxidizing enzyme tyrosine that catalyzes the aerobic action of tyrosine into melanin and other pigments is also inhibited by the presence of vitamin C. Vitamin C has been found to be effective in catalyzing the immune response to many viral and bacterial infections. Besides the many applicable uses set forth above, vitamin C is essential for collagen synthesis and wound healing.
- the adhesive matrix of the present invention can comprise a combination of vitamin C, vitamin E and other ingredients, such as moisturizers, collagen synthesis promoting agents and exfoliating agents.
- Skin treating compositions can be used in the present invention.
- Examples of skin treating compositions include vitamin C, vitamin C esters, vitamin E 1 vitamin E esters, and optionally, ⁇ -hydroxy acids, such as lactic and glycolic acids and other keratinolytics for the treatment or prevention of wrinkles and skin dryness.
- Skin conditioners, moisturizers and surfactants can be included in the present invention.
- Illustrative conditioners include mineral oil, petrolatum, vegetable oils (such as soybean or maleated soybean oil), dimethicone, dimethicone copolyol, cationic monomers and polymers (such as guar hydroxypropyl trimonium chloride and distearyl dimethyl ammonium chloride) as well as combinations thereof.
- Illustrative moisturizers are polyols such as sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol, polypropylene glycol, 1,3-butane diol, hexylene glycol, isoprene glycol, xylitol, fructose and mixtures thereof.
- polyols such as sorbitol, glycerin, propylene glycol, ethylene glycol, polyethylene glycol, polypropylene glycol, 1,3-butane diol, hexylene glycol, isoprene glycol, xylitol, fructose and mixtures thereof.
- the active ingredient may be substantially fixed within the film layer upon so that the active ingredient is substantially non-migratory.
- the active agent is non-migratory
- less than 50 weight % of the active ingredient is transferred to the skin surface, such as, for example, less than 25 weight %, or less than 15 weight %, or even less than 5 weight % in some embodiments.
- An example of such active agent is a light absorbing agent, such as an ultraviolet light absorber present in many sunscreens.
- These materials may be included in the polymer film by incorporating them into the polymer dispersions. These may include chemicals that absorb UVA and/or UVB radiation.
- UV absorbers include those ingredients currently approved for use in the United States, Europe, and Japan. Non-limiting examples of such UV absorbers include butyl methoxydibenzoylmethane, octyl methoxycinnamate, .
- a conventional surfactant or a combination of surfactants may be used as a stabilizer or solubility augmenting agent according to the present invention.
- suitable surfactants generally include all pharmaceutically-acceptable surfactants, in which the surfactant has an HLB value of at least 10, and preferably at least 15. HLB numbers and how they are determined for specific surfactants are well known to those skilled in the art.
- surfactants that can be used in the present invention are those selected from the anionic, cationic, nonionic, amphoteric, zwitterionic, and combinations thereof.
- anionic surfactants include salts of sarcosinate, taurate, cocoyl isethionate, docusate salts such as the sodium salt thereof.
- suitable pharmaceutically-acceptable anionic surfactants include, for example, those containing carboxylate, sulfonate, and sulfate ions such as for example, alkyl carboxylates, acyl lactylates, alkyl ether carboxylates, N-acyl sarcosinates, polyvalent alkyl carbonates, N-acyl glutamates, fatty acids having from 12 to 18 carbon atoms, polypeptide condensates and sulfuric acid esters.
- surfactants of choice include alkali or ammonium alkuylsulfate, alkylsulfonic acid or fatty acid, oxyethylated alkyl phenol, sulfosuccinates and their derivatives.
- a list of suitable surfactants is available in the treatise: McCutcheon's Emulsifiers and Detergents, North American Edition, MC Publishing Co, Glen Rock, NJ, 1997, the disclosure of which is incorporated herein by reference.
- Those surfactants containing carboxylate ions are sometimes referred to as soaps and are generally prepared by saponification of natural fatty acid glycerides in alkaline solutions. Cations associated with these surfactants include sodium, potassium, ammonium and triethanolamine.
- the chain length of the fatty acids range from 12 to 18.
- amphoteric surfactants are cocoamidopropylbetaine, lauroamphoacetate, capryloamphopropionate, and disodium caprylohydroxypropyl sulfonate.
- non-ionics examples include trialkylamine oxides, aikyl polyglycosides and methyl glucamides.
- suitable pharmaceutically-acceptable non-ionic surfactants include, for example, polyoxyethylene compounds, lecithin, ethoxylated alcohols, ethoxylated esters, ethoxylated amides, polyoxypropylene compounds, propoxylated alcohols, ethoxylated/propoxylated block polymers, propoxylated esters, alkanolamides, amine oxides, fatty acid esters of polyhydric alcohols, ethylene glycol esters, diethylene glycol esters, propylene glycol esters, glycerol esters, polyglycerol fatty acid esters, sorbitan esters, sucrose esters, glucose (dextrose) esters and simethicone.
- surfactants that can be used in the present invention are sucrose distearate, diglyceryldistearate, tetraglyceryl tristearate, decaglyceryl decastearate, diglyceryl monostearate, hexaglyceyl tristearate, decaglyceryl pentastearate, sorbitan monostearate, sorbitan tristearate, diethylene glycol monostearate, the ester of glycerol and of palmitic acid and stearic acid, monostearate polyoxyethylenated containing 2 oxyethylene units, glyceryl mono- and dibehe ⁇ ate and pentaerythrityl tetrastearate
- surfactants incfude are not limited to, alkali or ammonium alkysulfate, alkylsulfonic acid, or fatty acid having from 12 to 18 carbon atoms, oxyethylated alkyphenol, sulfosuccinates and derivatives, or any combination of anionic or non-ionic surfactants.
- suitable surfactant examples are lauryl sulfate, sodium salt, octylphenyl sulfonate, potassium salt, steric acid, ammonium salt, dodecyl sodium sulfosuccinate, and nonyl phenol 10 mole ethoxylate.
- a skin permeation enhancing agent or skin penetration enhancer may optionally be included in the polymer matrix.
- Agents known to accelerate the delivery of the drug through the skin have been referred to as skin-penetration enhancers, adjuvants, and absorption promoters, and are collectively referred to herein as "enhancers.”
- This class of agents includes those with diverse mechanisms of action including those which have the function of improving the solubility and diffusibility of the drug within the multiple polymers and those which improve percutaneous absorption, for example, by changing the ability of the stratum corneum to retain moisture, softening the skin, improving the skin's permeability, acting as penetration assistants or hair-follicle openers or changing the state of the skin including the boundary layer.
- enhancers are polyhydric alcohols such as dipropylene glycol, propylene glycol, and polyethylene glycol which enhance drug solubility; oils such as olive oil, squalene, and lanolin; fatty ethers such as acetyl ether and oleyl ether; fatty acid esters such as isopropyl myristate which enhance drug diffusibility; urea and urea derivatives such as allantoin which affect the ability of keratin to retain moisture; polar solvents such as dimethyldecylphosphoxide, methyloctylsulfoxide, dimethyllaurylamide, dodecylpyrrolidone, isosorbitol, dimethylacetonide, dimethylsulfoxide, decylmethylsulfoxide, and dimethylformamide which affect keratin permeability; salicylic acid which soft
- agents include oleic and linoleic acids, ascorbic acid, panthenol, butylated hydroxytoluene, tocopherol, tocopheryl acetate, tocopheryl linoleate, propyl oleate, and isopropyl palmitate.
- humectants for use in the layers of the composition and method of the invention are polyhydric alcohols such as glycerol, di- glycerol, triglycerol, polyglycerol, polyalkylene glycols and more preferably alkylene polyols and their derivatives, including propylene glycol, dipropylene glycol, polypropylene glycol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1 ,3-butylene glycol, isoprene glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and mixtures thereof.
- polyvinyl pyrrolidinone one found useful in small amounts is polyvinyl pyrrolidinone. Molecular weights suitable for this polymer when used to provide this functions are from 1000 to 100000 Daltons. This polymer may be used in combination with other hume
- Plasticizers useful in this invention are generally diols, triols, polyols, alcohol ethers, alcohol esters, esters, ethers, hydroxy acids, amides, carbonates, and mixtures thereof.
- Suitable diols are 1 ,2-propylene glycol, ethylene glycol, 1 ,3 propylene glycol, 2-methyl-1 ,3-propanediol, butylene glycol, hexanediol, octanediol, and the like, containing up to 10 carbon atoms.
- Suitable triols are glycerin, trihydroxybutane, trihydroxyhexane, and the like. Alcohols having up to six hydroxy! groups are suitable as plasticizers.
- Alcohol ethers suitable are diethylene glycol, dipropylene glycol, triethylene glycol, tetraethyene glycol, tripropylene glycol, and the like, alkoxylated alcohols such as ethoxylated alcohols, propoxylated alcohols, ethoxylated and propoxylated alcohols, where the alkoxylated alcohol is chosen from aliphatic, aromatic, alkary! and aralkyl hydroxy functional compounds containing from 1 to 10 carbons and from one to six hydro ⁇ yl moieties.
- Suitable alcohol ester plasticizers include propylene glycol acetate, glycerin diacetate (diacetin), ethylene glycol propionate, diethyl tartrate, diethyl citrate, triethyl citrate, tributyl citrate, sorbitol tetraacetate, propylene glycol mono-octoate, and the like.
- Suitable esters are triacetin, acetyl triethyl citrate, acetyl tributyl citrate, dimethyl malonate, dimethyl succinate, dimethyl adipate, diethyl malonate, diethyl oxylate, ethyl benzoate, and combinations thereof.
- Suitable ether plasticizers include methoxybe ⁇ zene, dimethoxy benzene, diethoxy benzene, Methylene glycol dimethoxyethylether, and the like.
- Suitable hydroxy acid plasticizers include glycolic, beta-hydroxy propionic acid, lactic acid, salicylic acid, citric acid, tartaric acid, and the like.
- Suitable amides include alkyl formamides such as methyl formamide, dimethyl formamide, diethyl formamide, hexyl formamide, aoetamide, ethyl benzamide, N,N-diethyl acetamide, N-methyl pyrrolidinone, N-ethyl beta lactam, N-methyl caprolactam, caprolactam, N, N-dimethyldecanamide and the like.
- Suitable carbonates include ethylene carbonate, propylene carbonate, glycerol carbonate, sorbitol bis-carbonate, and the like. Care should be taken in selecting the materials suggested above for use as plasticizers for skin contact since some may have regulatory limitations when used on the skin.
- plasticizers may have components of one or more of the classes noted above.
- Non-limiting examples include polyalkylene oxides, such as polyethylene glycol, polypropylene glycol, random or block polyethylene glycol-polypropyle ⁇ e glycol polymers, and random or block polyethylene glycol-polybutylene glycol.
- polymer plasticizers include polyvinyl alcohol, polyhydroxyethyl cellulose, polyhydroxypropyl cellulose, hydroxyethyl guar, polyacrylamide, polyacrylic acid, polyacryfic acid- co-maleic acid, polyacrylamide-co-acrylic acid, carboxymethyl cellulose, carboxymethyl cellulose acetate-butyrate, poly(sodium vinyl benzene sulfonate) and copolymers and combinations thereof. Amounts of these polymeric plasticizers may be from 1 to 10 weight percent based on the weight of the water-dispersible or water dissipatable polymer of this invention.
- Suitable agents may be added with the objective of controlling the polymer molecular weight.
- These are well known in the art, generally consisting of but not limited to mercaptans. Examples of these are alkyl mercaptans from 1 to 20 carbons, mercapto acids and esters such as mercaptopropionic acid, alkyl mercaptopropioic acid esters, thiol glycols or dithioglycols such as hydroxyethyl mercapatan, thioglycerol,
- the polymerization process of making modified "acrylic" latexes may also require adding to the monomer/hydrophobe mixture an initiator (oxidant), a reducing agent, or a catalyst.
- Suitable initiators include conventional initiators such as ammonium persulfate, sodium persulfate, hydrogen peroxide, t-butyl hydroperoxide, ammonium or alkali sulfate, di-benzoyl peroxide, lauryl peroxide, di-tertiarybutylperoxide, 2,2-azoblsisobutyronitrile, benzoyl peroxide and mixtures thereof.
- Suitable reducing agents are those which increase the rate of polymerization and include, for example, sodium bisulfite, sodium hydrosulfite, sodium formaldehyde sulfoxylate, ascorbic acid, isoascorbic acid, and mixtures thereof.
- Suitable catalysts are those compounds which promote decomposition of the polymerization initiator under the polymerization reaction conditions thereby increasing the rate of polymerization.
- Suitable catalysts include transition metal compounds and driers. Examples of such catalysts include, but are not limited to, ferrous sulfate heptahydrate, ferrous chloride, cupric sulfate, cupric chloride, cobalt acetate, cobaltous sulfate, and mixtures thereof.
- AAEM acetoacetoxy ethylmethacrylate
- acrylic, styrene/acrylic, or vinyl-acrylic resin referred to herein simply as an 'acrylic' resin
- AAEM acetoacetoxy ethylmethacrylate
- acrylic resin referred to herein simply as an 'acrylic' resin
- Petrolatum-coconut oil fatty acid modified acrylic resin generally exists as particles dispersed in water.
- the particles are generally spherical in shape.
- the particles may be structured (meaning non-homogeneous morphology) or unstructured. Structured particles include, but
- the miniemulsion polymerization process is used since miniemulsion allows the preparation of high molecular weight polymers at low viscosity unlike a solution or bulk polymerization. Shearing the mixture of monomer/water/surfactant/active agent forms small droplets of 50 to 500 nanometers, and thus form a miniemulsion, prior to polymerization, ensuring that the polymerized latex therefrom contains the active agent dispersed uniformly throughout the latex particles.
- the Petrolatum or other active ingredient portion of the modified resin represents 0.1 to 50 weight %, such as, for example, from 10 to 40 weight % of total solids of the latex, or from 10 to 30 weight percent.
- the coconut oil fatty acid portion of the modified resin represents 0.1 to 20 weight % of the total solids of the latex. In another embodiment, the coconut oil fatty acid portion of the modified resin represents 5 to 15 weight % of the total solids of the latex.
- the patch 100 is similar to the patch 10 described above. That is, the patch 100 has two protective layers 115 and 120 covering the adhesive matrix first layer 125 and the second layer 130. Attached to one surface of the protective layer 115 is a means 135 for grasping the protective layer. However, the second layer 130 has a discontinuous surface area. As seen in FIG. 5, the discontinuous surface of the second layer substantially covers the entire upper surface 140 of the first layer. The discontinuous second layer 130 comprises a plurality of individual grains that substantially form a non-tacky surface.
- the grains individually have sufficient distance between an adjacent grain that the collective surface area is non-tacky, but at the same time have a sufficient porosity to allow moisture vapor transmission through the first layer 115. This allows the patch 100 to have a high degree of comfort and flexibility while allowing the tissue to remain cool and relatively dry.
- Materials suitable for forming the discontinuous surface 130 can be any particulate material known to block or substantially reduce the tackiness of an adhesive.
- the discontinuous layer 130 can be natural or synthetic crystalline or amorphous materials.
- Non-limiting examples of such materials include: starches such as corn, potato, rice, and wheat; mica; serecite; talcs; pigments; butters such as cocoa, Shea, kokum, mango, sal; clays such as bentonite, french green, fuller's earth, rhassoul, kaolin (white, pink, yellow, red and rose), green illite, blue montmorillonite,ixie red, multani mitti; waxes such as camuba, beeswax, paraffin, synthetic waxes; rice bran; floral; hexagonal boron nitride ceramic powders; yucca shidigera powder; sodium ascorbyl phosphate; magnesium ascorbyl phosphate; hyaluronic acid; glass spheres,
- the discontinuous surface 130 is a polymeric material that has been applied to the upper surface 140 of the adhesive matrix layer 125.
- Such polymeric material should have a Tg of greater than +5°C and which may be "dusted" over the surface to reduce the upper surface tack.
- the patch 150 is similar to patch 100 described above, that is, it has two protective layers 165 and 170, a first layer 175 and a second layer 180, and a grasping means 185, with the notable exception that in this embodiment the adhesive first layer 175 is discontinuous.
- This embodiment allows for use of a more aggressive or tacky adhesive since the adhesive is applied intermittently.
- the discontinuous first layer 175 comprises a plurality of individual grains that form an adhesive surface.
- this allows the manufacturer to more precisely control the adhesive force of the patch as well as allow site treatment using one or more active agents placed adjacent to the user's skin without substantial diffusion, interaction or interference between different types or concentrations of active agents.
- the active agent(s) may be included in the first layer 10, 125, and 175, or the second layer 30, 130 and 180, or both layers.
- the active age ⁇ t(s), their concentrations or composition may be the same or different in each layer.
- at least one layer to include a water- dispersible or water-dissipatable polymer and at least one layer include from 0.1 to 50 weight % of an active agent, and the two are not necessarily in the same layer. However, the sum of the weight percentages for each layer would still equal 100 %. All such embodiments are within the teaching of the present invention.
- Elongation The elongation was measured on a free film (not in contact with a substrate or surface) according to the procedure of ASTM Method D882.
- the free film was prepared at a dry film thickness of 0.6 to 0.7 mil (0.0006 to 0.0007 inches thick) by making a drawdown with a suitable applicator on a release substrate.
- the release substrate may be any of a variety of substrates, so long as it is flat and non-porous, and have a low surface energy so that the film, when dry, may be readily separated from the substrate.
- Suitable substrates used include poly(tetrafluoroethylene), siliconized polyester film, siliconized paper, and wax paper. Drying conditions for this test were 22-25°C air and substrate temperature for 24 hours.
- the dried film was removed from the substrate and an elongation measured.
- the film must have an elongation of at least 50% and preferably is greater than 200%, when the sample was pulled at a rate of 10 inches per minute.
- Another aspect of the present invention is a method for making the dermal patch of the present invention.
- the method comprises the steps of applying a first layer to a first protective releasable substrate; joining a second layer to the first layer; and covering the second layer with a second protective releasable substrate, wherein at least one of the first or second layers fs a polymer matrix system having an active agent admixed therein, and at least one layer includes a water-dispersible or water-dissipatable polymer.
- the first layer is dried before being joined with the second layer.
- Water-dispersible sulfopolyester A was prepared as follows: in a round bottom flask equipped with ground-glass head, an agitator shaft, nitrogen inlet and a side arm was charged with isophthalic acid, dimethyl-5- sodiosulfoisophthalate (SIP), diethylene glycol (DEG), and 1,4- cyclohexanedimethanol (CHDM), in the mole percents as set forth below. A catalyst was added and the flask was immersed in a Belmont bath at 200 0 C for one hour under a nitrogen sweep. The temperature of the bath was increased to 230 0 C for one hour.
- SIP dimethyl-5- sodiosulfoisophthalate
- DEG diethylene glycol
- CHDM 1,4- cyclohexanedimethanol
- the temperature of the bath was increased to 280 0 C and the flask was heated for 45 minutes under reduced pressure of 0.5 to 0.1 mm of Hg- The flask was allowed to cool to room temperature and the copolyester was removed from the flask and was extruded and pelletized.
- Sulfopolyester A contained 18 mole percent dimethyl-5- sodiosulfoisophthalate and 82 mole percent isophthalic acid, and 46 mole percent 1 ,4-cyclohexanedimethanol and 54 mole percent diethylene glycol, based on 100 mole percent dicarboxylic acid and 100 mole percent diol.
- Sulfopolyester A has a Tg of 53°C (as determined by differential scanning calorimetery) and an Inherent Viscosity (I .V.) of 0.33 dl/g was measured at 23°C using 0.50 grams of polymer per 100 ml of a solvent consisting of 60% by weight phenol and 40% by weight tetrachloroethane).
- a dispersion of the polymer pellets was prepared by heating to 80 0 C 136 grams of deionized water in a 500 milliliter beaker. Then 64 grams of the polymer pellets were added with stirring, and the stirring continued for 30 minutes. The weight of the water that evaporated on heating was replaced as the formula cooled, giving a nearly clear polymer dispersion. The following ingredients were placed in a 1 once wide-mouth jar:
- the bottle was placed in a water-bath at 80 0 C for 1 hour.
- the bottle was removed, and was shaken rapidly on a Brinkman Vibratory Mill until it was cool.
- the emulsion was creamy and stable to separation.
- the mixture was drawn down on a release film (Polyester Liner L-25X available from Sil-Tech, 222 Mound Avenue, Miamisburg, OH 45342) with a 0.004 of an inch gap film applicator.
- the coating was baked for 5 minutes at 90 0 C.
- an acrylic water based adhesive (Eastarez 2050 available from Hexion Specialty Chemicals, Columbus, OH 43215) was applied to the mixture coating using a number ORK rod (approximately 0.15 mil wet) using a K-Control Coater (available from Testing Machine Company, 2 Fleetwood Court, Ronkonkoma, New York 11779).
- the coating was dried for 5 minutes at 90 0 C.
- the film had an approximate final thickness of less than 1.0 mils (25 microns) for both layers.
- the film When applied to skin, the film transferred cleanly from the release polyester, and was not tacky or greasy to the touch. The film was washed off with soap and water after two hours. The skin beneath the film felt smooth to the touch. •
- COFA was prepared as follows: To a 1000 mL resin kettle equipped with a condenser, nitrogen purge, and a subsurface feed tube was added 120 g of water. A nitrogen purge was begun and the contents heated and maintained at 80 0 C.
- the COFA- Petrolatum mixture in this example contained 10% Petrolatum (by weight of the total monomers).
- the monomers mix consisted of 415.0 grams styrene/2-ethylhexyl acrylate/acetoacetoxy ethylmethacrylate/methacylic acid/acrylic acid.
- the weight ratio of monomers in the monomer mix was 44.5/43.2/9.4/0.7/2.2.
- Water (365 grams) and 18.3 grams of surfactant were premixed, then the monomer/Petrolatum/COFA mix was added to form a pre-emulsion.
- Surfactants included Aerosol OT-NV (available from Cytec Industries) and/or Hitenol BC1025 (available from DKS) in ratio of 1.1:0.4.
- the pre-emulsion was sheared using an IKA (Model SD- 45) rotor/stator homogenizer by pumping through a flow cell which surrounded the shearing device with the homogenizer operating at maximum rpm to form a miniemulsion. Seventy-six grams (10%) of the miniemulsion was charged to the reactor. Then 0.6 g of ammonium persulfate was mixed in 10 g of water and charged to the reactor mixture and held at 80 0 C. After 15 minutes the remaining miniemulsion was fed over 180 minutes to the reactor.
- IKA Model SD- 45
- an initiator feed composed of 79.0 g of water, 0.84 g of ammonium persulfate, and 0.84 g of ammonium carbonate was also fed over 180 minutes.
- the reactor was held at 80 0 C for 60 minutes, before cooling to 50 0 C.
- a reductant solution consisting of 6.4 g water, 1.0 g isoascorbic acid, and 1.2 g of 0.5% iron sulfate heptahydrate, and 0.34 g of 28% ammonium hydroxide was added to the reactor.
- a solution of 19.0 g water and 1.10 g 70% t-butyl hydroperoxide was then fed over 48 minutes. The reaction mix was cooled to room temperature.
- the latex was filtered through a 100 mesh wire screen and filterable solids or scrap was determined as less than O.lweight %, based on the total batch weight.
- the droplet and particle sizes were measured using Microtrac UPA Particle Size Analyzer laser light-scattering device (180 degree backscattering). For this particle size measurement the sample was diluted approximately 1:50 in water.
- Tg of 5°C and 20 weight % Petrolatum and COFA was prepared with the following exceptions, the petrolatum amount was 82 grams.
- a miniemulsion having a Tg of -30 0 C and 20 weight % Petrolatum and COFA was prepared similar to that of Example 3 with the following exceptions, the styrene/2-ethylhexyl acrylate/acetoacetoxy ethylmethacrylate/methacylic acid/acrylic acid monomer ratios were 19.9/69.3/7.9/0.8/2.2.
- a miniemulsion having a Tg of -30 0 C and 20 weight % Petrolatum was prepared similar to that of Example 4 with the following exceptions, the COFA was eliminated.
- This example shows that a miniemulsion of petrolatum and monomers can be prepared using a high shear condition which could not otherwise be achieved using a conventional emulsion processes.
- a miniemulsion having a Tg of -30 0 C and 20 weight % Shea Butter was prepared similar to that of Example 5 with the following exceptions, the petrolatum was replaced by Shea Butter.
- Example 7 was prepared similar to that of Example 5 except that the monomer mix ratio was as follows: 2-ethylhexyl acrylate/methacrylic acid 65.0/35.0.
- Example 1 The liquid mixture from Example 1 was drawn down on release film (Polyester Liner L-25X, same film used in Example 2) with a 4 mil gap thin film applicator. The coating was baked for 5 minutes at 90 0 C. Then the miniemulsion from Example 4 was applied to the mixture coating above using a number 4RK wire wound rod (approximately 1.5 mil wet) and a K-Control Coater. This newly applied coating on the above film was dried for 5 minutes at 90 0 C. The resulting two-layer, dry film of 1.5 mil thickness, when applied to skin, transferred to the skin cleanly from the release polyester, and was not tacky or greasy to the touch. The film was washed off with soap and water after two hours. The skin beneath the film felt smooth to the touch.
- CMCAB carboxymethylcellulose acetate butyrate
- This example shows a film composition wherein both layers are prepared from two different miniemulsion compositions where each miniemulsion polymer has a Tg different than the other.
- the lower Tg polymer (30 0 C) resides on the side to be applied to the skin, and the second miniemulsion has a Tg of 5°C.
- Example 3 The latex from Example 3 (11.87g) was combined with 3.52 g of a 10% solution Vinol 523 (polyvinyl alcohol thickener available from Air Products, Inc.) and mixed by shaking. The blend was drawn down using a 5 mil gap applicator on Polyester Liner L-25X available from Sil-Tech, and the resultant film was baked at 100 0 C for 5 minutes. The film had a thickness of 0.016 millimeter and an elongation (determined by ASTM method D882) of 676 percent before breaking.
- Vinol 523 polyvinyl alcohol thickener available from Air Products, Inc.
- a similar film to that above was further coated using a ORK wire wound rod with the polymer emulsion of Example 4.
- the film composite was baked for 5 minutes at 100 0 C. When cool, the film was readily transferred to the skin on the back of the hand.
- the polyester liner backing was readily removed by peeling, leaving the miniemulsion composite film on the skin.
- the film was water resistant. The film remained on the skin for 2 hours. Upon removal by peeling from the skin, the skin felt smooth to the touch.
- Example 1 A dispersion similar to Example 1 (modified to include 20% petrolatum) was drawn down Polyester Liner L-25X available from Sil-Tech with a 5 mil gap applicator, and the resultant film was baked at 100 0 C for 5 minutes.
- a similar film to that above was further coated using a ORK wire wound rod with the polymer emulsion of Example 6.
- the film composite was baked for 5 minutes at 100 0 C. When cool, the film was readily transferred to the skin on the back of the hand.
- the polyester liner backing was readily removed by . peeling, leaving the miniemulsion composite film on the skin. The film remained on the skin for 2 hours. Upon removal of the film by washing with soap and water, the skin felt smooth to the touch.
- the mixing speed was increased by applying 60 volts to the transformer.
- the temperature of the mixture was 63°C.
- the emulsion was smooth and creamy.
- the jar was capped, and it was placed in a water bath at 85°C. for 1 hour.
- the mixture was then dispersed at 60 volts for 3 minutes, then stirred using a motorized slow speed agitator until it reached room temperature.
- the emulsion was thin and creamy.
- the mixture was drawn down on a release film (Polyester Liner L-25X) with a 4 mil gap film applicator.
- the coating was baked for 5 minutes at 90 0 C.
- an acrylic water based adhesive (Eastarez 2050 available from Hexion Specialty Chemicals, Columbus, OH 43215.) was applied to the mixture coating using a number ORK rod (approximately 0.15 mil (4 micrometer) wet) using a K-Control Coater (available from Testing Machine Company, 2 Fleetwood Court, Ronkonkoma, New York 11779).
- the coating was dried for 5 minutes at 90 0 C.
- the film had an approximate final thickness of less than 1.0 mil for both layers.
- the film transferred cleanly from the release polyester and was not tacky or greasy to the touch.
- the film was washed off with soap and water after two hours. The skin which had been beneath the film felt smooth to the touch.
- a miniemulsion having a Tg of 5°C and 10 weight % COFA was prepared as follows.
- a surfactant mixture was prepared by adding 385.9 grams of water, 5.51g Aerosol OT-NV (available from Cytec Industries) and 7.41g Hitenol BC1025 (available from DKS). Then the monomer-COFA mixture above was added to form a pre-emulsion.
- the pre-emulsion was sheared using an IKA (Model SD-45) rotor/stator homogenizer by pumping through a flow cell which surrounded the shearing device with the homogenizer operating at maximum rpm to form a miniemulsion.
- Ten weight percent (72.2 grams) of the miniemulsion was charged to a reactor held at 80 0 C.
- a reductant solution consisting of 6.34 g water, 1.0 g isoascorbic acid, and 1.2 g of 0.5% iron sulfate heptahydrate, and 0.34 g of 28% ammonium hydroxide was added to the reactor.
- a solution of 19.0 g water and 1.10 g 70% t-butyl hydroperoxide was then fed over 48 minutes.
- the reaction mix was cooled to room temperature.
- the latex was filtered through a 100 mesh wire screen and filterable solids or scrap was determined as less than 0.1% based on the total batch weight.
- the particle size was 390 nanomters as measured by using a Microtrac UPA Particle Size Analyzer - laser light-scattering device (180 degree backscattering). For this particle size measurement the sample was diluted approximately 1 :50 in water.
- Sulfopolyester B was prepared as follows.
- Example 2 In equipment similar to that used in Example 1 , the following composition was heated in a similar fashion: 11 mole percent dimethyl-5- sodiosulfoisophthalate and 89 mole percent isophthalic acid, and 21.5 mole percent 1,4-cyclohexanedimethanol and 78.5 mole percent diethylene glycol, based on 100 mole percent dicarboxylic acid and 100 mole percent diol.
- the resultant Sulfopolyester B has a Tg of 35°C and an I.V. of 0.32 dl/g.
- a dispersion of the polymer pellets was prepared by heating to 80 0 C, 136 grams of deionized water in a 500 milliliter beaker. Then 64 grams of the polymer pellets were added with stirring, and the stirring continued for 30 minutes. The weight of the water that evaporated on heating was replaced as the formula cooled, giving a slightly turbid polymer dispersion.
- Part A was prepared as follows. The following ingredients were placed in a 1 ounce wide-mouth jar:
- EASTMAN EB hydroxyethyl butyl ether
- the bottle was shaken without heating for 15 minutes.
- the emulsion was creamy and stable to separation.
- the mixture was drawn down on a release film (Polyester Liner L-25X available from Sil-Tech, Miamisburg, OH.) with a #8RK rod.
- the coating was baked for 5 minutes at 100°C.
- the resulting film was smooth, tacky and translucent.
- Part B was prepared as follows. The following ingredients were placed in a 1 ounce wide-mouth jar:
- Part A was applied to a coating described in Part B. Both layers were applied with a #8 RK Rod. The two-layer coating was baked at 100°Centigrade for 5 minutes. The coating was easily transferred from the release film onto the skin. The coating was removed by peeling.
- the polymer from Example 6 was applied to a coating described in Part B.
- the two-layer coating was baked at 100 0 C for 5 minutes.
- the resulting coating was only slightly tacky, but it was easily transferred from the release film onto the skin by applying hand pressure for less than 30 seconds.
- the coating was removed by washing with soap and water or by peeling.
- a miniemulsi ⁇ n having a Tg of -5°C and a high concentration of Petrolatum (20 weight %) was prepared as follows:
- a monomers premix was prepared having: 1. 345.0 grams of 2-ethylhexyl acrylate/methacrylic acid in the weight ratio of 65/35, 2. 300 grams of water, and 3. 15.5 grams of a surfactant blend having Aerosol OT-NV (available from Cytec Industries) and/or Hite ⁇ ol BC1025 (available from DKS) in ratio of 1.1:0.4.
- Aerosol OT-NV available from Cytec Industries
- Hite ⁇ ol BC1025 available from DKS
- Petrolatum (69 grams), purchased as Petroleum Jelly, was slowly added to the monomers premix and stirred for 3 hours to obtain a milky looking dispersion.
- the dispersion was sheared using an IKA (Model SD-45) rotor/stator homogenizer by pumping the dispersion through a flow cell operating at maximum rpm to form a miniemulsion.
- a reaction initiator feed was prepared having 90.0 g of water, 1 g of ammonium persulfate, and 1 g of ammonium carbonate.
- Ammonium persulfate (0.65 g) was mixed in 12 g of water and charged to the reactor mixture. After 15 minutes, the remaining miniemulsion was fed to the reactor over a period of 180 minutes. Concurrently with the miniemulsion feed, the initiator feed was also fed to the reactor but over a time period of 195 minutes.
- the reactor was held at 80 0 C for 60 minutes, then cooled to 50 0 C.
- a reductant solution consisting of 10 g water, 1.0 g isoascorbic acid, and 1.2 g of 0.5% iron sulfate heptahydrate, and 0.34 g of 28 weight % ammonium hydroxide was added to the reactor.
- This example illustrates a composition wherein both layers are composed of compositions removable from the skin by water washing.
- Aqueous Phase To a beaker were added sequentially with mild stirring while heating to 75°C the following ingredients:
- Organic Phase In a separate beaker were added the organic phase ingredients, also with stirring and heating to 80 to 90 0 C the following components:
- a drawdown of the mixture above was prepared, using a wire wound drawbar, on siliconized polyester substrate (Polyester Liner L-25X available from Sil-Tech, 222 Mound Avenue, Miamisburg, OH 45342) having a thickness of 1 mil.
- the dried film measured after 1 hour of drying at ambient conditions had a film thickness of 1 mil.
- a second drawdown was made exactly on top of the dried film above, using a water dispersible polyester adhesive blend and the same draw bar used above.
- This adhesive blend was prepared previously by heating together the following ingredients: i) 10.69g AQ55 polyester (34.6% solids in water); ii) 60.04g AQ1045 polyester (30.8% solids in water); iii) 0.92g glycerin; and iv) 0.99g triethyl citrate.
- a patch was constructed by applying Scotch Magic tape to one edge of the dried film, overlapping the tape onto the siliconized polyester substrate, then covering with a top sheet of the same siliconized polyester used for the initial coating substrate. Rectangular patches were cut from the sheet, with the tape along one edge only.
- the dry patch was applied to the skin of the volar wrist of a male volunteer. After two hours of wearing the patch, the patch was removed by washing with warm tap water and gentle rubbing. A day later, a second patch applied on the wrist was worn for 8 hours, and was removable in the same way. A day later a third patch worn on the wrist for 4 hours was removed using warm soapy water with gentle rubbing. No cracking of any of the films was observed while on the skin. No residue was apparent after any of the washings.
Abstract
Description
Claims
Priority Applications (4)
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BRPI0710234-8A BRPI0710234A2 (en) | 2006-05-08 | 2007-05-08 | dermal plaster, method for producing dermal plaster, and, composition |
JP2009509778A JP2009536647A (en) | 2006-05-08 | 2007-05-08 | Water dispersible patch containing active agent for skin delivery |
EP07776835A EP2018143A2 (en) | 2006-05-08 | 2007-05-08 | Water-dispersible patch containing an active agent for dermal delivery |
AU2007249963A AU2007249963A1 (en) | 2006-05-08 | 2007-05-08 | Water-dispersible patch containing an active agent for dermal delivery |
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US11/800,727 US20070259029A1 (en) | 2006-05-08 | 2007-05-07 | Water-dispersible patch containing an active agent for dermal delivery |
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WO2007133509A2 true WO2007133509A2 (en) | 2007-11-22 |
WO2007133509A3 WO2007133509A3 (en) | 2008-01-17 |
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PCT/US2007/011036 WO2007133509A2 (en) | 2006-05-08 | 2007-05-08 | Water-dispersible patch containing an active agent for dermal delivery |
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EP2599501A1 (en) * | 2010-07-29 | 2013-06-05 | Hisamitsu Pharmaceutical Co., Inc. | Adhesive patch for medical use |
WO2020194220A1 (en) * | 2019-03-26 | 2020-10-01 | Azista Industries Pvt Ltd | Sleep aid transdermal patch and its process of preparation |
NL2028566B1 (en) * | 2021-06-29 | 2023-01-09 | Simons Care Innovation Group B V | A zinc salt skin patch and methods |
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US11234905B2 (en) * | 2008-07-11 | 2022-02-01 | Kimberly-Clark Worldwide, Inc. | Formulations having improved compatibility with nonwoven substrates |
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Also Published As
Publication number | Publication date |
---|---|
AU2007249963A1 (en) | 2007-11-22 |
WO2007133509A3 (en) | 2008-01-17 |
BRPI0710234A2 (en) | 2011-08-02 |
US20070259029A1 (en) | 2007-11-08 |
JP2009536647A (en) | 2009-10-15 |
EP2018143A2 (en) | 2009-01-28 |
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