WO2008089495A3 - System with extended range of molecular sensing through integrated multi-modal data acquisition - Google Patents

System with extended range of molecular sensing through integrated multi-modal data acquisition Download PDF

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Publication number
WO2008089495A3
WO2008089495A3 PCT/US2008/051739 US2008051739W WO2008089495A3 WO 2008089495 A3 WO2008089495 A3 WO 2008089495A3 US 2008051739 W US2008051739 W US 2008051739W WO 2008089495 A3 WO2008089495 A3 WO 2008089495A3
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WO
WIPO (PCT)
Prior art keywords
interferometric
fluorescence
data acquisition
modal data
detector
Prior art date
Application number
PCT/US2008/051739
Other languages
French (fr)
Other versions
WO2008089495A2 (en
Inventor
Xuefeng Wang
David D Nolte
Manoj Varma
Brian Weichel
Timothy Norwood
Fouad Sayegh
Ming Zhao
Original Assignee
Purdue Research Foundation
Xuefeng Wang
David D Nolte
Manoj Varma
Brian Weichel
Timothy Norwood
Fouad Sayegh
Ming Zhao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation, Xuefeng Wang, David D Nolte, Manoj Varma, Brian Weichel, Timothy Norwood, Fouad Sayegh, Ming Zhao filed Critical Purdue Research Foundation
Publication of WO2008089495A2 publication Critical patent/WO2008089495A2/en
Publication of WO2008089495A3 publication Critical patent/WO2008089495A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus

Abstract

A multi-modal data acquisition system for detecting target material on a biological reaction surface, the system comprising a radiation source for generating an incoming beam that impinges on the biological reaction surface at an oblique incidence angle and produces a reflected beam, an interferometric detector for detecting an interferometric signal from the illuminated surface, the reflected beam being directed to the interferometric detector, a fluorescence detector for detecting a fluorescence signal from the illuminated surface; the fluorescence detector being positioned to substantially minimize the incidence of the reflected beam; and a processing system for receiving the interferometric and fluorescence signals and determining the presence or absence of target material on the biological reaction surface. A reaction surface conditioned for the simultaneous collection of fluorescence, interferometric and other signals. A multi-modal data acquisition system for collecting and processing additional modes, including multiple interferometric, fluorescence and scattering channels.
PCT/US2008/051739 2007-01-19 2008-01-22 System with extended range of molecular sensing through integrated multi-modal data acquisition WO2008089495A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88569807P 2007-01-19 2007-01-19
US60/885,698 2007-01-19
US91617707P 2007-05-04 2007-05-04
US60/916,177 2007-05-04

Publications (2)

Publication Number Publication Date
WO2008089495A2 WO2008089495A2 (en) 2008-07-24
WO2008089495A3 true WO2008089495A3 (en) 2008-10-09

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Family Applications (1)

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PCT/US2008/051739 WO2008089495A2 (en) 2007-01-19 2008-01-22 System with extended range of molecular sensing through integrated multi-modal data acquisition

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US (2) US7659968B2 (en)
WO (1) WO2008089495A2 (en)

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