WO2009094182A3 - Pump cassette and methods for use in medical treatment system using a plurality of fluid lines - Google Patents

Pump cassette and methods for use in medical treatment system using a plurality of fluid lines Download PDF

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Publication number
WO2009094182A3
WO2009094182A3 PCT/US2009/000436 US2009000436W WO2009094182A3 WO 2009094182 A3 WO2009094182 A3 WO 2009094182A3 US 2009000436 W US2009000436 W US 2009000436W WO 2009094182 A3 WO2009094182 A3 WO 2009094182A3
Authority
WO
WIPO (PCT)
Prior art keywords
pump chamber
fluid
membrane
methods
pump
Prior art date
Application number
PCT/US2009/000436
Other languages
French (fr)
Other versions
WO2009094182A2 (en
Inventor
David W. Mcgill
James D. Dale
Simon C. Helmore
Richard J. Lanigan
Jason A. Demers
Dean Kamen
Original Assignee
Deka Products Limited Partnership
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN200980110651.3A priority Critical patent/CN101977642B/en
Priority to KR1020177011106A priority patent/KR101803247B1/en
Application filed by Deka Products Limited Partnership filed Critical Deka Products Limited Partnership
Priority to KR1020187014966A priority patent/KR101935362B1/en
Priority to US12/864,378 priority patent/US9358332B2/en
Priority to CA2712945A priority patent/CA2712945C/en
Priority to EP22211648.5A priority patent/EP4167241A1/en
Priority to KR1020197037941A priority patent/KR102196092B1/en
Priority to EP16177497.1A priority patent/EP3100750B1/en
Priority to KR1020107018603A priority patent/KR101914625B1/en
Priority to KR1020187038036A priority patent/KR102060347B1/en
Priority to JP2010544338A priority patent/JP5416138B2/en
Priority to EP09703798.0A priority patent/EP2254616B1/en
Priority to EP20178703.3A priority patent/EP3761316B1/en
Priority to KR1020217043261A priority patent/KR102413397B1/en
Priority to MX2010008012A priority patent/MX2010008012A/en
Priority to KR1020157013247A priority patent/KR101971763B1/en
Priority to KR1020177033783A priority patent/KR101863753B1/en
Priority to KR1020207036873A priority patent/KR102346996B1/en
Publication of WO2009094182A2 publication Critical patent/WO2009094182A2/en
Publication of WO2009094182A3 publication Critical patent/WO2009094182A3/en
Priority to US13/667,696 priority patent/US9078971B2/en
Priority to US14/732,564 priority patent/US10201647B2/en
Priority to US15/174,969 priority patent/US10265451B2/en
Priority to US16/391,104 priority patent/US11478577B2/en
Priority to US16/507,302 priority patent/US11511024B2/en
Priority to US17/975,495 priority patent/US11833281B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/152—Details related to the interface between cassette and machine
    • A61M1/1522—Details related to the interface between cassette and machine the interface being evacuated interfaces to enhance contact
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/155—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit with treatment-fluid pumping means or components thereof
    • A—HUMAN NECESSITIES
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/156—Constructional details of the cassette, e.g. specific details on material or shape
    • A61M1/1561—Constructional details of the cassette, e.g. specific details on material or shape at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
    • A—HUMAN NECESSITIES
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    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • A61M1/156—Constructional details of the cassette, e.g. specific details on material or shape
    • A61M1/1565—Details of valves
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    • A61M1/159—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit specially adapted for peritoneal dialysis
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    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A—HUMAN NECESSITIES
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1654—Dialysates therefor
    • A61M1/1656—Apparatus for preparing dialysates
    • A61M1/166—Heating
    • A—HUMAN NECESSITIES
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/28—Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
    • A61M1/288—Priming
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
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    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16809—Flow controllers by repeated filling and emptying of an intermediate volume
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/0009—Special features
    • F04B43/0054—Special features particularities of the flexible members
    • G—PHYSICS
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    • G16H40/00—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60—ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
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    • A61M1/152—Details related to the interface between cassette and machine
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    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/06—Pumps having fluid drive
    • F04B43/073—Pumps having fluid drive the actuating fluid being controlled by at least one valve
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/08—Machines, pumps, or pumping installations having flexible working members having tubular flexible members
    • F04B43/086—Machines, pumps, or pumping installations having flexible working members having tubular flexible members with two or more tubular flexible members in parallel
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B53/00—Component parts, details or accessories not provided for in, or of interest apart from, groups F04B1/00 - F04B23/00 or F04B39/00 - F04B47/00
    • F04B53/22—Arrangements for enabling ready assembly or disassembly
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

A fluid handling cassette (24), such as that useable with an APD cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber (181) formed as a depression in a first side of the body and a plurality of flowpaths for fluid that includes a channel. A patient line port may be arranged for connection to a patient line (34) and be in fluid communication with the at least one pump chamber via at least one flowpath, and an optional membrane (15) may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion (151) with an unstressed shape that generally conforms to the pump chamber depression in the body and is arranged to be movable for movement of fluid in the useable space of the pump chamber. One or more spacers (50) may be provided in the pump chamber to prevent a pump membrane from contacting an inner wall of the pump chamber. Patient, drain (28) and/or heater bag lines (26) may be positioned to be separately occludable in relation to one or more solution lines (30) that are connectable to the cassette.
PCT/US2009/000436 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines WO2009094182A2 (en)

Priority Applications (24)

Application Number Priority Date Filing Date Title
EP20178703.3A EP3761316B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
EP09703798.0A EP2254616B1 (en) 2008-01-23 2009-01-23 Disposable fluid handling cassette for peritoneal dialysis
KR1020187014966A KR101935362B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US12/864,378 US9358332B2 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
CA2712945A CA2712945C (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
EP22211648.5A EP4167241A1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
KR1020197037941A KR102196092B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
EP16177497.1A EP3100750B1 (en) 2008-01-23 2009-01-23 Pump cassette for use in medical treatment system using a plurality of fluid lines
KR1020177011106A KR101803247B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
KR1020187038036A KR102060347B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
JP2010544338A JP5416138B2 (en) 2008-01-23 2009-01-23 Pump cassette and method for use in medical treatment systems using multiple fluid lines
CN200980110651.3A CN101977642B (en) 2008-01-23 2009-01-23 Pump cassette
KR1020217043261A KR102413397B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
KR1020107018603A KR101914625B1 (en) 2008-01-23 2009-01-23 Disposable fluid handling cassette for use with fluid handling system of medical infusion device
MX2010008012A MX2010008012A (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines.
KR1020157013247A KR101971763B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
KR1020177033783A KR101863753B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
KR1020207036873A KR102346996B1 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US13/667,696 US9078971B2 (en) 2008-01-23 2012-11-02 Medical treatment system and methods using a plurality of fluid lines
US14/732,564 US10201647B2 (en) 2008-01-23 2015-06-05 Medical treatment system and methods using a plurality of fluid lines
US15/174,969 US10265451B2 (en) 2008-01-23 2016-06-06 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US16/391,104 US11478577B2 (en) 2008-01-23 2019-04-22 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US16/507,302 US11511024B2 (en) 2008-01-23 2019-07-10 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US17/975,495 US11833281B2 (en) 2008-01-23 2022-10-27 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1196708P 2008-01-23 2008-01-23
US61/011,967 2008-01-23
US5846908P 2008-06-03 2008-06-03
US61/058,469 2008-06-03

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2009/000439 Continuation-In-Part WO2009094184A1 (en) 2008-01-23 2009-01-23 Fluid volume determination for medical treatment system
US86439110A Continuation-In-Part 2008-01-23 2010-12-03

Related Child Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2009/000440 Continuation-In-Part WO2009094185A2 (en) 2008-01-23 2009-01-23 Medical treatment system and methods using a plurality of fluid lines
US12/864,378 A-371-Of-International US9358332B2 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
US86435710A Continuation-In-Part 2008-01-23 2010-12-13
US12/931,310 Continuation-In-Part US20110217293A1 (en) 2008-07-29 2011-01-28 Uses of morelloflavone
US13/667,696 Continuation-In-Part US9078971B2 (en) 2008-01-23 2012-11-02 Medical treatment system and methods using a plurality of fluid lines
US15/174,969 Division US10265451B2 (en) 2008-01-23 2016-06-06 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines

Publications (2)

Publication Number Publication Date
WO2009094182A2 WO2009094182A2 (en) 2009-07-30
WO2009094182A3 true WO2009094182A3 (en) 2009-11-12

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Application Number Title Priority Date Filing Date
PCT/US2009/000440 WO2009094185A2 (en) 2008-01-23 2009-01-23 Medical treatment system and methods using a plurality of fluid lines
PCT/US2009/000439 WO2009094184A1 (en) 2008-01-23 2009-01-23 Fluid volume determination for medical treatment system
PCT/US2009/000441 WO2009094186A2 (en) 2008-01-23 2009-01-23 Disposable components for fluid line autoconnect systems and methods
PCT/US2009/000433 WO2009094179A2 (en) 2008-01-23 2009-01-23 Fluid flow occluder and methods of use for medical treatment systems
PCT/US2009/000436 WO2009094182A2 (en) 2008-01-23 2009-01-23 Pump cassette and methods for use in medical treatment system using a plurality of fluid lines
PCT/US2009/000437 WO2009094183A1 (en) 2008-01-23 2009-01-23 Fluid line autoconnect apparatus and methods for medical treatment system

Family Applications Before (4)

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PCT/US2009/000440 WO2009094185A2 (en) 2008-01-23 2009-01-23 Medical treatment system and methods using a plurality of fluid lines
PCT/US2009/000439 WO2009094184A1 (en) 2008-01-23 2009-01-23 Fluid volume determination for medical treatment system
PCT/US2009/000441 WO2009094186A2 (en) 2008-01-23 2009-01-23 Disposable components for fluid line autoconnect systems and methods
PCT/US2009/000433 WO2009094179A2 (en) 2008-01-23 2009-01-23 Fluid flow occluder and methods of use for medical treatment systems

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PCT/US2009/000437 WO2009094183A1 (en) 2008-01-23 2009-01-23 Fluid line autoconnect apparatus and methods for medical treatment system

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US (17) US9022969B2 (en)
EP (18) EP3594959A1 (en)
JP (24) JP5595930B2 (en)
KR (9) KR101935362B1 (en)
CN (2) CN104800903B (en)
CA (15) CA2712945C (en)
MX (12) MX2010008012A (en)
WO (6) WO2009094185A2 (en)

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