WO2007137245A3 - Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams - Google Patents

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams Download PDF

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Publication number
WO2007137245A3
WO2007137245A3 PCT/US2007/069414 US2007069414W WO2007137245A3 WO 2007137245 A3 WO2007137245 A3 WO 2007137245A3 US 2007069414 W US2007069414 W US 2007069414W WO 2007137245 A3 WO2007137245 A3 WO 2007137245A3
Authority
WO
WIPO (PCT)
Prior art keywords
filtration
systems
methods
fluid outlet
extraction fluid
Prior art date
Application number
PCT/US2007/069414
Other languages
French (fr)
Other versions
WO2007137245A2 (en
Inventor
Edward F Leonard
Alan C West
Christian Paul Aucoin
Edgar E Nanne
Original Assignee
Univ Columbia
Edward F Leonard
Alan C West
Christian Paul Aucoin
Edgar E Nanne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP07797637A priority Critical patent/EP2019658B1/en
Priority to CA002652173A priority patent/CA2652173A1/en
Priority to AT07797637T priority patent/ATE542583T1/en
Priority to AU2007253702A priority patent/AU2007253702A1/en
Application filed by Univ Columbia, Edward F Leonard, Alan C West, Christian Paul Aucoin, Edgar E Nanne filed Critical Univ Columbia
Priority to MX2008014732A priority patent/MX2008014732A/en
Priority to US11/814,117 priority patent/US7727399B2/en
Priority to JP2009512252A priority patent/JP2010506599A/en
Priority to BRPI0711896-1A priority patent/BRPI0711896A2/en
Publication of WO2007137245A2 publication Critical patent/WO2007137245A2/en
Publication of WO2007137245A3 publication Critical patent/WO2007137245A3/en
Priority to US12/759,157 priority patent/US8097153B2/en
Priority to US12/948,325 priority patent/US8092684B2/en
Priority to US12/948,284 priority patent/US8097162B2/en
Priority to US13/332,040 priority patent/US8257593B2/en
Priority to US13/566,592 priority patent/US8470180B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/32—Oxygenators without membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0496—Solvent extraction of solutions which are liquid by extraction in microfluidic devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7563—General characteristics of the apparatus with filters with means preventing clogging of filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/11—Laminar flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/0005—Field flow fractionation
    • G01N2030/004—Field flow fractionation characterised by opposing force
    • G01N2030/0045—Field flow fractionation characterised by opposing force normal, i.e. diffusion or thermal FFF

Abstract

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.
PCT/US2007/069414 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams WO2007137245A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
US11/814,117 US7727399B2 (en) 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
AT07797637T ATE542583T1 (en) 2006-05-22 2007-05-22 METHOD FOR MEMBRANE-LESS MICROFLUID EXCHANGE IN AN H-FILTER AND FILTERING OF THE EXTRACTION FLUID OUTPUT STREAMS
AU2007253702A AU2007253702A1 (en) 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
BRPI0711896-1A BRPI0711896A2 (en) 2006-05-22 2007-05-22 microfluid membrane-free exchange systems and methods using filtration of fluid extraction stream extraction.
MX2008014732A MX2008014732A (en) 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams.
CA002652173A CA2652173A1 (en) 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
JP2009512252A JP2010506599A (en) 2006-05-22 2007-05-22 A method for exchanging components between a first fluid and a second fluid, a method for cleaning a first component from a first fluid, a blood processing method, a fluid treatment device, a first fluid and first and second components Apparatus for exchanging components with second fluid, apparatus for exchanging components between first fluid and second fluid, and method for separating blood cells from plasma
EP07797637A EP2019658B1 (en) 2006-05-22 2007-05-22 Method of microfluidic membraneless exchange in an h-filter and filtration of the extraction fluid outlet streams
US12/759,157 US8097153B2 (en) 2006-05-22 2010-04-13 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
US12/948,325 US8092684B2 (en) 2006-05-22 2010-11-17 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
US12/948,284 US8097162B2 (en) 2006-05-22 2010-11-17 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
US13/332,040 US8257593B2 (en) 2006-05-22 2011-12-20 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
US13/566,592 US8470180B2 (en) 2006-05-22 2012-08-03 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80247106P 2006-05-22 2006-05-22
US60/802,471 2006-05-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/814,117 A-371-Of-International US7727399B2 (en) 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams
US12/759,157 Division US8097153B2 (en) 2006-05-22 2010-04-13 Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

Publications (2)

Publication Number Publication Date
WO2007137245A2 WO2007137245A2 (en) 2007-11-29
WO2007137245A3 true WO2007137245A3 (en) 2008-11-27

Family

ID=38724079

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069414 WO2007137245A2 (en) 2006-05-22 2007-05-22 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

Country Status (10)

Country Link
US (6) US7727399B2 (en)
EP (1) EP2019658B1 (en)
JP (1) JP2010506599A (en)
CN (1) CN101534917A (en)
AT (1) ATE542583T1 (en)
AU (1) AU2007253702A1 (en)
BR (1) BRPI0711896A2 (en)
CA (1) CA2652173A1 (en)
MX (1) MX2008014732A (en)
WO (1) WO2007137245A2 (en)

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