WO2008079672A4 - Flowable carrier compositions for orthopedic implants and methods of use - Google Patents
Flowable carrier compositions for orthopedic implants and methods of use Download PDFInfo
- Publication number
- WO2008079672A4 WO2008079672A4 PCT/US2007/087117 US2007087117W WO2008079672A4 WO 2008079672 A4 WO2008079672 A4 WO 2008079672A4 US 2007087117 W US2007087117 W US 2007087117W WO 2008079672 A4 WO2008079672 A4 WO 2008079672A4
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phosphate
- biodegradable polymer
- combinations
- composition
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B50/00—Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers
- A61B50/30—Containers specially adapted for packaging, protecting, dispensing, collecting or disposing of surgical or diagnostic appliances or instruments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
Abstract
A composition is provided for faster bone repair and early orthopedic implant fixation. The composition comprises an osteoinductive or osteopromotive biological factor embedded in a carrier slurry. The slurry is prepared by wetting a biodegradable polymer and calcium phosphate particles with a biocompatible fluid. The composition may be applied to the site of the bone fracture, to an orthopedic implant or to both during the surgical procedure. The composition utilizes low dosages of the biological factor and, therefore, is cost effective to be used routinely.
Claims
AMENDED CLAIMS received by the International Bureau on 24 December 2008 (24.12.2008)
7. The composition of claim 1, wherein the biodegradable polymer is a natural polymer selected from the group consisting of collagen, hyaluronic acid, chitosan, carboxymethylcellulose, alginate, silk, eastin, fibrin glue, bone marrow with or without thrombin, and combinations thereof.
8. The composition of claim 1, wherein the biodegradable polymer is a synthetic polymer selected from the group consisting of polyethylene glycol (PEG), polyvinyl alcohol (PVA), polyorthoester (POE), polylactic acid (PLA), polyglycolic acid (PGA), polyactic-glycolic acid (PLGA) and combinations thereof.
9. The composition of claim 1 , wherein the calcium phosphate compound is selected from the group consisting of amorphous calcium phosphate, biphasic calcium phosphate, calcium phosphate, dicalcium phosphate, dicalciυm phosphate dihydrate, calcium hydroxyapatite, carbonated calcium hydroxyapatite, monocalcium phosphate, monocalcium phosphate monohydrate, octacalcium phosphate, tricalcium phosphate, alpha-tricalcium phosphate, beta-tricalciυm phosphate, tetracalcium phosphate, and combinations thereof.
10. A medical kit comprising: a biological factor; a biodegradable polymer, a calcium phosphate compound; and an applicator.
11. The medical kit of claim 10 further comprising a biocompatible fluid.
12. The medical kit of claim 11, wherein the applicator is adapted for applying the biological factor and a carrier slurry resulting from hydrating the biodegradable polymer and the calcium phosphate compound with the biocompatible fluid to a site of bone repair orto an orthopedic implant
13. The medical kit of claim 10, wherein the biological factor and the biocompatible fluid are contained in separate containers.
14. The kit of claim 10, wherein the biodegradable polymer is a natural polymer selected from the group consisting of collagen, hyaluronic acid, chitosan, carboxyniethylcellulose, alginate, silk, elastin, fibrin glue, bone marrow with or without thrombin, and combinations thereof.
15. The kit of claim 10, wherein the biodegradable polymer is a synthetic polymer selected from the group consisting of polyethylene glycol (PEG), polyvinyl alcohol
(PVA), polyorthoester (POE), polylactic acid (PLA), polyglycolic acid (PGA). polyacticglycolic acid (PLGA) and combinations thereof.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07865523A EP2129318A2 (en) | 2006-12-19 | 2007-12-12 | Flowable carrier compositions for orthopedic implants and methods of use |
JP2009543070A JP2010512974A (en) | 2006-12-19 | 2007-12-12 | Flowable carrier composition and method of use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/612,853 US8048857B2 (en) | 2006-12-19 | 2006-12-19 | Flowable carrier compositions and methods of use |
US11/612,853 | 2006-12-19 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2008079672A2 WO2008079672A2 (en) | 2008-07-03 |
WO2008079672A3 WO2008079672A3 (en) | 2008-12-24 |
WO2008079672A4 true WO2008079672A4 (en) | 2009-02-19 |
Family
ID=39528417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/087117 WO2008079672A2 (en) | 2006-12-19 | 2007-12-12 | Flowable carrier compositions for orthopedic implants and methods of use |
Country Status (4)
Country | Link |
---|---|
US (1) | US8048857B2 (en) |
EP (1) | EP2129318A2 (en) |
JP (1) | JP2010512974A (en) |
WO (1) | WO2008079672A2 (en) |
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WO2009129101A1 (en) | 2008-04-14 | 2009-10-22 | Advanced Technologies And Regenerative Medicine, Llc | Liquid buffered gdf-5 formulations |
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FR2932687B1 (en) | 2008-06-23 | 2010-09-17 | Centre Nat Rech Scient | BIOMATERIALS BASED ON CALCIUM PHOSPHATES. |
CN101297980B (en) * | 2008-07-01 | 2011-11-23 | 北京奥精医药科技有限公司 | Bone repair material containing nano hydroxylapatite/collagen particle and preparation thereof |
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CN102205149B (en) * | 2011-05-10 | 2013-10-02 | 中国科学院合肥物质科学研究院 | Hydroxylapatite (HA)/chitosan/polylactic acid compound bone repair material and preparation method thereof |
US8623839B2 (en) | 2011-06-30 | 2014-01-07 | Depuy Mitek, Llc | Compositions and methods for stabilized polysaccharide formulations |
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US9682099B2 (en) | 2015-01-20 | 2017-06-20 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
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CN108601864A (en) * | 2015-10-30 | 2018-09-28 | 佰欧维恩图斯有限责任公司 | Matrix for enhancing the delivering of self-bone grafting molecule in Bone Defect Repari |
KR101780579B1 (en) * | 2016-01-20 | 2017-09-21 | 건양대학교산학협력단 | Preparation of injectable bone restorative materials using calcium phosphate-PLGA composites |
US11020160B2 (en) * | 2016-03-21 | 2021-06-01 | Warsaw Orthopedic, Inc. | Surgical injection system and method |
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-
2006
- 2006-12-19 US US11/612,853 patent/US8048857B2/en active Active
-
2007
- 2007-12-12 WO PCT/US2007/087117 patent/WO2008079672A2/en active Application Filing
- 2007-12-12 JP JP2009543070A patent/JP2010512974A/en not_active Withdrawn
- 2007-12-12 EP EP07865523A patent/EP2129318A2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
WO2008079672A2 (en) | 2008-07-03 |
US8048857B2 (en) | 2011-11-01 |
EP2129318A2 (en) | 2009-12-09 |
WO2008079672A3 (en) | 2008-12-24 |
US20080147065A1 (en) | 2008-06-19 |
JP2010512974A (en) | 2010-04-30 |
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