WO2008036710A2 - A surface-enhanced raman scattering analyzer - Google Patents
A surface-enhanced raman scattering analyzer Download PDFInfo
- Publication number
- WO2008036710A2 WO2008036710A2 PCT/US2007/078848 US2007078848W WO2008036710A2 WO 2008036710 A2 WO2008036710 A2 WO 2008036710A2 US 2007078848 W US2007078848 W US 2007078848W WO 2008036710 A2 WO2008036710 A2 WO 2008036710A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nanoparticles
- molecules
- analyzer
- chamber
- light
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
Definitions
- the invention relates to analyzers and particularly to light scattering analyzers. More particularly, the invention pertains to Raman light scattering analyzers.
- the invention is an analyzer based on electro-spray ionization and surface enhanced Raman scattering.
- Figure 2 is a diagram showing a chamber having inputs for a sample and nanoparticle solution, and an evolving nanoparticle droplet;
- Figure 3 reveals the chamber with an interaction of the analyte with nanoparticles .
- the breath of a person may contain rich information about that person, which may include the person's well being, nutrition, dietary habits, and so forth.
- a monitoring of the content of breath may offer great potential in clinical diagnosis, monitory ring, forensic science, and other fields.
- current technology such as mass spectroscopy , FTIR, colorimetry, and other technologies have limitations such as labeling required, non-real time measurements, difficulties of miniaturization, and more.
- One may propose to integrate an electrical spray ionization device (ESI) based real-time nanoparticle sprayer with a surface enhanced Raman scattering (SERS) light source and detector for breath analysis.
- a nanoparticle solution may be made up of multiple types of functionalized nanoparticles with suitable solvent.
- FIG. 1 is a diagram of an illustrative implementation of the present invention.
- This implementation may be a breath analyzer 10.
- Analyzer 10 may have a support structure 11 which may contain a port 12 for an injection of a nanoparticle spray 19 from an ESI nozzle 15 through the port into a chamber 14.
- Another port 13 may be an inlet for conveying a sample of analyte 16, such as a breath or some other matter for analysis into the chamber 14.
- the analyte 16 and the spray 19 may combine into a combination 23 of analyte 16 with molecules attached to the nanoparticles 28 from the spray 19.
- Port 13 may have an applicable mechanism 24 for conditioning the matter containing analyte 16, such as a breath.
- Mechanism 24 may be, for example, a filter for removing particles and moisture from the sample.
- There may be a light source and detector 17 situated at one end of chamber 14 for emanating a light 21 and detecting light 22 scattered by the combination 23.
- the emanated light 21 and detected light 22 may be provided to and conveyed from the chamber 14, respectively, with an optical fiber or other mechanism 38.
- a voltage may be applied across a metal pad 25 and nozzle 15, with the positive polarity connected to the nozzle. The polarity could instead be applied in reverse.
- Figure 2 reveals further details of the present system 10.
- a D. C. voltage source 26 of about 1000 volts may have a positive terminal connected to the nozzle 15 and a negative terminal connected to the cathode pad 25. Source 26 may be a battery or some other provision.
- a colloid of silver (Ag) nanoparticles 28 suspended in a solution 27 may be provided to nozzle 15 in the port 12.
- nanoparticles in addition to silver, such as gold, copper, and/or other noble metals, may be used as nanoparticles .
- This colloid of nanoparticles may be pushed through the nozzle 15 which may have a needle -like exit tip 29.
- the solution 27 may have nanoparticles 28 with positive charges (i.e., like ions) due to the positive voltage applied to the metal nozzle 15 relative to the cathode pad or plate 25 which may be connected to an electric charge generator or source.
- the solution or fluid may flow out of the tip in a form of a capillary jet 32 with a cone-shaped base 31 at the tip of the nozzle that narrows down to a fine liquid filament or jet 32.
- the base 31 form of the exiting solution may be regarded as a Taylor cone .
- Interfacial instabilities may break this filament 32 into droplets 33 of charged Ag nanoparticles 28 to form a plume 37.
- the solution may rapidly evaporate resulting in droplets without solution or cloud 34 of nanoparticles 28 in the plume 37.
- Each droplet 34 may subsequently result in a (Coulombic) break up or explode into individually bare and charged Ag nanoparticles 28 as shown in a dispersion 35 of particles 28 in Figure 3.
- the nanoparticles of this nature may be regarded as being aerosolized or an aerosol 35.
- An illustrative purpose of these nanoparticles 28 of chamber 14 is shown in Figure 3.
- Molecules 36 from the sample 16, such as a breath may attach to the charged Ag nanoparticles 28 floating in a vacuum, air or the like, in chamber 14.
- the nanoparticles 28 may be effectively an aerosol that constitutes a floating substrate for surface enhanced Raman scattering (SERS) .
- SERS surface enhanced Raman scattering
- Enhanced surface Raman scattered light 22 may exit from the molecules 36 chamber 14 to a light spectrometer, e.g., a Raman spectrophotometer.
- SERS signatures may be read from the spectrometer, which may provide information about and/or identify the respective molecules 36.
- Raman scattering There may be several kinds of Raman scattering. If a molecule absorbs energy (i.e., the resulting photon has lower energy) , then one has Stokes scattering. If the molecule loses energy (i.e., the resulting photon has higher energy) , then one has anti-Stokes scattering.
- the Stokes spectrum may be more intense than the anti-Stokes spectrum since a Boltzmann distribution may indicate that more molecules occupy lower energy levels than the higher levels in most cases .
- An absolute value should not depend on Stokes or anti-Stokes scattering.
- the energies of the different vibrational levels are of significance.
- the intensities of the Raman bonds may be dependent just on a number of molecules occupying different vibrational states, when the scattering process occurs.
- the rather weak Raman effect or scattering (i.e., relative to the Rayleigh scattering) from molecules may be greatly strengthened (by a factor of up to 14 orders of magnitude) if the molecules are attached to a surface such as that of metallic nanostructures, e.g., colloidal silver particles.
- This phenomenon of increased intensity of Raman scattering may be referred to as surface- enhanced Raman scattering (SERS) which appears strongest on silver, but is observable on gold and copper.
- SERS surface- enhanced Raman scattering
- Surface -enhanced Raman scattering may arise from several mechanisms.
- One may be an enhanced electromagnetic field produced at the surface of the metal.
- conduction electrons in the metal surface may be excited into an extended surface electronic excited state called a surface plasmon resonance .
- Molecules adsorbed or in close proximity to the surface may experience an exceptionally large electromagnetic field. Vibrational modes normal to the surface tend to be most strongly enhanced.
- Another mode of enhancement may be by a formation of a charge-transfer complex between the surface and the analyte molecule. Electronic transitions of many charge transfer complexes may be in the visible range, where a resonance enhancement can occur.
- Molecules with a lone pair electrons or pi clouds may show the strongest SERS.
- the effect was apparently noted with pyridine.
- Aromatic nitrogen or oxygen containing compounds, such as aromatic amines or phenols, may be strongly SERS active.
- the effect may also be seen with other electron-rich functionalities such as carboxylic acids.
- the intensity of a surface plasmon resonance may be dependent on many factors including the wavelength of incident light and the morphology of the metal surface. The wavelength should match the plasma wavelength of the metal. This wavelength may be about 382 nm for a 5 ⁇ m silver particle, but could be as high as 600 nm for larger ellipsoidal silver particles.
- An advantage of the present invention may include a high capturing efficiency of high mono or poly molecules. Proteins, small molecules, pollen, anything that can flow through the chamber 14 in a gas phase, may be detected.
- An example application may include a sniffer. No sample preparation is necessarily needed.
- the particle capture may be 93 to 98 percent.
- the present system may be fluorescent signal insensitive.
- the high energy increase of the surface enhanced approach may be even greater with charged nanoparticles compared to the classical surface substrate approach of enhancement. That is because the molecules are drawn closer to a charged floating substrate, i.e., charged nanoparticles suspended in space. Detection of certain molecules may occur at as low as 30 ppt .
- the present system may operate at room temperature. It may used as a portable mass spectrometer.
- the present system has advantages relative to the ordinary surface- enhanced Raman scattering approach.
- some of the matter may be of a hypothetical or prophetic nature although stated in another manner or tense.
Abstract
A surface enhanced Raman scatter (SERS) analyte analyzer (10). An injector (15) may provide a spray of charged nanoparticles (19) suspended in droplets of an evaporable solution (27) into a chamber (14). When the solution (27) quickly evaporates, droplets of nanoparticles (19) are left without a supporting solution. These droplets or cloud of charged.nanoparticles (28) may then explode into a dispersion or aerosol (35). The charged nanoparticles (19) may attract molecules (36) of a sample (IS) for attachment to their surfaces. A laser light (21) may impinge the attached molecules (36) which may result in surface enhanced Raman scattered light received by a detector or a light spectrometer (17). Wavelength signatures may then be obtained from the spectrometer. The signatures may provide information about the molecules (36).
Description
A SERS ANALYZER
Background
The invention relates to analyzers and particularly to light scattering analyzers. More particularly, the invention pertains to Raman light scattering analyzers.
Summary
The invention is an analyzer based on electro-spray ionization and surface enhanced Raman scattering.
Brief Description of the Drawing Figure 1 is a diagram of a basic layout of the present analyzer;
Figure 2 is a diagram showing a chamber having inputs for a sample and nanoparticle solution, and an evolving nanoparticle droplet; and
Figure 3 reveals the chamber with an interaction of the analyte with nanoparticles .
Description
The breath of a person may contain rich information about that person, which may include the person's well being, nutrition, dietary habits, and so forth. A monitoring of the content of breath may offer great potential in clinical diagnosis, monitory ring, forensic science, and other fields. However, current technology
such as mass spectroscopy , FTIR, colorimetry, and other technologies have limitations such as labeling required, non-real time measurements, difficulties of miniaturization, and more. One may propose to integrate an electrical spray ionization device (ESI) based real-time nanoparticle sprayer with a surface enhanced Raman scattering (SERS) light source and detector for breath analysis. A nanoparticle solution may be made up of multiple types of functionalized nanoparticles with suitable solvent.
During a spray, nanoclusters may be formed and analytes from a breath may bond or attach to the nanoparticles of the nanoclusters. A SERS signal may then be detected. This technique may feature miniaturizable, label-free, real-time, high sensitivity, and multiplexing. An example application of the present approach may include a portable ESI-SERS based breath analyzer. This analyzer may be used in clinics, resource-limited areas for disease monitoring, exposure identification, and so on. Figure 1 is a diagram of an illustrative implementation of the present invention. This implementation may be a breath analyzer 10. Analyzer 10 may have a support structure 11 which may contain a port 12 for an injection of a nanoparticle spray 19 from an ESI nozzle 15 through the port into a chamber 14.
Another port 13 may be an inlet for conveying a sample of
analyte 16, such as a breath or some other matter for analysis into the chamber 14. The analyte 16 and the spray 19 may combine into a combination 23 of analyte 16 with molecules attached to the nanoparticles 28 from the spray 19. Port 13 may have an applicable mechanism 24 for conditioning the matter containing analyte 16, such as a breath. Mechanism 24 may be, for example, a filter for removing particles and moisture from the sample. There may be a light source and detector 17 situated at one end of chamber 14 for emanating a light 21 and detecting light 22 scattered by the combination 23. The emanated light 21 and detected light 22 may be provided to and conveyed from the chamber 14, respectively, with an optical fiber or other mechanism 38. At the other end of chamber 14 may an outlet 18 for an exhaust of the product 23 of matter 16 and nanoparticles 28. A voltage may be applied across a metal pad 25 and nozzle 15, with the positive polarity connected to the nozzle. The polarity could instead be applied in reverse. Figure 2 reveals further details of the present system 10. A D. C. voltage source 26 of about 1000 volts may have a positive terminal connected to the nozzle 15 and a negative terminal connected to the cathode pad 25. Source 26 may be a battery or some other provision. A colloid of silver (Ag) nanoparticles 28 suspended in a solution 27 may be provided to nozzle 15 in the port 12.
Other metals, in addition to silver, such as gold, copper, and/or other noble metals, may be used as nanoparticles . This colloid of nanoparticles may be pushed through the nozzle 15 which may have a needle -like exit tip 29. The solution 27 may have nanoparticles 28 with positive charges (i.e., like ions) due to the positive voltage applied to the metal nozzle 15 relative to the cathode pad or plate 25 which may be connected to an electric charge generator or source. The solution or fluid may flow out of the tip in a form of a capillary jet 32 with a cone-shaped base 31 at the tip of the nozzle that narrows down to a fine liquid filament or jet 32. The base 31 form of the exiting solution may be regarded as a Taylor cone . There may be a spraying of SERS-active nanoparticles 28 suspended in the solution
27. Interfacial instabilities may break this filament 32 into droplets 33 of charged Ag nanoparticles 28 to form a plume 37. The solution may rapidly evaporate resulting in droplets without solution or cloud 34 of nanoparticles 28 in the plume 37. Each droplet 34 may subsequently result in a (Coulombic) break up or explode into individually bare and charged Ag nanoparticles 28 as shown in a dispersion 35 of particles 28 in Figure 3. The nanoparticles of this nature may be regarded as being aerosolized or an aerosol 35.
An illustrative purpose of these nanoparticles 28 of chamber 14 is shown in Figure 3. Molecules 36 from the sample 16, such as a breath, may attach to the charged Ag nanoparticles 28 floating in a vacuum, air or the like, in chamber 14. The nanoparticles 28 may be effectively an aerosol that constitutes a floating substrate for surface enhanced Raman scattering (SERS) . There may be a flow of nanoparticles 28, many with molecules 36 attached, (e.g., nanoparticle attached molecule ensembles 39), towards the exhaust port 18 of Figure 1.
Light 21, such as laser light, may be directed at one or more molecules 36 attached to the surfaces of nanoparticles 28. Enhanced surface Raman scattered light 22 may exit from the molecules 36 chamber 14 to a light spectrometer, e.g., a Raman spectrophotometer. SERS signatures may be read from the spectrometer, which may provide information about and/or identify the respective molecules 36.
To lead into a background of the present system, it may be noted that when light is scattered from an atom or molecule, most photons are elastically scattered (i.e., Rayleigh scattering) . The scattered photons may have the same frequency as the incident photons. However, a small fraction of light (e.g., about 1 in 107 photons) may be scattered at frequencies different from the frequency of the incident photons. This may be a result of inelastic
scattering. Such scattered light may provide information about the molecules vibrational quantum states. Although Raman scattering may occur with a charge in vibrational, rotational or electronic energy of a molecule; a primary concern is the vibrational Raman effect.
There may be several kinds of Raman scattering. If a molecule absorbs energy (i.e., the resulting photon has lower energy) , then one has Stokes scattering. If the molecule loses energy (i.e., the resulting photon has higher energy) , then one has anti-Stokes scattering. The Stokes spectrum may be more intense than the anti-Stokes spectrum since a Boltzmann distribution may indicate that more molecules occupy lower energy levels than the higher levels in most cases . An absolute value should not depend on Stokes or anti-Stokes scattering. The energies of the different vibrational levels are of significance. The intensities of the Raman bonds may be dependent just on a number of molecules occupying different vibrational states, when the scattering process occurs. The rather weak Raman effect or scattering (i.e., relative to the Rayleigh scattering) from molecules may be greatly strengthened (by a factor of up to 14 orders of magnitude) if the molecules are attached to a surface such as that of metallic nanostructures, e.g., colloidal silver particles. This phenomenon of increased intensity of Raman scattering may be referred to as surface-
enhanced Raman scattering (SERS) which appears strongest on silver, but is observable on gold and copper.
Surface -enhanced Raman scattering may arise from several mechanisms. One may be an enhanced electromagnetic field produced at the surface of the metal. When the wavelength of the incident light is close to the plasma wavelength of the metal, conduction electrons in the metal surface may be excited into an extended surface electronic excited state called a surface plasmon resonance . Molecules adsorbed or in close proximity to the surface may experience an exceptionally large electromagnetic field. Vibrational modes normal to the surface tend to be most strongly enhanced. Another mode of enhancement may be by a formation of a charge-transfer complex between the surface and the analyte molecule. Electronic transitions of many charge transfer complexes may be in the visible range, where a resonance enhancement can occur. Molecules with a lone pair electrons or pi clouds may show the strongest SERS. The effect was apparently noted with pyridine. Aromatic nitrogen or oxygen containing compounds, such as aromatic amines or phenols, may be strongly SERS active. The effect may also be seen with other electron-rich functionalities such as carboxylic acids.
The intensity of a surface plasmon resonance may be dependent on many factors including the wavelength of incident light and the morphology of the metal surface. The wavelength should match the plasma wavelength of the metal. This wavelength may be about 382 nm for a 5 μm silver particle, but could be as high as 600 nm for larger ellipsoidal silver particles.
An advantage of the present invention may include a high capturing efficiency of high mono or poly molecules. Proteins, small molecules, pollen, anything that can flow through the chamber 14 in a gas phase, may be detected. An example application may include a sniffer. No sample preparation is necessarily needed. The particle capture may be 93 to 98 percent. The present system may be fluorescent signal insensitive. The high energy increase of the surface enhanced approach may be even greater with charged nanoparticles compared to the classical surface substrate approach of enhancement. That is because the molecules are drawn closer to a charged floating substrate, i.e., charged nanoparticles suspended in space. Detection of certain molecules may occur at as low as 30 ppt . The present system may operate at room temperature. It may used as a portable mass spectrometer. It can function with a flow rate of spray as low as one nL/min. Yet the air flow rate in the chamber may be as fast as meters per second.
Consequently, an analysis may be fast (i.e., within milliseconds) . For these and other reasons, the present system has advantages relative to the ordinary surface- enhanced Raman scattering approach. In the present specification, some of the matter may be of a hypothetical or prophetic nature although stated in another manner or tense.
Although the invention has been described with respect to at least one illustrative example, many variations and modifications will become apparent to those skilled in the art upon reading the present specification. It is therefore the intention that the appended claims be interpreted as broadly as possible in view of the prior art to include all such variations and modifications.
Claims
1. A sample analyzer comprising: a chamber having a first end, a second end, a first input and a second input; a light source situated at the first end; and a detector situated at the first end; and wherein: the first input is for an injection of nanoparticles; and the second input is for an insertion of a sample having molecules .
2. The analyzer of claim 1, wherein the nanoparticles are for attachment of the molecules.
3. The analyzer of claim 2, wherein: the light source is for impinging the molecules attached to the nanoparticles; and the detector is for receiving light scattered by the molecules.
4. The analyzer of claim 3, further comprising an electrical source for providing charges to nanoparticles .
5. The analyzer of claim 3, wherein the detector is for receiving Raman scattered light.
6. The analyzer of claim 3, wherein the detector is a light spectrometer.
7. The analyzer of claim 3, wherein the light source is a laser.
8. The analyzer of claim 5, wherein the effect of nanoparticles relative to the molecules is a surface enhanced Raman scattering.
9. The analyzer of claim 4, wherein the nanoparticles comprise silver, gold, copper, and/or other noble metals.
10. The analyzer of claim 5, wherein the nanoparticles become aerosolized nanoparticles and provide a floating surface for surface enhanced Raman scattering by molecules attached to the aerosolized nanoparticles.
11. A method for analyzing a sample, comprising: providing a spray of charged surface enhanced
Raman scattering (SERS) nanoparticles; providing a sample having some molecules which attach to a charged SERS nanoparticle dispersion containing some of the nanoparticles, resulting in SERS nanoparticle attached molecule ensembles; and detecting surface enhanced Raman scattering from molecules of the SERS nanoparticle attached molecule ensembles .
12. The method of claim 11, wherein: the nanoparticles of the spray are initially suspended in a solution; and the spray turns into droplets of nanoparticles in the solution.
13. The method of claim 12, wherein: the solution evaporates from the sprayed droplets containing SERS nanoparticles; and the sprayed droplets containing SERS nanoparticles eventually breakdown into a charged SERS nanoparticle dispersion.
14. The method of claim 11, further comprising, prior to the detecting, an impinging of the SERS nanoparticle attached molecule ensembles with a light beam.
15. The method of claim 11, wherein the detecting of the Raman scattering is effected with a spectrometer.
16. The method of claim 15, further comprising reading wavelength signatures from the spectrometer to identify one or more properties of some of the molecules attached to the nanoparticles .
17. The method of claim 11, wherein the sample comprises a breath.
18. The method of claim 11, wherein nanoparticles comprise silver, gold, copper, and/or other noble metals .
19. A sample analyzer system comprising: a chamber; an injector having an end situated in the chamber; a sample port coupled to the chamber; a light source situated proximate to the chamber; a light detector situated proximate to the chamber; and a mechanism, connected to the injector, for providing nanoparticles suspended in an evaporable solution through the injector into the chamber.
20. The system of claim 19, further comprising: an electric charge source proximate to the chamber; and wherein: the nanoparticles become floating surfaces in the chamber upon evaporation of the evaporable solution of the suspended nanoparticles for attachment of molecules of a sample provided through the sample port ; and the electric charge source is for providing charges on the nanoparticles.
21. The system of claim 20, wherein: the light source is for emanating light which is scattered by some of the molecules attached to the nanoparticles; and the detector is for detecting surface enhanced Raman scattered light from some of the molecules attached to the nanoparticles .
22. The system of claim 21, wherein the detector is a spectrometer for detecting light wavelength signatures .
23. The system of claim 22, wherein the wavelength signatures are a basis for analysis and/or identification of the molecules.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/533,984 | 2006-09-21 | ||
US11/533,984 US7502106B2 (en) | 2006-09-21 | 2006-09-21 | SERS analyzer |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008036710A2 true WO2008036710A2 (en) | 2008-03-27 |
WO2008036710A3 WO2008036710A3 (en) | 2008-07-24 |
Family
ID=39167574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/078848 WO2008036710A2 (en) | 2006-09-21 | 2007-09-19 | A surface-enhanced raman scattering analyzer |
Country Status (2)
Country | Link |
---|---|
US (1) | US7502106B2 (en) |
WO (1) | WO2008036710A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102759520A (en) * | 2012-05-14 | 2012-10-31 | 北京化工大学 | Preparation method of active radical with surface-enhanced Raman scattering (SERS) effect |
US9664658B2 (en) | 2015-01-13 | 2017-05-30 | Src, Inc. | Method, device, and system for aerosol detection of chemical and biological threats |
WO2020192153A1 (en) * | 2019-03-27 | 2020-10-01 | 威朋(苏州)医疗器械有限公司 | Coherent anti-stokes raman scattering microscope imaging apparatus |
US11959859B2 (en) | 2021-06-02 | 2024-04-16 | Edwin Thomas Carlen | Multi-gas detection system and method |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198590B2 (en) * | 2008-10-30 | 2012-06-12 | Honeywell International Inc. | High reflectance terahertz mirror and related method |
US7864326B2 (en) | 2008-10-30 | 2011-01-04 | Honeywell International Inc. | Compact gas sensor using high reflectance terahertz mirror and related system and method |
US8790445B2 (en) * | 2009-06-02 | 2014-07-29 | Honeywell International Inc. | Approaches for removing CO2, SO2 and other gaseous contaminates from gas emissions |
US8559003B2 (en) | 2009-09-17 | 2013-10-15 | Huei Pei Kuo | Electrically driven devices for surface enhanced raman spectroscopy |
WO2011066512A2 (en) * | 2009-11-30 | 2011-06-03 | Spectrafluidics, Inc. | Sers devices for the remote analysis of analytes |
US9036144B2 (en) * | 2010-11-05 | 2015-05-19 | Ondavia, Inc. | Nano-/micro-droplets for the detection of analytes |
WO2013119228A1 (en) * | 2012-02-08 | 2013-08-15 | Hewlett-Packard Development Company, L.P. | Gas-phase delivery system for molecule sensing apparatus |
CN102944543B (en) * | 2012-11-05 | 2014-10-15 | 中物院成都科学技术发展中心 | Method and device for detecting ultra trace sample based on surface-enhanced Raman spectroscopy |
JP6138037B2 (en) * | 2013-12-10 | 2017-05-31 | アズビル株式会社 | Particle detection apparatus and particle detection method |
CN108663349A (en) * | 2018-05-14 | 2018-10-16 | 中国计量大学 | A kind of capture of aerosol droplets and Surface enhanced Raman spectroscopy detection device and method |
CN114839180B (en) * | 2022-04-28 | 2023-08-01 | 电子科技大学 | Preparation method of spray type bi-component composite Raman substrate |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5255067A (en) * | 1990-11-30 | 1993-10-19 | Eic Laboratories, Inc. | Substrate and apparatus for surface enhanced Raman spectroscopy |
US6028666A (en) * | 1998-11-19 | 2000-02-22 | The United States Of America As Represented By The Secretary Of The Navy | Fiber optic Raman sensor |
US20040109386A1 (en) * | 2002-11-18 | 2004-06-10 | Gold Kenneth S. | Particle analyzer with specimen tube in-line mixer and fluid detector |
US20050147980A1 (en) * | 2003-12-30 | 2005-07-07 | Intel Corporation | Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication |
US20060061762A1 (en) * | 2004-09-22 | 2006-03-23 | Dwight David W | Surface enhanced raman spectroscopy (SERS) substrates exhibiting uniform high enhancement and stability |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5266498A (en) | 1989-10-27 | 1993-11-30 | Abbott Laboratories | Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal |
US6174677B1 (en) | 1995-10-13 | 2001-01-16 | Ut-Battelle, Llc | Advanced surface-enhanced Raman gene probe systems and methods thereof |
US6040191A (en) | 1996-06-13 | 2000-03-21 | Grow; Ann E. | Raman spectroscopic method for determining the ligand binding capacity of biologicals |
JP4068677B2 (en) | 1996-10-25 | 2008-03-26 | アークレイ株式会社 | Gene analysis method and gene analysis kit used therefor |
US6149868A (en) | 1997-10-28 | 2000-11-21 | The Penn State Research Foundation | Surface enhanced raman scattering from metal nanoparticle-analyte-noble metal substrate sandwiches |
US6699724B1 (en) | 1998-03-11 | 2004-03-02 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
US6219137B1 (en) | 1998-12-03 | 2001-04-17 | Lockheed Martin Energy Research Corporation | Nanoprobe for surface-enhanced Raman spectroscopy in medical diagnostic and drug screening |
GB9907688D0 (en) | 1999-04-06 | 1999-05-26 | Univ Belfast | Solid matrices for surface-enhanced Raman spectroscopy |
PT1226422E (en) | 1999-10-06 | 2008-03-04 | Oxonica Inc | Surface enhanced spectroscopy-active composite nanoparticles |
US6623977B1 (en) | 1999-11-05 | 2003-09-23 | Real-Time Analyzers, Inc. | Material for surface-enhanced Raman spectroscopy, and SER sensors and method for preparing same |
US6406777B1 (en) | 2000-06-14 | 2002-06-18 | The United States Of America As Represented By The Secretary Of The Navy | Metal and glass structure for use in surface enhanced Raman spectroscopy and method for fabricating same |
US6947132B1 (en) | 2000-06-14 | 2005-09-20 | The United States Of America As Represented By The Secretary Of The Navy | Thermo-electrically cooled surface-enhanced raman spectroscopy sensor system to detect volatile organic compounds |
AU2002239726A1 (en) | 2001-05-25 | 2002-12-09 | Northwestern University | Non-alloying core shell nanoparticles |
WO2003010511A2 (en) | 2001-07-23 | 2003-02-06 | Trustees Of Boston University | Low resolution surface enhanced raman spectroscopy on sol-gel substrates |
US6972173B2 (en) * | 2002-03-14 | 2005-12-06 | Intel Corporation | Methods to increase nucleotide signals by raman scattering |
US20040023411A1 (en) | 2002-03-11 | 2004-02-05 | Fenn John B. | Electrospray air sampler |
US20040110208A1 (en) | 2002-03-26 | 2004-06-10 | Selena Chan | Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS) |
US7476501B2 (en) | 2002-03-26 | 2009-01-13 | Intel Corporation | Methods and device for DNA sequencing using surface enhanced raman scattering (SERS) |
US20030211488A1 (en) | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
US6878184B1 (en) | 2002-08-09 | 2005-04-12 | Kovio, Inc. | Nanoparticle synthesis and the formation of inks therefrom |
US7019828B2 (en) | 2003-03-12 | 2006-03-28 | Intel Corporation | Chemical enhancement in surface enhanced raman scattering using lithium salts |
US6858372B2 (en) | 2003-03-24 | 2005-02-22 | The United States Of America As Represented By The Secretary Of The Navy | Resist composition with enhanced X-ray and electron sensitivity |
TW593158B (en) | 2003-07-31 | 2004-06-21 | Ind Tech Res Inst | Magnetic nanoparticle |
US20050147963A1 (en) | 2003-12-29 | 2005-07-07 | Intel Corporation | Composite organic-inorganic nanoparticles and methods for use thereof |
US20050191665A1 (en) | 2003-12-29 | 2005-09-01 | Xing Su | Composite organic-inorganic nanoclusters |
US7560285B2 (en) | 2004-03-04 | 2009-07-14 | Intel Corporation | Micelle-controlled nanoparticle synthesis for SERS |
US7740883B2 (en) | 2004-03-28 | 2010-06-22 | University Of Debrecen | Nanoparticles from chitosan |
US20060093750A1 (en) * | 2004-10-28 | 2006-05-04 | Bang Woo Han | Method for patterning nano-sized structure |
-
2006
- 2006-09-21 US US11/533,984 patent/US7502106B2/en not_active Expired - Fee Related
-
2007
- 2007-09-19 WO PCT/US2007/078848 patent/WO2008036710A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5255067A (en) * | 1990-11-30 | 1993-10-19 | Eic Laboratories, Inc. | Substrate and apparatus for surface enhanced Raman spectroscopy |
US6028666A (en) * | 1998-11-19 | 2000-02-22 | The United States Of America As Represented By The Secretary Of The Navy | Fiber optic Raman sensor |
US20040109386A1 (en) * | 2002-11-18 | 2004-06-10 | Gold Kenneth S. | Particle analyzer with specimen tube in-line mixer and fluid detector |
US20050147980A1 (en) * | 2003-12-30 | 2005-07-07 | Intel Corporation | Nucleic acid sequencing by Raman monitoring of uptake of nucleotides during molecular replication |
US20060061762A1 (en) * | 2004-09-22 | 2006-03-23 | Dwight David W | Surface enhanced raman spectroscopy (SERS) substrates exhibiting uniform high enhancement and stability |
Non-Patent Citations (3)
Title |
---|
KNEIPP K ET AL: "Surface-Enhanced Raman Scattering (SERS) - A Tool for Single Molecule Detection in Solution" SINGLE MOLECULE DETECTION IN SOLUTION, WILEY,, US, vol. Chapter 4, 27 January 2003 (2003-01-27), pages 121-144, XP007904312 * |
MOSKOVITS M: "Surface-enhanced Raman spectroscopy: a brief retrospective" JOURNAL OF RAMAN SPECTROSCOPY, XX, XX, vol. 36, no. 6-7, June 2005 (2005-06), pages 485-496, XP007904311 * |
RUAN ET AL: "Surface-enhanced Raman scattering for perchlorate detection using cystamine-modified gold nanoparticles" ANALYTICA CHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 567, no. 1, 10 May 2006 (2006-05-10), pages 114-120, XP022213520 ISSN: 0003-2670 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102759520A (en) * | 2012-05-14 | 2012-10-31 | 北京化工大学 | Preparation method of active radical with surface-enhanced Raman scattering (SERS) effect |
US9664658B2 (en) | 2015-01-13 | 2017-05-30 | Src, Inc. | Method, device, and system for aerosol detection of chemical and biological threats |
US9977001B2 (en) | 2015-01-13 | 2018-05-22 | Src, Inc. | Method, device, and system for aerosol detection of chemical and biological threats |
WO2020192153A1 (en) * | 2019-03-27 | 2020-10-01 | 威朋(苏州)医疗器械有限公司 | Coherent anti-stokes raman scattering microscope imaging apparatus |
US11879780B2 (en) | 2019-03-27 | 2024-01-23 | Weipeng (Suzhou) Medical Devices Co., Ltd. | Coherent anti-Stokes Raman scattering microscope imaging apparatus |
US11959859B2 (en) | 2021-06-02 | 2024-04-16 | Edwin Thomas Carlen | Multi-gas detection system and method |
Also Published As
Publication number | Publication date |
---|---|
US7502106B2 (en) | 2009-03-10 |
US20080074662A1 (en) | 2008-03-27 |
WO2008036710A3 (en) | 2008-07-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7502106B2 (en) | SERS analyzer | |
De Giacomo et al. | Nanoparticle enhanced laser-induced breakdown spectroscopy for microdrop analysis at subppm level | |
US8372183B2 (en) | Detection system for airborne particles | |
Jiang et al. | Electrothermal vaporization for universal liquid sample introduction to dielectric barrier discharge microplasma for portable atomic emission spectrometry | |
Li et al. | Single molecule SERS and detection of biomolecules with a single gold nanoparticle on a mirror junction | |
Brüggemann et al. | Real-time analysis of ambient organic aerosols using aerosol flowing atmospheric-pressure afterglow mass spectrometry (AeroFAPA-MS) | |
US4968885A (en) | Method and apparatus for introduction of liquid effluent into mass spectrometer and other gas-phase or particle detectors | |
Wilson et al. | Thermal Vaporization of Biological Nanoparticles: Fragment-Free Vacuum Ultraviolet Photoionization Mass Spectra of Tryptophan, Phenylalanine− Glycine− Glycine, and β-Carotene | |
US7256396B2 (en) | Sensitive glow discharge ion source for aerosol and gas analysis | |
Güzel et al. | Effect of Au and Au@ Ag core–shell nanoparticles on the SERS of bridging organic molecules | |
US20040096981A1 (en) | Systems and methods for detection of low concentration of molecules using surface enhanced Raman spectroscopy | |
Groh et al. | Local effects of atomizing analyte droplets on the plasma parameters of the inductively coupled plasma | |
Galbács et al. | Nanoparticles in analytical laser and plasma spectroscopy–a review of recent developments in methodology and applications | |
JP3572319B2 (en) | Particle analyzer in liquid | |
US20180294149A1 (en) | Ion source and method for generating elemental ions from aerosol particles | |
Iwai et al. | Fundamental properties of a touchable high‐power pulsed microplasma jet and its application as a desorption/ionization source for ambient mass spectrometry | |
CN114383984B (en) | System for capturing particulate matter and measuring phase state, morphology and chemical components of particulate matter | |
CN108318473A (en) | A kind of surface-enhanced Raman scattering activity substrate and its preparation method and application | |
US3832060A (en) | Method of preparing analyte material for spectrochemical analysis | |
Wingen et al. | Probing surfaces of atmospherically relevant organic particles by easy ambient sonic-spray ionization mass spectrometry (EASI-MS) | |
El‐Aal et al. | Spark discharge deposition of au/cu nanoparticles for surface‐enhanced Raman scattering | |
Vonderach et al. | Fundamental studies on droplet throughput and the analysis of single cells using a downward-pointing ICP-time-of-flight mass spectrometer | |
Niu et al. | Individual micron-sized aerosol qualitative analysis-combined Raman spectroscopy and laser-induced breakdown spectroscopy by optical trapping in air | |
Chan et al. | Effect of single aerosol droplets on plasma impedance in the inductively coupled plasma | |
Bierwirth et al. | A new coupling setup of DMA, CPC and sp-ICP-MS with increased versatility |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07842744 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 07842744 Country of ref document: EP Kind code of ref document: A2 |