WO2007140351A3 - Flexible open tube sampling system for use with surface ionization technology - Google Patents

Flexible open tube sampling system for use with surface ionization technology Download PDF

Info

Publication number
WO2007140351A3
WO2007140351A3 PCT/US2007/069823 US2007069823W WO2007140351A3 WO 2007140351 A3 WO2007140351 A3 WO 2007140351A3 US 2007069823 W US2007069823 W US 2007069823W WO 2007140351 A3 WO2007140351 A3 WO 2007140351A3
Authority
WO
WIPO (PCT)
Prior art keywords
present
ions
sample
tubes
sampling system
Prior art date
Application number
PCT/US2007/069823
Other languages
French (fr)
Other versions
WO2007140351A2 (en
Inventor
Brian D Musselman
Original Assignee
Ionsense Inc
Brian D Musselman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ionsense Inc, Brian D Musselman filed Critical Ionsense Inc
Priority to JP2009513407A priority Critical patent/JP2009539115A/en
Priority to EP07797812A priority patent/EP2035122A4/en
Publication of WO2007140351A2 publication Critical patent/WO2007140351A2/en
Publication of WO2007140351A3 publication Critical patent/WO2007140351A3/en

Links

Classifications

    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/10Ion sources; Ion guns
    • H01J49/16Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0404Capillaries used for transferring samples or ions
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409Sample holders or containers
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples

Abstract

The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.
PCT/US2007/069823 2006-05-26 2007-05-25 Flexible open tube sampling system for use with surface ionization technology WO2007140351A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009513407A JP2009539115A (en) 2006-05-26 2007-05-25 Flexible open tube collection system for use in surface ionization technology
EP07797812A EP2035122A4 (en) 2006-05-26 2007-05-25 Flexible open tube sampling system for use with surface ionization technology

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80860906P 2006-05-26 2006-05-26
US60/808,609 2006-05-26

Publications (2)

Publication Number Publication Date
WO2007140351A2 WO2007140351A2 (en) 2007-12-06
WO2007140351A3 true WO2007140351A3 (en) 2008-04-17

Family

ID=38779395

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/069823 WO2007140351A2 (en) 2006-05-26 2007-05-25 Flexible open tube sampling system for use with surface ionization technology
PCT/US2007/069821 WO2007140349A2 (en) 2006-05-26 2007-05-25 Apparatus for holding solids for use with surface ionization technology

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/069821 WO2007140349A2 (en) 2006-05-26 2007-05-25 Apparatus for holding solids for use with surface ionization technology

Country Status (4)

Country Link
US (5) US7777181B2 (en)
EP (2) EP2035121A4 (en)
JP (2) JP2009539115A (en)
WO (2) WO2007140351A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895916B2 (en) 2009-05-08 2014-11-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US8963101B2 (en) 2011-02-05 2015-02-24 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US9558926B2 (en) 2014-06-15 2017-01-31 Ionsense, Inc. Apparatus and method for rapid chemical analysis using differential desorption

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9870907B2 (en) 2002-03-11 2018-01-16 Jp Scientific Limited Probe for extraction of molecules of interest from a sample
US7700913B2 (en) * 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8026477B2 (en) * 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
JP2009539115A (en) * 2006-05-26 2009-11-12 イオンセンス インコーポレイテッド Flexible open tube collection system for use in surface ionization technology
HU226837B1 (en) 2006-05-31 2009-12-28 Semmelweis Egyetem Desorption ionization method and device operated by liquid stream
US8440965B2 (en) 2006-10-13 2013-05-14 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
WO2008046111A2 (en) * 2006-10-13 2008-04-17 Ionsense, Inc. A sampling system for containment and transfer of ions into a spectroscopy system
US7547891B2 (en) * 2007-02-16 2009-06-16 Agilent Technologies, Inc. Ion sampling apparatuses in fast polarity-switching ion sources
US8178833B2 (en) * 2007-06-02 2012-05-15 Chem-Space Associates, Inc High-flow tube for sampling ions from an atmospheric pressure ion source
US20090317916A1 (en) * 2008-06-23 2009-12-24 Ewing Kenneth J Chemical sample collection and detection device using atmospheric pressure ionization
US7915579B2 (en) * 2008-09-05 2011-03-29 Ohio University Method and apparatus of liquid sample-desorption electrospray ionization-mass specrometry (LS-DESI-MS)
EP2335270A1 (en) * 2008-10-03 2011-06-22 National Research Council of Canada Plasma-based direct sampling of molecules for mass spectrometric analysis
CN102232238B (en) 2008-10-13 2015-08-05 普度研究基金会 For transfer ions for the system and method analyzed
CN101770924B (en) * 2008-12-30 2013-07-03 株式会社岛津制作所 Desorbing ionization device
US8704167B2 (en) * 2009-04-30 2014-04-22 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
CN105388205B (en) * 2009-05-27 2019-07-23 英国质谱有限公司 System and method for identifying biological tissue
CN102710376B (en) * 2009-12-07 2015-03-18 华为技术有限公司 Method and device for transmitting uplink control information
JP5581477B2 (en) * 2009-12-28 2014-09-03 国立大学法人東京工業大学 Sampling method and sampling apparatus using plasma
EP2561333B1 (en) 2010-04-19 2015-11-25 Battelle Memorial Institute Electrohydrodynamic spraying
US20110260048A1 (en) * 2010-04-22 2011-10-27 Wouters Eloy R Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member
WO2012003434A1 (en) * 2010-07-01 2012-01-05 Northrop Grumman Systems Corporation Systems and methods for automated collection of analytes
JP5756611B2 (en) * 2010-10-07 2015-07-29 株式会社 資生堂 Analysis method
US9198609B2 (en) 2011-04-19 2015-12-01 Porex Corporation Cards for sample storage and delivery comprising sintered porous plastic
GB201109414D0 (en) 2011-06-03 2011-07-20 Micromass Ltd Diathermy -ionisation technique
JP6182705B2 (en) * 2011-06-03 2017-08-23 パーキンエルマー ヘルス サイエンス インコーポレイテッドPerkinelmer Health Sciences Inc. Ion source for direct sample analysis
US9024254B2 (en) 2011-06-03 2015-05-05 Purdue Research Foundation Enclosed desorption electrospray ionization probes and method of use thereof
US8592758B1 (en) * 2011-06-06 2013-11-26 The United States Of America As Represented By The Secretary Of The Army Vapor sampling adapter for direct analysis in real time mass spectrometry
JP5771458B2 (en) * 2011-06-27 2015-09-02 株式会社日立ハイテクノロジーズ Mass spectrometer and mass spectrometry method
US8648297B2 (en) 2011-07-21 2014-02-11 Ohio University Coupling of liquid chromatography with mass spectrometry by liquid sample desorption electrospray ionization (DESI)
US8723111B2 (en) 2011-09-29 2014-05-13 Morpho Detection, Llc Apparatus for chemical sampling and method of assembling the same
JP6346567B2 (en) * 2011-12-28 2018-06-20 マイクロマス・ユーケー・リミテッド System and method for rapid evaporation ionization of liquid phase samples
CN108511315B (en) 2011-12-28 2021-01-08 英国质谱有限公司 Collision ion generator and separator
US8664589B2 (en) * 2011-12-29 2014-03-04 Electro Scientific Industries, Inc Spectroscopy data display systems and methods
JP6006548B2 (en) * 2012-07-04 2016-10-12 株式会社 資生堂 Component distribution visualization device, component distribution visualization method, and component distribution visualization program
EP2951852B1 (en) 2013-01-31 2020-07-22 Purdue Research Foundation Systems for analyzing an extracted sample
WO2014120552A1 (en) 2013-01-31 2014-08-07 Purdue Research Foundation Methods of analyzing crude oil
US8975573B2 (en) 2013-03-11 2015-03-10 1St Detect Corporation Systems and methods for calibrating mass spectrometers
EP3486937B1 (en) 2013-06-25 2022-07-27 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
WO2015128661A1 (en) * 2014-02-26 2015-09-03 Micromass Uk Limited Ambient ionisation with an impactor spray source
GB201403335D0 (en) * 2014-02-26 2014-04-09 Micromass Ltd Ambient ionisation with an impactor spray source
JP2017511571A (en) * 2014-04-02 2017-04-20 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Apparatus and method for submicron elemental image analysis by mass spectrometry
EP3155636B1 (en) * 2014-06-13 2023-11-22 JP Scientific Limited A probe for extraction of molecules of interest from a sample
JP6191778B2 (en) * 2014-08-20 2017-09-06 株式会社島津製作所 Mass spectrometer
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
WO2016127177A1 (en) 2015-02-06 2016-08-11 Purdue Reserach Foundation Probes, systems, cartridges, and methods of use thereof
EP3265818B1 (en) 2015-03-06 2020-02-12 Micromass UK Limited Imaging guided ambient ionisation mass spectrometry
EP3265822B1 (en) 2015-03-06 2021-04-28 Micromass UK Limited Tissue analysis by mass spectrometry or ion mobility spectrometry
WO2016142692A1 (en) 2015-03-06 2016-09-15 Micromass Uk Limited Spectrometric analysis
US10777397B2 (en) 2015-03-06 2020-09-15 Micromass Uk Limited Inlet instrumentation for ion analyser coupled to rapid evaporative ionisation mass spectrometry (“REIMS”) device
KR102017409B1 (en) 2015-03-06 2019-10-21 마이크로매스 유케이 리미티드 Improved Ionization Methods for Gaseous Samples
DE202016008460U1 (en) 2015-03-06 2018-01-22 Micromass Uk Limited Cell population analysis
JP6858705B2 (en) 2015-03-06 2021-04-14 マイクロマス ユーケー リミテッド Collision surface for improved ionization
CN107636794B (en) 2015-03-06 2020-02-28 英国质谱公司 Liquid trap or separator for electrosurgical applications
GB2554206B (en) 2015-03-06 2021-03-24 Micromass Ltd Spectrometric analysis of microbes
CN107580675B (en) 2015-03-06 2020-12-08 英国质谱公司 Rapid evaporative ionization mass spectrometry ("REIMS") and desorption electrospray ionization mass spectrometry ("DESI-MS") analysis of swab and biopsy samples
US11139156B2 (en) 2015-03-06 2021-10-05 Micromass Uk Limited In vivo endoscopic tissue identification tool
EP3265819B1 (en) 2015-03-06 2020-10-14 Micromass UK Limited Chemically guided ambient ionisation mass spectrometry
US11367605B2 (en) 2015-03-06 2022-06-21 Micromass Uk Limited Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue
GB2556436B (en) 2015-03-06 2022-01-26 Micromass Ltd Cell population analysis
GB201517195D0 (en) 2015-09-29 2015-11-11 Micromass Ltd Capacitively coupled reims technique and optically transparent counter electrode
US9899196B1 (en) 2016-01-12 2018-02-20 Jeol Usa, Inc. Dopant-assisted direct analysis in real time mass spectrometry
EP3423186A4 (en) 2016-03-02 2019-10-23 JP Scientific Limited Solid phase microextraction coating
EP3443354A1 (en) 2016-04-14 2019-02-20 Micromass UK Limited Spectrometric analysis of plants
US9953817B2 (en) * 2016-04-22 2018-04-24 Smiths Detection Inc. Ion transfer tube with sheath gas flow
JP6803400B2 (en) 2016-05-10 2020-12-23 ジェイ・ピィ・サイエンティフィック・リミテッドJp Scientific Limited Systems and methods for desorbing and detecting analytes adsorbed on solid-phase microextractors
KR102543773B1 (en) 2016-09-02 2023-06-16 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Acquisition Probes and Methods of Their Use
GB2593620B (en) 2017-04-11 2021-12-22 Micromass Ltd Ambient ionisation source unit
GB2561372B (en) 2017-04-11 2022-04-20 Micromass Ltd Method of producing ions
EP3631840A4 (en) * 2017-06-03 2021-02-24 Shimadzu Corporation Ion source for mass spectrometer
US10636640B2 (en) 2017-07-06 2020-04-28 Ionsense, Inc. Apparatus and method for chemical phase sampling analysis
CN111566481A (en) 2017-11-27 2020-08-21 得克萨斯州大学系统董事会 Minimally invasive collection probe and use method thereof
WO2019231859A1 (en) 2018-06-01 2019-12-05 Ionsense Inc. Apparatus and method for reducing matrix effects when ionizing a sample
US11219393B2 (en) 2018-07-12 2022-01-11 Trace Matters Scientific Llc Mass spectrometry system and method for analyzing biological samples
US10720315B2 (en) 2018-06-05 2020-07-21 Trace Matters Scientific Llc Reconfigurable sequentially-packed ion (SPION) transfer device
US10840077B2 (en) 2018-06-05 2020-11-17 Trace Matters Scientific Llc Reconfigureable sequentially-packed ion (SPION) transfer device
JP7348626B2 (en) * 2019-07-17 2023-09-21 国立大学法人山梨大学 Biological sample condition evaluation device, system, method, and program
US20210018248A1 (en) * 2019-07-19 2021-01-21 Lee C. Ditzler System and method to inhibit microbial growth in mass storage of produce
JP2022553600A (en) 2019-10-28 2022-12-26 イオンセンス インコーポレイテッド Pulsatile air real-time ionization
US11913861B2 (en) 2020-05-26 2024-02-27 Bruker Scientific Llc Electrostatic loading of powder samples for ionization

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552599A (en) * 1993-10-01 1996-09-03 Finnegan Mat Gmbh Mass spectrometer having an ICP source
US5959297A (en) * 1996-10-09 1999-09-28 Symyx Technologies Mass spectrometers and methods for rapid screening of libraries of different materials
US6359275B1 (en) * 1999-07-14 2002-03-19 Agilent Technologies, Inc. Dielectric conduit with end electrodes
US6600155B1 (en) * 1998-01-23 2003-07-29 Analytica Of Branford, Inc. Mass spectrometry from surfaces
US6670608B1 (en) * 2001-09-13 2003-12-30 The United States Of America As Represented By The United States Department Of Energy Gas sampling system for a mass spectrometer
US20040094706A1 (en) * 2001-04-09 2004-05-20 Thomas Covey Method of and apparatus for ionizing an analyte and ion source probe for use therewith
US20040129876A1 (en) * 2002-08-08 2004-07-08 Bruker Daltonik Gmbh Ionization at atomspheric pressure for mass spectrometric analyses

Family Cites Families (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE325726B (en) 1969-04-21 1970-07-06 Lkb Produkter Ab
SE442678B (en) 1973-10-18 1986-01-20 Scient Glass Eng Pty Ltd PROCEDURE FOR MANUFACTURING A MOLECULE COOLATOR
US4016421A (en) * 1975-02-13 1977-04-05 E. I. Du Pont De Nemours And Company Analytical apparatus with variable energy ion beam source
US4213326A (en) * 1979-02-14 1980-07-22 The Upjohn Company Sample supply device
JPS5935347A (en) 1982-08-20 1984-02-27 Masahiko Tsuchiya Ion generator
US4542293A (en) * 1983-04-20 1985-09-17 Yale University Process and apparatus for changing the energy of charged particles contained in a gaseous medium
US4654052A (en) 1985-06-24 1987-03-31 Daryl Sharp Variable molecular separator
US4861988A (en) 1987-09-30 1989-08-29 Cornell Research Foundation, Inc. Ion spray apparatus and method
US5012052A (en) 1988-03-22 1991-04-30 Indiana University Foundation Isotope-ratio-monitoring gas chromatography-mass spectrometry apparatus and method
IL90970A (en) * 1989-07-13 1993-07-08 Univ Ramot Mass spectrometer method and apparatus for analyzing materials
US5137553A (en) 1990-03-02 1992-08-11 Sge International Pty. Ltd. Molecular jet separator
AU2170392A (en) 1991-05-21 1992-12-30 Analytica Of Branford, Inc. Method and apparatus for improving electrospray ionization of solute species
IL103963A (en) * 1991-12-03 1996-03-31 Graseby Dynamics Ltd Corona discharge ionization source
US5192865A (en) 1992-01-14 1993-03-09 Cetac Technologies Inc. Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems
DE4202123C2 (en) 1992-01-27 1995-04-06 Bruker Franzen Analytik Gmbh Device for the mass spectrometric analysis of fast organic ions
US5352892A (en) 1992-05-29 1994-10-04 Cornell Research Foundation, Inc. Atmospheric pressure ion interface for a mass analyzer
JP3123843B2 (en) * 1992-12-17 2001-01-15 日本電子株式会社 Sample vaporizer using plasma flame
US5381008A (en) * 1993-05-11 1995-01-10 Mds Health Group Ltd. Method of plasma mass analysis with reduced space charge effects
US5448062A (en) 1993-08-30 1995-09-05 Mims Technology Development Co. Analyte separation process and apparatus
US5412208A (en) 1994-01-13 1995-05-02 Mds Health Group Limited Ion spray with intersecting flow
JP3725911B2 (en) * 1994-06-02 2005-12-14 株式会社ルネサステクノロジ Semiconductor device
US5624537A (en) * 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
DE19515271C2 (en) * 1995-04-26 1999-09-02 Bruker Daltonik Gmbh Device for the gas-guided transport of ions through a capillary tube
US5614711A (en) 1995-05-04 1997-03-25 Indiana University Foundation Time-of-flight mass spectrometer
US5559326A (en) * 1995-07-28 1996-09-24 Hewlett-Packard Company Self generating ion device for mass spectrometry of liquids
US5868322A (en) 1996-01-31 1999-02-09 Hewlett-Packard Company Apparatus for forming liquid droplets having a mechanically fixed inner microtube
GB9602158D0 (en) 1996-02-02 1996-04-03 Graseby Dynamics Ltd Corona discharge ion sources for analytical instruments
US5736741A (en) * 1996-07-30 1998-04-07 Hewlett Packard Company Ionization chamber and mass spectrometry system containing an easily removable and replaceable capillary
US5788166A (en) 1996-08-27 1998-08-04 Cornell Research Foundation, Inc. Electrospray ionization source and method of using the same
US5777324A (en) * 1996-09-19 1998-07-07 Sequenom, Inc. Method and apparatus for maldi analysis
US5997746A (en) 1998-05-29 1999-12-07 New Objective Inc. Evaporative packing of capillary columns
US6124675A (en) 1998-06-01 2000-09-26 University Of Montreal Metastable atom bombardment source
US6107628A (en) * 1998-06-03 2000-08-22 Battelle Memorial Institute Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum
DE19848542C2 (en) * 1998-10-22 2001-07-05 Trace Biotech Ag Sampling probe
US6486469B1 (en) * 1999-10-29 2002-11-26 Agilent Technologies, Inc. Dielectric capillary high pass ion filter
WO2001050499A1 (en) 1999-12-30 2001-07-12 Advion Biosciences, Inc. Multiple electrospray device, systems and methods
US6744041B2 (en) * 2000-06-09 2004-06-01 Edward W Sheehan Apparatus and method for focusing ions and charged particles at atmospheric pressure
US6395183B1 (en) 2001-01-24 2002-05-28 New Objectives, Inc. Method for packing capillary columns with particulate materials
US6806468B2 (en) 2001-03-01 2004-10-19 Science & Engineering Services, Inc. Capillary ion delivery device and method for mass spectroscopy
US6649907B2 (en) 2001-03-08 2003-11-18 Wisconsin Alumni Research Foundation Charge reduction electrospray ionization ion source
DE10120336C2 (en) 2001-04-26 2003-05-08 Bruker Saxonia Analytik Gmbh Ion mobility spectrometer with non-radioactive ion source
US6803565B2 (en) 2001-05-18 2004-10-12 Battelle Memorial Institute Ionization source utilizing a multi-capillary inlet and method of operation
US6583408B2 (en) 2001-05-18 2003-06-24 Battelle Memorial Institute Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation
WO2002095360A2 (en) 2001-05-24 2002-11-28 New Objective, Inc. Method and apparatus for multiple electrospray sample introduction
WO2002095362A2 (en) 2001-05-24 2002-11-28 New Objective, Inc. Method and apparatus for feedback controlled electrospray
US6784424B1 (en) 2001-05-26 2004-08-31 Ross C Willoughby Apparatus and method for focusing and selecting ions and charged particles at or near atmospheric pressure
US6956205B2 (en) 2001-06-15 2005-10-18 Bruker Daltonics, Inc. Means and method for guiding ions in a mass spectrometer
US7064317B2 (en) 2001-08-15 2006-06-20 Purdue Research Foundation Method of selectively inhibiting reaction between ions
US6683300B2 (en) * 2001-09-17 2004-01-27 Science & Engineering Services, Inc. Method and apparatus for mass spectrometry analysis of common analyte solutions
JP2005502993A (en) * 2001-09-17 2005-01-27 エムディーエス インコーポレイテッド ドゥーイング ビジネス アズ エムディーエス サイエックス Ion cooling and focusing method and apparatus
US6646256B2 (en) 2001-12-18 2003-11-11 Agilent Technologies, Inc. Atmospheric pressure photoionization source in mass spectrometry
AU2003220320A1 (en) 2002-03-21 2003-10-08 Thermo Finnigan Llc Ionization apparatus and method for mass spectrometer system
US6818889B1 (en) 2002-06-01 2004-11-16 Edward W. Sheehan Laminated lens for focusing ions from atmospheric pressure
US7095019B1 (en) 2003-05-30 2006-08-22 Chem-Space Associates, Inc. Remote reagent chemical ionization source
US7253406B1 (en) 2002-06-01 2007-08-07 Chem-Space Associates, Incorporated Remote reagent chemical ionization source
US6888132B1 (en) 2002-06-01 2005-05-03 Edward W Sheehan Remote reagent chemical ionization source
JP2004014177A (en) 2002-06-04 2004-01-15 Shimadzu Corp Mass spectrometer
US20060079002A1 (en) 2002-06-07 2006-04-13 Bogdan Gologan System and method for landing of ions on a gas/liquid interface
US7381373B2 (en) * 2002-06-07 2008-06-03 Purdue Research Foundation System and method for preparative mass spectrometry
US6949740B1 (en) 2002-09-13 2005-09-27 Edward William Sheehan Laminated lens for introducing gas-phase ions into the vacuum systems of mass spectrometers
US6943347B1 (en) 2002-10-18 2005-09-13 Ross Clark Willoughby Laminated tube for the transport of charged particles contained in a gaseous medium
US7078679B2 (en) * 2002-11-27 2006-07-18 Wisconsin Alumni Research Foundation Inductive detection for mass spectrometry
WO2004051225A2 (en) * 2002-12-02 2004-06-17 Griffin Analytical Technologies, Inc. Processes for designing mass separators and ion traps, methods for producing mass separators and ion traps. mass spectrometers, ion traps, and methods for analysing samples
WO2004057638A2 (en) * 2002-12-18 2004-07-08 Brigham Young University Method and apparatus for aerodynamic ion focusing
JP2004264043A (en) * 2003-01-31 2004-09-24 National Institute Of Advanced Industrial & Technology Ionizing device, and micro-area analyzer
US6791080B2 (en) 2003-02-19 2004-09-14 Science & Engineering Services, Incorporated Method and apparatus for efficient transfer of ions into a mass spectrometer
US6878930B1 (en) 2003-02-24 2005-04-12 Ross Clark Willoughby Ion and charged particle source for production of thin films
US6861647B2 (en) 2003-03-17 2005-03-01 Indiana University Research And Technology Corporation Method and apparatus for mass spectrometric analysis of samples
US6979816B2 (en) 2003-03-25 2005-12-27 Battelle Memorial Institute Multi-source ion funnel
US7112785B2 (en) 2003-04-04 2006-09-26 Jeol Usa, Inc. Method for atmospheric pressure analyte ionization
US6949741B2 (en) 2003-04-04 2005-09-27 Jeol Usa, Inc. Atmospheric pressure ion source
US6914243B2 (en) 2003-06-07 2005-07-05 Edward W. Sheehan Ion enrichment aperture arrays
US7015466B2 (en) 2003-07-24 2006-03-21 Purdue Research Foundation Electrosonic spray ionization method and device for the atmospheric ionization of molecules
US20050079631A1 (en) 2003-10-09 2005-04-14 Science & Engineering Services, Inc. Method and apparatus for ionization of a sample at atmospheric pressure using a laser
US7081618B2 (en) 2004-03-24 2006-07-25 Burle Technologies, Inc. Use of conductive glass tubes to create electric fields in ion mobility spectrometers
US7157699B2 (en) 2004-03-29 2007-01-02 Purdue Research Foundation Multiplexed mass spectrometer
US7335897B2 (en) 2004-03-30 2008-02-26 Purdue Research Foundation Method and system for desorption electrospray ionization
US7737382B2 (en) * 2004-04-01 2010-06-15 Lincoln Global, Inc. Device for processing welding wire
US7161145B2 (en) * 2004-04-21 2007-01-09 Sri International Method and apparatus for the detection and identification of trace organic substances from a continuous flow sample system using laser photoionization-mass spectrometry
US7498585B2 (en) 2006-04-06 2009-03-03 Battelle Memorial Institute Method and apparatus for simultaneous detection and measurement of charged particles at one or more levels of particle flux for analysis of same
GB0424426D0 (en) 2004-11-04 2004-12-08 Micromass Ltd Mass spectrometer
US7081621B1 (en) * 2004-11-15 2006-07-25 Ross Clark Willoughby Laminated lens for focusing ions from atmospheric pressure
US7138626B1 (en) * 2005-05-05 2006-11-21 Eai Corporation Method and device for non-contact sampling and detection
US7196525B2 (en) * 2005-05-06 2007-03-27 Sparkman O David Sample imaging
US20060266941A1 (en) 2005-05-26 2006-11-30 Vestal Marvin L Method and apparatus for interfacing separations techniques to MALDI-TOF mass spectrometry
US7423260B2 (en) * 2005-11-04 2008-09-09 Agilent Technologies, Inc. Apparatus for combined laser focusing and spot imaging for MALDI
US7576322B2 (en) 2005-11-08 2009-08-18 Science Applications International Corporation Non-contact detector system with plasma ion source
US7544933B2 (en) 2006-01-17 2009-06-09 Purdue Research Foundation Method and system for desorption atmospheric pressure chemical ionization
US7700913B2 (en) * 2006-03-03 2010-04-20 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US8026477B2 (en) * 2006-03-03 2011-09-27 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
US7723678B2 (en) * 2006-04-04 2010-05-25 Agilent Technologies, Inc. Method and apparatus for surface desorption ionization by charged particles
US7423261B2 (en) * 2006-04-05 2008-09-09 Agilent Technologies, Inc. Curved conduit ion sampling device and method
JP2009539115A (en) * 2006-05-26 2009-11-12 イオンセンス インコーポレイテッド Flexible open tube collection system for use in surface ionization technology
WO2008046111A2 (en) * 2006-10-13 2008-04-17 Ionsense, Inc. A sampling system for containment and transfer of ions into a spectroscopy system
US8440965B2 (en) * 2006-10-13 2013-05-14 Ionsense, Inc. Sampling system for use with surface ionization spectroscopy
WO2008054393A1 (en) 2006-11-02 2008-05-08 Eai Corporation Method and device for non-contact sampling and detection
US7893408B2 (en) 2006-11-02 2011-02-22 Indiana University Research And Technology Corporation Methods and apparatus for ionization and desorption using a glow discharge
US7847244B2 (en) 2006-12-28 2010-12-07 Purdue Research Foundation Enclosed desorption electrospray ionization
US8519354B2 (en) * 2008-02-12 2013-08-27 Purdue Research Foundation Low temperature plasma probe and methods of use thereof
US7929138B1 (en) * 2008-02-15 2011-04-19 The United States Of America As Represented By The United States Department Of Energy Ambient-atmosphere glow discharge for determination of elemental concentration in solutions in a high-throughput or transient fashion
US8207494B2 (en) 2008-05-01 2012-06-26 Indiana University Research And Technology Corporation Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
US8203117B2 (en) * 2008-09-30 2012-06-19 Prosolia, Inc. Method and apparatus for embedded heater for desorption and ionization of analytes
CN102232238B (en) * 2008-10-13 2015-08-05 普度研究基金会 For transfer ions for the system and method analyzed
US8207497B2 (en) 2009-05-08 2012-06-26 Ionsense, Inc. Sampling of confined spaces
WO2011072130A1 (en) 2009-12-10 2011-06-16 Purdue Research Foundation Methods for diagnosing or monitoring for recurrence of prostate cancer
WO2011106656A1 (en) 2010-02-26 2011-09-01 Purdue Research Foundation (Prf) Systems and methods for sample analysis

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5552599A (en) * 1993-10-01 1996-09-03 Finnegan Mat Gmbh Mass spectrometer having an ICP source
US5959297A (en) * 1996-10-09 1999-09-28 Symyx Technologies Mass spectrometers and methods for rapid screening of libraries of different materials
US6600155B1 (en) * 1998-01-23 2003-07-29 Analytica Of Branford, Inc. Mass spectrometry from surfaces
US6359275B1 (en) * 1999-07-14 2002-03-19 Agilent Technologies, Inc. Dielectric conduit with end electrodes
US20040094706A1 (en) * 2001-04-09 2004-05-20 Thomas Covey Method of and apparatus for ionizing an analyte and ion source probe for use therewith
US6670608B1 (en) * 2001-09-13 2003-12-30 The United States Of America As Represented By The United States Department Of Energy Gas sampling system for a mass spectrometer
US20040129876A1 (en) * 2002-08-08 2004-07-08 Bruker Daltonik Gmbh Ionization at atomspheric pressure for mass spectrometric analyses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2035122A4 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895916B2 (en) 2009-05-08 2014-11-25 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US9390899B2 (en) 2009-05-08 2016-07-12 Ionsense, Inc. Apparatus and method for sampling of confined spaces
US8963101B2 (en) 2011-02-05 2015-02-24 Ionsense, Inc. Apparatus and method for thermal assisted desorption ionization systems
US9514923B2 (en) 2011-02-05 2016-12-06 Ionsense Inc. Apparatus and method for thermal assisted desorption ionization systems
US8901488B1 (en) 2011-04-18 2014-12-02 Ionsense, Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US9105435B1 (en) 2011-04-18 2015-08-11 Ionsense Inc. Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system
US9558926B2 (en) 2014-06-15 2017-01-31 Ionsense, Inc. Apparatus and method for rapid chemical analysis using differential desorption

Also Published As

Publication number Publication date
JP2009539115A (en) 2009-11-12
US7705297B2 (en) 2010-04-27
WO2007140351A2 (en) 2007-12-06
EP2035121A4 (en) 2010-04-28
JP2009539114A (en) 2009-11-12
WO2007140349A2 (en) 2007-12-06
EP2035122A2 (en) 2009-03-18
US20080067348A1 (en) 2008-03-20
US20120112057A1 (en) 2012-05-10
US8421005B2 (en) 2013-04-16
US7714281B2 (en) 2010-05-11
US7777181B2 (en) 2010-08-17
EP2035121A2 (en) 2009-03-18
US20080067358A1 (en) 2008-03-20
US8481922B2 (en) 2013-07-09
US20080067359A1 (en) 2008-03-20
WO2007140349A3 (en) 2009-03-05
EP2035122A4 (en) 2010-05-05
US20100140468A1 (en) 2010-06-10

Similar Documents

Publication Publication Date Title
WO2007140351A3 (en) Flexible open tube sampling system for use with surface ionization technology
WO2008046111A3 (en) A sampling system for containment and transfer of ions into a spectroscopy system
CN202003947U (en) Mass spectrum sample introduction device capable of switching between capillary sample introduction and membrane sample introduction
EP2372746A3 (en) Low-Pressure Electron Ionization and Chemical Ionization for Mass Spectrometry
EP1635375A3 (en) Sampling device for mass spectrometer ion source with multiple inlets
WO2002071053A3 (en) Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry
WO2008036616A3 (en) Apparatus and method for field asymmetric ion mobility spectrometry combined with mass spectrometry.
WO2014020442A3 (en) Solid phase micro extraction (spme) vacuum inlet
WO2012031082A3 (en) System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry
CN102709147A (en) Electrospray ion source and mass spectrometer
CN102437005B (en) Membrane feeding device on gas analysis mass spectrometer
WO2007060421A3 (en) Mass spectrometer
CN106373855B (en) The mass spectrometric apparatus of organic pollution in a kind of quick analysis gas or liquid
EP3491659A1 (en) Low temperature plasma probe with auxiliary heated gas jet
WO2011088459A3 (en) Continuous flow mobility classifier interface with mass spectrometer
WO2008090600A1 (en) Mass analyzer
CN103236394A (en) Microwave plasma based atmospheric pressure desorption ion source and application thereof
US8734722B2 (en) Detection apparatus accompanying preconcentrated pulsed analyte via an aperture
WO2007060437A3 (en) Mass spectrometer
CN105489467B (en) A kind of chemi-ionization source device and its ionization detection method
CN103698387B (en) For the sampling device of ionic migration spectrometer and using method thereof and ionic migration spectrometer
Zhu et al. Development and application of a miniature mass spectrometer with continuous sub-atmospheric pressure interface and integrated ionization source
CN203367224U (en) Normal pressure direct ionization mass spectrum device of concealed ion source
WO2006103465A3 (en) Mass spectrometer
CN105632875B (en) Desorption ionization mass spectrometer interface for mass spectrographic imaging

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07797812

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009513407

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007797812

Country of ref document: EP