WO2010002862A3 - Fibroblast growth factor receptor 3 (fgfr3) binding proteins - Google Patents

Fibroblast growth factor receptor 3 (fgfr3) binding proteins Download PDF

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Publication number
WO2010002862A3
WO2010002862A3 PCT/US2009/049211 US2009049211W WO2010002862A3 WO 2010002862 A3 WO2010002862 A3 WO 2010002862A3 US 2009049211 W US2009049211 W US 2009049211W WO 2010002862 A3 WO2010002862 A3 WO 2010002862A3
Authority
WO
WIPO (PCT)
Prior art keywords
fgfr3
growth factor
factor receptor
fibroblast growth
binding proteins
Prior art date
Application number
PCT/US2009/049211
Other languages
French (fr)
Other versions
WO2010002862A2 (en
Inventor
Zhigang Weng
William M. Winston, Jr.
Lyne Breault
Kristan Meetze
Solly Weiler
Jeno Gyuris
Original Assignee
Aveo Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aveo Pharmaceuticals, Inc. filed Critical Aveo Pharmaceuticals, Inc.
Priority to EP09774313A priority Critical patent/EP2313435A4/en
Publication of WO2010002862A2 publication Critical patent/WO2010002862A2/en
Publication of WO2010002862A3 publication Critical patent/WO2010002862A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Abstract

Monoclonal antibodies that bind and inhibit activation of fibroblast growth factor receptor 3 (FGFR3) are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of FGFR3.
PCT/US2009/049211 2008-07-01 2009-06-30 Fibroblast growth factor receptor 3 (fgfr3) binding proteins WO2010002862A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09774313A EP2313435A4 (en) 2008-07-01 2009-06-30 Fibroblast growth factor receptor 3 (fgfr3) binding proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7727808P 2008-07-01 2008-07-01
US61/077,278 2008-07-01

Publications (2)

Publication Number Publication Date
WO2010002862A2 WO2010002862A2 (en) 2010-01-07
WO2010002862A3 true WO2010002862A3 (en) 2010-05-27

Family

ID=41464552

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/049211 WO2010002862A2 (en) 2008-07-01 2009-06-30 Fibroblast growth factor receptor 3 (fgfr3) binding proteins

Country Status (3)

Country Link
US (1) US8187601B2 (en)
EP (1) EP2313435A4 (en)
WO (1) WO2010002862A2 (en)

Cited By (1)

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US8410250B2 (en) 2009-03-25 2013-04-02 Genentech, Inc. Anti-FGFR3 antibodies and methods using same

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US11117975B2 (en) 2013-04-29 2021-09-14 Teva Pharmaceuticals Australia Pty Ltd Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B
US10780182B2 (en) 2014-04-25 2020-09-22 The Trustees Of The University Of Pennsylvania Methods and compositions for treating metastatic breast cancer and other cancers in the brain
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KR102550926B1 (en) 2014-05-13 2023-07-05 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 Compositions comprising aav expressing dual antibody constructs and uses thereof
CN107073121A (en) 2014-06-13 2017-08-18 基因泰克公司 Treatment and the method for prevention cancer drug resistance
MX2017001983A (en) * 2014-08-15 2017-05-23 Oncomed Pharm Inc Rspo1 binding agents and uses thereof.
MA40574A (en) 2014-09-16 2016-03-24 Oncomed Pharm Inc Treatment of fibrotic diseases
KR102639037B1 (en) 2014-10-29 2024-02-20 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 INTERFERON α2b VARIANTS
US10208120B2 (en) 2014-11-05 2019-02-19 Genentech, Inc. Anti-FGFR2/3 antibodies and methods using same
US20180237424A1 (en) 2015-03-03 2018-08-23 Inserm (Institut National De La Sante Et De La Recherche Medicale) Fgfr3 antagonists
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WO2017180530A1 (en) * 2016-04-14 2017-10-19 Academia Sinica Inhibition of scube2, a novel vegfr2 co-receptor, suppresses tumor angiogenesis
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EP4122955A1 (en) 2016-07-07 2023-01-25 Pfizer Inc. Soluble fibroblast growth factor receptor 3 (sfgfr3) polypeptides and uses thereof
US10722589B2 (en) 2017-04-03 2020-07-28 Covagen Ag FGFR3 binding molecules
JP2021531027A (en) * 2018-07-27 2021-11-18 アレクトル エルエルシー Anti-Siglec-5 antibody and how to use it
AR123306A1 (en) 2020-08-21 2022-11-16 Genzyme Corp FGFR3 ANTIBODIES AND METHODS OF USE
CN114716548A (en) * 2021-01-05 2022-07-08 (株)爱恩德生物 anti-FGFR 3 antibodies and uses thereof
US20230034817A1 (en) 2021-04-12 2023-02-02 Affinia Therapeutics Inc. Recombinant aav for treatment of neural disease
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Also Published As

Publication number Publication date
EP2313435A4 (en) 2012-08-08
US20100003258A1 (en) 2010-01-07
WO2010002862A2 (en) 2010-01-07
US8187601B2 (en) 2012-05-29
EP2313435A2 (en) 2011-04-27

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