WO2008011348A3 - Humanized antibody against amyloid beta - Google Patents

Humanized antibody against amyloid beta Download PDF

Info

Publication number
WO2008011348A3
WO2008011348A3 PCT/US2007/073504 US2007073504W WO2008011348A3 WO 2008011348 A3 WO2008011348 A3 WO 2008011348A3 US 2007073504 W US2007073504 W US 2007073504W WO 2008011348 A3 WO2008011348 A3 WO 2008011348A3
Authority
WO
WIPO (PCT)
Prior art keywords
humanized antibody
antibody against
amyloid beta
against amyloid
amyloidosis
Prior art date
Application number
PCT/US2007/073504
Other languages
French (fr)
Other versions
WO2008011348A2 (en
Inventor
Andrea Pfeifer
Maria Pihlgren
Andreas Muhs
Ryan Watts
Original Assignee
Ac Immune Sa
Genentech Inc
Andrea Pfeifer
Maria Pihlgren
Andreas Muhs
Ryan Watts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43063574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2008011348(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ac Immune Sa, Genentech Inc, Andrea Pfeifer, Maria Pihlgren, Andreas Muhs, Ryan Watts filed Critical Ac Immune Sa
Priority to KR1020197000092A priority Critical patent/KR20190003862A/en
Priority to CA2657681A priority patent/CA2657681C/en
Priority to NZ574188A priority patent/NZ574188A/en
Priority to PL11192705T priority patent/PL2468770T3/en
Priority to UAA200900880A priority patent/UA100672C2/en
Priority to RU2009104769/10A priority patent/RU2498999C2/en
Priority to MEP-2013-132A priority patent/ME01758B/en
Priority to EP17190333.9A priority patent/EP3309172B1/en
Priority to KR1020177023161A priority patent/KR20170098978A/en
Priority to PL07840408T priority patent/PL2046833T3/en
Priority to MX2009000476A priority patent/MX2009000476A/en
Priority to AU2007275467A priority patent/AU2007275467B2/en
Priority to MEP-2010-59A priority patent/ME01075B/en
Priority to KR1020167034680A priority patent/KR20160147066A/en
Priority to KR1020147027016A priority patent/KR20140125455A/en
Priority to BRPI0714713-9A priority patent/BRPI0714713B1/en
Priority to DK07840408.4T priority patent/DK2046833T5/en
Priority to JP2009519711A priority patent/JP2010528583A/en
Priority to RS20130515A priority patent/RS53160B/en
Priority to KR1020167010466A priority patent/KR20160049045A/en
Priority to SI200731343T priority patent/SI2046833T1/en
Priority to EP21191801.6A priority patent/EP3988566A1/en
Priority to KR1020097003136A priority patent/KR101605207B1/en
Priority to CN200780033976.7A priority patent/CN101516911B/en
Priority to EP07840408.4A priority patent/EP2046833B9/en
Priority to KR1020187011457A priority patent/KR20180043854A/en
Priority to ES07840408T priority patent/ES2436112T3/en
Priority to CN2007800445554A priority patent/CN101611054B/en
Priority to ES07867188.0T priority patent/ES2640095T3/en
Priority to BRPI0719763-2A priority patent/BRPI0719763A2/en
Priority to SI200731964T priority patent/SI2074145T1/en
Priority to EP07867188.0A priority patent/EP2074145B1/en
Priority to PL07867188T priority patent/PL2074145T3/en
Priority to KR1020147032970A priority patent/KR20150002879A/en
Priority to PCT/US2007/021134 priority patent/WO2008060364A2/en
Priority to DK07867188.0T priority patent/DK2074145T5/en
Priority to HUE07867188A priority patent/HUE033466T2/en
Priority to MX2009003468A priority patent/MX2009003468A/en
Priority to JP2009531414A priority patent/JP5641737B2/en
Priority to KR1020097009094A priority patent/KR101535684B1/en
Publication of WO2008011348A2 publication Critical patent/WO2008011348A2/en
Publication of WO2008011348A3 publication Critical patent/WO2008011348A3/en
Priority to NO20090156A priority patent/NO344963B1/en
Priority to IL196478A priority patent/IL196478B/en
Priority to NO20091284A priority patent/NO20091284L/en
Priority to HRP20090221AA priority patent/HRP20090221B1/en
Priority to HK10103596.0A priority patent/HK1139154A1/en
Priority to PH12012501882A priority patent/PH12012501882A1/en
Priority to AU2013202799A priority patent/AU2013202799C1/en
Priority to JP2014136443A priority patent/JP2014223075A/en
Priority to CR20140496A priority patent/CR20140496A/en
Priority to JP2016124266A priority patent/JP2016179998A/en
Priority to IL254065A priority patent/IL254065B/en
Priority to JP2017243730A priority patent/JP2018095647A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

Abstract

The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.
PCT/US2007/073504 2006-07-14 2007-07-13 Humanized antibody against amyloid beta WO2008011348A2 (en)

Priority Applications (52)

Application Number Priority Date Filing Date Title
KR1020197000092A KR20190003862A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
CA2657681A CA2657681C (en) 2006-07-14 2007-07-13 Humanized antibodies against beta amyloid protein
NZ574188A NZ574188A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
PL11192705T PL2468770T3 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta.
UAA200900880A UA100672C2 (en) 2006-07-14 2007-07-13 HUMANIZED ANTIBODY TO b-AMYLOID PROTEIN
RU2009104769/10A RU2498999C2 (en) 2006-07-14 2007-07-13 Humanised antibody to beta amyloid
MEP-2013-132A ME01758B (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
EP17190333.9A EP3309172B1 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
KR1020177023161A KR20170098978A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
PL07840408T PL2046833T3 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
MX2009000476A MX2009000476A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta.
AU2007275467A AU2007275467B2 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
MEP-2010-59A ME01075B (en) 2006-07-14 2007-07-13 Antibodies
KR1020167034680A KR20160147066A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
KR1020147027016A KR20140125455A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
BRPI0714713-9A BRPI0714713B1 (en) 2006-07-14 2007-07-13 HUMANIZED ANTIBODY OR AN ACTIVE FRAGMENT OF THE SAME, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, NON ANIMAL NOR VEGETABLE TRANSGENIC MICRO-ORGANISM, COMPOSITION, MIXTURE, USE OF HUMANIZED ANTIBODY, ANTIBODY OR HUMANIZED METHOD ASSETS OF THE SAME, IN VITRO METHOD FOR DETECTION OF AMYLOIDOSIS, IN VITRO METHOD TO DETERMINE THE DEGREE OF AMYLOIDOGEN PLATE LOAD
DK07840408.4T DK2046833T5 (en) 2006-07-14 2007-07-13 HUMANIZED ANTIBODY AGAINST AMYLOID BETA
JP2009519711A JP2010528583A (en) 2007-06-11 2007-07-13 Humanized antibody against amyloid β
RS20130515A RS53160B (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
KR1020167010466A KR20160049045A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
SI200731343T SI2046833T1 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
EP21191801.6A EP3988566A1 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
KR1020097003136A KR101605207B1 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
CN200780033976.7A CN101516911B (en) 2006-07-14 2007-07-13 Humanized antibody for amyloid-beta
EP07840408.4A EP2046833B9 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
KR1020187011457A KR20180043854A (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta
ES07840408T ES2436112T3 (en) 2006-07-14 2007-07-13 Humanized antibody
CN2007800445554A CN101611054B (en) 2006-10-02 2007-10-02 Humanized antibody against amyloid beta
ES07867188.0T ES2640095T3 (en) 2006-10-02 2007-10-02 Humanized antibody against beta-amyloid
BRPI0719763-2A BRPI0719763A2 (en) 2006-10-02 2007-10-02 ANTIBODY, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, CELL, COMPOSITION, MIXTURE, USE OF A CHEMICAL ANTIBODY OR A FRAGMENT OF THE SAME OR A FRAGMENT OF THE SAME AND / OR A PART OR A FUNCTION OR A PART OR A FUNCTION MIXTURE, METHODS FOR PREPARING A PHARMACEUTICAL COMPOSITION OR MIXTURE, TO PREVENT, TREAT OR RELIEVE THE EFFECTS OF A DISEASE, DIAGNOSTIC DISEASE, OR CONDITION ASSOCIATED WITH A DETERMINATION OF THE DETERMINATION OF CAROGUE DETERMINATION IN A FABRIC AND / OR BODY FLUIDS, TEST KITS FOR DISEASE AND DIAGNOSTIC TESTING AND CONDITIONS ASSOCIATED WITH AMYLOID, LIGHT CHAIN VARIABLE REGION, HEAVY CIRCLE, GENELE DESENGER, GENELE DIAGET LINES PRE-FORMED BETA-AMYLOID FIBERS TO PREVENT ABETA-INDUCED NEURON DEGRADATION, TO DIAGNOSE A PREDISPOSITION TO A DISEASE OR CO NDITION ASSOCIATED WITH AMYLOID IN A PATIENT, TO MONITOR MINIMUM RESIDUAL DISEASE IN A PATIENT, TO PROGNOSE LIABILITY OF A PATIENT WHO IS TREATED WITH AN ANTIBODY OR A COMPOSITION OF VACCINE, TO REDUCE THE CARBON LOAD TO THE CIRCLE THE NUMBER OF PLATES IN AN ANIMAL BRAIN, TO REDUCE THE TOTAL SOLUBLE OPEN QUANTITY IN AN ANIMAL BRAIN AND TO HOLD OR INCREASE COGNITIVE MEMORY CAPACITY IN A MAMMALIAN.
SI200731964T SI2074145T1 (en) 2006-10-02 2007-10-02 Humanized antibody against amyloid beta
EP07867188.0A EP2074145B1 (en) 2006-10-02 2007-10-02 Humanized antibody against amyloid beta
PL07867188T PL2074145T3 (en) 2006-10-02 2007-10-02 Humanized antibody against amyloid beta
KR1020147032970A KR20150002879A (en) 2006-10-02 2007-10-02 Humanized antibody against amyloid beta
PCT/US2007/021134 WO2008060364A2 (en) 2006-10-02 2007-10-02 Humani zed antibody against amyloid beta
DK07867188.0T DK2074145T5 (en) 2006-10-02 2007-10-02 HUMANIZED ANTIBODY AGAINST AMYLOID BETA
HUE07867188A HUE033466T2 (en) 2006-10-02 2007-10-02 Humanized antibody against amyloid beta
MX2009003468A MX2009003468A (en) 2006-07-14 2007-10-02 Antibodies.
JP2009531414A JP5641737B2 (en) 2006-07-14 2007-10-02 Humanized antibody against amyloid β
KR1020097009094A KR101535684B1 (en) 2006-07-14 2007-10-02 Humanized antibody against amyloid beta
NO20090156A NO344963B1 (en) 2006-07-14 2009-01-12 Humanized antibody
IL196478A IL196478B (en) 2006-07-14 2009-01-13 Humanized antibody and fragments thereof binding to amyloid beta and nucleic acids, vectors and cells for producing them, as well as pertinent therapeutic compositions, mixtures and uses thereof
NO20091284A NO20091284L (en) 2006-07-14 2009-03-30 Humanized antibodies to amyloid beta
HRP20090221AA HRP20090221B1 (en) 2006-07-14 2009-04-14 Humanized antibody
HK10103596.0A HK1139154A1 (en) 2006-10-02 2010-04-13 Humani zed antibody against amyloid beta
PH12012501882A PH12012501882A1 (en) 2006-07-14 2012-09-21 Humanized antibody against amyloid beta
AU2013202799A AU2013202799C1 (en) 2006-07-14 2013-04-07 Humanized antibody against amyloid beta
JP2014136443A JP2014223075A (en) 2006-10-02 2014-07-02 HUMANIZED ANTIBODY TO AMYLOID β
CR20140496A CR20140496A (en) 2006-07-14 2014-10-27 HUMANIZED ANTIBODIES AGAINST BETA-AMILOIDS
JP2016124266A JP2016179998A (en) 2006-10-02 2016-06-23 HUMANIZED ANTIBODIES AGAINST AMYLOID β
IL254065A IL254065B (en) 2006-07-14 2017-08-20 Humanized antibody against amyloid beta
JP2017243730A JP2018095647A (en) 2006-10-02 2017-12-20 HUMANIZED ANTIBODIES AGAINST AMYLOID β

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP06014730.3 2006-07-14
EP06014730 2006-07-14
EP06020765 2006-10-02
EP06020765.1 2006-10-02
EP06020766 2006-10-02
US94328907P 2007-06-11 2007-06-11
US60/943,289 2007-06-11
US94349907P 2007-06-12 2007-06-12
US60/943,499 2007-06-12

Publications (2)

Publication Number Publication Date
WO2008011348A2 WO2008011348A2 (en) 2008-01-24
WO2008011348A3 true WO2008011348A3 (en) 2008-07-10

Family

ID=43063574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/073504 WO2008011348A2 (en) 2006-07-14 2007-07-13 Humanized antibody against amyloid beta

Country Status (21)

Country Link
US (5) US7892544B2 (en)
EP (2) EP2046833B9 (en)
JP (1) JP5641737B2 (en)
KR (2) KR101605207B1 (en)
AR (1) AR062065A1 (en)
AU (1) AU2007275467B2 (en)
CA (1) CA2657681C (en)
CL (1) CL2007002070A1 (en)
CO (1) CO6150201A2 (en)
CR (1) CR10556A (en)
HR (1) HRP20090221B1 (en)
IL (1) IL196478B (en)
MA (1) MA30632B1 (en)
MX (2) MX2009000476A (en)
NO (2) NO344963B1 (en)
NZ (1) NZ574188A (en)
PL (2) PL2468770T3 (en)
RU (1) RU2498999C2 (en)
SG (1) SG173385A1 (en)
TW (1) TWI551607B (en)
WO (1) WO2008011348A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
AR052051A1 (en) 2004-12-15 2007-02-28 Neuralab Ltd AB HUMANIZED ANTIBODIES USED TO IMPROVE COGNITION
PL1954718T3 (en) 2005-11-30 2015-04-30 Abbvie Inc Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
WO2007064972A2 (en) 2005-11-30 2007-06-07 Abbott Laboratories Monoclonal antibodies against amyloid beta protein and uses thereof
RU2015111675A (en) 2005-12-12 2015-08-10 Ац Иммуне Са SPECIFIC IN RESPECT TO AMYLOID BETA (A BETA) 1-42 MONOCLONAL ANTIBODIES WITH THERAPEUTIC PROPERTIES
US8784810B2 (en) 2006-04-18 2014-07-22 Janssen Alzheimer Immunotherapy Treatment of amyloidogenic diseases
SG173385A1 (en) * 2006-07-14 2011-08-29 Ac Immune S A Ch Humanized antibody against amyloid beta
EP2074145B1 (en) * 2006-10-02 2017-08-16 AC Immune S.A. Humanized antibody against amyloid beta
MX2009005279A (en) 2006-11-24 2009-05-28 Ac Immune Sa N- (methyl) -1h- pyrazol- 3 -amine, n- (methyl) -pyridin-2-amine and n- (methyl) -thiaz0l-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's.
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
EP2117540A1 (en) 2007-03-01 2009-11-18 Probiodrug AG New use of glutaminyl cyclase inhibitors
US20090022728A1 (en) * 2007-03-09 2009-01-22 Rinat Neuroscience Corporation Methods of treating ophthalmic diseases
DK2142514T3 (en) 2007-04-18 2015-03-23 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US20090232801A1 (en) * 2007-05-30 2009-09-17 Abbot Laboratories Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
JP2010530744A (en) * 2007-06-12 2010-09-16 エーシー イミューン ソシエテ アノニム Humanized antibody against amyloid β
JP5889529B2 (en) 2007-07-27 2016-03-22 ヤンセン・サイエンシズ・アイルランド・ユーシー Treatment of amyloidogenic diseases
GB0718737D0 (en) * 2007-09-25 2007-11-07 Glaxo Group Ltd Antibodies
CN101998863B (en) * 2007-10-05 2015-09-16 基因技术公司 The purposes of anti-amyloid beta antibody in oculopathy
ES2612788T3 (en) * 2007-10-05 2017-05-18 Genentech, Inc. Methods and compositions for the diagnosis and treatment of amyloidosis
JO3076B1 (en) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
JPWO2009104736A1 (en) * 2008-02-22 2011-06-23 田平 武 Tissue amyloid plaque affinity antibody and pharmaceutical composition using the same
KR20110014607A (en) 2008-04-29 2011-02-11 아보트 러보러터리즈 Dual variable domain immunoglobulins and uses thereof
US9109026B2 (en) 2008-06-03 2015-08-18 Abbvie, Inc. Dual variable domain immunoglobulins and uses thereof
EP3002299A1 (en) 2008-06-03 2016-04-06 AbbVie Inc. Dual variable domain immunoglobulins and uses thereof
CA2729949A1 (en) 2008-07-08 2010-01-14 Abbott Laboratories Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
US9067981B1 (en) 2008-10-30 2015-06-30 Janssen Sciences Ireland Uc Hybrid amyloid-beta antibodies
AU2010221418B2 (en) 2009-03-02 2015-06-04 Dignity Health Diagnostic devices and methods of use
US20140024050A1 (en) * 2009-03-10 2014-01-23 Abbott Laboratories Antibodies which detect pivkaii and methods of use thereof
EP2475428B1 (en) 2009-09-11 2015-07-01 Probiodrug AG Heterocylcic derivatives as inhibitors of glutaminyl cyclase
EP2311823A1 (en) 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases
CA2775959A1 (en) 2009-10-15 2011-04-21 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
KR101160153B1 (en) * 2009-12-10 2012-06-27 서울대학교산학협력단 Method for diagnosing type 2 diabetes mellitus by measuring the level of beta-amyloid autoantibody in body fluids and diagnostic kit for type 2 diabetes mellitus using same
JP6026284B2 (en) 2010-03-03 2016-11-16 プロビオドルグ エージー Inhibitors of glutaminyl cyclase
WO2011107507A1 (en) 2010-03-03 2011-09-09 Boehringer Ingelheim International Gmbh Biparatopic abeta binding polypeptides
MX2012010470A (en) 2010-03-10 2012-10-09 Probiodrug Ag Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5).
SG184832A1 (en) 2010-04-16 2012-11-29 Ac Immune Sa Novel compounds for the treatment of diseases associated with amyloid or amyloid-like proteins
JP5945532B2 (en) 2010-04-21 2016-07-05 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
SG188190A1 (en) 2010-08-03 2013-04-30 Abbott Lab Dual variable domain immunoglobulins and uses thereof
SG10201509330XA (en) 2010-08-12 2015-12-30 Lilly Co Eli Anti-N3pGlu Amyloid Beta Peptide Antibodies And Uses Thereof
JP6147665B2 (en) 2010-08-14 2017-06-14 アッヴィ・インコーポレイテッド Amyloid beta-binding protein
CN103260639A (en) 2010-08-26 2013-08-21 Abbvie公司 Dual variable domain immunoglobulins and uses thereof
LT2646470T (en) 2010-11-30 2017-06-12 F. Hoffmann-La Roche Ag Low affinity anti-transferrin receptor antibodies and their use to transfer therapeutic scfv across the blood brain barrier
US8703137B2 (en) 2011-01-31 2014-04-22 Intellect Neurosciences Inc. Treatment of tauopathies
EP2487242A1 (en) 2011-02-09 2012-08-15 Ruprecht-Karls-Universität Heidelberg B-type plexin antagonists and uses thereof
EP2497782A1 (en) 2011-03-08 2012-09-12 Alzinova AB Anti oligomer antibodies and uses thereof
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
US20130209449A9 (en) 2011-06-13 2013-08-15 Abgenomics Cooperatief U.A. Anti-psgl-1 antibodies and uses thereof
CN102260349A (en) * 2011-07-12 2011-11-30 山西医科大学 Anti-amyloid beta protein (A beta) 31-35 antibody for treating and preventing Alzheimer's disease (AD), and preparation method thereof
WO2013055404A1 (en) * 2011-10-10 2013-04-18 City Of Hope Meditopes and meditope-binding antibodies and uses thereof
US20140302021A1 (en) * 2011-10-25 2014-10-09 Onclave Therapeutics Limited Antibody formulations and methods
BR112014010198B1 (en) 2011-10-28 2022-12-06 Prothena Biosciences Limited HUMANIZED ANTIBODIES THAT RECOGNIZE ALPHA-SYNUCLEIN
CN102516360B (en) * 2011-12-08 2013-11-06 清华大学 Polypeptide capable of inhibiting beta-secretase digestion effect and application thereof
CA2861610A1 (en) 2011-12-30 2013-07-04 Abbvie Inc. Dual specific binding proteins directed against il-13 and/or il-17
WO2013112945A1 (en) 2012-01-27 2013-08-01 Neotope Biosciences Limited Humanized antibodies that recognize alpha-synuclein
SG10201709555SA (en) 2012-05-18 2017-12-28 Genentech Inc High-concentration monoclonal antibody formulations
SG11201407669QA (en) 2012-05-21 2014-12-30 Genentech Inc Methods for improving safety of blood-brain barrier transport
UA118441C2 (en) 2012-10-08 2019-01-25 Протена Біосаєнсиз Лімітед Antibodies recognizing alpha-synuclein
ME03751B (en) * 2012-10-15 2021-04-20 Medimmune Ltd Antibodies to amyloid beta
BR112015009961B1 (en) 2012-11-01 2020-10-20 Abbvie Inc. binding protein capable of binding to dll4 and vegf, as well as a composition comprising it as a composition comprising it
SG11201503878XA (en) 2012-11-19 2015-06-29 Temasek Life Sciences Lab Ltd Monoclonal antibodies targeting neutralizing epitopes on h7 influenza viruses
CN105324396A (en) 2013-03-15 2016-02-10 艾伯维公司 Dual specific binding proteins directed against il-1 beta and il-17
KR102293064B1 (en) 2013-05-20 2021-08-23 제넨테크, 인크. Anti-transferrin receptor antibodies and methods of use
US10513555B2 (en) 2013-07-04 2019-12-24 Prothena Biosciences Limited Antibody formulations and methods
NZ718144A (en) 2013-09-13 2022-05-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
JP6546178B2 (en) 2013-09-13 2019-07-17 ジェネンテック, インコーポレイテッド Compositions and methods for detecting and quantifying host cell proteins and recombinant polypeptide products in cell lines
JP6685912B2 (en) * 2014-02-08 2020-04-22 ジェネンテック, インコーポレイテッド Alzheimer's disease treatment method
SG10201901076WA (en) * 2014-02-08 2019-03-28 Genentech Inc Methods of treating alzheimer's disease
EP3129051A1 (en) 2014-04-08 2017-02-15 Prothena Biosciences Limited Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein
WO2016081643A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Anti-transferrin receptor antibodies and methods of use
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
EP3262070A4 (en) 2015-02-24 2018-07-25 Rpeptide, LLC Anti-amyloid-beta antibodies
MA41867A (en) 2015-04-01 2018-02-06 Anaptysbio Inc T-CELL IMMUNOGLOBULIN AND MUCINE PROTEIN 3 ANTIBODIES (TIM-3)
TW201710286A (en) 2015-06-15 2017-03-16 艾伯維有限公司 Binding proteins against VEGF, PDGF, and/or their receptors
AU2016354688B2 (en) 2015-11-09 2021-12-16 The University Of British Columbia Epitopes in Amyloid beta mid-region and conformationally-selective antibodies thereto
JOP20170004B1 (en) 2016-01-15 2022-09-15 Lilly Co Eli ANTl-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
CA3011739A1 (en) * 2016-01-20 2017-07-27 Genentech, Inc. High dose treatments for alzheimer's disease
TW201740944A (en) * 2016-03-15 2017-12-01 美國禮來大藥廠 Combination therapy
TWI735600B (en) 2016-07-01 2021-08-11 美商美國禮來大藥廠 ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
WO2018064076A1 (en) 2016-09-27 2018-04-05 Cero Therapeutics, Inc. Chimeric engulfment receptor molecules
EP3689419A1 (en) 2016-11-01 2020-08-05 AnaptysBio, Inc. Antibodies directed against t cell immunoglobulin and mucin protein 3 (tim-3)
US20180125920A1 (en) 2016-11-09 2018-05-10 The University Of British Columbia Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
IL267439B2 (en) 2016-12-22 2023-02-01 Genentech Inc Methods and formulations for reducing reconstitution time of lyophilized polypeptides
TW202319068A (en) 2017-01-09 2023-05-16 美商提薩羅有限公司 Methods of treating cancer with anti-tim-3 antibodies
JOP20190247A1 (en) 2017-04-20 2019-10-20 Lilly Co Eli ANTI-N3pGlu AMYLOID BETA PEPTIDE ANTIBODIES AND USES THEREOF
CA3067597C (en) 2017-06-29 2023-03-21 The Trustees Of Columbia University In The City Of New York Chimeric antibodies for treatment of amyloid deposition diseases
US20200181247A1 (en) * 2017-07-18 2020-06-11 The University Of British Columbia Antibodies to Amyloid Beta
US11382974B2 (en) 2017-08-01 2022-07-12 The Trustees Of Columbia University In The City Of New York Methods and compositions for treatment of amyloid deposition diseases
KR20200100598A (en) 2017-09-26 2020-08-26 세로 테라퓨틱스, 인코포레이티드 Chimeric phagocytosis receptor molecules and methods of use
ES2812698T3 (en) 2017-09-29 2021-03-18 Probiodrug Ag Glutaminyl cyclase inhibitors
EP3774864A1 (en) 2018-03-28 2021-02-17 Cero Therapeutics, Inc. Chimeric engulfment receptors and uses thereof for neurodegenerative diseases
CA3106116A1 (en) 2018-07-17 2020-01-23 Jiangsu Hengrui Medicine Co., Ltd. Anti-abeta antibody, antigen-binding fragment thereof and application thereof
WO2020201828A1 (en) 2019-04-05 2020-10-08 Tauc3 Biologics Limited Anti-tauc3 antibodies and uses thereof
MX2023000949A (en) 2020-07-23 2023-02-22 Othair Prothena Ltd Anti-abeta antibodies.
TW202300517A (en) 2021-03-12 2023-01-01 美商美國禮來大藥廠 Anti-amyloid beta antibodies and uses thereof
WO2022251048A1 (en) 2021-05-24 2022-12-01 Eli Lilly And Company Anti-amyloid beta antibodies and uses thereof
WO2023004386A1 (en) 2021-07-22 2023-01-26 Genentech, Inc. Brain targeting compositions and methods of use thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072880A2 (en) * 1999-05-28 2000-12-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
WO2001062801A2 (en) * 2000-02-24 2001-08-30 Washington University Humanized antibodies that sequester amyloid beta peptide
WO2002096937A2 (en) * 2001-05-29 2002-12-05 Neurochem, Inc. Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
WO2003070760A2 (en) * 2002-02-20 2003-08-28 F. Hoffmann-La Roche Ag Anti-amyloid beta antibodies and their use
WO2006055178A2 (en) * 2004-10-25 2006-05-26 Merck & Co., Inc. Anti-addl antibodies and uses thereof
WO2006066171A1 (en) * 2004-12-15 2006-06-22 Neuralab Limited Amyloid βετα antibodies for use in improving cognition
WO2007068412A2 (en) * 2005-12-12 2007-06-21 Ac Immune Sa A beta 1-42 specific monoclonal antibodies with therapeutic properties

Family Cites Families (211)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666829A (en) 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
US5525339A (en) 1986-08-27 1996-06-11 Dms Pharmaceutical Inc. Isolated components of dense microspheres derived from mammalian brain tissue and antibodies thereto
US5231170A (en) 1986-08-27 1993-07-27 Paul Averback Antibodies to dense microspheres
DE3702789A1 (en) 1987-01-30 1988-08-18 Bayer Ag PROCUREMENT PROTEIN OF APC POLYPEPTIDE, FOR CODING DNA AND DIAGNOSTIC USE OF DNA AND PROTEIN
IT1217123B (en) 1987-02-05 1990-03-14 Rotta Research Lab OPTICALLY ACTIVE DERIVATIVES OF ACID 5 PENTILAMINE 5 OXO PENTANOIC R WITH ANTAGONIST ACTIVITY OF THE CHOLECISTOKININ AND PROCEDURE FOR THEIR PREPARATION
DE3805744C2 (en) 1987-03-04 1999-09-23 Novartis Ag Phenylcarbamate for the inhibition of acetylcholinesterase
DE3883899T3 (en) 1987-03-18 1999-04-22 Sb2 Inc CHANGED ANTIBODIES.
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
FI95572C (en) 1987-06-22 1996-02-26 Eisai Co Ltd Process for the preparation of a medicament useful as a piperidine derivative or its pharmaceutical salt
JPS6412935A (en) 1987-07-02 1989-01-17 Mitsubishi Electric Corp Constant-speed travel device for vehicle
CA1340802C (en) 1987-08-15 1999-10-26 Yasuyuki Takahashi Senile amyloid precursor protein and an antibody specific for the same
US5004697A (en) 1987-08-17 1991-04-02 Univ. Of Ca Cationized antibodies for delivery through the blood-brain barrier
US5231000A (en) 1987-10-08 1993-07-27 The Mclean Hospital Antibodies to A4 amyloid peptide
US5843708A (en) 1988-01-05 1998-12-01 Ciba-Geigy Corporation Chimeric antibodies
AU3204689A (en) 1988-02-10 1989-09-06 Children's Medical Center Corporation Amyloid protein precursors, genetic probes, antibodies, and methods of use
US6287793B1 (en) 1988-08-19 2001-09-11 Elan Pharmaceuticals, Inc. Diagnostic methods for alzheimer's disease
US5215889A (en) 1988-11-18 1993-06-01 The Regents Of The University Of California Catalytic and reactive polypeptides and methods for their preparation and use
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US20040049014A1 (en) 1988-12-28 2004-03-11 Protein Design Labs, Inc. Humanized immunoglobulins
US5262332A (en) 1989-04-05 1993-11-16 Brigham And Women's Hospital Diagnostic method for Alzheimer's disease: examination of non-neural tissue
US5234814A (en) 1989-06-01 1993-08-10 Du Pont Merck Pharmaceutical Company Diagnostic assay for alzheimer's disease
US5268164A (en) 1990-04-23 1993-12-07 Alkermes, Inc. Increasing blood-brain barrier permeability with permeabilizer peptides
US5112596A (en) 1990-04-23 1992-05-12 Alkermes, Inc. Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability
ES2136092T3 (en) 1991-09-23 1999-11-16 Medical Res Council PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES.
WO1993010459A1 (en) 1991-11-12 1993-05-27 The University Of Melbourne A method for assaying and treating alzheimer's disease
US5811517A (en) * 1992-01-27 1998-09-22 Icos Corporation ICAM-related protein variants
US5837822A (en) 1992-01-27 1998-11-17 Icos Corporation Humanized antibodies specific for ICAM related protein
US20010029293A1 (en) * 1992-01-27 2001-10-11 Icos Corporation Icam-related protein
US5538845A (en) 1992-02-05 1996-07-23 Athena Neurosciences, Inc. Beta-amyloid peptide production inhibitors and methods for their identification
US5441870A (en) 1992-04-15 1995-08-15 Athena Neurosciences, Inc. Methods for monitoring cellular processing of β-amyloid precursor protein
US5604102A (en) 1992-04-15 1997-02-18 Athena Neurosciences, Inc. Methods of screening for β-amyloid peptide production inhibitors
US5837672A (en) 1992-07-10 1998-11-17 Athena Neurosciences, Inc. Methods and compositions for the detection of soluble β-amyloid peptide
US6610493B1 (en) 1993-06-17 2003-08-26 Brigham And Women's Hospital Screening compounds for the ability to alter the production of amyloid-β peptide
US5766846A (en) 1992-07-10 1998-06-16 Athena Neurosciences Methods of screening for compounds which inhibit soluble β-amyloid peptide production
WO1994002178A1 (en) 1992-07-27 1994-02-03 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeting of liposomes to the blood-brain barrier
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
US5605811A (en) 1992-10-26 1997-02-25 Athena Neurosciences, Inc. Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein
US5891623A (en) 1992-11-09 1999-04-06 Consorzio Per Le Biotecnologie Diagnosis and treatment of AIDS onset
ZA938243B (en) 1992-11-12 1995-05-04 Hybritech Inc Altered affinity polypeptides of metal chelate binding antibodies
US5955317A (en) 1993-01-25 1999-09-21 Takeda Chemical Industries, Ltd. Antibodies to β-amyloids or their derivatives and use thereof
DE69432629T3 (en) 1993-01-25 2008-01-17 Takeda Pharmaceutical Co. Ltd. ANTIBODIES AGAINST BETA AMYLOID OR DERIVATIVES AND ITS USE
CA2115900A1 (en) 1993-02-22 1994-08-23 Gerald W. Becker Pharmaceutical screens and antibodies
AU7949394A (en) * 1993-11-19 1995-06-06 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human medulloblastomatous cell
US5626332A (en) * 1994-07-29 1997-05-06 Harris Corporation Vibration isolation system using plural signals for control
US7129337B1 (en) 1994-10-21 2006-10-31 Innogenetics N.V. Sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
US6114133A (en) 1994-11-14 2000-09-05 Elan Pharmaceuticals, Inc. Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41)
US5589154A (en) 1994-11-22 1996-12-31 Rutgers, The State University Of New Jersey Methods for the prevention or treatment of vascular hemorrhaging and Alzheimer's disease
US5688651A (en) 1994-12-16 1997-11-18 Ramot University Authority For Applied Research And Development Ltd. Prevention of protein aggregation
US5786180A (en) 1995-02-14 1998-07-28 Bayer Corporation Monoclonal antibody 369.2B specific for β A4 peptide
US5756662A (en) 1995-03-14 1998-05-26 Corixa Corporation Compounds and methods for the detection of T. cruzi infection
US6303567B1 (en) 1995-03-14 2001-10-16 Praecis Pharmaceuticals, Inc . Modulators of β-amyloid peptide aggregation comprising D-amino acids
AU5752696A (en) 1995-05-18 1996-11-29 Regents Of The University Of Michigan, The Dna binding antibodies
US6632976B1 (en) 1995-08-29 2003-10-14 Kirin Beer Kabushiki Kaisha Chimeric mice that are produced by microcell mediated chromosome transfer and that retain a human antibody gene
AU707484B2 (en) 1995-09-14 1999-07-08 Regents Of The University Of California, The Antibodies specific for native PrPsc
JPH09178743A (en) 1995-12-27 1997-07-11 Oriental Yeast Co Ltd Determinationof soluble app
AU720643B2 (en) * 1996-08-13 2000-06-08 P.N. Gerolymatos S.A. Use of the chelating agent clioquinol for the manufacture of a pharmaceutical composition for the treatment of Alzheimer's disease
US20030068316A1 (en) 1997-02-05 2003-04-10 Klein William L. Anti-ADDL antibodies and uses thereof
US6218506B1 (en) 1997-02-05 2001-04-17 Northwestern University Amyloid β protein (globular assembly and uses thereof)
US20020086847A1 (en) 1997-04-09 2002-07-04 Mindset Biopharmaceuticals (Usa) Recombinant antibodies specific for beta-amyloid ends, DNA encoding and methods of use thereof
IT1293511B1 (en) 1997-07-30 1999-03-01 Gentili Ist Spa MONOCLONAL CATALYTIC ANTIBODIES WITH PROTEASIC ACTIVITY FOR THE SELECTIVE LYSIS OF THE PROTEIN COMPONENT OF PLATES AND RELATED AGGREGATES
WO1999015159A2 (en) * 1997-09-24 1999-04-01 Nova Molecular, Inc. Methods for increasing apoe levels for the treatment of neurodegenerative disease
US7179892B2 (en) 2000-12-06 2007-02-20 Neuralab Limited Humanized antibodies that recognize beta amyloid peptide
US6913745B1 (en) 1997-12-02 2005-07-05 Neuralab Limited Passive immunization of Alzheimer's disease
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
US6761888B1 (en) 2000-05-26 2004-07-13 Neuralab Limited Passive immunization treatment of Alzheimer's disease
US6905686B1 (en) 1997-12-02 2005-06-14 Neuralab Limited Active immunization for treatment of alzheimer's disease
US6750324B1 (en) 1997-12-02 2004-06-15 Neuralab Limited Humanized and chimeric N-terminal amyloid beta-antibodies
US6787523B1 (en) 1997-12-02 2004-09-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
DK1071700T3 (en) 1998-04-20 2010-06-07 Glycart Biotechnology Ag Glycosylation modification of antibodies to enhance antibody-dependent cellular cytotoxicity
CA2327505A1 (en) 1998-04-28 1999-11-04 Smithkline Beecham Corporation Monoclonal antibodies with reduced immunogenicity
US20030147882A1 (en) 1998-05-21 2003-08-07 Alan Solomon Methods for amyloid removal using anti-amyloid antibodies
US7083950B2 (en) 1998-09-25 2006-08-01 Regeneron Pharmaceuticals, Inc. High affinity fusion proteins and therapeutic and diagnostic methods for use
NZ539776A (en) 1999-01-15 2006-12-22 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6998124B1 (en) * 1999-04-14 2006-02-14 Smithkline Beecham Corporation Erythropoietin receptor antibodies
US6787637B1 (en) 1999-05-28 2004-09-07 Neuralab Limited N-Terminal amyloid-β antibodies
PT1409654E (en) 1999-06-16 2008-11-25 Boston Biomedical Res Inst Immunological control of beta-amyloid levels in vivo
JP2003509020A (en) 1999-09-03 2003-03-11 ラモット・ユニバーシティ・オーソリティ・フォー・アプライド・リサーチ・アンド・インダストリアル・ディベロップメント・リミテッド Pharmaceuticals, compositions, and uses thereof useful for diagnosis, treatment, and prevention of plaque forming diseases
US20040013647A1 (en) 1999-09-03 2004-01-22 Ramot At Tel-Aviv University Ltd. Methods and compositions for treating a plaque-forming disease
US6294171B2 (en) 1999-09-14 2001-09-25 Milkhaus Laboratory, Inc. Methods for treating disease states comprising administration of low levels of antibodies
CN1433321A (en) 1999-11-29 2003-07-30 尼奥切姆公司 Vaccine for prevention and treatment of Alzhermer's and amyloid related diseases
RU2156929C1 (en) * 1999-12-28 2000-09-27 Панин Александр Андреевич Air refrigerating plant, turbo-expander - electric compressor and turbine wheel of turbo-expander
US20020182660A1 (en) 2000-02-18 2002-12-05 Fong Kei-Lai L. N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43)
EP1130032A1 (en) 2000-02-28 2001-09-05 Gesellschaft für biotechnologische Forschung mbH (GBF) Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR)
WO2001075165A2 (en) 2000-03-30 2001-10-11 Elan Pharmaceuticals, Inc. Screening markers and methods for neurodegenerative disorders
US7371365B2 (en) 2000-04-04 2008-05-13 Mayo Foundation For Medical Education And Research Methods for detecting parenchymal plaques in vivo
US20020009445A1 (en) 2000-07-12 2002-01-24 Yansheng Du Human beta-amyloid antibody and use thereof for treatment of alzheimer's disease
US6514221B2 (en) 2000-07-27 2003-02-04 Brigham And Women's Hospital, Inc. Blood-brain barrier opening
EP2044839A3 (en) 2000-08-03 2009-07-01 Therapeutic Human Polyclonals, Inc. Production of humanized antibodies in transgenic animals
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
WO2002017930A2 (en) 2000-08-30 2002-03-07 The Board Of Trustees Of The Leland Stanford Junior University Glucocorticoid blocking agents for increasing blood-brain barrier permeability
PT1317479E (en) 2000-09-06 2009-10-29 Univ Pasteur Methods and compositions for diseases associated with amyloidosis
US7034036B2 (en) 2000-10-30 2006-04-25 Pain Therapeutics, Inc. Inhibitors of ABC drug transporters at the blood-brain barrier
US20030083299A1 (en) 2000-11-04 2003-05-01 Ferguson Ian A. Non-invasive delivery of polypeptides through the blood-brain barrier
PE20020574A1 (en) 2000-12-06 2002-07-02 Wyeth Corp HUMANIZED ANTIBODIES THAT RECOGNIZE THE AMYLOID PEPTIDE BETA
US20040191264A1 (en) 2001-02-19 2004-09-30 Nielsen Klaus Gregorius Synthetic vaccine agents
US6815175B2 (en) 2001-03-16 2004-11-09 Cornell Research Foundation, Inc. Anti-amyloid peptide antibody based diagnosis and treatment of a neurological disease or disorder
ES2312569T3 (en) 2001-04-30 2009-03-01 Eli Lilly And Company HUMANIZED ANTIBODIES.
EP2165714B1 (en) 2001-04-30 2013-10-23 Eli Lilly And Company Humanized antibodies recognizing the beta-amyloid peptide
DE10121982B4 (en) 2001-05-05 2008-01-24 Lts Lohmann Therapie-Systeme Ag Nanoparticles of protein with coupled apolipoprotein E to overcome the blood-brain barrier and process for their preparation
EP1270592B1 (en) 2001-06-12 2004-09-29 Wiltfang, Jens Monoclonal antibody, mAb 1E8, which is specific for the first 2 amino-terminal amino acids of beta-amyloid peptides and its use in the detection of beta-amyloid peptides or sAPPs
US6638722B2 (en) * 2001-06-13 2003-10-28 Invitrogen Corporation Method for rapid amplification of DNA
WO2003000714A2 (en) 2001-06-22 2003-01-03 Panacea Pharmaceuticals, Inc. Compositions and methods for preventing protein aggregation in neurodegenerative diseases
CN1396183A (en) 2001-07-13 2003-02-12 张小如 Human fusion antibody for reducing cerebral amyloid fibers associated with senile dementia
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2003014162A1 (en) 2001-08-03 2003-02-20 Medical & Biological Laboratories Co., Ltd. ANTIBODY RECOGNIZING GM1 GANGLIOSIDE-BOUND AMYLOID β-PROTEIN AND DNA ENCODING THE ANTIBODY
CN1555411A (en) 2001-08-03 2004-12-15 ���迨�����\���ɷݹ�˾ Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
WO2003016466A2 (en) 2001-08-17 2003-02-27 Eli Lilly And Company ANTI-Aβ ANTIBODIES
US7771722B2 (en) 2001-08-17 2010-08-10 Eli Lilly And Company Assay method for alzheimer's disease
WO2003016467A2 (en) 2001-08-17 2003-02-27 Eli Lilly And Company Use of antibodies having high affinity for soluble ass to treat conditions and diseases related to ass
EP1519740A4 (en) * 2001-08-17 2005-11-09 Lilly Co Eli Rapid improvement of cognition in conditions related to a-beta
US20030082191A1 (en) 2001-08-29 2003-05-01 Poduslo Joseph F. Treatment for central nervous system disorders
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
US7060270B2 (en) 2001-11-02 2006-06-13 Diagenics International Corporation Methods and compositions of monoclonal antibodies specific for beta-amyloid proteins
EP1975179A1 (en) 2001-12-26 2008-10-01 Araclon Biotech, S.L. Polyclonal antibodies, preparation method thereof and use of same
US20030162695A1 (en) 2002-02-27 2003-08-28 Schatzberg Alan F. Glucocorticoid blocking agents for increasing blood-brain barrier permeability
AU2003222254A1 (en) 2002-03-07 2003-09-22 Advisys, Inc. Electrode assembly for constant-current electroporation and use
MY139983A (en) 2002-03-12 2009-11-30 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
US20030190689A1 (en) 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
AU2003226356A1 (en) 2002-04-12 2003-10-27 Ramot At Tel Aviv University Ltd. Prevention of brain inflammation as a result of induced autoimmune response
JP4662719B2 (en) 2002-04-19 2011-03-30 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント Immunological methods and compositions for the treatment of Alzheimer's disease
AU2003223474B2 (en) 2002-04-25 2008-09-04 Eli Lilly And Company Method for treating anxiety and mood disorders in older subjects
AU2003250102B2 (en) 2002-07-24 2009-09-17 Innogenetics N.V. Fragments of beta-amyloid as targets for vaccination against alzheimer disease
WO2005025516A2 (en) 2003-09-12 2005-03-24 The Regents Of The University Of California Monoclonal antibodies specific for conformational epitopes of prefibrillar aggregates
CA2498407A1 (en) 2002-09-12 2004-03-25 The Regents Of The University Of California Immunogens and corresponding antibodies specific for high molecular weight aggregation intermediates common to amyloids formed from proteins of differing sequence
WO2004029629A1 (en) 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. N-11 truncated amyloid-beta nomoclonal antibodies, compositions, methods and uses
US7541440B2 (en) 2002-09-30 2009-06-02 Immunomedics, Inc. Chimeric, human and humanized anti-granulocyte antibodies and methods of use
US20070213512A1 (en) 2002-10-01 2007-09-13 Krafft Grant A Amyloid beta peptide analogs and assemblies thereof
EP1545582A4 (en) 2002-10-01 2008-09-17 Univ Northwestern Amyloid beta-derived diffusible ligands (addls), addl-surrogates, addl-binding molecules, and uses thereof
BR0315157A (en) 2002-10-09 2005-08-09 Rinat Neuroscience Corp Methods of treating alzheimer's disease by employing antibodies directed against amyloid beta peptide and compositions thereof
DE10256900A1 (en) 2002-11-29 2004-06-24 Nemod Immuntherapie Ag Tumor-specific recognition molecules
AU2003302676A1 (en) 2002-12-03 2004-06-23 Blanchette Rockefeller Neurosciences Institute Artificial low-density lipoprotein carriers for transport of substances across the blood-brain barrier
US20070010435A1 (en) 2002-12-19 2007-01-11 New York University Method for treating amyloid disease
EP1439192A1 (en) * 2003-01-15 2004-07-21 Xerion Pharmaceuticals AG Neuropilin-1 inhibitors
CA2511606A1 (en) 2002-12-24 2004-07-15 Neurochem (International) Limited Therapeutic formulations for the treatment of beta-amyloid related diseases
US20050031651A1 (en) 2002-12-24 2005-02-10 Francine Gervais Therapeutic formulations for the treatment of beta-amyloid related diseases
CA2512729C (en) 2003-01-09 2014-09-16 Macrogenics, Inc. Identification and engineering of antibodies with variant fc regions and methods of using same
AT413945B (en) 2003-01-14 2006-07-15 Mattner Frank Dr Use of a compound having a binding capacity to an antibody specific for the natural N-terminal AB42 sequence, for preparing a vaccine for preventing and treating Alzheimer's disease
WO2004065569A2 (en) 2003-01-23 2004-08-05 The Regents Of The University Of California Multi-functional antibodies
DE10303974A1 (en) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid β (1-42) oligomers, process for their preparation and their use
CA2513722A1 (en) 2003-02-01 2004-08-19 Neuralab Limited Active immunization to generate antibodies to soluble a-beta
ATE468886T1 (en) 2003-02-10 2010-06-15 Applied Molecular Evolution ABETA-BINDING MOLECULES
US8663650B2 (en) 2003-02-21 2014-03-04 Ac Immune Sa Methods and compositions comprising supramolecular constructs
US20040242845A1 (en) 2003-02-21 2004-12-02 Nicolau Yves Claude Methods and compositions comprising supramolecular antigenic constructs and antibodies elicited against them
CA2520853A1 (en) 2003-03-28 2005-03-31 Centocor, Inc. Anti-amyloid antibodies, compositions, methods and uses
EP1469312A1 (en) 2003-04-18 2004-10-20 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis of Alzheimer's disease
US20040223912A1 (en) 2003-05-07 2004-11-11 Montalto Michael Christopher Compositions and methods for non-invasive imaging of soluble beta-amyloid
ES2246178B1 (en) 2003-05-08 2007-03-01 Universidad De Zaragoza. USE OF ANTIBODIES FOR THE TREATMENT OF AMYLOID DISEASES.
EP1480041A1 (en) 2003-05-22 2004-11-24 Innogenetics N.V. Method for the prediction, diagnosis and differential diagnosis of Alzheimer's disease
TWI374893B (en) 2003-05-30 2012-10-21 Janssen Alzheimer Immunotherap Humanized antibodies that recognize beta amyloid peptide
JP2007535905A (en) 2003-06-06 2007-12-13 オンコマックス アクイジション コーポレイション Specific antibody of cancer-associated antigen SM5-1 and use thereof
WO2005011599A2 (en) 2003-08-01 2005-02-10 Northwestern University Antibodies specific for toxic amyloid beta protein oligomers
WO2005018424A2 (en) 2003-08-18 2005-03-03 Research Foundation For Mental Hygiene, Inc. Antibodies specific for fibrillar amyloid and a procedure to detect fibrillar amyloid deposits
US20070031416A1 (en) 2003-09-09 2007-02-08 Takeda Pharmaceutical Company Limited Use of antibody
WO2005025511A2 (en) 2003-09-10 2005-03-24 Cedars-Sinai Medical Center Potassium channel mediated delivery of agents through the blood-brain barrier
WO2005037209A2 (en) 2003-10-14 2005-04-28 University Of South Florida A method for the separation anti-amyloid beta antibody with amyloid beta peptide
JP4870348B2 (en) 2003-12-04 2012-02-08 株式会社ペルセウスプロテオミクス Antibody acquisition and antigen identification against cell surface antigens
EP2336147B1 (en) 2003-12-17 2014-04-30 Janssen Alzheimer Immunotherapy A beta immunogenic peptide carrier conjugates and methods of producing same
EP1717250A4 (en) 2004-02-20 2008-10-01 Immuno Biological Lab Co Ltd Monoclonal antibody and use thereof
BRPI0507856A (en) 2004-02-23 2007-07-10 Lilly Co Eli pharmaceutical composition and process for preparing the abeta antibody
EP1741783A4 (en) 2004-04-27 2009-05-27 Chemo Sero Therapeut Res Inst Human antiamyloid beta peptide antibody and antibody fragment thereof
US20110142858A1 (en) 2004-06-07 2011-06-16 Ramot At Tel Aviv University Ltd. Method of Passsive Immunization Against Disease or Disorder Charcterized by Amyloid Aggregation with Diminished Risk of Neuroinflammation
SE0401601D0 (en) 2004-06-21 2004-06-21 Bioarctic Neuroscience Ab Protofibril specific antibodies and uses thereof
AU2005269940A1 (en) 2004-07-02 2006-02-09 Northwestern University Monolocal antibodies that target pathological assemblies of amyloid beta (Abeta)
WO2006006172A2 (en) 2004-07-15 2006-01-19 Ramot At Tel Aviv University Ltd. Use of anti-amyloid agents for treating and typing pathogen infections
KR20070040824A (en) 2004-07-30 2007-04-17 리나트 뉴로사이언스 코퍼레이션 Antibodies directed against amyloid-beta peptide and methods using same
EP1787998A4 (en) 2004-08-11 2008-08-27 Mitsubishi Chem Corp Antibody and utilization of the same
TWI374935B (en) 2004-08-27 2012-10-21 Pfizer Ireland Pharmaceuticals Production of α-abeta
TWI309240B (en) 2004-09-17 2009-05-01 Hoffmann La Roche Anti-ox40l antibodies
WO2006039470A2 (en) 2004-09-29 2006-04-13 Centocor, Inc. Anti- amyloid antibodies, compositions, methods and uses
WO2006039327A2 (en) 2004-10-01 2006-04-13 Merck & Co., Inc. Methods of treatment or prophylaxis of amyloidogenic diseases of the eye or optic nerve
DE602005026219D1 (en) 2004-10-01 2011-03-17 Max Planck Gesellschaft AGAINST THE MAMMALIAN EAG1 ION CHANNEL PROPER ANTIBODIES
KR20070084170A (en) 2004-10-13 2007-08-24 아블린쓰 엔.브이. Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenerative neural diseases such as alzheimer's disease
WO2006047670A2 (en) 2004-10-26 2006-05-04 Wyeth Methods for assessing antibodies to neurodegenerative disease-associated antigens
MX2007005053A (en) 2004-10-28 2007-06-19 Eisai R&D Man Co Ltd Method of examining alzheimer s disease and diagnostic reagent.
EP1838854B1 (en) 2004-12-15 2012-10-31 Janssen Alzheimer Immunotherapy Antibodies that recognize Beta Amyloid Peptide
AR052051A1 (en) 2004-12-15 2007-02-28 Neuralab Ltd AB HUMANIZED ANTIBODIES USED TO IMPROVE COGNITION
US20090074775A1 (en) 2004-12-22 2009-03-19 David Michael Holtzman Use Of Anti-AB Antibody To Treat Traumatic Brain Injury
EP1841455A1 (en) 2005-01-24 2007-10-10 Amgen Inc. Humanized anti-amyloid antibody
GT200600031A (en) 2005-01-28 2006-08-29 ANTI-BETA ANTIBODY FORMULATION
BRPI0608076A2 (en) 2005-03-05 2009-11-10 Abbott Gmbh & Co Kg selection method, process for purifying non-diffusible beta-a oligomers, selective antibodies against said non-diffusible beta-a oligomers and a process for manufacturing said antibodies
ES2259270B1 (en) 2005-03-09 2007-11-01 Consejo Superior De Investigaciones Cientificas IN VITRO DIAGNOSTIC METHOD OF ALZHEIMER'S DISEASE BY A MONOCLONAL ANTIBODY.
UY29504A1 (en) 2005-04-29 2006-10-31 Rinat Neuroscience Corp DIRECTED ANTIBODIES AGAINST BETA AMYLOID PEPTIDE AND METHODS USING THE SAME.
CA2611815A1 (en) 2005-06-17 2006-12-28 Elan Pharma International Limited Methods of purifying anti a beta antibodies
JP2007077103A (en) 2005-09-16 2007-03-29 Yokohama City Univ Prophylactic or therapeutic agent for alzheimer's disease
PL1954718T3 (en) 2005-11-30 2015-04-30 Abbvie Inc Anti-a globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies
EP1963363A2 (en) 2005-11-30 2008-09-03 Abbott Laboratories Methods of preparation of recombinant forms of human beta-amyloid protein and uses of these proteins
WO2007064972A2 (en) 2005-11-30 2007-06-07 Abbott Laboratories Monoclonal antibodies against amyloid beta protein and uses thereof
WO2007064919A2 (en) 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
JP5302007B2 (en) 2005-12-13 2013-10-02 アストラゼネカ アクチボラグ Binding protein specific for insulin-like growth factor and use thereof
AU2007233831B2 (en) * 2006-03-30 2013-02-14 Glaxo Group Limited Antibodies against amyloid-beta peptide
US7427342B2 (en) 2006-06-02 2008-09-23 General Electric Company Method and apparatus for shifting current distribution in electrodeionization systems
SG173385A1 (en) * 2006-07-14 2011-08-29 Ac Immune S A Ch Humanized antibody against amyloid beta
WO2008008463A2 (en) 2006-07-14 2008-01-17 Trustees Of Columbia University In The City Of New York METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING SAPPβ
EP2074145B1 (en) 2006-10-02 2017-08-16 AC Immune S.A. Humanized antibody against amyloid beta
MX2009005279A (en) 2006-11-24 2009-05-28 Ac Immune Sa N- (methyl) -1h- pyrazol- 3 -amine, n- (methyl) -pyridin-2-amine and n- (methyl) -thiaz0l-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's.
JP2008135645A (en) 2006-11-29 2008-06-12 Toshiba Corp Multilayer printed wiring board and interlayer joining method for the same
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US20090022728A1 (en) 2007-03-09 2009-01-22 Rinat Neuroscience Corporation Methods of treating ophthalmic diseases
PE20090329A1 (en) 2007-05-30 2009-03-27 Abbott Lab HUMANIZED ANTIBODIES AGAINST GLOBULOMER AB (20-42) AND ITS USES
US20090232801A1 (en) 2007-05-30 2009-09-17 Abbot Laboratories Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof
JP2010530744A (en) 2007-06-12 2010-09-16 エーシー イミューン ソシエテ アノニム Humanized antibody against amyloid β
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
CA2690434C (en) 2007-06-12 2018-05-22 Ac Immune S.A. Monoclonal anti beta amyloid antibody
US8613923B2 (en) * 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
ES2445590T3 (en) 2007-10-05 2014-03-04 Genentech, Inc. Use of anti-beta amyloid antibody in eye diseases
CN101998863B (en) 2007-10-05 2015-09-16 基因技术公司 The purposes of anti-amyloid beta antibody in oculopathy
ES2612788T3 (en) 2007-10-05 2017-05-18 Genentech, Inc. Methods and compositions for the diagnosis and treatment of amyloidosis
JO3076B1 (en) 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap Immunotherapy regimes dependent on apoe status
NZ606357A (en) 2010-07-30 2015-05-29 Genentech Inc Safe and functional humanized anti beta-amyloid antibody

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000072880A2 (en) * 1999-05-28 2000-12-07 Neuralab Limited Prevention and treatment of amyloidogenic disease
WO2001062801A2 (en) * 2000-02-24 2001-08-30 Washington University Humanized antibodies that sequester amyloid beta peptide
WO2002096937A2 (en) * 2001-05-29 2002-12-05 Neurochem, Inc. Vaccine for the prevention and treatment of alzheimer's and amyloid related diseases
WO2003070760A2 (en) * 2002-02-20 2003-08-28 F. Hoffmann-La Roche Ag Anti-amyloid beta antibodies and their use
WO2006055178A2 (en) * 2004-10-25 2006-05-26 Merck & Co., Inc. Anti-addl antibodies and uses thereof
WO2006066171A1 (en) * 2004-12-15 2006-06-22 Neuralab Limited Amyloid βετα antibodies for use in improving cognition
WO2007068412A2 (en) * 2005-12-12 2007-06-21 Ac Immune Sa A beta 1-42 specific monoclonal antibodies with therapeutic properties

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARD F ET AL: "Epitope and isotype specificities of antobodies to beta-amyloid peptide for protection against Alzheimer's disease-like neuropathology", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 100, no. 4, 18 February 2003 (2003-02-18), pages 2023 - 2028, XP002982464, ISSN: 0027-8424 *
LIU RUITIAN ET AL: "Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent Abeta-induced neurotoxicity", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 43, no. 22, 12 May 2004 (2004-05-12), pages 6959 - 6967, XP002395890, ISSN: 0006-2960 *
SOLOMON B ET AL: "MONOCLONAL ANTIBODIES INHIBIT IN VITRO FIBRILLAR AGGREGATION OF THE ALZHEIMER BETA-AMYLOID PEPTIDE", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, US, vol. 93, January 1996 (1996-01-01), pages 452 - 455, XP002942850, ISSN: 0027-8424 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US9146244B2 (en) 2007-06-12 2015-09-29 Ac Immune S.A. Polynucleotides encoding an anti-beta-amyloid monoclonal antibody
US9403902B2 (en) 2007-10-05 2016-08-02 Ac Immune S.A. Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9221900B2 (en) 2010-07-30 2015-12-29 Ac Immune S.A. Methods for identifying safe and functional humanized antibodies

Also Published As

Publication number Publication date
PL2468770T3 (en) 2018-07-31
US20130164278A1 (en) 2013-06-27
RU2009104769A (en) 2010-08-27
HRP20090221B1 (en) 2015-11-20
US20100080800A1 (en) 2010-04-01
HRP20090221A2 (en) 2009-11-30
US8124353B2 (en) 2012-02-28
US8246954B2 (en) 2012-08-21
TWI551607B (en) 2016-10-01
CA2657681A1 (en) 2008-01-24
EP2046833B1 (en) 2013-08-21
US8796439B2 (en) 2014-08-05
EP2468770B1 (en) 2017-12-20
KR20090039790A (en) 2009-04-22
AU2007275467B2 (en) 2013-12-05
US20120329149A1 (en) 2012-12-27
WO2008011348A2 (en) 2008-01-24
CL2007002070A1 (en) 2008-02-08
US20090093002A1 (en) 2009-04-09
NO20091284L (en) 2009-06-22
CO6150201A2 (en) 2010-04-20
KR101605207B1 (en) 2016-03-22
AU2007275467A2 (en) 2009-06-18
KR101535684B1 (en) 2015-07-10
RU2498999C2 (en) 2013-11-20
AU2007275467A1 (en) 2008-01-24
JP2010505415A (en) 2010-02-25
CR10556A (en) 2009-04-03
US20100150906A1 (en) 2010-06-17
MX2009003468A (en) 2009-04-15
IL196478B (en) 2018-01-31
KR20090088869A (en) 2009-08-20
MA30632B1 (en) 2009-08-03
AR062065A1 (en) 2008-10-15
US7892544B2 (en) 2011-02-22
NO20090156L (en) 2009-03-27
NO344963B1 (en) 2020-08-03
NZ574188A (en) 2012-05-25
EP2468770A1 (en) 2012-06-27
EP2046833A2 (en) 2009-04-15
MX2009000476A (en) 2009-01-28
SG173385A1 (en) 2011-08-29
CA2657681C (en) 2019-03-19
EP2046833B9 (en) 2014-02-19
IL196478A0 (en) 2011-08-01
JP5641737B2 (en) 2014-12-17
TW200827372A (en) 2008-07-01
PL2046833T3 (en) 2014-01-31

Similar Documents

Publication Publication Date Title
WO2008011348A3 (en) Humanized antibody against amyloid beta
WO2008156622A8 (en) Humanized antibodies to amyloid beta
WO2008060364A3 (en) Humani zed antibody against amyloid beta
MX2009013503A (en) Monoclonal anti beta amyloid antibody.
WO2007068412A3 (en) A beta 1-42 specific monoclonal antibodies with therapeutic properties
WO2008067464A3 (en) NEW Aβ CONFORMER SELECTIVE ANTI-Aβ GLOBULOMER MONOCLONAL ANTIBODIES
WO2012016173A3 (en) Safe and functional humanized anti beta-amyloid antibody
WO2007064972A3 (en) Monoclonal antibodies against amyloid beta protein and uses thereof
EP2650308A3 (en) Use of anti-amyloid beta antibody in ocular diseases
EP2586795A3 (en) Use of anti-amyloid beta antibody in ocular diseases
EP2535355A3 (en) Antibodies against CD38 for treatment of multiple myeloma
WO2006040153A3 (en) Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease
WO2008156713A3 (en) Anti-cd20 therapeutic compositions and methods
HRP20110203T1 (en) Improved protofibril selective antibodies and the use thereof
WO2009048537A3 (en) Humanized antibody
PH12012501882A1 (en) Humanized antibody against amyloid beta
UA102368C2 (en) SPECIFIC IN RELATION b-AMYLOID 1-42 MONOKLONAL'NI ANTIBODIES WHICH ARE THERAPEUTIC CHARACTERISTICS
WO2008112840A3 (en) Novel composition and methods for the treatment of immune related diseases
AR112975A2 (en) HUMANIZED ANTIBODY
WO2009120659A3 (en) Human monoclonal antibodies against amyloid beta protein, and their use as therapeutic agents
WO2008070284A3 (en) Amyloid beta peptides and methods of uses thereof
WO2009120657A3 (en) Human monoclonal antibodies against amyloid beta protein, and their use as therapeutic agents
TH95385B (en) Humanized antibodies

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200780033976.7

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07840408

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2007275467

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2657681

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2009519711

Country of ref document: JP

Ref document number: 2009010055

Country of ref document: EG

Ref document number: 241/CHENP/2009

Country of ref document: IN

Ref document number: MX/A/2009/000476

Country of ref document: MX

Ref document number: 12009500117

Country of ref document: PH

WWE Wipo information: entry into national phase

Ref document number: CR2009-010556

Country of ref document: CR

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 574188

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 09007328A

Country of ref document: CO

Ref document number: 13291212

Country of ref document: CO

Ref document number: 14105077

Country of ref document: CO

Ref document number: 09007328

Country of ref document: CO

ENP Entry into the national phase

Ref document number: 2007275467

Country of ref document: AU

Date of ref document: 20070713

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2007840408

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2009104769

Country of ref document: RU

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020097003136

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: P20090221A

Country of ref document: HR

WWE Wipo information: entry into national phase

Ref document number: P-2013/0515

Country of ref document: RS

WWE Wipo information: entry into national phase

Ref document number: CR2014-000496

Country of ref document: CR

ENP Entry into the national phase

Ref document number: PI0714713

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20090113

WWE Wipo information: entry into national phase

Ref document number: 1020157019161

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1020167010466

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: IDP00201607727

Country of ref document: ID

WWE Wipo information: entry into national phase

Ref document number: 1020167034680

Country of ref document: KR