WO2009094189A1 - Delivery systems and methods of implantation for prosthetic heart valves - Google Patents
Delivery systems and methods of implantation for prosthetic heart valves Download PDFInfo
- Publication number
- WO2009094189A1 WO2009094189A1 PCT/US2009/000446 US2009000446W WO2009094189A1 WO 2009094189 A1 WO2009094189 A1 WO 2009094189A1 US 2009000446 W US2009000446 W US 2009000446W WO 2009094189 A1 WO2009094189 A1 WO 2009094189A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- wires
- delivery system
- stent
- distal end
- wire
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/013—Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2403—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with pivoting rigid closure members
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- A61F2/02—Prostheses implantable into the body
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- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
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- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2439—Expansion controlled by filaments
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/003—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in adsorbability or resorbability, i.e. in adsorption or resorption time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0039—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in diameter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Definitions
- the present invention relates to prosthetic heart valves. More particularly, it relates to devices, methods, and delivery systems for percutaneously implanting prosthetic heart valves.
- Heart valve surgeries can be repaired or replaced using a variety of different types of heart valve surgeries.
- Typical heart valve surgeries involve an open-heart surgical procedure that is conducted under general anesthesia, during which the heart is stopped while blood flow is controlled by a heart-lung bypass machine.
- This type of valve surgery is highly invasive and exposes the patient to a number of potentially serious risks, such as infection, stroke, renal failure, and adverse effects associated with use of the heart-lung machine, for example.
- the replacement pulmonary valve may be implanted to replace native pulmonary valves or prosthetic pulmonary valves located in valved conduits.
- Various types and configurations of prosthetic heart valves are used in percutaneous valve procedures to replace diseased natural human heart valves.
- any particular prosthetic heart valve is dependent to some extent upon the valve being replaced (i.e., mitral valve, tricuspid valve, aortic valve, or pulmonary valve), hi general, the prosthetic heart valve designs attempt to replicate the function of the valve being replaced and thus will include valve leaflet-like structures used with either bioprostheses or mechanical heart valve prostheses.
- the replacement valves may include a valved vein segment that is mounted in some manner within an expandable stent to make a stented valve.
- the stented valve can be initially provided in an expanded or uncrimped condition, then crimped or compressed around the balloon portion of a catheter until it is as close to the diameter of the catheter as possible.
- valve is sutured to an expandable stent within a previously implanted valved or non-valved conduit, or a previously implanted valve. Again, radial expansion of the secondary valve stent is used for placing and maintaining the replacement valve.
- valve and corresponding delivery system that ' allow for full or partial repositionability and/or retractability of the valve once it is positioned in the patient, hi addition, it would be advantageous to provide a delivery system that can consistently release a heart valve without inducing the application of force to the stented valve that can dislodge the valve from the desired implantation location.
- transcatheter valved stents and the complex anatomies that they are designed to accommodate present a need to be able to sequentially release specific regions or portions of the transcatheter valved stent. This enables specific advantages to position the devices more accurately and/or deploy specific features for anchoring, sealing, or docking of the devices.
- Replacement heart valves that can be used with delivery systems of the invention each include a stent within which a valve structure can be attached.
- the stents used with delivery systems and methods of the invention include a wide variety of structures and features that can be used alone or in combination with other stent features.
- these stents provide a number of different docking and/or anchoring structures that are conducive to percutaneous delivery thereof.
- Many of the stent structures are thus compressible to a relatively small diameter for percutaneous delivery to the heart of the patient, and then are expandable either via removal of external compressive forces (e.g., self-expanding stents), or through application of an outward radial force (e.g., balloon expandable stents).
- the devices delivered by the delivery systems described herein can be used to deliver stents, valved stents, or other interventional devices such as ASD (atrial septal defect) closure devices, VSD (ventricular septal defect) closure devices, or PFO (patent foramen ovale) occluders.
- ASD atrial septal defect
- VSD ventricular septal defect
- PFO pattern foramen ovale
- Methods for insertion of the replacement heart valves of the invention include delivery systems that can maintain the stent structures in their compressed state during their insertion and allow or cause the stent structures to expand once they are in their desired location.
- the methods of implanting a stent can include the use of delivery systems or a valved stent having a plurality of wires with coiled or pigtail ends attached to features of the stent frame.
- the coiled wire ends can be straightened or uncoiled to release the stent to which they are attached.
- the coiled or pigtail wire end configuration allows for positive, consistent release of the stent from the delivery system without the associated complications that can be caused by incomplete release and/or sticking that can occur with other delivery systems.
- Delivery systems and methods of the invention can include features that allow the stents to be retrieved for removal or relocation thereof after they have been deployed or partially deployed from the stent delivery systems.
- the methods may include implantation of the stent structures using either an antegrade or retrograde approach.
- the stent structure is rotatable in vivo to allow the stent structure to be positioned in a desired orientation.
- Delivery systems and methods of the invention provide for sequential release of portions of the heart valve.
- the delivery system has actuation capabilities for disengaging from one or more structural features of a heart valve in a first step, then disengaging from additional structural features of that heart valve in one or more sequential steps.
- the deployment of the heart valve can be performed relatively gradually, which can provide the clinician with the opportunity to reposition or relocate the heart valve before it is completely released from the delivery system.
- Figure 1 is a perspective view of one embodiment of a delivery system of the invention
- Figure 2 is a perspective view of a proximal end of the delivery system illustrated in Figure 1 ;
- Figure 3 is a perspective view of a cartridge having plural wires with coiled ends as the wires are being attached to a stent frame;
- Figure 4 is an enlarged side view of the cartridge of Figure 3 attached to the crowns at one end of a stent;
- Figure 5 is a side view of the cartridge and attached stent of Figure 4 in proximity to a portion of a delivery system to which they will be attached;
- Figure 6 is a side view of a delivery system of the invention with an attached stent
- Figure 7 is an enlarged perspective view of the coiled or pigtail ends of wires of a delivery system attached to a stent;
- Figures 8-10 are side views illustrating various stages of a stent being deployed from a delivery system of the invention.
- Figure 1 1 is a side view of a portion of a delivery system having wires of different lengths with coiled or pigtail ends;
- Figure 12 is a side view of a portion of another delivery system having wires with ends that are coiled to form different numbers of loops;
- Figure 13 is a side view of a portion of another delivery system of the invention.
- Figures 14-16 are sequential cross-sectional side views of a stent crown in various stages of being deployed from the pigtail end of a delivery system of the type illustrated in Figure 13;
- Figure 17 is a schematic front view of another embodiment of a delivery system of the invention.
- Figure 18 is an enlarged front view of a portion of the delivery system of Figure 17, showing plural coiled wires attached to crowns of a stent;
- Figure 19 is an enlarged front view of the same portion of the delivery system shown in Figure 18, further showing some of the coiled wires detached from the crowns;
- Figure 20 is a schematic front view of the delivery system of Figure 17, with the stent detached from all of the coiled wires of the delivery system;
- Figure 21 is an enlarged front view of a portion of the delivery system of Figure 20;
- Figure 22 is a perspective view of one of the wires of a pigtail delivery system of the invention.
- Figure 23 is a side view of a stent crown positioned relative to an embodiment of a delivery system
- Figure 24 is a side view of a stent crown positioned relative to another embodiment of a delivery system; and [00034] Figure 25 is a perspective view of a sequential wire release configuration of a stent delivery system.
- the prosthetic heart valves used in accordance with the various devices and methods of heart valve delivery may include a wide variety of different configurations, such as a prosthetic heart valve having tissue leaflets or a synthetic heart valve having polymeric, metallic, or tissue-engineered leaflets, and can be specifically configured for replacing any heart valve. That is, while much of the description herein refers to replacement of aortic valves, the prosthetic heart valves of the invention can also generally be used for replacement of native mitral, pulmonic, or tricuspid valves, for use as a venous valve, or to replace a failed bioprosthesis, such as in the area of an aortic valve or mitral valve, for example.
- each of the valves used with the delivery devices and methods described herein can include leaflets attached within an interior area of a stent; however, such leaflets are not shown in many of the illustrated embodiments for clarity purposes.
- the stents used with the delivery systems and methods described herein include a support structure comprising a number of strut or wire portions arranged relative to each other to provide a desired compressibility and strength to the heart valve.
- other stent structures can also be configured for use with delivery systems and methods of the invention, including stents that consist of foil or metal frames or inflatable lumens that can be filled with a hardenable material or agent, such as that proposed in U.S. Patent No. 5,554,185 (Block), for example.
- the stents described herein are generally tubular or cylindrical support structures, although the diameter and shape can vary along the length of the stent, and leaflets can be secured to the support structure to provide a valved stent.
- the leaflets can be formed from a variety of materials, such as autologous tissue, xenograph material, or synthetics as are known in the art.
- the leaflets may be provided as a homogenous, biological valve structure, such as a porcine, bovine, or equine valve.
- the leaflets can be provided independent of one another (e.g., bovine or equine pericardial leaflets) and subsequently assembled to the support structure of the stent.
- the stent and leaflets can be fabricated at the same time, such as may be accomplished using high strength nano- manufactured NiTi films of the type produced by Advanced Bio Prosthetic Surfaces Ltd. (ABPS) of San Antonio, Texas, for example.
- the support structures are generally configured to accommodate three leaflets; however, the prosthetic heart valves described herein can incorporate more or less than three leaflets.
- the combination of a support structure with one or more leaflets can assume a variety of other configurations that differ from those shown and described, including any known prosthetic heart valve design, hi certain embodiments of the invention, the support structure with leaflets can be any known expandable prosthetic heart valve configuration, whether balloon expandable, self-expanding, or unfurling (as described, for example, in U.S. Patent Nos. 3,671,979; 4,056,854; 4,994,077; 5,332,402; 5,370,685; 5,397,351 ; 5,554,185; 5,855,601; and 6,168,614; U.S. Patent Application Publication No.
- Optional orientation and positioning of the stents of the invention may be accomplished either by self-orientation of the stents (such as by interference between features of the stent and a previously implanted stent or valve structure) or by manual orientation of the stent to align its features with anatomical or previous bioprosthetic features, such as can be accomplished using fluoroscopic visualization techniques, for example.
- self-orientation of the stents such as by interference between features of the stent and a previously implanted stent or valve structure
- manual orientation of the stent to align its features with anatomical or previous bioprosthetic features such as can be accomplished using fluoroscopic visualization techniques, for example.
- aligning the stents of the invention with native anatomical structures they should be aligned so as to not block the coronary arteries, and native mitral or tricuspid valves should be aligned relative to the anterior leaflet and/or the trigones/commissures.
- the support structures of the stents can be wires formed from a shape memory material such as a nickel titanium alloy (e.g., Nitinol). With shape memory material, the support structure is self-expandable from a contracted state to an expanded state, such as by the application of heat, energy, and the like, or by the removal of external forces (e.g., compressive forces). This support structure can also be repeatedly compressed and re- expanded without damaging the structure of the stent.
- the support structure of such an embodiment may be laser cut from a single piece of material or may be assembled from a number of different components.
- one example of a delivery system that can be used includes a catheter with a retractable sheath that covers the stent until it is to be deployed, at which point the sheath can be retracted to allow the stent to expand.
- the stents can alternatively be a series of wires or wire segments arranged so that they are capable of trans itioning from a collapsed state to an expanded state with the application or removal of external and/or internal forces.
- These individual wires comprising the support structure can be formed of a metal or other material. Further, the wires are arranged in such a way that the stent can be folded or compressed to a contracted state in which its internal diameter is considerably smaller than its internal diameter when the structure is in an expanded state. In its collapsed state, such a support structure with an attached valve can be mounted over a delivery device, such as a balloon catheter, for example.
- the support structure is configured so that it can be changed to its expanded state when desired, such as by the expansion of a balloon catheter or removal of external forces that are provided by a sheath, for example.
- the delivery systems used for such a stent can be provided with degrees of rotational and axial orientation capabilities in order to properly position the new stent at its desired location.
- This system can include a cartridge for initial attachment of a stent and/or stent device to the stent base device and subsequent attachment to the delivery system, thereby providing quick and simple attachment of a stent to a delivery system by an operator.
- the attachment mechanism is a dovetail type of connection, which includes a mating feature on both a cartridge and a delivery system that allows the stent to be preloaded to the cartridge and easily attached by the clinician to the delivery system.
- Other connection means are also contemplated, such as snap-fit connections, threaded connections, clips, pins, magnets, and/or the like.
- the pigtail delivery system may include more permanently attached components that do not use features of a cartridge-based system.
- One delivery system of the invention can further include a series of wires for connecting the stented valve to the delivery system.
- each of the wires can be formed at its distal end into a coiled or "pigtail" configuration.
- the coiled end of each wire can be secured to a feature of a stent, such as a stent crown, when the wire end is coiled. Straightening the wire can then release the stent feature to which it was secured, as is described below in further detail.
- a wire 20 having a coiled distal end 82 and a proximal end 84 is illustrated in Figure 22.
- the wire can be bent at approximately a 90 degree angle between the distal end 82 and proximal end 84, or it can be bent at an angle other than 90 degrees, or it can be a straight wire portion with no bend or curves.
- the distal end 82 of the wire 20 is shaped to create approximately 1-1/2 coils or loops; however, the wire 20 may include more or less coils or loops than shown.
- the wires can be made of a wide variety of materials, such as high tensile strength spring wire material or NiTi, for example. Alternatively, the wire can be somewhat malleable such that it does not necessarily return to the original coil shape once any stented valve features have been released from the wire.
- the size and exact configuration of the pigtail end portion of each wire can be chosen or designed so that the forces required to retract and deploy the stent are within a desirable range.
- the pigtail portion of the wire should be strong enough to prevent inadvertent release from the delivery system during stent positioning, resheathing, repositioning, and/or the like, hi addition, the pigtail portion of the wire should be sufficiently flexible that it does not require excessive force to straighten it during implant device deployment.
- the wire 20 is approximately 0.010 inches in diameter, thereby requiring approximately 7 pounds of pull force to uncoil the distal end 82 of the wire 20.
- different materials and different sized wires can be used for the pigtail wires that provide different delivery system properties.
- each of the wires 20 is fixed to a hub or base portion that is located on a center lumen of the cartridge or delivery system.
- the wire 20 can be secured to the hub or base portion using various mechanical methods and/or adhesives.
- the coiled or pigtail portions at the distal end 82 are initially coiled around the wires of one end of a stent and then are fully or partially straightened to deploy the stented valve.
- the wire can be made of spring materials or shape memory materials that may be cured or "set" via a heat treating process so that the coiled wire end can be retracted, clocked, redeployed, disengaged, or the like without the use of additional tools or the management of removed parts.
- the wires that have a pigtail portion at their distal ends are retracted relative to one or more tubes in which they are enclosed until the pigtail portions are adjacent to one end of one of the tubes. That is, the wires are pulled relative to the tube(s), the tube(s) are pushed forward relative to the wires, or both the wires and the tubes are moved relative to each other.
- the diameter of the coil circle or loop can be relatively large in size as compared to the diameter of the tube opening into which they are being pulled so that the coils will contact and interfere with the end of the tube when they are pulled toward it.
- the wires are then pulled further back into the tube, thereby straightening the pigtail portions until they are released from the stent wires they had been encircling.
- Figure 1 illustrates one exemplary delivery system 10 for a pigtail type of system that generally includes a proximal end 12 and a distal end 14.
- FIG 2 shows an enlarged view of the proximal end 12 of the delivery system 10 of Figure 1, which includes a first knob 30 and a second knob 32 for use in controlling the delivery and deployment of a stent at the generally distal end 14, as will be described in further detail below.
- a delivery system for percutaneous stent and valve delivery can comprise a relatively long delivery system that can be maneuvered through a patient's vasculature until a desired anatomical location is reached.
- the delivery system can include features that allow it to deliver a stent to a desired location in a patient's body.
- a cartridge 16 is illustrated in Figure 3 adjacent to a stent 18 to which it will be attached.
- the stent 18 is then illustrated in Figure 4 as attached to the cartridge 16 via the coiled or pigtail ends of the wires 20.
- the cartridge 16 includes a post 19 having a series of wires 20 extending from one end and a dovetail attachment portion 22 at the opposite end.
- Each of the wires 20 includes a generally straight portion that is connected to the post 19 at its proximal end 84 and further includes a "pigtail" or curled portion at its distal end 82.
- Each wire 20 is made of a shape-memory type of material (e.g., Nitinol) such that it can be straightened by applying an external force when in the proximity of a stent to which it will be attached and return generally to its curled configuration when the straightening force is removed.
- a wire can be used that is permanently deformed when sufficient force has been applied to it to release the stented valve from the delivery system.
- the curled end of each wire 20 can be straightened or partially straightened and placed adjacent to one of the crowns or "V" ends of the stent.
- each wire 20 can then be removed or reduced so that the distal end of the wire coils back toward its pigtail configuration, thereby wrapping around and capturing one crown of the stent 18, as is shown in Figure 4.
- a malleable type of wire material can be used, wherein the coil can be formed by wrapping the wire around the stent crown during the stent loading process. If a different stent construction is used, the coiled wires can instead engage with some other feature of that type of stent.
- the cartridge is preferably provided with the same number of wires having pigtail or coiled wire ends as the number of crowns provided on the corresponding stent, although the cartridge can be provided with more or less wires having coiled ends.
- a single crown of a stent may have more than one pigtail wire attached to it.
- the cartridge and stent combination can then be attached to the delivery system 10.
- the use of a cartridge with the delivery systems of the invention can provide advantages to the stent loading process. For example, a cartridge and stent can be provided to the clinician with the stent pre-attached to the cartridge so that the clinician does not need to perform the stent attachment step prior to surgery.
- the exemplary stent 18, one end of which is shown in the Figures, is made of a series of wires that are compressible and expandable through the application and removal of external forces, and may include a series of Nitinol wires that are approximately 0.01 1-0.015 inches in diameter, for example. That is, the stent 18 may be considered to be a self-expanding stent.
- the stent to which the pigtail wire portions of the invention are attached can have a number of different configurations and can be made of a wide variety of different materials.
- the stent is preferably designed with at least one point or feature to which a coiled wire end can be attached. That is, while an open-ended type of stent crown is shown, other stent end configurations can alternatively be used, such as eyelets, loops, or other openings.
- Figure 5 illustrates one end of the delivery system 10 as having a dovetail portion 24 that can mate or attach to a corresponding dovetail attachment portion 22 of the cartridge 16 by positioning the two pieces so that they become engaged with each other.
- This particular dovetail arrangement is exemplary and it is understood that a different mechanical arrangement of cooperating elements on two portions of a delivery system can instead be used, where the stent structure is attached to one of the pieces of the delivery system, which in turn is mechanically attachable to another piece of the delivery system.
- the wires with pigtail ends are not part of a cartridge-based system, but that the wires are instead attached directly to a delivery system that does not include a cartridge.
- the cartridge 16 and its attached stent 18 are then retracted into a hollow tube or lumen 26 of the delivery system by moving or pulling the cartridge 16 toward the proximal end of the delivery device. This movement is continued until the crowns of the stent 18 are adjacent to the end of the lumen 26.
- the lumen 26 may be an outer sheath of the system or that it may be an inner lumen such that another sheath or tube can be positioned on the outside of it.
- the cartridge 16 Due to the compressible nature of the stent 18, continued movement of the cartridge 16 toward the proximal end of the delivery device will pull the wires 20 toward a central lumen 28 of the delivery system, thereby also pulling the wires of the stent 18 toward the central lumen 28.
- the cartridge 16 can then continue to be moved toward the proximal end of the device until the stent 18 is completely enclosed within the lumen 26, as is illustrated in Figure 1.
- One exemplary procedure that can be used for such a retraction of the stent 18 into the lumen 26 is to turn the knob 32 (see Figure 2) in a first direction (e.g., clockwise) until the knob is fully forward.
- Figures 8-10 illustrate the deployment of the stent 18 via a delivery system, which would be initiated once the stent 18 is generally located in its desired anatomic position within a lumen (e.g. heart valve area) of the patient.
- Figure 8 shows the proximal end of a delivery system as the lumen 26 is being moved away from a distal tip 29 of the delivery system, thereby exposing the free end of the stent 18 (i.e., the end of stent 18 that is not attached to the coiled wires 20).
- Figure 9 illustrates the next step in the process, where the lumen 26 is moved even further from the distal tip 28 of the system, thereby allowing the entire length of the stent 18 to be released from the interior portion of lumen 26 for expansion thereof.
- the wires 20 are then pulled via an actuating mechanism of the delivery system back toward the proximal end of the device until the coiled or pigtail portions are immediately adjacent to the end of the lumen 26, as illustrated in Figure 10.
- the cartridge 16 with extending wires 20, along with the lumen 26 to which they are attached are pulled further toward the proximal end of the device until the coiled ends of the wires 20 contact and interfere with the end of the lumen 26, which thereby forces the wires 20 to uncoil or straighten at their distal ends.
- knob 32 see Figure 2
- Knob 30 can then be retracted, thereby fully releasing the stent 18 from the delivery system.
- the stent can be retracted back into the lumen 26 at any point in the process prior to the time that the wires 20 are disengaged from the stent 18, such as for repositioning of the stent if it is determined that the stent is not optimally positioned relative to the patient's anatomy. In this case, the steps described above can be repeated until the desired positioning of the stent is achieved.
- a cartridge can alternatively be pre-attached to a valved stent, packaged together within a gluteraldehyde solution, and provided in this pre-assembled manner to a clinician.
- the clinician can simply remove the assembly at the time of the implantation procedure and attach it to the delivery system, which can reduce the amount of time the valved stent needs to be manipulated immediately prior to the time of implantation.
- full or partial blood flow through the valve can advantageously be maintained during the period when the stented valve is being deployed into the patient but is not yet released from its delivery system.
- This feature can help to prevent complications that may occur when blood flow is stopped or blocked during valve implantation with some other known delivery systems.
- This also eliminates or reduces the need for additional procedural steps, such as rapid pacing, circulatory assist, and/or other procedures.
- the system and process described above can include simultaneous or generally simultaneous straightening of the wires so that they all uncoil or straighten at their distal ends to disengage from the stent in a single step.
- the wires can be straightened in a serial manner, where individual wires, pairs of wires, or other combinations of wires are selectively straightened in some predetermined order to sequentially deploy portions of the stent. This can be accomplished either by the structure of the delivery device and/or the structure of the stent and/or through the operation of the delivery system being used.
- One exemplary actuating mechanism that can be used with the delivery system can engage all or some of the wires to allow for sequential release of the various stent crowns.
- This serial release of crowns can be advantageous in that it allows for a high level of control of the diametric deflection (e.g., expansion) of the proximal end of the stented valve.
- release of high radial force stents sequentially can minimize injury and trauma to the anatomy. Having control of the diametric expansion of all or a portion of the stent can minimize the possibility for device migration, tissue injury and/or embolic events during device deployment.
- the serial or sequential release of crowns can require less force for any one wire or set of wires as compared to the amount of force that is required to release all of the wires at the same time.
- regions of the stent such as fixation anchors, petals, and the like could be released in a desired sequent to optimize the positioning and consistency of deployment.
- release of specific regions of the stent at different axial zones or regions of varying geometry (inflow flares, bulbous regions, and the like) and/or varying radial force can enable more accurate and stable positioning and device release.
- Figure 25 illustrates one embodiment of a portion of a sequential wire release configuration of a stent delivery system, which includes a first disk 200 and a second disk 202 spaced from disk 200 generally along the same longitudinal axis.
- Disk 200 includes a surface 204 from which three wires 206 extend.
- Disk 202 includes a surface 208 from which three wires 210 extend and three apertures 212 through which the wires 206 of disk 200 can extend.
- the number of wires and apertures of each disk can be more or less than three, as desired. It is further understood that more than two disks may be provided, with one or more wires being attached to each of the disks.
- All of the wires 206, 210 terminate at their distal ends with a coiled portion that can include any of the coiled wire properties discussed herein.
- Each of the wires in the sets of wires 206, 210 can have the same length or a different length so that the coiled ends are at the same or a different distance from the surface 208 of disk 202.
- This wire release configuration further includes activation members that are shown schematically as wires 214, 216, where wires 214 extend through a center aperture 218 of disk 200 and attach to the disk 202 and wires 216 are attached to the disk 200.
- the wires 214, 216 can be independently activated to axially move the disks 200 and 202 with their attached wires 210, 206, respectively.
- the activation wires 214, 216 are intended to be representative activation means, where other activation means can instead be used to provide independent axial movement of the disks 200, 202.
- multiple wires can be released from a stent in a sequence that includes radially releasing stent wires as individual wires, wire pairs, or groups of wires around the periphery of the stent.
- stent wires on opposite sides of the circumference can be released as a pair, and then the sequence can continue in a clockwise or counterclockwise direction until all of the wires are released from the stent. This can be performed on wires in the same axial plane. It is further advantageous, in accordance with the invention, to sequentially release the wires from the stent among various axial planes. This can be valuable for stents that have varying radial force in planes.
- FIG. 11 illustrates one exemplary embodiment of an end portion of a delivery system that includes another embodiment of a lumen 40 from which the distal ends of multiple wires 42 extend. As shown, the distal end of each of the wires 42 has the same number of coils or loops; however, the distance between each of these coils and an end 44 of the lumen 40 is different.
- the shortest wire 42 will contact the lumen 40 first. Enough interference is preferably created between the wire 42 and the lumen 40 so that as this shortest wire 42 is pulled into the lumen 40, it is straightened and ultimately released from the stent feature to which it is attached. The wires 42 will continue to be moved further toward the end 44 of lumen 40 until the next longest wire 42 contacts the lumen, which also will be uncoiled or straightened to release it from the stent. This process will be repeated until all of the wires 42 are released from the stent and the stent is fully deployed.
- wires 42 Although only three wires 42 are shown in this figure, a different number of wires can instead be provided, and preferably the number of wires provided matches the number of crowns on the stent that is being delivered by the delivery system.
- all of the wires can have different lengths and/or numbers of windings at their distal ends, or at least one of the wires can be configured identically to at least one other wire of that delivery system.
- the delivery system can include identical pairs of wires such that each wire pair releases from a stent simultaneously during the stent deployment process.
- Figure 12 illustrates another exemplary embodiment of an end portion of a delivery system that is similar to that of Figure 1 1 in that it includes a lumen 50 from which the distal ends of multiple wires 52 extend.
- the wires 52 are not all configured identically to each other.
- the distal ends of each of the wires 52 has a different number of windings at its coiled end so that when the wires 52 are attached to a stent and pulled toward an end 54 of the lumen 50, the coiled portions of all or most of the wires 52 will contact the end 54 at generally the same time.
- FIG. 13-16 A distal end of another exemplary embodiment of a delivery system of the invention is illustrated in Figures 13-16.
- This delivery system provides a structure for attachment of a stent or stented valve that allows for full diametric expansion and assessment of the stent or stented valve prior to its release from the delivery system.
- the hemodynamic performance, stability, and effect on adjacent anatomical structures can be assessed and if found to be inadequate or inaccurate, the stent can be recaptured and repositioned before final release of the stent from the delivery system.
- the entire stent can be removed from a patient before it is released from the delivery system if any undesirable results are obtained during the process of deploying the stent.
- an end portion of a delivery system which generally includes a lumen 60 having an end 64 from which the distal ends of multiple wires 62 extend.
- This lumen 60 may be the outer sheath of the delivery system.
- Each of the wires 62 is partially enclosed within a tube 66, and a coiled end of each of the wires 62 extends beyond a distal end 68 of each of the tubes 66.
- Each wire 62 is longitudinally moveable or slideable relative to its respective tube 66.
- the tubes 66 are preferably sized so that when the wires 62 are pulled toward the lumen 60, the coiled ends of the wires 62 will contact and interfere with the ends 68 of the tubes 66.
- the tubes 66 are preferably relatively incompressible to allow sufficient tension in the coiled portion of the wires 62 for the wires to straighten when pulled toward the lumen.
- the incompressibility of the tubes under tension can simulate flexible columns that resist buckling when the coiled wire ends are pulled against them. In an .
- the wires 62 can have different lengths and/or different numbers of windings in their coils (such as in Figures 11 and 12, for example), to provide for sequential release of the wires.
- the tubes 66 can have different lengths, thereby providing different sizes of gaps between the end of the tubes 66 and the coiled portion of the wires 62.
- FIG. 23 Another alternative stent wire release embodiment is illustrated in Figure 23 with an end portion of a tube 150 in which a coiled end 152 of a wire 154 is positioned. Coiled end 152 is attached to a stent crown 156 and is at least partially enclosed or contained within the tube 150.
- a retraction force is applied to wire 154 until the stent crown 156 contacts an end 158 of the tube 150, which will limit further movement of the stent.
- Continued application of force to wire 154 will cause the coiled end 152 to unfurl, thereby releasing the coiled end 152 from the stent crown 156.
- Figure 24 illustrates a similar wire release embodiment to that illustrated in Figure 23, but with an additional tube 160 positioned within tube 150.
- the wire can be unfurled by interference between an end 162 of tube 160 and the coiled wire end and/or can be unfurled by movement of the wire relative to the tube 150, as described relative to Figure 23.
- the wire coils in these and other embodiments of the invention can include a complete or partial coil with multiple windings or a partial winding, depending on the desired release properties.
- FIGS 17-21 illustrate an exemplary delivery system 100 that can be used to provide sequential release of wires that have their coiled ends engaged with a stent 120, where the wires all have generally the same configuration (i.e., length, number of coils, and the like).
- Delivery system 100 includes a lumen 102 having an end 104 from which the distal ends of multiple wires 106 extend. Each of the wires 106 is partially enclosed within a tube 108. A coiled end 1 12 of each of the wires 106 extends beyond a distal end 1 10 of each of the tubes 108. Each wire 106 is longitudinally moveable or slideable relative to its respective tube 108.
- the tubes 108 are preferably sized so that when the wires 106 are pulled toward the lumen 102 (or when the tubes 108 are moved relative to the wires 106), the coiled ends 112 of the wires 106 will contact the distal ends 110 of the tubes 108. Continued movement of the wires 106 relative to the tubes 108 will then cause the coiled ends 112 of the wires 106 to straighten, thereby facilitating release of the stent 120 from the delivery system 100.
- Delivery system 100 further includes a handle 130 from which the lumen 102 extends.
- the handle 130 includes control aspects for deployment of the stent 120.
- handle 130 includes a proximal control knob 132, an intermediate control knob 134, and a distal control knob 136. These control knobs are provided for controlling the delivery and deployment of the stent 120. In one exemplary embodiment of the invention, these knobs are spring-loaded such that they need to be pressed toward the handle in order to move them along a path to a new location.
- the handle 130 can also be provided with a series of detents that define the specific locations where the knobs can be located.
- the delivery system 100 may also include additional knobs, levers, or the like that can be used to control the movement of the individual wires 106 or groups of wires.
- the control knobs 132, 134, 136 are moved into a position that can be referred to as the "loading position”. Specific detents or other markings can be provided on the delivery system to indicate the correct position for the knobs.
- the cartridge can then be attached to the delivery system using a dovetail connection or some other type of secure attachment mechanism.
- the proximal knob 132 can then be moved to a "prepare to sheath position", while the distal knob 136 is moved to the "sheath position”.
- the sheath will be moved to a position in which the stent is protected by the sheath.
- the delivery system can then be inserted into the patient in its desired position that facilitates deployment of the stent.
- Moving the proximal knob 132 into the "proximal end open position” and the distal knob 136 to the "load position” can then deploy the stent 120.
- a switch on the delivery system (not shown) or some other control mechanism can be moved into an "open position”
- the distal knob 136 can be moved to the "discharge position”
- the proximal knob 132 can be moved to its "discharge position".
- the intermediate knob 134 can be manipulated at the same time as the other knobs in order to facilitate the loading, sheathing, deployment, and discharge procedures.
- the delivery system 100 further comprises a dual-control procedure and mechanism to sequentially pull the wires 106 into the tubes 108 to disconnect them from the crowns of the stent 120.
- a first group of wires 106 can first be removed from the stent 120, and then a second group of wires 106 can be removed from the stent 120 to thereby release the stent 120 from the delivery system 100.
- each of the groups of wires 106 may include half of the wires, or there may be a different percentage of wires 106 in each of the groups.
- the division of wires into groups may further include having every other wire be included in one group and the alternating wires are included in a second group, although the wires may be grouped in a different pattern. It is further contemplated that additional mechanisms can be provided so that the wires are divided into more than two groups that are controlled by separate mechanisms for sequential wire release.
- Figures 17 and 18 illustrate the step in which the wires 106 are each attached at their distal end 1 12 to a crown of stent 120.
- Figure 19 illustrates the step in which some of the wires 106 have been pulled into their respective tubes 108, thereby straightening the distal end of the wires and detaching them from the stent 120. However, the remainder of the wires 106 remains attached to the crowns of the stent 120.
- Figures 20 and 21 illustrate the step when the remaining wires 106 have been pulled into their respective tubes 108, thereby straightening the distal end of the wires and detaching them from the stent 120.
- the release of the stent 120 from the delivery system 100 is more gradual than when all of the wires are detached from the stent at the same time.
- the components of the delivery system can alternatively comprise different components than shown to accomplish the serial wire release shown more generally in Figures 18, 19, and 21.
- the delivery systems of the invention can be used for both apical and transfemoral procedures, for example, and may have the ability to be able to clock the stent, as desired.
- the delivery systems may further include a removable outer sheath that can accommodate stents of different sizes.
- the process of pulling the wires toward the lumen in many of the described embodiments of the invention can be accomplished in a number of ways, such as by rotating the device over coarse threads or pushing a button to slide it to pull the wires toward the lumen. That is, a number of different mechanisms can be used to accomplish this movement of the wires relative to the delivery system.
- coiled wire ends described herein are generally shown to be engaging with the end crowns of a stent, the coiled wire ends can instead engage with intermediate stent crowns or other stent features.
- the coiled wire ends are illustrated herein as interfacing with stent crowns that are uniformly provided at the ends of a cylindrical stent, the coiled wire designs described can also accommodate delivery of valved stents that have non-uniform axial or longitudinal stent crowns of stent feature attachment geometries.
- the delivery systems of the invention having a stent attached via coiled wire ends, can be delivered through a percutaneous opening (not shown) in the patient.
- the implantation location can be located by inserting a guide wire into the patient, which guide wire extends from a distal end of the delivery system. The delivery system is then advanced distally along the guide wire until the stent is positioned relative to the implantation location.
- the stent is delivered to an implantation location via a minimally invasive surgical incision (i.e., non-percutaneously).
- the stent is delivered via open heart/chest surgery.
- the stent can include a radiopaque, echogenic, or MRJ visible material to facilitate visual confirmation of proper placement of the stent. Alternatively, other known surgical visual aids can be incorporated into the stent.
- the techniques described relative to placement of the stent within the heart can be used both to monitor and correct the placement of the stent in a longitudinal direction relative to the length of the anatomical structure in which it is positioned.
- One or more markers on the valve, along with a corresponding imaging system e.g., echo, MRI, etc.
- a corresponding imaging system e.g., echo, MRI, etc.
- a number of factors can be considered, alone or in combination, to verify that the valve is properly placed in an implantation site, where some exemplary factors are as follows: (1) lack of paravalvular leakage around the replacement valve, which can be advantageously examined while blood is flowing through the valve since these delivery systems allow for flow through and around the valve; (2) optimal rotational orientation of the replacement valve relative to the coronary arteries; (3) the presence of coronary flow with the replacement valve in place; (4) correct longitudinal alignment of the replacement valve annulus with respect to the native patient anatomy; (5) verification that the position of the sinus region of the replacement valve does not interfere with native coronary flow; (6) verification that the sealing skirt is aligned with anatomical features to minimize paravalvular leakage; (7) verification that the replacement valve does not induce arrhythmias prior to final release; and (8) verification that the replacement valve does not interfere with function of an adjacent valve, such as the mitral valve.
Abstract
Description
Claims
Priority Applications (4)
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EP09704814.4A EP2254515B1 (en) | 2008-01-24 | 2009-01-23 | Delivery systems for prosthetic heart valves |
AU2009206672A AU2009206672B2 (en) | 2008-01-24 | 2009-01-23 | Delivery systems and methods of implantation for prosthetic heart valves |
CN200980110514.XA CN101980670B (en) | 2008-01-24 | 2009-01-23 | Delivery systems and methods of implantation for prosthetic heart valves |
JP2010544346A JP5628688B2 (en) | 2008-01-24 | 2009-01-23 | Delivery system and method for implantation of a prosthetic heart valve |
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US8157853B2 (en) | 2012-04-17 |
CN101980670B (en) | 2014-04-23 |
US20210361425A1 (en) | 2021-11-25 |
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EP2254515B1 (en) | 2015-01-07 |
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US10758343B2 (en) | 2020-09-01 |
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US8685077B2 (en) | 2014-04-01 |
CN101980670A (en) | 2011-02-23 |
US11607311B2 (en) | 2023-03-21 |
US8157852B2 (en) | 2012-04-17 |
EP2254515A1 (en) | 2010-12-01 |
JP2011509806A (en) | 2011-03-31 |
US9333100B2 (en) | 2016-05-10 |
AU2009206672B2 (en) | 2014-06-12 |
AU2009206672A1 (en) | 2009-07-30 |
US20090198316A1 (en) | 2009-08-06 |
US20090192585A1 (en) | 2009-07-30 |
JP5628688B2 (en) | 2014-11-19 |
US20210322161A1 (en) | 2021-10-21 |
US20140081383A1 (en) | 2014-03-20 |
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