WO2008073441A3 - Compositions and methods for treating pathologic angiogenesis and vascular permeability - Google Patents

Compositions and methods for treating pathologic angiogenesis and vascular permeability Download PDF

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Publication number
WO2008073441A3
WO2008073441A3 PCT/US2007/025354 US2007025354W WO2008073441A3 WO 2008073441 A3 WO2008073441 A3 WO 2008073441A3 US 2007025354 W US2007025354 W US 2007025354W WO 2008073441 A3 WO2008073441 A3 WO 2008073441A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
vascular permeability
pathologic angiogenesis
inhibiting vascular
Prior art date
Application number
PCT/US2007/025354
Other languages
French (fr)
Other versions
WO2008073441A2 (en
Inventor
Dean Li
Christopher Jones
Nyall London
Original Assignee
Univ Utah Res Found
Dean Li
Christopher Jones
Nyall London
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Utah Res Found, Dean Li, Christopher Jones, Nyall London filed Critical Univ Utah Res Found
Priority to US12/518,730 priority Critical patent/US7994130B2/en
Priority to JP2009540334A priority patent/JP2010512327A/en
Priority to BRPI0720038-2A2A priority patent/BRPI0720038A2/en
Priority to CA002672297A priority patent/CA2672297A1/en
Priority to EP07867716A priority patent/EP2104509A4/en
Publication of WO2008073441A2 publication Critical patent/WO2008073441A2/en
Publication of WO2008073441A3 publication Critical patent/WO2008073441A3/en
Priority to US13/111,776 priority patent/US8309519B2/en
Priority to US13/644,614 priority patent/US20130102534A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/16—Ophthalmology
    • G01N2800/164—Retinal disorders, e.g. retinopathy

Abstract

Compounds, compositions and methods for inhibiting vascular permeability and pathologic angiogenesis are described herein. Methods for producing and screening compounds and compositions capable of inhibiting vascular permeability and pathologic angiogenesis are also described herein. Pharmaceutical compositions are included in the compositions described herein. The compositions described herein are useful in, for example, methods of inhibiting vascular permeability and pathologic angiogenesis, including methods of inhibiting vascular permeability and pathologic angiogenesis induced by specific angiogenic, permeability and inflammatory factors, such as, for example VEGF, bFGF and thrombin. Methods for treating specific diseases and conditions are also provided herein.
PCT/US2007/025354 2006-12-11 2007-12-11 Compositions and methods for treating pathologic angiogenesis and vascular permeability WO2008073441A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US12/518,730 US7994130B2 (en) 2006-12-11 2007-12-11 Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability
JP2009540334A JP2010512327A (en) 2006-12-11 2007-12-11 Compositions and methods for the treatment of pathological angiogenesis and vascular permeability
BRPI0720038-2A2A BRPI0720038A2 (en) 2006-12-11 2007-12-11 METHODS TO INHIBIT VASCULAR PERMEABILITY IN TISSUE, TO TRIAL OR EVALUATE AN AGENT THAT INHIBITS VASCULAR PERMEABILITY, TO TREAT OR PREVENT RESPIRATORY ANGUS, SYNDROME TO PREMATULAR DIABETARY RATE, INDIVIDUALS WITH REPULSIVE OR MIMETIC SUGGESTIONS AND TO PROMOTE ANGIOGENESIS IN A FABRIC, ISOLATED POLYPEPTIDE, ISOLATED NUCLEIC ACID, AND, VECTOR
CA002672297A CA2672297A1 (en) 2006-12-11 2007-12-11 Compositions and methods for treating pathologic angiogenesis and vascular permeability
EP07867716A EP2104509A4 (en) 2006-12-11 2007-12-11 Compositions and methods for treating pathologic angiogenesis and vascular permeability
US13/111,776 US8309519B2 (en) 2006-12-11 2011-05-19 Compositions and methods for inhibiting vascular permeability
US13/644,614 US20130102534A1 (en) 2006-12-11 2012-10-04 Compositions and methods for treating pathologic angiogenesis and vascular permeability

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86952606P 2006-12-11 2006-12-11
US60/869,526 2006-12-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/518,730 A-371-Of-International US7994130B2 (en) 2006-12-11 2007-12-11 Compositions and methods for treating ocular pathologic angiogenesis and vascular permeability
US13/111,776 Continuation US8309519B2 (en) 2006-12-11 2011-05-19 Compositions and methods for inhibiting vascular permeability

Publications (2)

Publication Number Publication Date
WO2008073441A2 WO2008073441A2 (en) 2008-06-19
WO2008073441A3 true WO2008073441A3 (en) 2008-12-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/025354 WO2008073441A2 (en) 2006-12-11 2007-12-11 Compositions and methods for treating pathologic angiogenesis and vascular permeability

Country Status (8)

Country Link
US (3) US7994130B2 (en)
EP (1) EP2104509A4 (en)
JP (1) JP2010512327A (en)
KR (1) KR20090089462A (en)
CN (1) CN101600451A (en)
BR (1) BRPI0720038A2 (en)
CA (1) CA2672297A1 (en)
WO (1) WO2008073441A2 (en)

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BRPI0915287A2 (en) * 2008-12-12 2016-02-16 Univ Utah Res Found uses of at least one slit polypeptide, at least one inhibitor of at least one arf gtp (arf-gef) exchange factor, and one compound
HRP20231277T1 (en) 2009-08-24 2024-02-02 Stealth Biotherapeutics Inc. Peptide for use in preventing or treating macular degeneration
KR101297037B1 (en) * 2010-03-26 2013-08-14 숙명여자대학교산학협력단 Peptides for Promotion of Angiogenesis and the use thereof
CA2739107C (en) 2010-06-15 2022-12-06 The Hospital For Sick Children Methods and uses for inhibiting platelet coagulation comprising slit protein
CA2831938C (en) * 2011-03-30 2015-01-06 University Of Manitoba Methods and uses of semaphorin 3e polypeptides and polynucleotides involving an airway inflammatory disease
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CN105051062A (en) * 2013-03-15 2015-11-11 王慧茹 Biological therapeutics for infection-relating disorders or conditions
KR101470795B1 (en) * 2014-07-11 2014-12-08 경북대학교 산학협력단 Markers for Diagnosing of Diabetic Retinopathy and Use Thereof
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EP3527225A4 (en) 2016-10-12 2020-06-10 Daiichi Sankyo Company, Limited Composition containing anti-robo4 antibody and other agents
CN106706775B (en) * 2016-11-22 2018-07-13 中国药科大学 A method of screening active constituent and active compound
KR101851684B1 (en) * 2017-12-15 2018-04-24 한국가스안전공사 Testing device for hydrogen jet flame and testing method for hydrogen jet flame using that
TWI702615B (en) * 2019-07-26 2020-08-21 長佳智能股份有限公司 Retinopathy assessment model establishment method and system
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