WO2008064265A3 - Compounds modulating c-fms and/or c-kit activity and uses therefor - Google Patents
Compounds modulating c-fms and/or c-kit activity and uses therefor Download PDFInfo
- Publication number
- WO2008064265A3 WO2008064265A3 PCT/US2007/085299 US2007085299W WO2008064265A3 WO 2008064265 A3 WO2008064265 A3 WO 2008064265A3 US 2007085299 W US2007085299 W US 2007085299W WO 2008064265 A3 WO2008064265 A3 WO 2008064265A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fms
- uses therefor
- kit activity
- compounds modulating
- kit
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
Compounds active on the receptor protein tyrosine kinases c-kit and/or c-fms are provided herewith. Also provided herewith are compositions useful for treatment of c-kit mediated diseases or conditions and/or c-fms-mediated diseases or conditions, and methods for the use thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86074906P | 2006-11-22 | 2006-11-22 | |
US60/860,749 | 2006-11-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008064265A2 WO2008064265A2 (en) | 2008-05-29 |
WO2008064265A3 true WO2008064265A3 (en) | 2008-11-13 |
Family
ID=39322825
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/083910 WO2008063888A2 (en) | 2006-11-22 | 2007-11-07 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PCT/US2007/085289 WO2008064255A2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PCT/US2007/085299 WO2008064265A2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/083910 WO2008063888A2 (en) | 2006-11-22 | 2007-11-07 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PCT/US2007/085289 WO2008064255A2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Country Status (35)
Country | Link |
---|---|
US (8) | US7893075B2 (en) |
EP (1) | EP2086972B1 (en) |
JP (4) | JP2010510321A (en) |
KR (1) | KR101506044B1 (en) |
CN (2) | CN103497188B (en) |
AR (1) | AR063878A1 (en) |
AU (1) | AU2007323644B2 (en) |
BR (1) | BRPI0721137B8 (en) |
CA (1) | CA2670362C (en) |
CL (1) | CL2007003326A1 (en) |
CO (1) | CO6180438A2 (en) |
CR (1) | CR10817A (en) |
DK (1) | DK2086972T3 (en) |
EC (1) | ECSP099357A (en) |
ES (1) | ES2447779T3 (en) |
GT (1) | GT200700101A (en) |
HK (1) | HK1133649A1 (en) |
IL (1) | IL198624A (en) |
MX (1) | MX2009005428A (en) |
MY (1) | MY158447A (en) |
NI (1) | NI200900093A (en) |
NO (1) | NO342175B1 (en) |
NZ (1) | NZ577011A (en) |
PE (1) | PE20081226A1 (en) |
PL (1) | PL2086972T3 (en) |
PT (1) | PT2086972E (en) |
RU (1) | RU2452738C2 (en) |
SG (1) | SG176511A1 (en) |
SI (1) | SI2086972T1 (en) |
SV (1) | SV2007002813A (en) |
TW (1) | TWI432431B (en) |
UA (1) | UA97816C2 (en) |
UY (1) | UY30732A1 (en) |
WO (3) | WO2008063888A2 (en) |
ZA (1) | ZA200903458B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8741920B2 (en) | 2009-08-03 | 2014-06-03 | Hoffmann-La Roche, Inc. | Process for the manufacture of pharmaceutically active compounds |
US9096593B2 (en) | 2009-11-06 | 2015-08-04 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US9169250B2 (en) | 2006-11-22 | 2015-10-27 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1925855B (en) | 2003-12-19 | 2010-06-16 | 普莱希科公司 | Compounds and methods for development of Ret modulators |
US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
NZ565255A (en) * | 2005-06-22 | 2010-04-30 | Plexxikon Inc | Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors |
PE20081581A1 (en) * | 2006-12-21 | 2008-11-12 | Plexxikon Inc | PIRROLO [2,3-b] PYRIDINES COMPOUNDS AS KINASE MODULATORS |
WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
BRPI0814423B1 (en) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Kinase modulating compounds and pharmaceutical composition comprising the same |
CN101952296B (en) * | 2008-02-25 | 2013-08-21 | 霍夫曼-拉罗奇有限公司 | Pyrrolopyrazine kinase inhibitors |
CA2712507A1 (en) * | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
JP5485178B2 (en) * | 2008-02-25 | 2014-05-07 | エフ.ホフマン−ラ ロシュ アーゲー | Pyrrolopyrazine kinase inhibitor |
EP2245033B1 (en) | 2008-02-25 | 2011-08-31 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
RU2503676C2 (en) * | 2008-02-25 | 2014-01-10 | Ф.Хоффманн-Ля Рош Аг | Pyrrolopyrazine kinase inhibitors |
WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
WO2009152083A1 (en) * | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor |
US8592448B2 (en) * | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
JP5657566B2 (en) * | 2008-12-24 | 2015-01-21 | バイアル ポルテラ アンド シーエイ エス エイBIAL−Portela & Ca, S.A. | Medicine |
NZ594398A (en) | 2009-04-03 | 2014-03-28 | Plexxikon Inc | Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof |
TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
KR20120089459A (en) | 2009-08-24 | 2012-08-10 | 에즈셉피온 파마슈티컬즈, 인코포레이티드 | 5,6-bicyclic heteroaryl-containing urea compounds as kinase inhibitors |
BR112012011792A2 (en) | 2009-11-18 | 2015-10-13 | Plexxikon Inc | "compounds and methods for modulating kinases, and indications thereof" |
KR20120112623A (en) | 2009-12-23 | 2012-10-11 | 플렉시콘, 인코퍼레이티드 | Compounds and methods for kinase modulation, and indications therefor |
AU2010343102B2 (en) | 2009-12-29 | 2016-03-24 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
US8518945B2 (en) | 2010-03-22 | 2013-08-27 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
RU2017144535A (en) | 2010-03-30 | 2019-02-18 | Версеон Корпорейшн | MULTI-DISPLACED AROMATIC COMPOUNDS AS THROMBINE INHIBITORS |
TWI510487B (en) | 2010-04-21 | 2015-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081331A1 (en) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME |
AR081626A1 (en) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS |
AR081039A1 (en) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | QUINASA FUSIONED BICYCLE INHIBITORS |
US20130072495A1 (en) | 2010-05-14 | 2013-03-21 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
TWI496785B (en) | 2010-05-20 | 2015-08-21 | Hoffmann La Roche | Pyrrolopyrazine kinase inhibitors |
DK2672967T3 (en) | 2011-02-07 | 2019-01-02 | Plexxikon Inc | RELATIONSHIPS AND METHODS FOR CHINESE MODULATION AND INDICATIONS THEREOF |
AR085279A1 (en) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | SOLID FORMS OF {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDE OF PROPANE ACID-1- SULFONIC |
US8791112B2 (en) | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
WO2012158957A2 (en) * | 2011-05-17 | 2012-11-22 | Plexxikon Inc. | Kinase modulation and indications therefor |
EP2736904B1 (en) | 2011-07-27 | 2016-03-16 | AB Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
US8841301B2 (en) * | 2011-09-26 | 2014-09-23 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
US9382239B2 (en) | 2011-11-17 | 2016-07-05 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-terminal kinase (JNK) |
CN103242225B (en) * | 2012-02-13 | 2016-01-06 | 湖南化工研究院 | Picolinate amino pyridine compound and preparation method thereof |
US9358235B2 (en) * | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
JP6318156B2 (en) | 2012-09-06 | 2018-04-25 | プレキシコン インコーポレーテッドPlexxikon Inc. | Compounds and methods for modulating kinases and indicators thereof |
WO2014053968A1 (en) | 2012-10-04 | 2014-04-10 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
US10112927B2 (en) | 2012-10-18 | 2018-10-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
USRE48175E1 (en) | 2012-10-19 | 2020-08-25 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
ME03000B (en) | 2012-12-21 | 2018-10-20 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
US9783805B2 (en) * | 2013-02-28 | 2017-10-10 | City Of Hope | Replication capable rAAV vectors encoding inhibitory siRNA and methods of their use |
WO2014151253A1 (en) * | 2013-03-15 | 2014-09-25 | Janssen Pharmaceutica Nv | 4-cyano-n-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetramethyltetrahydro-2h-pyran-4-yl)pyridin-3-yl)-1h-imidazole-2-carboxamide for the treatment of hodgkin's lymphoma |
EP2968297B1 (en) | 2013-03-15 | 2018-09-26 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
MX2015011567A (en) | 2013-03-15 | 2016-04-25 | Verseon Corp | Halogenopyrazoles as inhibitors of thrombin. |
PE20151997A1 (en) | 2013-03-15 | 2016-01-13 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND USES OF THEM |
US20160082015A1 (en) * | 2013-04-18 | 2016-03-24 | President And Fellows Of Harvard College | Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders |
KR20160013028A (en) | 2013-05-30 | 2016-02-03 | 플렉시콘, 인코퍼레이티드 | Compounds for kinase modulation, and indications therefor |
AU2014337122B2 (en) | 2013-10-18 | 2019-01-03 | Dana-Farber Cancer Institute, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
US10047070B2 (en) | 2013-10-18 | 2018-08-14 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
CN104710417B (en) * | 2013-12-11 | 2020-09-08 | 上海科州药物研发有限公司 | Azaindole derivatives and synthesis method thereof |
WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US10017477B2 (en) | 2014-04-23 | 2018-07-10 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
AR101106A1 (en) | 2014-07-02 | 2016-11-23 | Pharmacyclics Llc | BRUTON THYROSINE QUINASE INHIBITORS |
ES2774177T3 (en) | 2014-09-15 | 2020-07-17 | Plexxikon Inc | Heterocyclic compounds and uses of these |
SG11201701940UA (en) | 2014-09-17 | 2017-04-27 | Verseon Corp | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
EP3009435B1 (en) * | 2014-10-15 | 2016-08-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban |
WO2016105528A2 (en) | 2014-12-23 | 2016-06-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
CA2977993A1 (en) | 2015-02-27 | 2016-09-01 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
WO2016164641A1 (en) | 2015-04-08 | 2016-10-13 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
ES2820827T3 (en) * | 2015-05-06 | 2021-04-22 | Plexxikon Inc | Solid forms of a kinase modulator compound |
CN107531706A (en) * | 2015-05-06 | 2018-01-02 | 普莱希科公司 | Adjust the synthesis of 1H pyrrolo-es [2,3 b] pyridine derivate of kinases |
WO2016188816A1 (en) | 2015-05-22 | 2016-12-01 | Ucb Biopharma Sprl | Treatment of epilepsy |
WO2016191296A1 (en) | 2015-05-22 | 2016-12-01 | Plexxikon Inc. | Plx-8394 or plx-7904 for use in the treatment of braf-v600-related diseases |
CN107771178B (en) | 2015-05-22 | 2021-04-06 | 普莱希科公司 | Synthesis of heterocyclic compounds |
CA2987179C (en) * | 2015-05-29 | 2020-08-25 | Pfizer Inc. | Heterocyclic compounds as inhibitors of vanin-1 enzyme |
US10702527B2 (en) | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
SG10201912699RA (en) * | 2015-07-20 | 2020-02-27 | Genzyme Corp | Colony stimulating factor-1 receptor (csf-1r) inhibitors |
WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP3347018B1 (en) | 2015-09-09 | 2021-09-01 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
CN108137585B (en) | 2015-09-21 | 2021-10-22 | 普莱希科公司 | Heterocyclic compounds and their use |
CA3007462C (en) | 2015-12-07 | 2023-10-24 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP3430005B1 (en) | 2016-03-16 | 2021-12-08 | Plexxikon Inc. | Compounds and methods for kinase modulation and indications therefore |
CN109153677B (en) * | 2016-06-17 | 2021-03-12 | 苏州科睿思制药有限公司 | Hydrochloride crystal form of PLX3397 and preparation method and application thereof |
TW201815766A (en) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | Compounds and methods for IDO and TDO modulation, and indications therefor |
AU2017342928B2 (en) * | 2016-10-10 | 2021-09-09 | Development Center For Biotechnology | Quinoxaline compounds as type III receptor tyrosine kinase inhibitors |
MA46716A (en) | 2016-11-03 | 2019-09-11 | Juno Therapeutics Inc | CELL THERAPY AND MICROGLIA INHIBITOR POLYTHERAPY |
JP7193460B2 (en) | 2016-12-23 | 2022-12-20 | プレキシコン インコーポレーテッド | Compounds and methods for CDK8 modulation and indications thereof |
WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
ES2896502T3 (en) | 2017-03-20 | 2022-02-24 | Plexxikon Inc | Crystal forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1H-pyrrolo[3,2-b]pyridin acid -3- yl)benzoic that inhibit the bromodomain |
KR101798840B1 (en) * | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | Novel Compounds as Autotaxin Inhibitors and Pharmaceutical Compositions Comprising the Same |
US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
EP3630132A1 (en) | 2017-06-02 | 2020-04-08 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
US11740231B2 (en) | 2017-06-02 | 2023-08-29 | Juno Therapeutics, Inc. | Articles of manufacture and methods related to toxicity associated with cell therapy |
US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
JP7131837B2 (en) * | 2017-06-19 | 2022-09-06 | アビスコ セラピューティクス カンパニー リミテッド | AZAaryl DERIVATIVE HAVING CSF-1R INHIBITING ACTIVITY, PRODUCTION AND APPLICATION THEREOF |
CN111050545A (en) | 2017-06-29 | 2020-04-21 | 朱诺治疗学股份有限公司 | Mouse model for evaluating toxicity associated with immunotherapy |
AU2018307910A1 (en) * | 2017-07-25 | 2020-01-23 | Daiichi Sankyo Company, Limited | Formulations of a compound modulating kinases |
WO2019046832A1 (en) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | Gene expression and assessment of risk of developing toxicity following cell therapy |
US10717735B2 (en) | 2017-10-13 | 2020-07-21 | Plexxikon Inc. | Solid forms of a compound for modulating kinases |
CN112165958A (en) | 2017-10-27 | 2021-01-01 | 普莱希科公司 | Formulations of compounds for modulating kinases |
US11564946B2 (en) | 2017-11-01 | 2023-01-31 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
BR112020015072A2 (en) | 2018-01-31 | 2021-01-05 | Heparegenix Gmbh | PROTEIN KINASE MKK4 INHIBITORS TO PROMOTE LIVER REGENERATION, OR REDUCE, OR PREVENT HEPATOCYT DEATH |
JP2021518367A (en) | 2018-03-20 | 2021-08-02 | プレキシコン インコーポレーテッドPlexxikon Inc. | Compounds and methods for IDO and TDO regulation, and signs for them |
US11731968B2 (en) | 2018-06-21 | 2023-08-22 | Heparegenix Gmbh | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
JP7365393B2 (en) | 2018-07-16 | 2023-10-19 | ヘパリジェニックス ゲーエムベーハー | Protein kinase inhibitors for promoting liver regeneration or suppressing or preventing hepatocyte death |
CN110845476B (en) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | High-selectivity CSF1R inhibitor, preparation method and pharmaceutical application thereof |
US11142525B2 (en) | 2018-11-15 | 2021-10-12 | Pfizer Inc. | Azalactam compounds as HPK1 inhibitors |
JP2022513689A (en) | 2018-11-30 | 2022-02-09 | ジュノー セラピューティクス インコーポレイテッド | Methods for Administration and Treatment of B-Cell Malignancies in Adoptive Cell Therapy |
CA3120869A1 (en) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
US20220162206A1 (en) * | 2019-03-29 | 2022-05-26 | Kowa Company, Ltd. | Novel azaindole derivative |
AU2020271836A1 (en) | 2019-04-09 | 2021-10-28 | Opna Bio SA | Condensed azines for EP300 or CBP modulation and indications therefor |
US20230053787A1 (en) | 2019-12-06 | 2023-02-23 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating b cell malignancies |
CN111233857B (en) * | 2020-01-16 | 2021-01-08 | 河南应用技术职业学院 | Synthetic method for continuously producing pexidininib |
WO2021144360A1 (en) | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Small molecule csf-1r inhibitors in therapeutic and cosmetic uses |
CN113444083A (en) * | 2020-03-25 | 2021-09-28 | 上海天慈国际药业有限公司 | Preparation method of small molecule tyrosine kinase inhibitor |
AR121846A1 (en) * | 2020-04-16 | 2022-07-13 | Teijin Pharma Ltd | DERIVATIVE OF ARYL OR HETEROARYL |
EP4139296A1 (en) | 2020-04-23 | 2023-03-01 | Opna Immuno Oncology, SA | Compounds and methods for cd73 modulation and indications therefor |
MX2022013401A (en) | 2020-05-01 | 2022-11-14 | Pfizer | Azalactam compounds as hpk1 inhibitors. |
CN116322690A (en) | 2020-08-21 | 2023-06-23 | 奥普纳生物有限公司 | Combination pharmaceutical anticancer therapies |
US20240092774A1 (en) * | 2020-09-21 | 2024-03-21 | Hutchison Medipharma Limited | Heteroaromatic compounds and uses thereof |
CN112409353A (en) * | 2020-11-27 | 2021-02-26 | 苏州艾缇克药物化学有限公司 | Preparation method of 7-azaindole derivative |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
CN117377657A (en) | 2021-06-15 | 2024-01-09 | 庄信万丰股份有限公司 | Method for preparing pexidasatinib |
CN113816956A (en) * | 2021-10-26 | 2021-12-21 | 湖北工业大学 | Synthesis method of pexidaltinib |
WO2023081923A1 (en) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
CN114736204A (en) * | 2022-05-06 | 2022-07-12 | 湖北工业大学 | Preparation method of pexidaltinib structural analogue and application of pexidaltinib structural analogue in tumor resistance |
WO2024011253A1 (en) | 2022-07-08 | 2024-01-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Impeding platinum-based chemotherapeutic induced ototoxicity using a colony stimulating factor 1 receptor inhibitor |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997049703A2 (en) * | 1996-06-25 | 1997-12-31 | Takeda Chemical Industries, Ltd. | Oxazolone derivatives and their use as anti-helicobacter pylori agents |
WO2005062795A2 (en) * | 2003-12-19 | 2005-07-14 | Plexxikon, Inc. | Compounds and methods for development of ret modulators |
WO2006009797A1 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
WO2007013896A2 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
WO2007106236A2 (en) * | 2006-02-27 | 2007-09-20 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
Family Cites Families (326)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB145299A (en) | 1919-08-14 | 1920-07-02 | Carl Theodor Thorssell | Improvements in or relating to apparatus for the production of nitrogen products |
US2234705A (en) | 1940-04-12 | 1941-03-11 | Eastman Kodak Co | Cellulose organic derivative composition containing esters of monoalkoxy benzoic acids |
US2413258A (en) | 1942-07-07 | 1946-12-24 | United Gas Improvement Co | Polystyrene-type resins plasticized with high boiling fatty acid alkyl esters |
GB1198301A (en) | 1966-10-21 | 1970-07-08 | Minnesota Mining & Mfg | Perfluoroalkylsulfonamides |
AU7915675A (en) | 1974-03-20 | 1976-09-23 | Bayer Ag | Alkoxycarbonylphenylureas |
DE2413258A1 (en) | 1974-03-20 | 1975-10-02 | Bayer Ag | Herbicidal N-(alkoxycarbonyl-phenyl)-N'-methyl-urea derivs - prepd by reacting alkoxycarbonyl-phenyl isocyanates with methylamines |
GB1573212A (en) | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
US4301159A (en) | 1980-06-20 | 1981-11-17 | Shionogi & Co., Ltd. | N-(Diethylaminoethyl)-2-alkoxy-benzamide derivatives |
AU547405B2 (en) | 1981-07-08 | 1985-10-17 | Sanofi | Amidobenzamides |
US4664504A (en) | 1983-01-20 | 1987-05-12 | Tokyo Shibaura Denki Kabushiki Kaisha | Image forming apparatus |
US4568649A (en) | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
US4626513A (en) | 1983-11-10 | 1986-12-02 | Massachusetts General Hospital | Method and apparatus for ligand detection |
AU567140B2 (en) | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
EP0154734B1 (en) | 1984-03-15 | 1990-08-29 | Immunex Corporation | Immediate ligand detection assay, a test kit and its formation |
IT1196133B (en) | 1984-06-06 | 1988-11-10 | Ausonia Farma Srl | FURANIC DERIVATIVES WITH ANTI-ULCER ACTIVITY |
US4714693A (en) | 1986-04-03 | 1987-12-22 | Uop Inc. | Method of making a catalyst composition comprising uniform size metal components on carrier |
DE3642315A1 (en) | 1986-12-11 | 1988-06-23 | Boehringer Mannheim Gmbh | NEW PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
US5688655A (en) | 1988-02-10 | 1997-11-18 | Ict Pharmaceuticals, Inc. | Method of screening for protein inhibitors and activators |
US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US5658775A (en) | 1988-05-17 | 1997-08-19 | Sloan-Kettering Institute For Cancer Research | Double copy retroviral vector |
JP2528706B2 (en) | 1988-05-30 | 1996-08-28 | ゼリア新薬工業株式会社 | Pharmaceutical composition of dihydropyridine compound |
WO1990002806A1 (en) | 1988-09-01 | 1990-03-22 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
AU7906691A (en) | 1990-05-23 | 1991-12-10 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Adeno-associated virus (aav)-based eucaryotic vectors |
DE4022414A1 (en) | 1990-07-13 | 1992-01-16 | Bayer Ag | SUBSTITUTED PYRROLO-PYRIDINE |
US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
ES2111065T5 (en) | 1991-04-16 | 2005-06-16 | Nippon Shinyaku Company, Limited | PROCEDURE TO PRODUCE A SOLID DISPERSION. |
EP0659209A1 (en) | 1991-07-26 | 1995-06-28 | The University Of Rochester | Cancer therapy utilizing malignant cells |
US5632957A (en) | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
GB9127531D0 (en) | 1991-12-31 | 1992-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compound |
FR2687402B1 (en) | 1992-02-14 | 1995-06-30 | Lipha | NOVEL AZAINDOLES, METHODS OF PREPARATION AND MEDICAMENTS CONTAINING THEM. |
JPH05236997A (en) | 1992-02-28 | 1993-09-17 | Hitachi Ltd | Chip for catching polynucleotide |
JPH06135946A (en) | 1992-10-30 | 1994-05-17 | Otsuka Pharmaceut Co Ltd | Pyrazine derivative |
AU686115B2 (en) | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
ES2134929T3 (en) | 1993-03-01 | 1999-10-16 | Merck Sharp & Dohme | PIRROLO-PIRIDINA DERIVATIVES AS LINKS FOR DOPAMINE RECEPTORS. |
AU679040B2 (en) | 1993-03-01 | 1997-06-19 | Merck Sharp & Dohme Limited | Pyrrolo-pyridine derivatives as dopamine receptor ligands |
WO1994020497A1 (en) | 1993-03-01 | 1994-09-15 | Merck Sharp & Dohme Limited | Pyrrolo-pyridine derivatives |
US5576319A (en) | 1993-03-01 | 1996-11-19 | Merck, Sharp & Dohme Ltd. | Pyrrolo-pyridine derivatives |
US5840485A (en) | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
ES2289194T3 (en) | 1993-05-27 | 2008-02-01 | Aventis Pharmaceuticals Inc. | SOLID PHASE LIBRARIES CODED, TOPOLOGICALLY SECREGATED. |
IT1265057B1 (en) | 1993-08-05 | 1996-10-28 | Dompe Spa | TROPIL 7-AZAINDOLIL-3-CARBOXYAMIDE |
US5631236A (en) | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US5426039A (en) | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
GB9319297D0 (en) | 1993-09-17 | 1993-11-03 | Wellcome Found | Indole derivatives |
US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
US5965452A (en) | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
US6468742B2 (en) | 1993-11-01 | 2002-10-22 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
US5486525A (en) | 1993-12-16 | 1996-01-23 | Abbott Laboratories | Platelet activating factor antagonists: imidazopyridine indoles |
US5360882A (en) | 1994-02-04 | 1994-11-01 | Isp Investments Inc. | Eutectic compositions of divinyl imidazolidone and vinyl caprolactam |
EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
GB9408577D0 (en) | 1994-04-29 | 1994-06-22 | Fujisawa Pharmaceutical Co | New compound |
US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
US5763198A (en) | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
GB9416189D0 (en) | 1994-08-10 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
US5830901A (en) | 1994-08-10 | 1998-11-03 | Merch Sharp & Dohme Ltd | Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-B!pyridine |
GB9416162D0 (en) | 1994-08-10 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
GB9420521D0 (en) | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
US5556752A (en) | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5830645A (en) | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5837815A (en) | 1994-12-15 | 1998-11-17 | Sugen, Inc. | PYK2 related polypeptide products |
GB9503400D0 (en) | 1995-02-21 | 1995-04-12 | Merck Sharp & Dohme | Therpeutic agents |
GB2298199A (en) | 1995-02-21 | 1996-08-28 | Merck Sharp & Dohme | Synthesis of azaindoles |
US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US6117681A (en) | 1995-03-29 | 2000-09-12 | Bavarian Nordic Research Inst. A/S | Pseudotyped retroviral particles |
GB9507291D0 (en) | 1995-04-07 | 1995-05-31 | Merck Sharp & Dohme | Therapeutic agents |
GB2299581A (en) | 1995-04-07 | 1996-10-09 | Merck Sharp & Dohme | 3-(Tetrahydropyridin-1-yl-methyl)pyrrolo[2,3-b]pyridine derivatives as ligands for dopamine receptor subtypes |
GB9511220D0 (en) | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
US6110456A (en) | 1995-06-07 | 2000-08-29 | Yale University | Oral delivery or adeno-associated viral vectors |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
WO1997003967A1 (en) | 1995-07-22 | 1997-02-06 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
US5866411A (en) | 1995-09-08 | 1999-02-02 | Pedersen; Finn Skou | Retroviral vector, a replication system for said vector and avian or mammalian cells transfected with said vector |
US5747276A (en) | 1995-09-15 | 1998-05-05 | The Scripps Research Institute | Screening methods for the identification of novel antibiotics |
US5721118A (en) | 1995-10-31 | 1998-02-24 | The Regents Of The University Of California, San Diego | Mammalian artificial chromosomes and methods of using same |
US6022963A (en) | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
US6013440A (en) | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
US6025155A (en) | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US5908401A (en) | 1996-05-08 | 1999-06-01 | The Aps Organization, Llp | Method for iontophoretic delivery of antiviral agents |
US5725838A (en) | 1996-05-31 | 1998-03-10 | Resolution Pharmaceuticals, Inc. | Radiolabeled D4 receptor ligands |
WO1997046313A1 (en) | 1996-06-07 | 1997-12-11 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
CA2263425C (en) | 1996-08-12 | 2008-09-30 | Yoshitomi Pharmaceutical Industries Ltd. | Pharmaceutical agent containing rho kinase inhibitor |
JPH10130269A (en) | 1996-09-04 | 1998-05-19 | Nippon Chemiphar Co Ltd | Carboline derivative |
JPH1087629A (en) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | New isoquinoline derivative, and its medicinal use |
HUP9903330A2 (en) | 1996-11-19 | 2000-03-28 | Amgen Inc. | Aryl and heteroaryl substituted fused pyrrole derivatives, as antiinflammatory agents containing the same |
US6294330B1 (en) | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
AU6443498A (en) | 1997-03-07 | 1998-09-22 | Tropix, Inc. | Protease inhibtor assay |
US5977131A (en) | 1997-04-09 | 1999-11-02 | Pfizer Inc. | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents |
WO1998047899A1 (en) | 1997-04-24 | 1998-10-29 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
US6096718A (en) | 1997-06-05 | 2000-08-01 | Gene Targeting Corp. | Tissue specific adenovirus vectors for breast cancer treatment |
SG72827A1 (en) | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
AU8096798A (en) | 1997-06-27 | 1999-01-19 | Resolution Pharmaceuticals Inc. | Dopamine d4 receptor ligands |
US6235769B1 (en) | 1997-07-03 | 2001-05-22 | Sugen, Inc. | Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase |
US6826296B2 (en) | 1997-07-25 | 2004-11-30 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
DK0901786T3 (en) | 1997-08-11 | 2007-10-08 | Pfizer Prod Inc | Solid pharmaceutical dispersions with increased bioavailability |
US6161776A (en) | 1997-08-12 | 2000-12-19 | Nibco Inc. | Multi-layered, porous mat turf irrigation apparatus and method |
JP2001514906A (en) | 1997-08-15 | 2001-09-18 | ハイセック,インコーポレーテッド | Methods and compositions for detecting or quantifying nucleic acid species |
JP2001515735A (en) | 1997-09-11 | 2001-09-25 | ジェノベイションズ, インコーポレイテッド | Method of making high-density array |
US6178384B1 (en) | 1997-09-29 | 2001-01-23 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for selecting a molecule based on conformational free energy |
US6465178B2 (en) | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
IL136767A0 (en) | 1997-12-22 | 2001-06-14 | Bayer Ag | Inhibition of raf kinase using substituted heterocyclic ureas |
US6268387B1 (en) | 1997-12-23 | 2001-07-31 | Warner-Lambert Company | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis |
GB9800569D0 (en) | 1998-01-12 | 1998-03-11 | Glaxo Group Ltd | Heterocyclic compounds |
CA2326185A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU3368299A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
JP2002510685A (en) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
AU3118399A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU3210899A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
JP2002510628A (en) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
EP1068356B8 (en) | 1998-04-03 | 2007-01-03 | Adnexus Therapeutics, Inc. | Addressable protein arrays |
US6048695A (en) | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
CA2319495A1 (en) | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
US6113913A (en) | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
CA2339664A1 (en) | 1998-08-28 | 2000-03-09 | Astrazeneca Ab | Thieno{2,3,-d}pyrimidinedione derivatives and their use as immunosuppressants |
US6410540B1 (en) | 1998-08-28 | 2002-06-25 | Scios, Inc. | Inhibitors of p38-αkinase |
JP2002527359A (en) | 1998-09-18 | 2002-08-27 | ビーエーエスエフ アクチェンゲゼルシャフト | 4-aminopyrrolipyrimidine as a kinase inhibitor |
US6594527B2 (en) | 1998-09-18 | 2003-07-15 | Nexmed Holdings, Inc. | Electrical stimulation apparatus and method |
US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
US6277628B1 (en) | 1998-10-02 | 2001-08-21 | Incyte Genomics, Inc. | Linear microarrays |
IT1303759B1 (en) | 1998-11-17 | 2001-02-23 | Dompe Spa | IMPROVED PROCEDURE FOR THE PREPARATION OF 7-AZAINDOLYL-3-CARBOXYLIC ACID. |
US6277489B1 (en) | 1998-12-04 | 2001-08-21 | The Regents Of The University Of California | Support for high performance affinity chromatography and other uses |
US20010001449A1 (en) | 1998-12-30 | 2001-05-24 | Thomas R. Kiliany | Low-pressure hydrocracking process |
AU771920B2 (en) | 1999-03-05 | 2004-04-08 | Daiichi Suntory Pharma Co., Ltd | Heterocyclic compounds having effect of activating nicotinic acetylcholine alpha4beta2 receptor |
US6792306B2 (en) | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
CA2368097C (en) | 1999-03-17 | 2010-01-19 | Astrazeneca Ab | Amide derivatives of 3,4-dihydroquinazolinone compounds useful as cytokine inhibitors |
AR028475A1 (en) | 1999-04-22 | 2003-05-14 | Wyeth Corp | DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. |
US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
US6221653B1 (en) | 1999-04-27 | 2001-04-24 | Agilent Technologies, Inc. | Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids |
FR2793793B1 (en) | 1999-05-19 | 2004-02-27 | Adir | NOVEL SUBSTITUTED DIMERIC DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
TWI234557B (en) | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
US7049312B1 (en) | 1999-06-03 | 2006-05-23 | Abbott Gmbh & Co. Kg | Benzothiazinone and benzoxazinone compounds |
CA2380644A1 (en) | 1999-07-30 | 2001-02-08 | Basf Aktiengesellschaft | 2-pyrazolin-5-ones |
US6653151B2 (en) | 1999-07-30 | 2003-11-25 | Large Scale Proteomics Corporation | Dry deposition of materials for microarrays using matrix displacement |
WO2001024236A1 (en) | 1999-09-27 | 2001-04-05 | Infineon Technologies North America Corp. | Semiconductor structures having a capacitor and manufacturing methods |
GB9924962D0 (en) | 1999-10-21 | 1999-12-22 | Mrc Collaborative Centre | Allosteric sites on muscarinic receptors |
US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
EP1106603A3 (en) | 1999-12-06 | 2003-11-19 | Fuji Photo Film Co., Ltd. | DNA chip and reactive solid carrier |
WO2001046196A1 (en) | 1999-12-21 | 2001-06-28 | Sugen, Inc. | 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors |
DE60029138T2 (en) | 1999-12-22 | 2007-06-06 | Sugen, Inc., San Francisco | Use of indolinone compounds for the production of pharmaceuticals for the modulation of the function c-kit protein tyrosine kinase |
FR2805259B1 (en) | 2000-02-17 | 2002-03-29 | Inst Nat Sante Rech Med | NOVEL N-MERCAPTOACYL AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US20020061892A1 (en) | 2000-02-22 | 2002-05-23 | Tao Wang | Antiviral azaindole derivatives |
JP2001278886A (en) | 2000-03-28 | 2001-10-10 | Dai Ichi Seiyaku Co Ltd | Benzoxazine derivative and medicament containing the same |
GB0007934D0 (en) | 2000-03-31 | 2000-05-17 | Darwin Discovery Ltd | Chemical compounds |
US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
UA74370C2 (en) | 2000-06-26 | 2005-12-15 | Пфайзер Продактс Інк. | Pyrrole(2,3-d)pyrimidine compounds as immunosuppressors |
AU2001266575A1 (en) | 2000-06-26 | 2002-01-08 | Lilly Icos Llc | Chemical compounds |
EA200300205A1 (en) | 2000-08-31 | 2003-06-26 | Пфайзер Продактс Инк. | DERIVATIVES OF PYRAZOL AND THEIR APPLICATION AS PROTEINKINASE INHIBITORS |
US6618625B2 (en) | 2000-11-29 | 2003-09-09 | Leon M. Silverstone | Method and apparatus for treatment of viral diseases |
KR20030077042A (en) | 2001-02-27 | 2003-09-29 | 아스트라제네카 아베 | Pharmaceutical formulation comprising bicalutamide |
GB0107368D0 (en) | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
CN100411686C (en) | 2001-04-11 | 2008-08-20 | 千寿制药株式会社 | Visual function improving agents |
AU2002258971A1 (en) | 2001-04-24 | 2002-11-05 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
JP2004536057A (en) | 2001-05-11 | 2004-12-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | Derivatives of 2,5-disubstituted pyridines, pyrimidines, pyridazines and 1,2,4-triazines used as p38 inhibitors |
GB0114417D0 (en) | 2001-06-13 | 2001-08-08 | Boc Group Plc | Lubricating systems for regenerative vacuum pumps |
EP1267111A1 (en) | 2001-06-15 | 2002-12-18 | Dsm N.V. | Pressurized fluid conduit |
WO2002102783A1 (en) | 2001-06-19 | 2002-12-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
SE0102300D0 (en) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
US20030091974A1 (en) | 2001-06-29 | 2003-05-15 | Alain Moussy | Method for screening compounds capable of depleting mast cells |
SE0102439D0 (en) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
UA75425C2 (en) | 2001-07-09 | 2006-04-17 | Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds | |
GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
US6858860B2 (en) | 2001-07-24 | 2005-02-22 | Seiko Epson Corporation | Apparatus and method for measuring natural period of liquid |
GB0118479D0 (en) | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
AU2002334355A1 (en) | 2001-09-06 | 2003-03-18 | Prochon Biotech Ltd. | Protein tyrosine kinase inhibitors |
WO2003028724A1 (en) | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
EP1452525A4 (en) | 2001-10-30 | 2005-01-26 | Nippon Shinyaku Co Ltd | Amide derivatives and drugs |
US20030119839A1 (en) | 2001-12-13 | 2003-06-26 | Nan-Horng Lin | Protein kinase inhibitors |
GEP20063909B (en) | 2002-01-22 | 2006-08-25 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES |
CA2473572C (en) | 2002-02-01 | 2011-05-10 | Astrazeneca Ab | Quinazoline compounds |
US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
US20040171062A1 (en) | 2002-02-28 | 2004-09-02 | Plexxikon, Inc. | Methods for the design of molecular scaffolds and ligands |
FR2836914B1 (en) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
US6884889B2 (en) | 2002-03-25 | 2005-04-26 | Bristol-Myers Squibb Co. | Processes for the preparation of antiviral 7-azaindole derivatives |
AU2003214412A1 (en) | 2002-03-28 | 2003-10-13 | Eisai R & D Management Co., Ltd. | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders |
US7291630B2 (en) | 2002-03-28 | 2007-11-06 | Eisai Co., Ltd. | Azaindoles as inhibitors of c-Jun N-terminal kinases |
EP1495016A2 (en) | 2002-04-09 | 2005-01-12 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
AU2003247959B2 (en) | 2002-07-09 | 2010-07-29 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
US6878887B2 (en) | 2002-08-07 | 2005-04-12 | Matsushita Electric Industrial Co., Ltd. | Anti-malfunction mechanism for variable output device |
EP1388541A1 (en) | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
SE0202463D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
ES2377318T3 (en) | 2002-09-06 | 2012-03-26 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for the delivery of covalently bound therapeutic agents to them |
WO2004024895A2 (en) | 2002-09-16 | 2004-03-25 | Plexxikon, Inc. | Crystal structure of pim-1 kinase |
US6766199B2 (en) | 2002-10-10 | 2004-07-20 | Proventure (Far East), Limited | Skin/hair treatment method and system |
US7183241B2 (en) | 2002-10-15 | 2007-02-27 | Exxonmobil Research And Engineering Company | Long life lubricating oil composition with very low phosphorus content |
GB0226370D0 (en) | 2002-11-12 | 2002-12-18 | Novartis Ag | Organic compounds |
SE0203654D0 (en) | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
EP1569647B1 (en) | 2002-12-13 | 2008-08-20 | Smithkline Beecham Corporation | Cyclohexyl compounds as ccr5 antagonists |
BR0317230A (en) | 2002-12-13 | 2005-10-25 | Smithkline Beecham Corp | Compound, composition, methods of antagonizing a ccr-5 chemokine receptor activity, and treating a viral infection in a patient, and use of a compound |
UA80171C2 (en) | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
US7696225B2 (en) | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
SE0300120D0 (en) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
SE0300119D0 (en) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
US20050085463A1 (en) | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
US20050048573A1 (en) | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
CN101091695B (en) | 2003-02-03 | 2011-01-19 | 诺瓦提斯公司 | Pharmaceutical formulation |
JP2006517966A (en) | 2003-02-14 | 2006-08-03 | ワイス | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
SE0300456D0 (en) | 2003-02-19 | 2003-02-19 | Astrazeneca Ab | Novel compounds |
JP2007524374A (en) | 2003-02-28 | 2007-08-30 | プレキシコン,インコーポレーテッド | PYK2 crystal structure and use |
EP1599475A2 (en) | 2003-03-06 | 2005-11-30 | Eisai Co., Ltd. | Jnk inhibitors |
US7612086B2 (en) | 2003-05-16 | 2009-11-03 | Eisai R & D Management Co. Ltd. | JNK inhibitors |
US20050079548A1 (en) | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
PL1648889T3 (en) | 2003-07-11 | 2009-03-31 | Warner Lambert Co | Isethionate salt of a selective cdk4 inhibitor |
DK1648867T3 (en) | 2003-07-17 | 2013-12-16 | Plexxikon Inc | PPAR ACTIVE CONNECTIONS |
US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
CL2004001884A1 (en) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS. |
AR045595A1 (en) | 2003-09-04 | 2005-11-02 | Vertex Pharma | USEFUL COMPOSITIONS AS INHIBITORS OF KINASE PROTEINS |
WO2005044181A2 (en) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors |
WO2005028624A2 (en) | 2003-09-15 | 2005-03-31 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
JP2007506741A (en) | 2003-09-23 | 2007-03-22 | メルク エンド カムパニー インコーポレーテッド | Pyrazole modulators of metabotropic glutamate receptors |
KR100793095B1 (en) | 2003-10-01 | 2008-01-10 | 주식회사 프로메디텍 | Novel Sulfone Amide Derivatives Capable Of Inhibiting BACE |
MXPA06003996A (en) | 2003-10-08 | 2006-07-05 | Irm Llc | Compounds and compositions as protein kinase inhibitors. |
DE10357510A1 (en) | 2003-12-09 | 2005-07-07 | Bayer Healthcare Ag | Heteroaryl-substituted benzenes |
US7517970B2 (en) | 2003-12-19 | 2009-04-14 | Plexxikon, Inc. | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same |
US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
CA2550800A1 (en) | 2003-12-24 | 2005-07-21 | Danisco A/S | Methods to produce variant glycolipid acyltransferases and variant glycolipid acyltransferases with enhanced activity towards glycolipids. |
GB0330042D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
GB0330043D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
CN1918158B (en) | 2004-02-14 | 2011-03-02 | Irm责任有限公司 | Compounds and compositions as protein kinase inhibitors |
GB0403635D0 (en) | 2004-02-18 | 2004-03-24 | Devgen Nv | Pyridinocarboxamides with improved activity as kinase inhibitors |
JP4866723B2 (en) | 2004-02-26 | 2012-02-01 | 協和発酵キリン株式会社 | Preventive and / or therapeutic agent for neutrophilic inflammatory disease |
GB0405055D0 (en) | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
WO2005086904A2 (en) | 2004-03-08 | 2005-09-22 | Amgen Inc. | Therapeutic modulation of ppar (gamma) activity |
KR20050091462A (en) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | Furopyrimidine compound and ddr2 tyrosine kinase activity inhibitor comprising the same |
RS51830B (en) | 2004-03-30 | 2012-02-29 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of jak and other protein kinases |
CA2561724A1 (en) | 2004-04-02 | 2005-11-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
WO2006078287A2 (en) | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Pde4b inhibitors and uses therefor |
EP1773305A2 (en) | 2004-05-25 | 2007-04-18 | Yale University Corporation | Method for treating skeletal disorders resulting from fgfr malfunction |
EP1773836B1 (en) | 2004-05-27 | 2012-09-05 | Pfizer Products Inc. | Pyrrolopyrimidine derivatives useful in cancer treatment |
US20090105218A1 (en) | 2004-05-29 | 2009-04-23 | 7Tm Pharma A/S | CRTH2 Receptor Ligands For Therapeutic Use |
US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
WO2006004984A1 (en) | 2004-06-30 | 2006-01-12 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of protein kinases |
US7140816B2 (en) | 2004-07-20 | 2006-11-28 | H&S Tool, Inc. | Multi-functional tube milling head |
EP2264033A1 (en) | 2004-07-27 | 2010-12-22 | SGX Pharmaceuticals, Inc. | 3,5-DIPHENYL-SUBSTITUTED PYRROLO[2,3b]PYRIDINES USEFUL AS KINASE INHIBITORS |
US7626021B2 (en) | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
US7709645B2 (en) | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
SG156685A1 (en) | 2004-07-27 | 2009-11-26 | Sgx Pharmaceuticals Inc | Fused ring heterocycle kinase modulators |
US20060024361A1 (en) | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
US20090196912A1 (en) | 2004-07-30 | 2009-08-06 | Gpc Botech Ag | Pyridinylamines |
EP1786813A2 (en) | 2004-09-03 | 2007-05-23 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
AU2005311826A1 (en) | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as PPAR active compounds |
WO2006060456A2 (en) | 2004-11-30 | 2006-06-08 | Plexxikon, Inc. | Indole derivatives for use as ppar ppar active compounds |
US20060160135A1 (en) | 2004-12-08 | 2006-07-20 | Weiru Wang | SF-1 and LRH-1 modulator development |
EP1828180A4 (en) | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1h-pyrrolo[2,3-beta]pyridines |
WO2006114180A1 (en) | 2005-04-25 | 2006-11-02 | Merck Patent Gmbh | Novel aza- heterocycles serving as kinase inhibitors |
FR2884821B1 (en) | 2005-04-26 | 2007-07-06 | Aventis Pharma Sa | SUBSTITUTED PYRROLOPYRIDINES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
CA2609126A1 (en) | 2005-05-20 | 2006-11-30 | Vertex Pharmaceuticals Incorporated | Pyrrolopyridines useful as inhibitors of protein kinase |
JP2008507567A (en) | 2005-05-23 | 2008-03-13 | テバ ファーマシューティカル インダストリーズ リミティド | Amorphous cinacalcet hydrochloride and its preparation |
MX295245B (en) | 2005-06-21 | 2012-01-26 | Mitsui Chemicals Inc | Amide derivative and pesticide containing such compound. |
NZ565255A (en) | 2005-06-22 | 2010-04-30 | Plexxikon Inc | Pyrrolo[2,3-b] pyridine derivatives as protein kinase inhibitors |
DE102005034406A1 (en) | 2005-07-22 | 2007-02-01 | Ratiopharm Gmbh | New salts of rosiglitazone |
GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
JP2009507846A (en) | 2005-09-07 | 2009-02-26 | プレキシコン,インコーポレーテッド | PPAR active compounds |
NZ567162A (en) | 2005-09-07 | 2011-06-30 | Plexxikon Inc | 1, 3-disubstituted indole derivatives for use as PPAR modulators |
AU2006287528A1 (en) | 2005-09-07 | 2007-03-15 | Plexxikon, Inc. | 1 , 4 and 1 , 5-disubstituted indole derivatives for use as PPAR active compounds |
CN101494979A (en) | 2006-03-20 | 2009-07-29 | 沃泰克斯药物股份有限公司 | Pharmaceutical compositions |
US7963673B2 (en) | 2006-05-30 | 2011-06-21 | Finn Bruce L | Versatile illumination system |
EP2099774A4 (en) | 2006-11-15 | 2010-11-24 | Ym Biosciences Australia Pty L | Inhibitors of kinase activity |
WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
GB0624084D0 (en) | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amino acid salts |
US8093246B2 (en) | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
WO2008079909A1 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
WO2008080015A2 (en) | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
PE20081581A1 (en) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | PIRROLO [2,3-b] PYRIDINES COMPOUNDS AS KINASE MODULATORS |
PE20090159A1 (en) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | INDOL-PROPIONIC ACID DERIVED COMPOUNDS AS PPARs MODULATORS |
US20080221127A1 (en) | 2007-03-08 | 2008-09-11 | Plexxikon Inc | Ppar active compounds |
CN101702878B (en) | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | Pharmaceutical compositions for poorly soluble drugs |
CL2008001540A1 (en) | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compounds derived from pyrrolopyridines and pyrazolopyridines; pharmaceutical composition; and use in the treatment of cancer. |
BRPI0814423B1 (en) | 2007-07-17 | 2022-04-19 | Plexxikon, Inc | Kinase modulating compounds and pharmaceutical composition comprising the same |
BRPI0721883A2 (en) | 2007-07-23 | 2014-02-18 | Pharmathen Sa | PHARMACEUTICAL COMPOSITION CONTAINING DIHYDROPYRIDINE CALCIUM CHANNEL ANTAGONIST AND PROCESS FOR PREPARING THEM |
JP2009077712A (en) | 2007-09-11 | 2009-04-16 | F Hoffmann La Roche Ag | DIAGNOSTIC TEST FOR SUSCEPTIBILITY TO B-Raf KINASE INHIBITOR |
KR20100117686A (en) | 2008-02-29 | 2010-11-03 | 어레이 바이오파마 인크. | Pyrazole [3,4-b] pyridine raf inhibitors |
CA2716947A1 (en) | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | Imidazo [4,5-b] pyridine derivatives used as raf inhibitors |
EP2265574A1 (en) | 2008-02-29 | 2010-12-29 | Array Biopharma, Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
CL2009000447A1 (en) | 2008-02-29 | 2010-01-04 | Array Biopharma Inc Y Genentech Inc | Compounds derived from (1h-pyrrolo {2,3-b} pyridin-5-yl) -sulfonamido-substituted benzamide; preparation procedure; pharmaceutical composition; and its use in the treatment of cancer, through the inhibition of raf. |
WO2009115084A2 (en) | 2008-03-20 | 2009-09-24 | Schebo Biotech Ag | Novel pyrrolopyrimidine derivatives and the use thereof |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
WO2009143018A2 (en) | 2008-05-19 | 2009-11-26 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
PE20091846A1 (en) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | PIRROLO [2,3-d] -PYRIMIDINE DERIVATIVES AS KINE MODULATORS |
WO2009152083A1 (en) | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b] pyrazine derivatives for kinase modulation, and indications therefor |
US8110576B2 (en) | 2008-06-10 | 2012-02-07 | Plexxikon Inc. | Substituted pyrrolo[2,3b]pyrazines and methods for treatment of raf protein kinase-mediated indications |
EP2384326B1 (en) | 2008-08-20 | 2014-04-23 | Zoetis LLC | Pyrrolo[2,3-d]pyrimidine compounds |
AR074199A1 (en) | 2008-11-20 | 2010-12-29 | Glaxosmithkline Llc | COMPOSITE OF 6- (4-PYRIMIDINYL) -1H-INDAZOL, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE IT AND ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OR DECREASE OF CANCER GRAVITY. |
TW201036973A (en) | 2009-03-11 | 2010-10-16 | Plexxikon Inc | Compounds and uses thereof |
WO2010104973A1 (en) | 2009-03-11 | 2010-09-16 | Plexxikon, Inc. | Pyrrolo [2, 3-b] pyridine derivatives for the inhibition of raf kinases |
WO2010111527A1 (en) | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
NZ594398A (en) | 2009-04-03 | 2014-03-28 | Plexxikon Inc | Propane-1-sulfonic acid (3-[5-(4-chloro-phenyl)-1h-pyrrol [2, 3-b] pyridine-3-carbonyl]-2,4-difluoro-phenyl} -amide compositions and uses thereof |
MX2011011735A (en) | 2009-05-04 | 2011-11-29 | Plexxikon Inc | Compounds and methods for inhibition of renin, and indications therefor. |
TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
AU2010315126B2 (en) | 2009-11-06 | 2015-06-25 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
BR112012011792A2 (en) | 2009-11-18 | 2015-10-13 | Plexxikon Inc | "compounds and methods for modulating kinases, and indications thereof" |
KR20120112623A (en) | 2009-12-23 | 2012-10-11 | 플렉시콘, 인코퍼레이티드 | Compounds and methods for kinase modulation, and indications therefor |
TWI510487B (en) | 2010-04-21 | 2015-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
FR2964757B1 (en) | 2010-09-09 | 2013-04-05 | Giroptic | OPTICAL DEVICE FOR CAPTURING IMAGES ACCORDING TO A 360 ° FIELD |
EP2616467A1 (en) | 2010-09-13 | 2013-07-24 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
DK2672967T3 (en) | 2011-02-07 | 2019-01-02 | Plexxikon Inc | RELATIONSHIPS AND METHODS FOR CHINESE MODULATION AND INDICATIONS THEREOF |
AR085279A1 (en) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | SOLID FORMS OF {3- [5- (4-CHLORINE-PHENYL) -1H-PIRROLO [2,3-B] PIRIDINA-3-CARBONIL] -2,4-DIFLUOR-PHENIL} -AMIDE OF PROPANE ACID-1- SULFONIC |
WO2012138809A1 (en) | 2011-04-05 | 2012-10-11 | Dawei Zhang | Heterocyclic compounds as kinase inhibitors |
WO2012158957A2 (en) | 2011-05-17 | 2012-11-22 | Plexxikon Inc. | Kinase modulation and indications therefor |
US20130172375A1 (en) | 2011-12-13 | 2013-07-04 | Hoffmann-La Roche Inc. | Pharmaceutical composition |
US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
DE102012213092B3 (en) | 2012-07-25 | 2013-08-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Transmission device and sensor system |
JP6318156B2 (en) | 2012-09-06 | 2018-04-25 | プレキシコン インコーポレーテッドPlexxikon Inc. | Compounds and methods for modulating kinases and indicators thereof |
ME03000B (en) | 2012-12-21 | 2018-10-20 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
PE20151997A1 (en) | 2013-03-15 | 2016-01-13 | Plexxikon Inc | HETEROCYCLIC COMPOUNDS AND USES OF THEM |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
KR20160013028A (en) | 2013-05-30 | 2016-02-03 | 플렉시콘, 인코퍼레이티드 | Compounds for kinase modulation, and indications therefor |
WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
ES2774177T3 (en) | 2014-09-15 | 2020-07-17 | Plexxikon Inc | Heterocyclic compounds and uses of these |
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Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997049703A2 (en) * | 1996-06-25 | 1997-12-31 | Takeda Chemical Industries, Ltd. | Oxazolone derivatives and their use as anti-helicobacter pylori agents |
WO2005062795A2 (en) * | 2003-12-19 | 2005-07-14 | Plexxikon, Inc. | Compounds and methods for development of ret modulators |
WO2006009797A1 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
WO2006009755A2 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
WO2007013896A2 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
WO2007106236A2 (en) * | 2006-02-27 | 2007-09-20 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9169250B2 (en) | 2006-11-22 | 2015-10-27 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US9487515B2 (en) | 2006-11-22 | 2016-11-08 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US8741920B2 (en) | 2009-08-03 | 2014-06-03 | Hoffmann-La Roche, Inc. | Process for the manufacture of pharmaceutically active compounds |
US9096593B2 (en) | 2009-11-06 | 2015-08-04 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
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