WO2008080001A3 - Compounds and methods for kinase modulation, and indications therefor - Google Patents

Compounds and methods for kinase modulation, and indications therefor Download PDF

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Publication number
WO2008080001A3
WO2008080001A3 PCT/US2007/088412 US2007088412W WO2008080001A3 WO 2008080001 A3 WO2008080001 A3 WO 2008080001A3 US 2007088412 W US2007088412 W US 2007088412W WO 2008080001 A3 WO2008080001 A3 WO 2008080001A3
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WO
WIPO (PCT)
Prior art keywords
compounds
methods
kinase modulation
indications therefor
indications
Prior art date
Application number
PCT/US2007/088412
Other languages
French (fr)
Other versions
WO2008080001A2 (en
Inventor
Prabha N Ibrahim
Ryan Bremer
Chao Zhang
Jiazhong Zhang
Klaus-Peter Hirth
Guoxian Wu
Hongyao Zhu
Original Assignee
Plexxikon Inc
Prabha N Ibrahim
Ryan Bremer
Chao Zhang
Jiazhong Zhang
Klaus-Peter Hirth
Guoxian Wu
Hongyao Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Plexxikon Inc, Prabha N Ibrahim, Ryan Bremer, Chao Zhang, Jiazhong Zhang, Klaus-Peter Hirth, Guoxian Wu, Hongyao Zhu filed Critical Plexxikon Inc
Priority to AU2007336811A priority Critical patent/AU2007336811A1/en
Priority to MX2009006688A priority patent/MX2009006688A/en
Priority to EP07871726A priority patent/EP2094701A2/en
Priority to CA002673736A priority patent/CA2673736A1/en
Priority to JP2009543230A priority patent/JP2010514695A/en
Priority to BRPI0720695-0A2A priority patent/BRPI0720695A2/en
Publication of WO2008080001A2 publication Critical patent/WO2008080001A2/en
Publication of WO2008080001A3 publication Critical patent/WO2008080001A3/en
Priority to IL199278A priority patent/IL199278A0/en
Priority to NO20092612A priority patent/NO20092612L/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Compounds according to formulae IIa, IIIa, IIIc and IVb active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
PCT/US2007/088412 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor WO2008080001A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2007336811A AU2007336811A1 (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor
MX2009006688A MX2009006688A (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor.
EP07871726A EP2094701A2 (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor
CA002673736A CA2673736A1 (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor
JP2009543230A JP2010514695A (en) 2006-12-21 2007-12-20 Compounds and methods for kinase regulation and indications therefor
BRPI0720695-0A2A BRPI0720695A2 (en) 2006-12-21 2007-12-20 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS FOR THESE
IL199278A IL199278A0 (en) 2006-12-21 2009-06-10 Coumpounds and methods for kinase modulation, and indications therefor
NO20092612A NO20092612L (en) 2006-12-21 2009-07-10 Compounds and method of kinase modulation and indications for this

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87705206P 2006-12-21 2006-12-21
US60/877,052 2006-12-21

Publications (2)

Publication Number Publication Date
WO2008080001A2 WO2008080001A2 (en) 2008-07-03
WO2008080001A3 true WO2008080001A3 (en) 2009-01-08

Family

ID=39129228

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/088443 WO2008080015A2 (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor
PCT/US2007/088412 WO2008080001A2 (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2007/088443 WO2008080015A2 (en) 2006-12-21 2007-12-20 Compounds and methods for kinase modulation, and indications therefor

Country Status (12)

Country Link
US (1) US7872018B2 (en)
EP (1) EP2094701A2 (en)
JP (1) JP2010514695A (en)
CN (1) CN101641351A (en)
AU (1) AU2007336811A1 (en)
BR (1) BRPI0720695A2 (en)
CA (1) CA2673736A1 (en)
IL (1) IL199278A0 (en)
MX (1) MX2009006688A (en)
NO (1) NO20092612L (en)
RU (1) RU2009122670A (en)
WO (2) WO2008080015A2 (en)

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