WO2007140351A3 - Flexible open tube sampling system for use with surface ionization technology - Google Patents
Flexible open tube sampling system for use with surface ionization technology Download PDFInfo
- Publication number
- WO2007140351A3 WO2007140351A3 PCT/US2007/069823 US2007069823W WO2007140351A3 WO 2007140351 A3 WO2007140351 A3 WO 2007140351A3 US 2007069823 W US2007069823 W US 2007069823W WO 2007140351 A3 WO2007140351 A3 WO 2007140351A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- present
- ions
- sample
- tubes
- sampling system
- Prior art date
Links
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0404—Capillaries used for transferring samples or ions
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0409—Sample holders or containers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
Abstract
The present invention is a device to restrict the sampling of analyte ions and neutral molecules from surfaces with mass spectrometry and thereby sample from a defined area or volume. In various embodiments of the present invention, a tube is used to sample ions formed with a defined spatial resolution from desorption ionization at or near atmospheric pressures. In an embodiment of the present invention, electrostatic fields are used to direct ions to either individual tubes or a plurality of tubes positioned in close proximity to the surface of the sample being analyzed. In an embodiment of the present invention, wide diameter sampling tubes can be used in combination with a vacuum inlet to draw ions and neutrals into the spectrometer for analysis. In an embodiment of the present invention, wide diameter sampling tubes in combination with electrostatic fields improve the efficiency of ion collection.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009513407A JP2009539115A (en) | 2006-05-26 | 2007-05-25 | Flexible open tube collection system for use in surface ionization technology |
EP07797812A EP2035122A4 (en) | 2006-05-26 | 2007-05-25 | Flexible open tube sampling system for use with surface ionization technology |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80860906P | 2006-05-26 | 2006-05-26 | |
US60/808,609 | 2006-05-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007140351A2 WO2007140351A2 (en) | 2007-12-06 |
WO2007140351A3 true WO2007140351A3 (en) | 2008-04-17 |
Family
ID=38779395
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/069823 WO2007140351A2 (en) | 2006-05-26 | 2007-05-25 | Flexible open tube sampling system for use with surface ionization technology |
PCT/US2007/069821 WO2007140349A2 (en) | 2006-05-26 | 2007-05-25 | Apparatus for holding solids for use with surface ionization technology |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/069821 WO2007140349A2 (en) | 2006-05-26 | 2007-05-25 | Apparatus for holding solids for use with surface ionization technology |
Country Status (4)
Country | Link |
---|---|
US (5) | US7777181B2 (en) |
EP (2) | EP2035121A4 (en) |
JP (2) | JP2009539115A (en) |
WO (2) | WO2007140351A2 (en) |
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US8963101B2 (en) | 2011-02-05 | 2015-02-24 | Ionsense, Inc. | Apparatus and method for thermal assisted desorption ionization systems |
US9558926B2 (en) | 2014-06-15 | 2017-01-31 | Ionsense, Inc. | Apparatus and method for rapid chemical analysis using differential desorption |
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WO2008046111A2 (en) * | 2006-10-13 | 2008-04-17 | Ionsense, Inc. | A sampling system for containment and transfer of ions into a spectroscopy system |
US7547891B2 (en) * | 2007-02-16 | 2009-06-16 | Agilent Technologies, Inc. | Ion sampling apparatuses in fast polarity-switching ion sources |
US8178833B2 (en) * | 2007-06-02 | 2012-05-15 | Chem-Space Associates, Inc | High-flow tube for sampling ions from an atmospheric pressure ion source |
US20090317916A1 (en) * | 2008-06-23 | 2009-12-24 | Ewing Kenneth J | Chemical sample collection and detection device using atmospheric pressure ionization |
US7915579B2 (en) * | 2008-09-05 | 2011-03-29 | Ohio University | Method and apparatus of liquid sample-desorption electrospray ionization-mass specrometry (LS-DESI-MS) |
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US8704167B2 (en) * | 2009-04-30 | 2014-04-22 | Purdue Research Foundation | Mass spectrometry analysis of microorganisms in samples |
US9500572B2 (en) | 2009-04-30 | 2016-11-22 | Purdue Research Foundation | Sample dispenser including an internal standard and methods of use thereof |
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US20110260048A1 (en) * | 2010-04-22 | 2011-10-27 | Wouters Eloy R | Ion Transfer Tube for a Mass Spectrometer Having a Resistive Tube Member and a Conductive Tube Member |
WO2012003434A1 (en) * | 2010-07-01 | 2012-01-05 | Northrop Grumman Systems Corporation | Systems and methods for automated collection of analytes |
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US9198609B2 (en) | 2011-04-19 | 2015-12-01 | Porex Corporation | Cards for sample storage and delivery comprising sintered porous plastic |
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US9024254B2 (en) | 2011-06-03 | 2015-05-05 | Purdue Research Foundation | Enclosed desorption electrospray ionization probes and method of use thereof |
US8592758B1 (en) * | 2011-06-06 | 2013-11-26 | The United States Of America As Represented By The Secretary Of The Army | Vapor sampling adapter for direct analysis in real time mass spectrometry |
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US8723111B2 (en) | 2011-09-29 | 2014-05-13 | Morpho Detection, Llc | Apparatus for chemical sampling and method of assembling the same |
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US8664589B2 (en) * | 2011-12-29 | 2014-03-04 | Electro Scientific Industries, Inc | Spectroscopy data display systems and methods |
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Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552599A (en) * | 1993-10-01 | 1996-09-03 | Finnegan Mat Gmbh | Mass spectrometer having an ICP source |
US5959297A (en) * | 1996-10-09 | 1999-09-28 | Symyx Technologies | Mass spectrometers and methods for rapid screening of libraries of different materials |
US6359275B1 (en) * | 1999-07-14 | 2002-03-19 | Agilent Technologies, Inc. | Dielectric conduit with end electrodes |
US6600155B1 (en) * | 1998-01-23 | 2003-07-29 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
US6670608B1 (en) * | 2001-09-13 | 2003-12-30 | The United States Of America As Represented By The United States Department Of Energy | Gas sampling system for a mass spectrometer |
US20040094706A1 (en) * | 2001-04-09 | 2004-05-20 | Thomas Covey | Method of and apparatus for ionizing an analyte and ion source probe for use therewith |
US20040129876A1 (en) * | 2002-08-08 | 2004-07-08 | Bruker Daltonik Gmbh | Ionization at atomspheric pressure for mass spectrometric analyses |
Family Cites Families (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE325726B (en) | 1969-04-21 | 1970-07-06 | Lkb Produkter Ab | |
SE442678B (en) | 1973-10-18 | 1986-01-20 | Scient Glass Eng Pty Ltd | PROCEDURE FOR MANUFACTURING A MOLECULE COOLATOR |
US4016421A (en) * | 1975-02-13 | 1977-04-05 | E. I. Du Pont De Nemours And Company | Analytical apparatus with variable energy ion beam source |
US4213326A (en) * | 1979-02-14 | 1980-07-22 | The Upjohn Company | Sample supply device |
JPS5935347A (en) | 1982-08-20 | 1984-02-27 | Masahiko Tsuchiya | Ion generator |
US4542293A (en) * | 1983-04-20 | 1985-09-17 | Yale University | Process and apparatus for changing the energy of charged particles contained in a gaseous medium |
US4654052A (en) | 1985-06-24 | 1987-03-31 | Daryl Sharp | Variable molecular separator |
US4861988A (en) | 1987-09-30 | 1989-08-29 | Cornell Research Foundation, Inc. | Ion spray apparatus and method |
US5012052A (en) | 1988-03-22 | 1991-04-30 | Indiana University Foundation | Isotope-ratio-monitoring gas chromatography-mass spectrometry apparatus and method |
IL90970A (en) * | 1989-07-13 | 1993-07-08 | Univ Ramot | Mass spectrometer method and apparatus for analyzing materials |
US5137553A (en) | 1990-03-02 | 1992-08-11 | Sge International Pty. Ltd. | Molecular jet separator |
AU2170392A (en) | 1991-05-21 | 1992-12-30 | Analytica Of Branford, Inc. | Method and apparatus for improving electrospray ionization of solute species |
IL103963A (en) * | 1991-12-03 | 1996-03-31 | Graseby Dynamics Ltd | Corona discharge ionization source |
US5192865A (en) | 1992-01-14 | 1993-03-09 | Cetac Technologies Inc. | Atmospheric pressure afterglow ionization system and method of use, for mass spectrometer sample analysis systems |
DE4202123C2 (en) | 1992-01-27 | 1995-04-06 | Bruker Franzen Analytik Gmbh | Device for the mass spectrometric analysis of fast organic ions |
US5352892A (en) | 1992-05-29 | 1994-10-04 | Cornell Research Foundation, Inc. | Atmospheric pressure ion interface for a mass analyzer |
JP3123843B2 (en) * | 1992-12-17 | 2001-01-15 | 日本電子株式会社 | Sample vaporizer using plasma flame |
US5381008A (en) * | 1993-05-11 | 1995-01-10 | Mds Health Group Ltd. | Method of plasma mass analysis with reduced space charge effects |
US5448062A (en) | 1993-08-30 | 1995-09-05 | Mims Technology Development Co. | Analyte separation process and apparatus |
US5412208A (en) | 1994-01-13 | 1995-05-02 | Mds Health Group Limited | Ion spray with intersecting flow |
JP3725911B2 (en) * | 1994-06-02 | 2005-12-14 | 株式会社ルネサステクノロジ | Semiconductor device |
US5624537A (en) * | 1994-09-20 | 1997-04-29 | The University Of British Columbia - University-Industry Liaison Office | Biosensor and interface membrane |
DE19515271C2 (en) * | 1995-04-26 | 1999-09-02 | Bruker Daltonik Gmbh | Device for the gas-guided transport of ions through a capillary tube |
US5614711A (en) | 1995-05-04 | 1997-03-25 | Indiana University Foundation | Time-of-flight mass spectrometer |
US5559326A (en) * | 1995-07-28 | 1996-09-24 | Hewlett-Packard Company | Self generating ion device for mass spectrometry of liquids |
US5868322A (en) | 1996-01-31 | 1999-02-09 | Hewlett-Packard Company | Apparatus for forming liquid droplets having a mechanically fixed inner microtube |
GB9602158D0 (en) | 1996-02-02 | 1996-04-03 | Graseby Dynamics Ltd | Corona discharge ion sources for analytical instruments |
US5736741A (en) * | 1996-07-30 | 1998-04-07 | Hewlett Packard Company | Ionization chamber and mass spectrometry system containing an easily removable and replaceable capillary |
US5788166A (en) | 1996-08-27 | 1998-08-04 | Cornell Research Foundation, Inc. | Electrospray ionization source and method of using the same |
US5777324A (en) * | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
US5997746A (en) | 1998-05-29 | 1999-12-07 | New Objective Inc. | Evaporative packing of capillary columns |
US6124675A (en) | 1998-06-01 | 2000-09-26 | University Of Montreal | Metastable atom bombardment source |
US6107628A (en) * | 1998-06-03 | 2000-08-22 | Battelle Memorial Institute | Method and apparatus for directing ions and other charged particles generated at near atmospheric pressures into a region under vacuum |
DE19848542C2 (en) * | 1998-10-22 | 2001-07-05 | Trace Biotech Ag | Sampling probe |
US6486469B1 (en) * | 1999-10-29 | 2002-11-26 | Agilent Technologies, Inc. | Dielectric capillary high pass ion filter |
WO2001050499A1 (en) | 1999-12-30 | 2001-07-12 | Advion Biosciences, Inc. | Multiple electrospray device, systems and methods |
US6744041B2 (en) * | 2000-06-09 | 2004-06-01 | Edward W Sheehan | Apparatus and method for focusing ions and charged particles at atmospheric pressure |
US6395183B1 (en) | 2001-01-24 | 2002-05-28 | New Objectives, Inc. | Method for packing capillary columns with particulate materials |
US6806468B2 (en) | 2001-03-01 | 2004-10-19 | Science & Engineering Services, Inc. | Capillary ion delivery device and method for mass spectroscopy |
US6649907B2 (en) | 2001-03-08 | 2003-11-18 | Wisconsin Alumni Research Foundation | Charge reduction electrospray ionization ion source |
DE10120336C2 (en) | 2001-04-26 | 2003-05-08 | Bruker Saxonia Analytik Gmbh | Ion mobility spectrometer with non-radioactive ion source |
US6803565B2 (en) | 2001-05-18 | 2004-10-12 | Battelle Memorial Institute | Ionization source utilizing a multi-capillary inlet and method of operation |
US6583408B2 (en) | 2001-05-18 | 2003-06-24 | Battelle Memorial Institute | Ionization source utilizing a jet disturber in combination with an ion funnel and method of operation |
WO2002095360A2 (en) | 2001-05-24 | 2002-11-28 | New Objective, Inc. | Method and apparatus for multiple electrospray sample introduction |
WO2002095362A2 (en) | 2001-05-24 | 2002-11-28 | New Objective, Inc. | Method and apparatus for feedback controlled electrospray |
US6784424B1 (en) | 2001-05-26 | 2004-08-31 | Ross C Willoughby | Apparatus and method for focusing and selecting ions and charged particles at or near atmospheric pressure |
US6956205B2 (en) | 2001-06-15 | 2005-10-18 | Bruker Daltonics, Inc. | Means and method for guiding ions in a mass spectrometer |
US7064317B2 (en) | 2001-08-15 | 2006-06-20 | Purdue Research Foundation | Method of selectively inhibiting reaction between ions |
US6683300B2 (en) * | 2001-09-17 | 2004-01-27 | Science & Engineering Services, Inc. | Method and apparatus for mass spectrometry analysis of common analyte solutions |
JP2005502993A (en) * | 2001-09-17 | 2005-01-27 | エムディーエス インコーポレイテッド ドゥーイング ビジネス アズ エムディーエス サイエックス | Ion cooling and focusing method and apparatus |
US6646256B2 (en) | 2001-12-18 | 2003-11-11 | Agilent Technologies, Inc. | Atmospheric pressure photoionization source in mass spectrometry |
AU2003220320A1 (en) | 2002-03-21 | 2003-10-08 | Thermo Finnigan Llc | Ionization apparatus and method for mass spectrometer system |
US6818889B1 (en) | 2002-06-01 | 2004-11-16 | Edward W. Sheehan | Laminated lens for focusing ions from atmospheric pressure |
US7095019B1 (en) | 2003-05-30 | 2006-08-22 | Chem-Space Associates, Inc. | Remote reagent chemical ionization source |
US7253406B1 (en) | 2002-06-01 | 2007-08-07 | Chem-Space Associates, Incorporated | Remote reagent chemical ionization source |
US6888132B1 (en) | 2002-06-01 | 2005-05-03 | Edward W Sheehan | Remote reagent chemical ionization source |
JP2004014177A (en) | 2002-06-04 | 2004-01-15 | Shimadzu Corp | Mass spectrometer |
US20060079002A1 (en) | 2002-06-07 | 2006-04-13 | Bogdan Gologan | System and method for landing of ions on a gas/liquid interface |
US7381373B2 (en) * | 2002-06-07 | 2008-06-03 | Purdue Research Foundation | System and method for preparative mass spectrometry |
US6949740B1 (en) | 2002-09-13 | 2005-09-27 | Edward William Sheehan | Laminated lens for introducing gas-phase ions into the vacuum systems of mass spectrometers |
US6943347B1 (en) | 2002-10-18 | 2005-09-13 | Ross Clark Willoughby | Laminated tube for the transport of charged particles contained in a gaseous medium |
US7078679B2 (en) * | 2002-11-27 | 2006-07-18 | Wisconsin Alumni Research Foundation | Inductive detection for mass spectrometry |
WO2004051225A2 (en) * | 2002-12-02 | 2004-06-17 | Griffin Analytical Technologies, Inc. | Processes for designing mass separators and ion traps, methods for producing mass separators and ion traps. mass spectrometers, ion traps, and methods for analysing samples |
WO2004057638A2 (en) * | 2002-12-18 | 2004-07-08 | Brigham Young University | Method and apparatus for aerodynamic ion focusing |
JP2004264043A (en) * | 2003-01-31 | 2004-09-24 | National Institute Of Advanced Industrial & Technology | Ionizing device, and micro-area analyzer |
US6791080B2 (en) | 2003-02-19 | 2004-09-14 | Science & Engineering Services, Incorporated | Method and apparatus for efficient transfer of ions into a mass spectrometer |
US6878930B1 (en) | 2003-02-24 | 2005-04-12 | Ross Clark Willoughby | Ion and charged particle source for production of thin films |
US6861647B2 (en) | 2003-03-17 | 2005-03-01 | Indiana University Research And Technology Corporation | Method and apparatus for mass spectrometric analysis of samples |
US6979816B2 (en) | 2003-03-25 | 2005-12-27 | Battelle Memorial Institute | Multi-source ion funnel |
US7112785B2 (en) | 2003-04-04 | 2006-09-26 | Jeol Usa, Inc. | Method for atmospheric pressure analyte ionization |
US6949741B2 (en) | 2003-04-04 | 2005-09-27 | Jeol Usa, Inc. | Atmospheric pressure ion source |
US6914243B2 (en) | 2003-06-07 | 2005-07-05 | Edward W. Sheehan | Ion enrichment aperture arrays |
US7015466B2 (en) | 2003-07-24 | 2006-03-21 | Purdue Research Foundation | Electrosonic spray ionization method and device for the atmospheric ionization of molecules |
US20050079631A1 (en) | 2003-10-09 | 2005-04-14 | Science & Engineering Services, Inc. | Method and apparatus for ionization of a sample at atmospheric pressure using a laser |
US7081618B2 (en) | 2004-03-24 | 2006-07-25 | Burle Technologies, Inc. | Use of conductive glass tubes to create electric fields in ion mobility spectrometers |
US7157699B2 (en) | 2004-03-29 | 2007-01-02 | Purdue Research Foundation | Multiplexed mass spectrometer |
US7335897B2 (en) | 2004-03-30 | 2008-02-26 | Purdue Research Foundation | Method and system for desorption electrospray ionization |
US7737382B2 (en) * | 2004-04-01 | 2010-06-15 | Lincoln Global, Inc. | Device for processing welding wire |
US7161145B2 (en) * | 2004-04-21 | 2007-01-09 | Sri International | Method and apparatus for the detection and identification of trace organic substances from a continuous flow sample system using laser photoionization-mass spectrometry |
US7498585B2 (en) | 2006-04-06 | 2009-03-03 | Battelle Memorial Institute | Method and apparatus for simultaneous detection and measurement of charged particles at one or more levels of particle flux for analysis of same |
GB0424426D0 (en) | 2004-11-04 | 2004-12-08 | Micromass Ltd | Mass spectrometer |
US7081621B1 (en) * | 2004-11-15 | 2006-07-25 | Ross Clark Willoughby | Laminated lens for focusing ions from atmospheric pressure |
US7138626B1 (en) * | 2005-05-05 | 2006-11-21 | Eai Corporation | Method and device for non-contact sampling and detection |
US7196525B2 (en) * | 2005-05-06 | 2007-03-27 | Sparkman O David | Sample imaging |
US20060266941A1 (en) | 2005-05-26 | 2006-11-30 | Vestal Marvin L | Method and apparatus for interfacing separations techniques to MALDI-TOF mass spectrometry |
US7423260B2 (en) * | 2005-11-04 | 2008-09-09 | Agilent Technologies, Inc. | Apparatus for combined laser focusing and spot imaging for MALDI |
US7576322B2 (en) | 2005-11-08 | 2009-08-18 | Science Applications International Corporation | Non-contact detector system with plasma ion source |
US7544933B2 (en) | 2006-01-17 | 2009-06-09 | Purdue Research Foundation | Method and system for desorption atmospheric pressure chemical ionization |
US7700913B2 (en) * | 2006-03-03 | 2010-04-20 | Ionsense, Inc. | Sampling system for use with surface ionization spectroscopy |
US8026477B2 (en) * | 2006-03-03 | 2011-09-27 | Ionsense, Inc. | Sampling system for use with surface ionization spectroscopy |
US7723678B2 (en) * | 2006-04-04 | 2010-05-25 | Agilent Technologies, Inc. | Method and apparatus for surface desorption ionization by charged particles |
US7423261B2 (en) * | 2006-04-05 | 2008-09-09 | Agilent Technologies, Inc. | Curved conduit ion sampling device and method |
JP2009539115A (en) * | 2006-05-26 | 2009-11-12 | イオンセンス インコーポレイテッド | Flexible open tube collection system for use in surface ionization technology |
WO2008046111A2 (en) * | 2006-10-13 | 2008-04-17 | Ionsense, Inc. | A sampling system for containment and transfer of ions into a spectroscopy system |
US8440965B2 (en) * | 2006-10-13 | 2013-05-14 | Ionsense, Inc. | Sampling system for use with surface ionization spectroscopy |
WO2008054393A1 (en) | 2006-11-02 | 2008-05-08 | Eai Corporation | Method and device for non-contact sampling and detection |
US7893408B2 (en) | 2006-11-02 | 2011-02-22 | Indiana University Research And Technology Corporation | Methods and apparatus for ionization and desorption using a glow discharge |
US7847244B2 (en) | 2006-12-28 | 2010-12-07 | Purdue Research Foundation | Enclosed desorption electrospray ionization |
US8519354B2 (en) * | 2008-02-12 | 2013-08-27 | Purdue Research Foundation | Low temperature plasma probe and methods of use thereof |
US7929138B1 (en) * | 2008-02-15 | 2011-04-19 | The United States Of America As Represented By The United States Department Of Energy | Ambient-atmosphere glow discharge for determination of elemental concentration in solutions in a high-throughput or transient fashion |
US8207494B2 (en) | 2008-05-01 | 2012-06-26 | Indiana University Research And Technology Corporation | Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry |
US8203117B2 (en) * | 2008-09-30 | 2012-06-19 | Prosolia, Inc. | Method and apparatus for embedded heater for desorption and ionization of analytes |
CN102232238B (en) * | 2008-10-13 | 2015-08-05 | 普度研究基金会 | For transfer ions for the system and method analyzed |
US8207497B2 (en) | 2009-05-08 | 2012-06-26 | Ionsense, Inc. | Sampling of confined spaces |
WO2011072130A1 (en) | 2009-12-10 | 2011-06-16 | Purdue Research Foundation | Methods for diagnosing or monitoring for recurrence of prostate cancer |
WO2011106656A1 (en) | 2010-02-26 | 2011-09-01 | Purdue Research Foundation (Prf) | Systems and methods for sample analysis |
-
2007
- 2007-05-25 JP JP2009513407A patent/JP2009539115A/en not_active Withdrawn
- 2007-05-25 US US11/754,115 patent/US7777181B2/en active Active
- 2007-05-25 WO PCT/US2007/069823 patent/WO2007140351A2/en active Application Filing
- 2007-05-25 JP JP2009513406A patent/JP2009539114A/en not_active Withdrawn
- 2007-05-25 WO PCT/US2007/069821 patent/WO2007140349A2/en active Application Filing
- 2007-05-25 EP EP07797811A patent/EP2035121A4/en not_active Ceased
- 2007-05-25 US US11/754,189 patent/US7705297B2/en active Active
- 2007-05-25 EP EP07797812A patent/EP2035122A4/en not_active Withdrawn
- 2007-05-25 US US11/754,158 patent/US7714281B2/en active Active
-
2010
- 2010-02-19 US US12/709,157 patent/US8421005B2/en active Active
-
2011
- 2011-12-23 US US13/336,984 patent/US8481922B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552599A (en) * | 1993-10-01 | 1996-09-03 | Finnegan Mat Gmbh | Mass spectrometer having an ICP source |
US5959297A (en) * | 1996-10-09 | 1999-09-28 | Symyx Technologies | Mass spectrometers and methods for rapid screening of libraries of different materials |
US6600155B1 (en) * | 1998-01-23 | 2003-07-29 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
US6359275B1 (en) * | 1999-07-14 | 2002-03-19 | Agilent Technologies, Inc. | Dielectric conduit with end electrodes |
US20040094706A1 (en) * | 2001-04-09 | 2004-05-20 | Thomas Covey | Method of and apparatus for ionizing an analyte and ion source probe for use therewith |
US6670608B1 (en) * | 2001-09-13 | 2003-12-30 | The United States Of America As Represented By The United States Department Of Energy | Gas sampling system for a mass spectrometer |
US20040129876A1 (en) * | 2002-08-08 | 2004-07-08 | Bruker Daltonik Gmbh | Ionization at atomspheric pressure for mass spectrometric analyses |
Non-Patent Citations (1)
Title |
---|
See also references of EP2035122A4 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8895916B2 (en) | 2009-05-08 | 2014-11-25 | Ionsense, Inc. | Apparatus and method for sampling of confined spaces |
US9390899B2 (en) | 2009-05-08 | 2016-07-12 | Ionsense, Inc. | Apparatus and method for sampling of confined spaces |
US8963101B2 (en) | 2011-02-05 | 2015-02-24 | Ionsense, Inc. | Apparatus and method for thermal assisted desorption ionization systems |
US9514923B2 (en) | 2011-02-05 | 2016-12-06 | Ionsense Inc. | Apparatus and method for thermal assisted desorption ionization systems |
US8901488B1 (en) | 2011-04-18 | 2014-12-02 | Ionsense, Inc. | Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system |
US9105435B1 (en) | 2011-04-18 | 2015-08-11 | Ionsense Inc. | Robust, rapid, secure sample manipulation before during and after ionization for a spectroscopy system |
US9558926B2 (en) | 2014-06-15 | 2017-01-31 | Ionsense, Inc. | Apparatus and method for rapid chemical analysis using differential desorption |
Also Published As
Publication number | Publication date |
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JP2009539115A (en) | 2009-11-12 |
US7705297B2 (en) | 2010-04-27 |
WO2007140351A2 (en) | 2007-12-06 |
EP2035121A4 (en) | 2010-04-28 |
JP2009539114A (en) | 2009-11-12 |
WO2007140349A2 (en) | 2007-12-06 |
EP2035122A2 (en) | 2009-03-18 |
US20080067348A1 (en) | 2008-03-20 |
US20120112057A1 (en) | 2012-05-10 |
US8421005B2 (en) | 2013-04-16 |
US7714281B2 (en) | 2010-05-11 |
US7777181B2 (en) | 2010-08-17 |
EP2035121A2 (en) | 2009-03-18 |
US20080067358A1 (en) | 2008-03-20 |
US8481922B2 (en) | 2013-07-09 |
US20080067359A1 (en) | 2008-03-20 |
WO2007140349A3 (en) | 2009-03-05 |
EP2035122A4 (en) | 2010-05-05 |
US20100140468A1 (en) | 2010-06-10 |
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