WO2008019062A3 - Polypeptide derivatives of parathyroid hormone (pth) - Google Patents

Polypeptide derivatives of parathyroid hormone (pth) Download PDF

Info

Publication number
WO2008019062A3
WO2008019062A3 PCT/US2007/017338 US2007017338W WO2008019062A3 WO 2008019062 A3 WO2008019062 A3 WO 2008019062A3 US 2007017338 W US2007017338 W US 2007017338W WO 2008019062 A3 WO2008019062 A3 WO 2008019062A3
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide derivatives
polypeptides
parathyroid hormone
present
pth
Prior art date
Application number
PCT/US2007/017338
Other languages
French (fr)
Other versions
WO2008019062A2 (en
Inventor
Henry M Kronenberg
John T Potts
Thomas J Gardella
Original Assignee
Gen Hospital Corp
Henry M Kronenberg
John T Potts
Thomas J Gardella
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Hospital Corp, Henry M Kronenberg, John T Potts, Thomas J Gardella filed Critical Gen Hospital Corp
Priority to EP07811043A priority Critical patent/EP2054077A4/en
Priority to JP2009522881A priority patent/JP2009545320A/en
Priority to US12/376,389 priority patent/US8143374B2/en
Publication of WO2008019062A2 publication Critical patent/WO2008019062A2/en
Publication of WO2008019062A3 publication Critical patent/WO2008019062A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone (parathormone); Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention is related to novel parathyroid hormone polypeptide derivatives, and to pharmaceutical composition containing the polypeptides, as well as synthetic and recombinant methods for producing the polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing the polypeptides of the present invention. The present invention further provides diagnostic and therapeutic methods using the polypeptide derivatives.
PCT/US2007/017338 2006-08-04 2007-08-03 Polypeptide derivatives of parathyroid hormone (pth) WO2008019062A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07811043A EP2054077A4 (en) 2006-08-04 2007-08-03 Polypeptide derivatives of parathyroid hormone (pth)
JP2009522881A JP2009545320A (en) 2006-08-04 2007-08-03 Polypeptide derivative of parathyroid hormone (PTH)
US12/376,389 US8143374B2 (en) 2006-08-04 2007-08-03 Polypeptide derivatives of parathyroid hormone (PTH)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83542206P 2006-08-04 2006-08-04
US60/835,422 2006-08-04

Publications (2)

Publication Number Publication Date
WO2008019062A2 WO2008019062A2 (en) 2008-02-14
WO2008019062A3 true WO2008019062A3 (en) 2009-04-09

Family

ID=39033491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/017338 WO2008019062A2 (en) 2006-08-04 2007-08-03 Polypeptide derivatives of parathyroid hormone (pth)

Country Status (4)

Country Link
US (1) US8143374B2 (en)
EP (1) EP2054077A4 (en)
JP (1) JP2009545320A (en)
WO (1) WO2008019062A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1961765A1 (en) * 2006-12-08 2008-08-27 Zealand Pharma A/S Truncated PTH peptides with a cyclic conformation
MX346714B (en) 2007-08-01 2017-03-24 The General Hospital Corp * Screening methods using g-protein coupled receptors and related compositions.
EP2411038B1 (en) 2009-03-27 2016-12-28 Van Andel Research Institute Parathyroid hormone peptides and parathyroid hormone-related protein peptides and methods of use
US9492508B2 (en) 2010-05-13 2016-11-15 The General Hospital Corporation Parathyroid hormone analogs and uses thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006846A1 (en) * 1991-10-10 1993-04-15 Pang Peter K T Parathyroid hormone analogues and use in osteoporosis treatment
US6537965B1 (en) * 1998-11-25 2003-03-25 The General Hospital Corporation Amino-terminal modified parathyroid hormone (PTH) analogs
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050282749A1 (en) * 2000-09-18 2005-12-22 Henriksen Dennis B Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086196A (en) 1975-03-28 1978-04-25 Armour Pharmaceutical Company Parathyroid hormone
US4849338A (en) 1982-07-16 1989-07-18 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4843000A (en) 1979-12-26 1989-06-27 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
US4423037A (en) 1982-05-13 1983-12-27 The General Hospital Corporation Inhibitors of peptide hormone action
US4512922A (en) 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4518526A (en) 1982-12-22 1985-05-21 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4620948A (en) 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4511502A (en) 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4736866A (en) 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
IL78342A (en) 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
US4761406A (en) 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
US5010010A (en) 1986-10-22 1991-04-23 Selmer-Sande, A.S. Production of human parathyroid hormone from microorganisms
US4771124A (en) * 1987-05-26 1988-09-13 Merck & Co., Inc. Parathyroid hormone antagonists with simplified synthetic methodology
US5527772A (en) 1987-10-20 1996-06-18 Holick; Michael F. Regulation of cell proliferation and differentiation using peptides
US5605815A (en) 1988-03-14 1997-02-25 Yale University Nucleic acids encoding and expression of parathyroid hormone-like peptide
EP0341962B1 (en) 1988-05-09 1995-03-15 Merck & Co. Inc. Humoral hypercalcemic factor antagonists
US5217896A (en) 1988-12-30 1993-06-08 Oncogene Science, Inc. Monoclonal antibodies recognizing parathyroid hormone-like protein
JPH04503306A (en) 1989-02-01 1992-06-18 ザ・ジェネラル・ホスピタル・コーポレーション Herpes simplex virus type 1 expression vector
US5350836A (en) 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
ES2090297T5 (en) 1989-11-06 2005-03-01 Cell Genesys, Inc. PRODUCTION OF PROTEINS THAT USE HOMOLOGICAL RECOMBINATION.
IT1238348B (en) 1989-11-16 1993-07-13 PROCESS FOR THE PREPARATION OF GENETIC BUILDINGS FOR THE EXPRESSION OF THE NERVE GROWTH FACTOR IN EUCARIOT CELLS.
US5453517A (en) 1992-02-25 1995-09-26 Molecular Probes, Inc. Reactive derivatives of bapta used to make ion-selective chelators
US5723218A (en) 1990-04-16 1998-03-03 Molecular Probes, Inc. Dipyrrometheneboron difluoride labeled flourescent microparticles
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5433896A (en) 1994-05-20 1995-07-18 Molecular Probes, Inc. Dibenzopyrrometheneboron difluoride dyes
US5405975A (en) 1993-03-29 1995-04-11 Molecular Probes, Inc. Fluorescent ion-selective diaryldiaza crown ether conjugates
US5227487A (en) 1990-04-16 1993-07-13 Molecular Probes, Inc. Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes
US5274113A (en) 1991-11-01 1993-12-28 Molecular Probes, Inc. Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates
US5648270A (en) 1995-02-06 1997-07-15 Molecular Probes, Inc. Methods of sensing with fluorescent conjugates of metal-chelating nitrogen heterocycles
US5459276A (en) 1994-05-20 1995-10-17 Molecular Probes, Inc. Benzazolylcoumarin-based ion indicators for heavy metals
EP0464533B1 (en) 1990-06-28 1998-07-29 Hoechst Aktiengesellschaft Fusionproteins with parts of immunoglobulins, their production and use
US7253264B1 (en) 1990-06-28 2007-08-07 Sanofi-Arentideutschland GmbH Immunoglobulin fusion proteins, their production and use
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
JPH0532696A (en) 1990-09-28 1993-02-09 Takeda Chem Ind Ltd Parathyroid hormone derivative
US7150974B1 (en) 1991-04-05 2006-12-19 The General Hospital Corporation Parathyroid hormone receptor binding method
US7132260B2 (en) 1991-04-05 2006-11-07 The General Hospital Corporation DNA encoding parathyroid hormone receptor
US5494806A (en) 1991-04-05 1996-02-27 The General Hospital Corporation DNA and vectors encoding the parathyroid hormone receptor, transformed cells, and recombinant production of PTHR proteins and peptides
US5261686A (en) 1992-04-06 1993-11-16 Buckler Clive E Semi-recumbent
US5208041A (en) 1991-05-23 1993-05-04 Allelix Biopharmaceuticals Inc. Essentially pure human parathyroid hormone
DE4138621A1 (en) 1991-11-25 1993-06-17 Boehringer Ingelheim Int METHOD FOR SCREENING SUBSTANCES WITH MODULATING EFFECT ON A RECEPTACLE-RELATED CELLULAR SIGNAL TRANSMISSION PATH
EP0618805A1 (en) 1991-12-17 1994-10-12 PROCTER & GAMBLE PHARMACEUTICALS, INC. Methods for the treatment of osteoporosis using bisphosphonates and parathyroid hormone
US5434246A (en) 1992-03-19 1995-07-18 Takeda Chemical Industries, Ltd. Parathyroid hormone derivatives
US5382658A (en) 1992-04-03 1995-01-17 Allelix Biopharmaceuticals Inc. Stability-enhanced variants of parathyroid hormone
US5814603A (en) 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5821225A (en) 1992-07-14 1998-10-13 Syntex (U.S.A.) Inc. Method for the treatment of corticosteroid induced osteopenia comprising administration of modified PTH or PTHrp
US5589452A (en) 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
US5977070A (en) 1992-07-14 1999-11-02 Piazza; Christin Teresa Pharmaceutical compositions for the nasal delivery of compounds useful for the treatment of osteoporosis
AU672790B2 (en) 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
IT1255723B (en) 1992-10-09 1995-11-13 USE OF PARATORMONE, ITS BIOLOGICALLY ACTIVE FRAGMENTS AND RELATED PEPTIDES, FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS USEFUL IN THE PREVENTION AND THERAPY OF ABORTION AND PRETERMONE BIRTH AND IN GENERAL FOR THE TREATMENT OF GESTATION
US5871486A (en) 1993-01-21 1999-02-16 Acumed, Inc. Variable pitch bone screw
EP0705334A1 (en) 1993-06-14 1996-04-10 Basf Aktiengesellschaft Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5496801A (en) 1993-12-23 1996-03-05 Allelix Biopharmaceuticals Inc. Parathyroid hormone formulation
US5763416A (en) 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5656465A (en) 1994-05-04 1997-08-12 Therion Biologics Corporation Methods of in vivo gene delivery
US5714353A (en) 1994-05-24 1998-02-03 Research Corporation Technologies, Inc. Safe vectors for gene therapy
CA2126132A1 (en) 1994-06-17 1995-12-18 Witold Neugebauer Peptide synthesis on chitosan
US5556940A (en) 1994-06-20 1996-09-17 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
US5836905A (en) 1994-06-20 1998-11-17 Lemelson; Jerome H. Apparatus and methods for gene therapy
DE4434551A1 (en) 1994-09-28 1996-04-04 Forssmann Wolf Georg Prof Dr D Peptides from the sequence of hPTH (1-37)
US5717062A (en) 1995-06-07 1998-02-10 Beth Israel Hospital Association Cyclic analogs of PTH and PTHrP
CA2178894A1 (en) 1995-06-15 1996-12-16 Tsunehiko Fukuda Parathyroid hormone derivatives and their use
US5723577A (en) 1995-07-13 1998-03-03 Biomeasure Inc. Analogs of parathyroid hormone
JP4142743B2 (en) 1996-07-31 2008-09-03 ザ・ジェネラル・ホスピタル・コーポレイション Novel peptide analogues related to parathyroid hormone
US5917123A (en) 1997-03-14 1999-06-29 University Of Pittsburgh Transgenic mice containing a nucleic acid encoding tumor necrosis factor-α under the control of a cardiac specific regulatory region
US6183974B1 (en) 1997-07-31 2001-02-06 The General Hospital Corporation Screening assays for G protein coupled receptor agonists and antagonists
EP1123401A1 (en) 1998-10-22 2001-08-16 The General Hospital Corporation BIOACTIVE PEPTIDES AND PEPTIDE DERIVATIVES OF PARATHYROID HORMONE (PTH) AND PARATHYROID HORMONE-RELATED PEPTIDE (PTHrP)
US6417333B1 (en) 1998-11-25 2002-07-09 The General Hospital Corporation Modified human parathyroid hormone
WO2000032771A1 (en) 1998-11-30 2000-06-08 The General Hospital Corporation Pth1r and pth3r receptors, methods and uses thereof
AU2023499A (en) 1998-12-31 2000-07-24 General Hospital Corporation, The Pth receptor and screening assay utilizing the same
US7057012B1 (en) 1998-12-31 2006-06-06 The General Hospital Corporation PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules
US7022815B1 (en) 1999-09-29 2006-04-04 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (PTH)
WO2001023521A2 (en) 1999-09-29 2001-04-05 The General Hospital Corporation Polypeptide derivatives of parathyroid hormone (pth)
US6838264B2 (en) 2000-12-05 2005-01-04 Immutopics, Inc. Antibodies and peptide antigens for producing antibodies having a selective binding specificity to bioactive intact parathyroid hormone (PTH) 1-84
WO2002068585A2 (en) 2001-01-17 2002-09-06 The General Hospital Corporation Tip39 polypeptides
JP4837888B2 (en) 2001-07-23 2011-12-14 ザ ジェネラル ホスピタル コーポレイション Conformationally restricted parathyroid hormone (PTH) analog
CA2472472A1 (en) 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
US7521528B2 (en) 2003-01-24 2009-04-21 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs with lactam bridges
AU2003220380A1 (en) 2003-03-19 2004-11-19 Bristol-Myers Squibb Company CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONES WITH Alpha-HELIX STABILIZERS
JP4871128B2 (en) 2003-07-17 2012-02-08 ザ ジェネラル ホスピタル コーポレイション A conformationally constrained parathyroid hormone (PTH) analog
CA2504920C (en) 2004-05-14 2014-04-01 Euroscreen S.A. Ligand for g-protein coupled receptor fprl2 and uses thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006846A1 (en) * 1991-10-10 1993-04-15 Pang Peter K T Parathyroid hormone analogues and use in osteoporosis treatment
US6537965B1 (en) * 1998-11-25 2003-03-25 The General Hospital Corporation Amino-terminal modified parathyroid hormone (PTH) analogs
US6756480B2 (en) * 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050124537A1 (en) * 2000-04-27 2005-06-09 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20050282749A1 (en) * 2000-09-18 2005-12-22 Henriksen Dennis B Use of GLP-2 and related compounds for the treatment, prevention, diagnosis, and prognosis of bone-related disorders and calcium homeostasis related syndromes

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ROSOL ET AL.: "Sequences of the cDNAs encoding canine parathyroid hormone-related protein and parathyroid hormone", GENE, vol. 160, 1995, pages 241 - 243, XP004042151 *
See also references of EP2054077A4 *

Also Published As

Publication number Publication date
US8143374B2 (en) 2012-03-27
WO2008019062A2 (en) 2008-02-14
EP2054077A4 (en) 2010-10-13
JP2009545320A (en) 2009-12-24
US20100081612A1 (en) 2010-04-01
EP2054077A2 (en) 2009-05-06

Similar Documents

Publication Publication Date Title
UA98962C2 (en) Thyroid hormone analogues, pharmaceutical composition comprising thereof, method for the treatment using thereof, use thereof and preparation method
WO2007115571A3 (en) Erbb receptor-derived peptide fragments
HK1131167A1 (en) Muteins of tear lipocalin and methods for obtaining the same
IN2015DN02553A (en)
TW200630327A (en) Substituted phenylalkanoic acids
IL187328A (en) N-methyl-2-fluoro-{4-[3-(4-cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxo-imidazolidin-1-yl]}benzamide, pharmaceutical compositions comprising the same and uses thereof in the manufacture of medicaments
MXPA04003858A (en) Mch antagonists for the treatment of obesity.
JO2984B1 (en) HER2 Antibody Composition
WO2008130320A3 (en) Novel n- (8-heteroaryltetrahydronaphtalene-2yl) or n- (5- heteroarylchromane-3-yl) carboxamide derivatives for the treatment of pain
NO20054769L (en) Substituted phenylalkanoic acids
EA201000785A1 (en) COMPOSITIONS FOR DELIVERY IN LIGHT
EA201171197A8 (en) SUBSTITUTED DERIVATIVES AZOANTHRACENE, PHARMACEUTICAL COMPOSITIONS AND METHODS OF THEIR APPLICATION
DE602007004324D1 (en) 11-beta-hydroxysteroid-dehydrogenase-1-hemmer
WO2006093857A3 (en) Method of providing readily available cellular material derived from peripheral blood and a composition thereof
TW200637874A (en) Peptides with neuropeptide-2 receptor (Y2R) agonist activity
EP3241558A3 (en) Highly soluble leptins
MX2009007068A (en) Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from hiv-tat.
Chen et al. Selective lysine modification of native peptides via aza-Michael addition
IL159960A (en) Indane acetic acid derivatives, pharmaceutical compositions comprising them and uses thereof for the preparation of medicaments
WO2011034406A3 (en) Rhodanobacter ginsenosidimutans kctc22231t-derived ginsenoside glycosidase, and use thereof
TW200745122A (en) New compounds I
TN2009000194A1 (en) Novel antiproliferation antibodies
EA201070725A1 (en) BIS-Pyridylpyridones as antagonists of receptor 1 melaninconcentrating hormone
TW200800979A (en) Halogenated sulfonamide derivatives
WO2008019062A3 (en) Polypeptide derivatives of parathyroid hormone (pth)

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07811043

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009522881

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2007811043

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU

WWE Wipo information: entry into national phase

Ref document number: 12376389

Country of ref document: US