WO2010033578A3 - Noninvasive diagnosis of fetal aneuploidy by sequencing - Google Patents
Noninvasive diagnosis of fetal aneuploidy by sequencing Download PDFInfo
- Publication number
- WO2010033578A3 WO2010033578A3 PCT/US2009/057136 US2009057136W WO2010033578A3 WO 2010033578 A3 WO2010033578 A3 WO 2010033578A3 US 2009057136 W US2009057136 W US 2009057136W WO 2010033578 A3 WO2010033578 A3 WO 2010033578A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- chromosome
- sequence tags
- dna
- sequencing
- counting
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/38—Pediatrics
- G01N2800/385—Congenital anomalies
- G01N2800/387—Down syndrome; Trisomy 18; Trisomy 13
Abstract
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK09815105.3T DK2334812T3 (en) | 2008-09-20 | 2009-09-16 | Non-invasive diagnosis of fetal aneuploidy by sequencing |
EP18156359.4A EP3378951B1 (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of aneuploidy by sequencing |
LTEP09815105.3T LT2334812T (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
EP20174078.4A EP3751005A3 (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
CA2737643A CA2737643C (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
AU2009293354A AU2009293354B2 (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
ES09815105.3T ES2620012T3 (en) | 2008-09-20 | 2009-09-16 | Non-invasive diagnosis of fetal aneuploidy by sequencing |
SI200931631A SI2334812T1 (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
EP09815105.3A EP2334812B1 (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
IL211794A IL211794A (en) | 2008-09-20 | 2011-03-17 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
AU2015202167A AU2015202167B2 (en) | 2008-09-20 | 2015-04-28 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
IL243655A IL243655A (en) | 2008-09-20 | 2016-01-18 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
CY20171100339T CY1118802T1 (en) | 2008-09-20 | 2017-03-16 | NON-INVESTIGATIVE DIAGNOSIS OF EMBRYOPATHIC DISEASE WITH CONTROL |
HRP20170435TT HRP20170435T1 (en) | 2008-09-20 | 2017-03-17 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
AU2018201920A AU2018201920B2 (en) | 2008-09-20 | 2018-03-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
AU2021200569A AU2021200569B2 (en) | 2008-09-20 | 2021-01-29 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9875808P | 2008-09-20 | 2008-09-20 | |
US61/098,758 | 2008-09-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010033578A2 WO2010033578A2 (en) | 2010-03-25 |
WO2010033578A3 true WO2010033578A3 (en) | 2010-05-14 |
Family
ID=42040105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/057136 WO2010033578A2 (en) | 2008-09-20 | 2009-09-16 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
Country Status (17)
Country | Link |
---|---|
US (9) | US20100112575A1 (en) |
EP (5) | EP3751005A3 (en) |
AU (1) | AU2009293354B2 (en) |
CA (4) | CA3069081C (en) |
CY (2) | CY1118802T1 (en) |
DK (2) | DK2334812T3 (en) |
ES (2) | ES2620294T3 (en) |
HK (1) | HK1217354A1 (en) |
HR (2) | HRP20170435T1 (en) |
HU (2) | HUE031848T2 (en) |
IL (2) | IL211794A (en) |
LT (2) | LT2334812T (en) |
PL (2) | PL2562268T3 (en) |
PT (2) | PT2562268T (en) |
SG (1) | SG10201500567VA (en) |
SI (2) | SI2334812T1 (en) |
WO (1) | WO2010033578A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8318430B2 (en) | 2010-01-23 | 2012-11-27 | Verinata Health, Inc. | Methods of fetal abnormality detection |
CN103525939A (en) * | 2013-10-28 | 2014-01-22 | 广州爱健生物技术有限公司 | Method and system for noninvasive detection of fetus chromosome aneuploid |
CN111755068B (en) * | 2020-06-19 | 2021-02-19 | 深圳吉因加医学检验实验室 | Method and device for identifying tumor purity and absolute copy number based on sequencing data |
Families Citing this family (187)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2552262C (en) | 2004-02-02 | 2016-04-19 | The University Of British Columbia | Scodaphoresis and methods and apparatus for moving and concentrating particles |
US8518228B2 (en) | 2011-05-20 | 2013-08-27 | The University Of British Columbia | Systems and methods for enhanced SCODA |
US8529744B2 (en) | 2004-02-02 | 2013-09-10 | Boreal Genomics Corp. | Enrichment of nucleic acid targets |
US10337054B2 (en) | 2004-02-02 | 2019-07-02 | Quantum-Si Incorporated | Enrichment of nucleic acid targets |
US20100216153A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
US8024128B2 (en) * | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
US8515679B2 (en) * | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
US20070178501A1 (en) * | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
US20070027636A1 (en) * | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
DK3002338T3 (en) | 2006-02-02 | 2019-08-05 | Univ Leland Stanford Junior | NON-INVASIVE FEET GENETIC SCREENING BY DIGITAL ANALYSIS |
EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US20080070792A1 (en) | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
US8137912B2 (en) * | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
US20100112590A1 (en) * | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
CA3176319A1 (en) | 2007-07-23 | 2009-01-29 | The Chinese University Of Hong Kong | Analyzing tumor dna in a cell-free sample |
ES2380844T3 (en) | 2007-09-07 | 2012-05-18 | Fluidigm Corporation | Determination of the variation in the number of copies, methods and systems |
US8475641B2 (en) | 2008-02-01 | 2013-07-02 | The University Of British Columbia | Methods and apparatus for particle introduction and recovery |
US20110033862A1 (en) * | 2008-02-19 | 2011-02-10 | Gene Security Network, Inc. | Methods for cell genotyping |
US20110092763A1 (en) * | 2008-05-27 | 2011-04-21 | Gene Security Network, Inc. | Methods for Embryo Characterization and Comparison |
CN104732118B (en) | 2008-08-04 | 2017-08-22 | 纳特拉公司 | Allele calls the method with ploidy calling |
US8962247B2 (en) * | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
SI2334812T1 (en) | 2008-09-20 | 2017-05-31 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
WO2010085815A1 (en) * | 2009-01-26 | 2010-07-29 | Artemis Health, Inc. | Methods and compositions for identifying a fetal cell |
WO2010121381A1 (en) | 2009-04-21 | 2010-10-28 | The University Of British Columbia | System and methods for detection of particles |
ES2640776T3 (en) | 2009-09-30 | 2017-11-06 | Natera, Inc. | Methods for non-invasively calling prenatal ploidy |
ES2564656T3 (en) | 2009-10-26 | 2016-03-28 | Lifecodexx Ag | Means and methods for the non-invasive diagnosis of chromosomal aneuploidy |
EP2516680B1 (en) | 2009-12-22 | 2016-04-06 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
WO2011091046A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic dna by whole genome sequencing |
US20120010085A1 (en) | 2010-01-19 | 2012-01-12 | Rava Richard P | Methods for determining fraction of fetal nucleic acids in maternal samples |
WO2011091063A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Partition defined detection methods |
US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
US9260745B2 (en) | 2010-01-19 | 2016-02-16 | Verinata Health, Inc. | Detecting and classifying copy number variation |
US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
DK3260555T3 (en) * | 2010-01-19 | 2019-01-21 | Verinata Health Inc | Hitherto UNKNOWN PROTOCOL FOR PREPARING SEQUENCE LIBRARIES |
US20120100548A1 (en) | 2010-10-26 | 2012-04-26 | Verinata Health, Inc. | Method for determining copy number variations |
WO2011130880A1 (en) * | 2010-04-23 | 2011-10-27 | 深圳华大基因科技有限公司 | Detection method of fetal chromosomal aneuploidy |
US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
CA2798758C (en) | 2010-05-18 | 2019-05-07 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
ES2552343T3 (en) * | 2010-08-13 | 2015-11-27 | Bgi Genomics Co., Ltd. | A procedure for the analysis of cell chromosomes |
CN103370456A (en) * | 2010-08-24 | 2013-10-23 | 比奥Dx股份有限公司 | Defining diagnostic and therapeutic targets of conserved free floating fetal DNA in maternal circulating blood |
EP2649199A2 (en) | 2010-12-07 | 2013-10-16 | Stanford University | Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale |
AU2011348100B2 (en) | 2010-12-22 | 2016-08-25 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
US10131947B2 (en) * | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
CA2824387C (en) | 2011-02-09 | 2019-09-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
DK2697392T3 (en) | 2011-04-12 | 2016-03-29 | Verinata Health Inc | SOLUTION OF GENOME FRACTIONS USING Polymorphism COUNTS |
GB2484764B (en) * | 2011-04-14 | 2012-09-05 | Verinata Health Inc | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies |
WO2012141712A1 (en) * | 2011-04-14 | 2012-10-18 | Verinata Health, Inc. | Normalizing chromosomes for the determination and verification of common and rare chromosomal aneuploidies |
US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
HUE031239T2 (en) * | 2011-05-31 | 2017-07-28 | Berry Genomics Co Ltd | A device for detecting copy number of fetal chromosomes or tumor cell chromosomes |
WO2012177792A2 (en) | 2011-06-24 | 2012-12-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of a genetic variation |
SG191757A1 (en) * | 2011-06-29 | 2013-08-30 | Bgi Health Service Co Ltd | Noninvasive detection of fetal genetic abnormality |
WO2013015793A1 (en) * | 2011-07-26 | 2013-01-31 | Verinata Health, Inc. | Method for determining the presence or absence of different aneuploidies in a sample |
US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
CN103764841B (en) * | 2011-09-21 | 2016-06-29 | 深圳华大基因股份有限公司 | Determine the method and system of unicellular chromosomal aneuploidy |
US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US20140242588A1 (en) | 2011-10-06 | 2014-08-28 | Sequenom, Inc | Methods and processes for non-invasive assessment of genetic variations |
US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
JP6073902B2 (en) * | 2011-10-06 | 2017-02-01 | セクエノム, インコーポレイテッド | Methods and processes for non-invasive assessment of genetic variation |
US8688388B2 (en) * | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
DK2768978T3 (en) | 2011-10-18 | 2017-12-18 | Multiplicom Nv | Fetal CHROMOSOMAL ANEUPLOIDID DIAGNOSIS |
WO2013060762A1 (en) * | 2011-10-25 | 2013-05-02 | Roche Diagnostics Gmbh | Method for diagnosing a disease based on plasma-dna distribution |
AU2012327251A1 (en) | 2011-10-27 | 2013-05-23 | Verinata Health, Inc. | Set membership testers for aligning nucleic acid samples |
KR101922129B1 (en) | 2011-12-05 | 2018-11-26 | 삼성전자주식회사 | Method and apparatus for compressing and decompressing genetic information using next generation sequencing(NGS) |
WO2013086352A1 (en) * | 2011-12-07 | 2013-06-13 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
WO2013086744A1 (en) * | 2011-12-17 | 2013-06-20 | 深圳华大基因研究院 | Method and system for determining whether genome is abnormal |
WO2013104994A2 (en) | 2012-01-13 | 2013-07-18 | The University Of British Columbia | Multiple arm apparatus and methods for separation of particles |
EP2826865B8 (en) * | 2012-01-20 | 2017-08-16 | BGI Genomics Co., Ltd. | Method and system for determining whether copy number variation exists in sample genome, and computer readable medium |
HUE059847T2 (en) | 2012-01-20 | 2023-01-28 | Sequenom Inc | Diagnostic processes that factor experimental conditions |
EP4155401A1 (en) | 2012-03-02 | 2023-03-29 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
AU2013232123B2 (en) | 2012-03-13 | 2014-10-30 | The Chinese University Of Hong Kong | Methods for analyzing massively parallel sequencing data for noninvasive prenatal diagnosis |
EP4239081A3 (en) * | 2012-03-26 | 2023-11-08 | The Johns Hopkins University | Rapid aneuploidy detection |
CN108485940B (en) * | 2012-04-12 | 2022-01-28 | 维里纳塔健康公司 | Detection and classification of copy number variation |
EP2844773B1 (en) | 2012-05-04 | 2017-08-16 | Boreal Genomics Corp. | Biomarker analysis using scodaphoresis |
US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
CA2878979C (en) | 2012-07-13 | 2021-09-14 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
EP2875156A4 (en) | 2012-07-19 | 2016-02-24 | Ariosa Diagnostics Inc | Multiplexed sequential ligation-based detection of genetic variants |
CN104685064A (en) | 2012-07-24 | 2015-06-03 | 纳特拉公司 | Highly multiplex PCR methods and compositions |
US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US20160040229A1 (en) | 2013-08-16 | 2016-02-11 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
CA3190199A1 (en) | 2012-09-04 | 2014-03-13 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US11913065B2 (en) | 2012-09-04 | 2024-02-27 | Guardent Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
TWI489305B (en) * | 2012-11-21 | 2015-06-21 | Bgi Diagnosis Co Ltd | Non-invasive detection of fetus genetic abnormality |
US10643738B2 (en) | 2013-01-10 | 2020-05-05 | The Chinese University Of Hong Kong | Noninvasive prenatal molecular karyotyping from maternal plasma |
US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
KR101614471B1 (en) * | 2013-02-28 | 2016-04-21 | 주식회사 테라젠이텍스 | Method and apparatus for diagnosing fetal chromosomal aneuploidy using genomic sequencing |
EP3597774A1 (en) | 2013-03-13 | 2020-01-22 | Sequenom, Inc. | Primers for dna methylation analysis |
US9340835B2 (en) | 2013-03-15 | 2016-05-17 | Boreal Genomics Corp. | Method for separating homoduplexed and heteroduplexed nucleic acids |
EP3409791B1 (en) * | 2013-03-15 | 2021-06-30 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
US10930368B2 (en) | 2013-04-03 | 2021-02-23 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
IL300163B1 (en) | 2013-05-24 | 2024-02-01 | Sequenom Inc | Methods and processes for non-invasive assessment of genetic variations |
KR102299305B1 (en) | 2013-06-21 | 2021-09-06 | 시쿼넘, 인코포레이티드 | Methods and processes for non-invasive assessment of genetic variations |
US20160154931A1 (en) * | 2013-07-17 | 2016-06-02 | Bgi Genomics Co., Limited | Method and device for detecting chromosomal aneuploidy |
US9499870B2 (en) | 2013-09-27 | 2016-11-22 | Natera, Inc. | Cell free DNA diagnostic testing standards |
US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
US10262755B2 (en) | 2014-04-21 | 2019-04-16 | Natera, Inc. | Detecting cancer mutations and aneuploidy in chromosomal segments |
EP4258269A3 (en) | 2013-10-04 | 2024-01-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3055427B1 (en) | 2013-10-07 | 2018-09-12 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
US10851414B2 (en) * | 2013-10-18 | 2020-12-01 | Good Start Genetics, Inc. | Methods for determining carrier status |
KR102429186B1 (en) | 2013-10-21 | 2022-08-03 | 베리나타 헬스, 인코포레이티드 | Method for improving the sensitivity of detection in determining copy number variations |
ES2784450T3 (en) | 2013-12-28 | 2020-09-25 | Guardant Health Inc | Methods and systems to detect genetic variants |
WO2015138774A1 (en) | 2014-03-13 | 2015-09-17 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
EP3149202A1 (en) * | 2014-05-26 | 2017-04-05 | Ebios Futura S.r.l. | Method of prenatal diagnosis |
JP6659672B2 (en) | 2014-05-30 | 2020-03-04 | ベリナタ ヘルス インコーポレイテッド | Detection of fetal chromosome partial aneuploidy and copy number variation |
US20160026759A1 (en) * | 2014-07-22 | 2016-01-28 | Yourgene Bioscience | Detecting Chromosomal Aneuploidy |
AU2015292311B2 (en) | 2014-07-25 | 2022-01-20 | University Of Washington | Methods of determining tissues and/or cell types giving rise to cell-free DNA, and methods of identifying a disease or disorder using same |
WO2016019042A1 (en) | 2014-07-30 | 2016-02-04 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
DK3230469T3 (en) | 2014-12-12 | 2019-07-15 | Verinata Health Inc | Use of cell-free DNA fragment size to determine copy number variations |
US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
CN113957124A (en) | 2015-02-10 | 2022-01-21 | 香港中文大学 | Mutation detection for cancer screening and fetal analysis |
US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
US10395759B2 (en) | 2015-05-18 | 2019-08-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for copy number variant detection |
WO2016185284A1 (en) | 2015-05-20 | 2016-11-24 | Boreal Genomics, Inc. | Method for isolating target nucleic acid using heteroduplex binding proteins |
EP3666902A1 (en) | 2015-05-22 | 2020-06-17 | Nipd Genetics Public Company Limited | Multiplexed parallel analysis of targeted genomic regions for non-invasive prenatal testing |
EP3118323A1 (en) | 2015-07-13 | 2017-01-18 | Cartagenia N.V. | System and methodology for the analysis of genomic data obtained from a subject |
EP3636777A1 (en) | 2015-07-13 | 2020-04-15 | Agilent Technologies Belgium NV | System and methodology for the analysis of genomic data obtained from a subject |
WO2017106768A1 (en) | 2015-12-17 | 2017-06-22 | Guardant Health, Inc. | Methods to determine tumor gene copy number by analysis of cell-free dna |
US10095831B2 (en) * | 2016-02-03 | 2018-10-09 | Verinata Health, Inc. | Using cell-free DNA fragment size to determine copy number variations |
EP4198146A3 (en) | 2016-03-25 | 2023-08-23 | Karius, Inc. | Methods using synthetic nucleic acid spike-ins |
EP3491560A1 (en) | 2016-07-27 | 2019-06-05 | Sequenom, Inc. | Genetic copy number alteration classifications |
EP3518974A4 (en) | 2016-09-29 | 2020-05-27 | Myriad Women's Health, Inc. | Noninvasive prenatal screening using dynamic iterative depth optimization |
WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
EP3574424A1 (en) | 2017-01-24 | 2019-12-04 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
EP3585889A1 (en) | 2017-02-21 | 2020-01-01 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
CA3059370C (en) | 2017-04-12 | 2022-05-10 | Karius, Inc. | Methods for concurrent analysis of dna and rna in mixed samples |
US11342047B2 (en) | 2017-04-21 | 2022-05-24 | Illumina, Inc. | Using cell-free DNA fragment size to detect tumor-associated variant |
CA3068198A1 (en) | 2017-07-07 | 2019-01-10 | Nipd Genetics Public Company Limited | Enrichment of targeted genomic regions for multiplexed parallel analysis |
PL3649260T3 (en) | 2017-07-07 | 2022-10-17 | Nipd Genetics Public Company Limited | Target-enriched multiplexed parallel analysis for assessment of tumor biomarkers |
PL3649259T3 (en) | 2017-07-07 | 2022-08-08 | Nipd Genetics Public Company Limited | Target-enriched multiplexed parallel analysis for assessment of risk for genetic conditions |
PT3649258T (en) | 2017-07-07 | 2022-05-25 | Nipd Genetics Public Company Ltd | Target-enriched multiplexed parallel analysis for assessment of fetal dna samples |
HUE055063T2 (en) | 2017-07-26 | 2021-10-28 | Trisomytest S R O | A method for non-invasive prenatal detection of fetal chromosome aneuploidy from maternal blood based on bayesian network |
EP3662480A4 (en) | 2017-08-04 | 2021-05-19 | BillionToOne, Inc. | Target-associated molecules for characterization associated with biological targets |
WO2019025004A1 (en) | 2017-08-04 | 2019-02-07 | Trisomytest, S.R.O. | A method for non-invasive prenatal detection of fetal sex chromosomal abnormalities and fetal sex determination for singleton and twin pregnancies |
US11519024B2 (en) | 2017-08-04 | 2022-12-06 | Billiontoone, Inc. | Homologous genomic regions for characterization associated with biological targets |
EP3662085B1 (en) | 2017-08-04 | 2022-06-22 | Billiontoone, Inc. | Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets |
US20200299677A1 (en) | 2017-10-27 | 2020-09-24 | Juno Diagnostics, Inc. | Devices, systems and methods for ultra-low volume liquid biopsy |
EP3735470B1 (en) | 2018-01-05 | 2023-11-22 | BillionToOne, Inc. | Quality control templates for ensuring validity of sequencing-based assays |
EP3781714A1 (en) | 2018-04-14 | 2021-02-24 | Natera, Inc. | Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna |
GB201810571D0 (en) | 2018-06-27 | 2018-08-15 | Cs Genetics Ltd | Reagents and methods for the analysis of circulating microparticles |
US11525159B2 (en) | 2018-07-03 | 2022-12-13 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
CA3118990A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
JP2022519159A (en) | 2018-12-17 | 2022-03-22 | ナテラ, インコーポレイテッド | Analytical method of circulating cells |
CN109637586B (en) * | 2018-12-27 | 2020-11-17 | 北京优迅医学检验实验室有限公司 | Method and device for correcting sequencing depth |
CN109628579B (en) * | 2019-01-13 | 2022-11-15 | 清华大学 | Detection method for determining whether chromosome number in biological sample is abnormal |
GB201909325D0 (en) | 2019-06-28 | 2019-08-14 | Cs Genetics Ltd | Reagents and methods for analysis for microparticles |
CN111627498B (en) * | 2020-05-21 | 2022-10-04 | 北京吉因加医学检验实验室有限公司 | Method and device for correcting GC bias of sequencing data |
BR112023021616A2 (en) | 2021-04-22 | 2024-01-16 | Natera Inc | METHODS FOR DETERMINING THE SPEED OF TUMOR GROWTH |
WO2023014597A1 (en) | 2021-08-02 | 2023-02-09 | Natera, Inc. | Methods for detecting neoplasm in pregnant women |
WO2023133131A1 (en) | 2022-01-04 | 2023-07-13 | Natera, Inc. | Methods for cancer detection and monitoring |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050221341A1 (en) * | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
US20070202525A1 (en) * | 2006-02-02 | 2007-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
US20070212689A1 (en) * | 2003-10-30 | 2007-09-13 | Bianchi Diana W | Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid |
US20070238105A1 (en) * | 2006-04-07 | 2007-10-11 | Agilent Technologies, Inc. | High resolution chromosomal mapping |
US20080213775A1 (en) * | 2005-06-16 | 2008-09-04 | Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And | Methods and materials for identifying polymorphic variants, diagnosing susceptibilities, and treating disease |
Family Cites Families (420)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4508625A (en) | 1982-10-18 | 1985-04-02 | Graham Marshall D | Magnetic separation using chelated magnetic ions |
US4675286A (en) | 1985-01-28 | 1987-06-23 | Aspen Diagnostics, Inc. | Fetal cell separation and testing |
US5164598A (en) | 1985-08-05 | 1992-11-17 | Biotrack | Capillary flow device |
US7115709B1 (en) | 1986-01-16 | 2006-10-03 | The Regents Of The University Of California | Methods of staining target chromosomal DNA employing high complexity nucleic acid probes |
US5721098A (en) | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
US4800159A (en) * | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
US4789628A (en) | 1986-06-16 | 1988-12-06 | Vxr, Inc. | Devices for carrying out ligand/anti-ligand assays, methods of using such devices and diagnostic reagents and kits incorporating such devices |
US4971904A (en) | 1987-06-26 | 1990-11-20 | E. I. Du Pont De Nemours And Company | Heterogeneous immunoassay |
US4977078A (en) | 1987-12-22 | 1990-12-11 | Olympus Optical Co., Ltd. | Plate substrate immunoassay device and method for performing a multi-test immunoassay on a specimen |
CA1339210C (en) | 1988-05-31 | 1997-08-05 | John Lewicki | Recombinant techniques for production of novel natriuretic and vasodilator peptides |
US5215926A (en) | 1988-06-03 | 1993-06-01 | Cellpro, Inc. | Procedure for designing efficient affinity cell separation processes |
ATE161960T1 (en) | 1988-12-06 | 1998-01-15 | Flinders Technologies Pty Ltd | ISOLATION OF FETAL CELLS FROM MATERNAL BLOOD TO PERFORM PRENATAL DIAGNOSTICS |
CA1340565C (en) | 1989-06-29 | 1999-05-25 | Thomas B. Okarma | Device and process for cell capture and recovery |
US5641628A (en) * | 1989-11-13 | 1997-06-24 | Children's Medical Center Corporation | Non-invasive method for isolation and detection of fetal DNA |
DE69031984T2 (en) | 1989-11-13 | 1998-09-10 | Childrens Medical Center | A NON-INVASIVE METHOD FOR SEPARATING AND DETECTING FETAL DNA |
US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
US6176962B1 (en) * | 1990-02-28 | 2001-01-23 | Aclara Biosciences, Inc. | Methods for fabricating enclosed microchannel structures |
US5153117A (en) | 1990-03-27 | 1992-10-06 | Genetype A.G. | Fetal cell recovery method |
JPH05507404A (en) | 1990-04-23 | 1993-10-28 | セルプロ インコーポレイティド | Method for enrichment of fetal cells from maternal blood |
US5646001A (en) | 1991-03-25 | 1997-07-08 | Immunivest Corporation | Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof |
AU2765992A (en) * | 1991-10-03 | 1993-05-03 | Indiana University Foundation | Method for screening for alzheimer's disease |
US5486335A (en) * | 1992-05-01 | 1996-01-23 | Trustees Of The University Of Pennsylvania | Analysis based on flow restriction |
US5498392A (en) * | 1992-05-01 | 1996-03-12 | Trustees Of The University Of Pennsylvania | Mesoscale polynucleotide amplification device and method |
US5637469A (en) * | 1992-05-01 | 1997-06-10 | Trustees Of The University Of Pennsylvania | Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems |
US5726026A (en) | 1992-05-01 | 1998-03-10 | Trustees Of The University Of Pennsylvania | Mesoscale sample preparation device and systems for determination and processing of analytes |
ATE140025T1 (en) | 1992-05-01 | 1996-07-15 | Univ Pennsylvania | MICRO-MADE DEVICES FOR SPERM HANDLING |
US5296375A (en) | 1992-05-01 | 1994-03-22 | Trustees Of The University Of Pennsylvania | Mesoscale sperm handling devices |
US5304487A (en) | 1992-05-01 | 1994-04-19 | Trustees Of The University Of Pennsylvania | Fluid handling in mesoscale analytical devices |
US6156270A (en) | 1992-05-21 | 2000-12-05 | Biosite Diagnostics, Inc. | Diagnostic devices and apparatus for the controlled movement of reagents without membranes |
US6143576A (en) | 1992-05-21 | 2000-11-07 | Biosite Diagnostics, Inc. | Non-porous diagnostic devices for the controlled movement of reagents |
US5629147A (en) | 1992-07-17 | 1997-05-13 | Aprogenex, Inc. | Enriching and identifying fetal cells in maternal blood for in situ hybridization |
WO1994003638A1 (en) | 1992-07-30 | 1994-02-17 | Applied Biosystems, Inc. | Method of detecting aneuploidy by amplified short tandem repeats |
DE4228389C2 (en) | 1992-08-26 | 1994-07-21 | Kuebler Gmbh Dr | Collection and cultivation of transformed cells |
WO1994007138A1 (en) * | 1992-09-14 | 1994-03-31 | Fodstad Oystein | Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations |
US6953668B1 (en) | 1992-11-05 | 2005-10-11 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen |
ATE342356T1 (en) | 1992-11-05 | 2006-11-15 | Sloan Kettering Inst Cancer | PROSTATE-SPECIFIC MEMBRANE ANTIGEN |
US5427663A (en) | 1993-06-08 | 1995-06-27 | British Technology Group Usa Inc. | Microlithographic array for macromolecule and cell fractionation |
US5556773A (en) | 1993-08-06 | 1996-09-17 | Yourno; Joseph | Method and apparatus for nested polymerase chain reaction (PCR) with single closed reaction tubes |
WO1995009245A1 (en) | 1993-09-27 | 1995-04-06 | Oncor, Inc. | Methods for detecting and analyzing individual rare cells in a population |
US5432054A (en) | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
NO180658C (en) | 1994-03-10 | 1997-05-21 | Oeystein Fodstad | Method and Device for Detecting Specific Target Cells in Specialized or Mixed Cell Populations and Solutions Containing Mixed Cell Populations |
US5962332A (en) | 1994-03-17 | 1999-10-05 | University Of Massachusetts | Detection of trinucleotide repeats by in situ hybridization |
US5840502A (en) | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
US5707799A (en) | 1994-09-30 | 1998-01-13 | Abbott Laboratories | Devices and methods utilizing arrays of structures for analyte capture |
US5662813A (en) | 1994-10-21 | 1997-09-02 | Bioseparations, Inc. | Method for separation of nucleated fetal erythrocytes from maternal blood samples |
CN1110369C (en) | 1994-11-14 | 2003-06-04 | 宾夕法尼亚州大学信托人 | Mesoscale sample preparation device and system for determination and processing of analytes |
US5750339A (en) | 1994-11-30 | 1998-05-12 | Thomas Jefferson University | Methods for identifying fetal cells |
CA2212846A1 (en) | 1995-02-24 | 1996-08-29 | Sloan-Kettering Institute For Cancer Research | Prostate-specific membrane antigen and uses thereof |
US5709943A (en) * | 1995-05-04 | 1998-01-20 | Minnesota Mining And Manufacturing Company | Biological adsorption supports |
US5639669A (en) | 1995-06-07 | 1997-06-17 | Ledley; Robert | Separation of fetal cells from maternal blood |
US5715946A (en) * | 1995-06-07 | 1998-02-10 | Reichenbach; Steven H. | Method and apparatus for sorting particles suspended in a fluid |
US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
AU1867397A (en) | 1995-11-16 | 1997-06-05 | Michael W. Dahm | Method of quantifying tumour cells in a body fluid and a suitable test kit |
JP2000501414A (en) | 1995-11-22 | 2000-02-08 | ザ・ジョンズ・ホプキンス・ユニバーシティー | Ligand enhances cellular uptake of biomolecules |
US20030119724A1 (en) | 1995-11-22 | 2003-06-26 | Ts`O Paul O.P. | Ligands to enhance cellular uptake of biomolecules |
US6718053B1 (en) | 1996-11-27 | 2004-04-06 | Chromavision Medical Systems, Inc. | Method and apparatus for automated image analysis of biological specimens |
NO961031D0 (en) | 1996-03-13 | 1996-03-13 | Det Norske Radiumshospital Tum | Procedure for killing unwanted target cells |
US5972721A (en) | 1996-03-14 | 1999-10-26 | The United States Of America As Represented By The Secretary Of The Air Force | Immunomagnetic assay system for clinical diagnosis and other purposes |
EP0929694A4 (en) | 1996-03-15 | 2002-05-02 | Penn State Res Found | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
US5891651A (en) | 1996-03-29 | 1999-04-06 | Mayo Foundation For Medical Education And Research | Methods of recovering colorectal epithelial cells or fragments thereof from stool |
US7297331B2 (en) | 1996-04-03 | 2007-11-20 | The Rogosin Institute | Beads containing restricted cancer cells producing material suppressing cancer cell proliferation |
WO1997038313A1 (en) | 1996-04-05 | 1997-10-16 | The Johns Hopkins University | A method of enriching rare cells |
US6958245B2 (en) | 1996-04-25 | 2005-10-25 | Bioarray Solutions Ltd. | Array cytometry |
US6387707B1 (en) | 1996-04-25 | 2002-05-14 | Bioarray Solutions | Array Cytometry |
WO1997046882A1 (en) | 1996-06-07 | 1997-12-11 | Immunivest Corporation | Magnetic separation employing external and internal gradients |
US6890426B2 (en) | 1996-06-07 | 2005-05-10 | Immunivest Corporation | Magnetic separation apparatus and methods |
EP0907412B1 (en) | 1996-06-28 | 2008-08-27 | Caliper Life Sciences, Inc. | High-throughput screening assay systems in microscale fluidic devices |
IT1294964B1 (en) | 1996-07-12 | 1999-04-23 | Domenico Valerio | INSULATION AND CULTURE OF FETAL CELLS FROM THE MATERNAL PERIPHERAL BLOOD |
US6074827A (en) | 1996-07-30 | 2000-06-13 | Aclara Biosciences, Inc. | Microfluidic method for nucleic acid purification and processing |
US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
AU4164597A (en) | 1996-08-26 | 1998-03-19 | Princeton University | Reversibly sealable microstructure sorting devices |
CA2264389A1 (en) | 1996-09-04 | 1998-03-12 | Technical University Of Denmark | A micro flow system for particle separation and analysis |
GB9620209D0 (en) | 1996-09-27 | 1996-11-13 | Cemu Bioteknik Ab | Method of sequencing DNA |
NO308755B1 (en) | 1996-12-20 | 2000-10-23 | Iystein Fodstad | Method for characterizing abnormal cells, use and kits for carrying out the method |
US6235474B1 (en) | 1996-12-30 | 2001-05-22 | The Johns Hopkins University | Methods and kits for diagnosing and determination of the predisposition for diseases |
US6008007A (en) | 1997-01-31 | 1999-12-28 | Oncotech, Inc. | Radiation resistance assay for predicting treatment response and clinical outcome |
GB9704444D0 (en) * | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
US20010051341A1 (en) * | 1997-03-04 | 2001-12-13 | Isis Innovation Limited | Non-invasive prenatal diagnosis |
WO1998043067A1 (en) | 1997-03-25 | 1998-10-01 | Immunivest Corporation | Apparatus and methods for capture and analysis of particulate entities |
US6391622B1 (en) | 1997-04-04 | 2002-05-21 | Caliper Technologies Corp. | Closed-loop biochemical analyzers |
SI0970126T1 (en) | 1997-04-14 | 2001-08-31 | Micromet Ag | Novel method for the production of antihuman antigen receptors and uses thereof |
US6066449A (en) | 1997-04-15 | 2000-05-23 | The Trustees Of Columbia University In The City Of New York | Method of detecting metastatic thyroid cancer |
US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
WO1998049344A1 (en) | 1997-04-28 | 1998-11-05 | Lockheed Martin Energy Research Corporation | Method and apparatus for analyzing nucleic acids |
US6632619B1 (en) | 1997-05-16 | 2003-10-14 | The Governors Of The University Of Alberta | Microfluidic system and methods of use |
US6156273A (en) | 1997-05-27 | 2000-12-05 | Purdue Research Corporation | Separation columns and methods for manufacturing the improved separation columns |
US6566101B1 (en) | 1997-06-16 | 2003-05-20 | Anthony P. Shuber | Primer extension methods for detecting nucleic acids |
US6294331B1 (en) | 1997-08-08 | 2001-09-25 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for assessing genetic and phenotypic markers by simultaneous multicolor visualization of chromogenic dyes using brightfield microscopy and spectral imaging |
US6368871B1 (en) | 1997-08-13 | 2002-04-09 | Cepheid | Non-planar microstructures for manipulation of fluid samples |
US6540895B1 (en) | 1997-09-23 | 2003-04-01 | California Institute Of Technology | Microfabricated cell sorter for chemical and biological materials |
US5842787A (en) * | 1997-10-09 | 1998-12-01 | Caliper Technologies Corporation | Microfluidic systems incorporating varied channel dimensions |
US5962234A (en) | 1997-10-20 | 1999-10-05 | Applied Imaging Corporation | Use of anti-embryonic epsilon hemoglobin antibodies to identify fetal cells |
US6111096A (en) * | 1997-10-31 | 2000-08-29 | Bbi Bioseq, Inc. | Nucleic acid isolation and purification |
US6120985A (en) | 1997-10-31 | 2000-09-19 | Bbi Bioseq, Inc. | Pressure-enhanced extraction and purification |
AU9233698A (en) | 1997-11-22 | 1999-06-17 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer cells and/or hematologic progenitor cells in whole blood |
US6197523B1 (en) * | 1997-11-24 | 2001-03-06 | Robert A. Levine | Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood |
WO1999040226A2 (en) | 1998-02-04 | 1999-08-12 | Perkin-Elmer Corporation | Determination of a genotype of an amplification product at multiple allelic sites |
US20020172987A1 (en) | 1998-02-12 | 2002-11-21 | Terstappen Leon W.M.M. | Methods and reagents for the rapid and efficient isolation of circulating cancer cells |
DE69941689D1 (en) | 1998-02-12 | 2010-01-07 | Univ Texas | METHOD AND REAGENTS FOR RAPID AND EFFICIENT INSULATION OF CIRCULATING CANCER CELLS |
AU2785699A (en) | 1998-02-27 | 1999-09-15 | Cli Oncology, Inc. | Method and compositions for differential detection of primary tumor cells and metastatic cells |
GB9805918D0 (en) | 1998-03-19 | 1998-05-13 | Nycomed Amersham Plc | Sequencing by hybridisation |
US20070092917A1 (en) | 1998-05-01 | 2007-04-26 | Isabelle Guyon | Biomarkers for screening, predicting, and monitoring prostate disease |
US6200765B1 (en) * | 1998-05-04 | 2001-03-13 | Pacific Northwest Cancer Foundation | Non-invasive methods to detect prostate cancer |
EP1190229B1 (en) | 1998-05-22 | 2011-10-26 | California Institute Of Technology | Microfabricated cell sorter |
US6576478B1 (en) | 1998-07-14 | 2003-06-10 | Zyomyx, Inc. | Microdevices for high-throughput screening of biomolecules |
US6897073B2 (en) | 1998-07-14 | 2005-05-24 | Zyomyx, Inc. | Non-specific binding resistant protein arrays and methods for making the same |
US20030022207A1 (en) | 1998-10-16 | 2003-01-30 | Solexa, Ltd. | Arrayed polynucleotides and their use in genome analysis |
FR2782730B1 (en) * | 1998-08-25 | 2002-05-17 | Biocom Sa | CELL SEPARATION PROCESS FOR THE ISOLATION OF PATHOGENIC CELLS, PARTICULARLY RARE CANCERES, EQUIPMENT AND REAGENT FOR IMPLEMENTING THE PROCESS AND APPLICATION OF THE PROCESS |
US6245227B1 (en) | 1998-09-17 | 2001-06-12 | Kionix, Inc. | Integrated monolithic microfabricated electrospray and liquid chromatography system and method |
WO2000017390A1 (en) * | 1998-09-18 | 2000-03-30 | Micromet Ag | Dna amplification of a single cell |
US6656697B1 (en) * | 1998-09-28 | 2003-12-02 | Lifescan, Inc. | Diagnostics based on tetrazolium compounds |
US6637463B1 (en) | 1998-10-13 | 2003-10-28 | Biomicro Systems, Inc. | Multi-channel microfluidic system design with balanced fluid flow distribution |
WO2000026666A2 (en) | 1998-10-29 | 2000-05-11 | Cell Works Inc. | Multiple marker characterization of single cells |
ES2310055T3 (en) | 1998-12-16 | 2008-12-16 | Novartis Vaccines & Diagnostic | CYCLIN DEPENDENT HUMAN KINASE (HPNQALRE). |
US6887693B2 (en) | 1998-12-24 | 2005-05-03 | Cepheid | Device and method for lysing cells, spores, or microorganisms |
GB9828785D0 (en) | 1998-12-30 | 1999-02-17 | Amersham Pharm Biotech Ab | Sequencing systems |
US6960449B2 (en) | 1999-02-10 | 2005-11-01 | Cell Works Diagnostics, Inc. | Class characterization of circulating cancer cells isolated from body fluids and methods of use |
US6858439B1 (en) * | 1999-03-15 | 2005-02-22 | Aviva Biosciences | Compositions and methods for separation of moieties on chips |
AU3567900A (en) * | 1999-03-30 | 2000-10-16 | Solexa Ltd. | Polynucleotide sequencing |
US6942771B1 (en) | 1999-04-21 | 2005-09-13 | Clinical Micro Sensors, Inc. | Microfluidic systems in the electrochemical detection of target analytes |
US6511967B1 (en) * | 1999-04-23 | 2003-01-28 | The General Hospital Corporation | Use of an internalizing transferrin receptor to image transgene expression |
US6994969B1 (en) | 1999-04-30 | 2006-02-07 | Methexis Genomics, N.V. | Diagnostic sequencing by a combination of specific cleavage and mass spectrometry |
US7166573B1 (en) | 1999-05-28 | 2007-01-23 | Ludwig Institute For Cancer Research | Breast, gastric and prostate cancer associated antigens and uses therefor |
US6818395B1 (en) | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
US7192698B1 (en) | 1999-08-17 | 2007-03-20 | Purdue Research Foundation | EphA2 as a diagnostic target for metastatic cancer |
US6613581B1 (en) * | 1999-08-26 | 2003-09-02 | Caliper Technologies Corp. | Microfluidic analytic detection assays, devices, and integrated systems |
US7244559B2 (en) | 1999-09-16 | 2007-07-17 | 454 Life Sciences Corporation | Method of sequencing a nucleic acid |
WO2001029265A1 (en) * | 1999-10-15 | 2001-04-26 | Ventana Medical Systems, Inc. | Method of detecting single gene copies in-situ |
AU1592501A (en) | 1999-11-10 | 2001-06-06 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
US20060128006A1 (en) | 1999-11-10 | 2006-06-15 | Gerhardt Antimony L | Hydrodynamic capture and release mechanisms for particle manipulation |
US6692952B1 (en) | 1999-11-10 | 2004-02-17 | Massachusetts Institute Of Technology | Cell analysis and sorting apparatus for manipulation of cells |
US6361958B1 (en) * | 1999-11-12 | 2002-03-26 | Motorola, Inc. | Biochannel assay for hybridization with biomaterial |
US6875619B2 (en) | 1999-11-12 | 2005-04-05 | Motorola, Inc. | Microfluidic devices comprising biochannels |
WO2001037192A1 (en) | 1999-11-18 | 2001-05-25 | Ikonisys, Inc. | Method and apparatus for computer controlled cell based diagnosis |
JP2003523185A (en) | 2000-01-13 | 2003-08-05 | イムニベスト・コーポレイション | Arrays based on ferrofluids |
US6618679B2 (en) | 2000-01-28 | 2003-09-09 | Althea Technologies, Inc. | Methods for analysis of gene expression |
WO2001073133A1 (en) * | 2000-03-27 | 2001-10-04 | Thomas Jefferson University | Compositions and methods for identifying and targeting cancer cells |
US20030170631A1 (en) | 2000-04-03 | 2003-09-11 | Corixa Corporation | Methods, compositions and kits for the detection and monitoring of breast cancer |
DE60126592T2 (en) * | 2000-04-03 | 2007-11-22 | Corixa Corp., Hamilton | METHODS, COMPOSITIONS AND KITS FOR IDENTIFYING AND MONITORING BREAST CANCER |
US7510834B2 (en) * | 2000-04-13 | 2009-03-31 | Hidetoshi Inoko | Gene mapping method using microsatellite genetic polymorphism markers |
US7641856B2 (en) | 2004-05-14 | 2010-01-05 | Honeywell International Inc. | Portable sample analyzer with removable cartridge |
MXPA03000506A (en) * | 2000-07-18 | 2004-09-10 | Correlogic Systems Inc | A process for discriminating between biological states based on hidden patterns from biological data. |
US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
CA2417341A1 (en) | 2000-08-08 | 2002-02-14 | Jing Cheng | Methods for manipulating moieties in microfluidic systems |
US20040005582A1 (en) * | 2000-08-10 | 2004-01-08 | Nanobiodynamics, Incorporated | Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators |
US6610499B1 (en) | 2000-08-31 | 2003-08-26 | The Regents Of The University Of California | Capillary array and related methods |
GB0021617D0 (en) | 2000-09-02 | 2000-10-18 | Imp College Innovations Ltd | Diagnosis and treatment of cancer |
AU8843701A (en) | 2000-09-09 | 2002-03-22 | Univ New York State Res Found | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
US20020164825A1 (en) | 2000-09-09 | 2002-11-07 | Wen-Tien Chen | Cell separation matrix |
EP1334347A1 (en) | 2000-09-15 | 2003-08-13 | California Institute Of Technology | Microfabricated crossflow devices and methods |
WO2002028523A2 (en) | 2000-09-30 | 2002-04-11 | Aviva Biosciences Corporation | Apparatuses containing multiple force generating elements and uses thereof |
US6689615B1 (en) * | 2000-10-04 | 2004-02-10 | James Murto | Methods and devices for processing blood samples |
AU2001296516A1 (en) | 2000-10-09 | 2002-04-22 | Aviva Biosciences Coropration | Compositions and methods for separation of moieties on chips |
EP1328342A4 (en) | 2000-10-10 | 2006-03-15 | Aviva Biosciences Corp | An integrated biochip system for sample preparation and analysis |
US6664056B2 (en) * | 2000-10-17 | 2003-12-16 | The Chinese University Of Hong Kong | Non-invasive prenatal monitoring |
US20030007894A1 (en) * | 2001-04-27 | 2003-01-09 | Genoptix | Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles |
EP1368369A4 (en) | 2000-11-15 | 2006-02-22 | Hoffmann La Roche | Methods and reagents for identifying rare fetal cells in the material circulation |
US6495340B2 (en) | 2000-11-28 | 2002-12-17 | Medis El Ltd. | Cell carrier grids |
EP1355672A2 (en) | 2000-12-01 | 2003-10-29 | Cell Works Inc. | Conjugates of glycosylated/galactosylated peptide, bifunctional linker, and nucleotidic monomers/polymers, and related compositions and methods of use |
US6770434B2 (en) | 2000-12-29 | 2004-08-03 | The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin | Biological assay method |
US6993169B2 (en) | 2001-01-11 | 2006-01-31 | Trestle Corporation | System and method for finding regions of interest for microscopic digital montage imaging |
DE60221115T2 (en) | 2001-01-18 | 2008-03-13 | The Regents Of The University Of Michigan, Ann Arbor | COMPOSITIONS AND METHODS FOR USE OF FIBRONECTIN FRAGMENTS IN CANCER DIAGNOSIS |
US20020110835A1 (en) | 2001-02-13 | 2002-08-15 | Rajan Kumar | Microfluidic devices and methods |
AU2002251946A1 (en) * | 2001-02-14 | 2002-08-28 | Science And Technology Corporation @ Unm | Nanostructured devices for separation and analysis |
US6913697B2 (en) | 2001-02-14 | 2005-07-05 | Science & Technology Corporation @ Unm | Nanostructured separation and analysis devices for biological membranes |
GB0104690D0 (en) | 2001-02-26 | 2001-04-11 | Cytogenetic Dna Services Ltd | Diagnostic test |
US20050196785A1 (en) * | 2001-03-05 | 2005-09-08 | California Institute Of Technology | Combinational array for nucleic acid analysis |
WO2002073204A2 (en) | 2001-03-12 | 2002-09-19 | Monogen, Inc | Cell-based detection and differentiation of disease states |
US20030190602A1 (en) | 2001-03-12 | 2003-10-09 | Monogen, Inc. | Cell-based detection and differentiation of disease states |
US20020160518A1 (en) * | 2001-04-03 | 2002-10-31 | Hayenga Jon W. | Microfluidic sedimentation |
EP1384022A4 (en) * | 2001-04-06 | 2004-08-04 | California Inst Of Techn | Nucleic acid amplification utilizing microfluidic devices |
US20020164816A1 (en) * | 2001-04-06 | 2002-11-07 | California Institute Of Technology | Microfluidic sample separation device |
US20020155587A1 (en) * | 2001-04-20 | 2002-10-24 | Sequenom, Inc. | System and method for testing a biological sample |
WO2003027223A2 (en) | 2001-04-25 | 2003-04-03 | Cornell Research Foundation, Inc. | Devices and methods for pharmacokinetic-based cell culture system |
FR2824144B1 (en) * | 2001-04-30 | 2004-09-17 | Metagenex S A R L | METHOD OF PRENATAL DIAGNOSIS ON FETAL CELLS ISOLATED FROM MATERNAL BLOOD |
US7262030B2 (en) | 2001-05-09 | 2007-08-28 | Virginia Commonwealth University | Multiple sequencible and ligatible structures for genomic analysis |
US20020166760A1 (en) | 2001-05-11 | 2002-11-14 | Prentiss Mara G. | Micromagentic systems and methods for microfluidics |
DE10127079A1 (en) * | 2001-06-02 | 2002-12-12 | Ulrich Pachmann | Method for the quantitative detection of vital epithelial tumor cells in a body fluid |
US7118907B2 (en) | 2001-06-06 | 2006-10-10 | Li-Cor, Inc. | Single molecule detection systems and methods |
US7189507B2 (en) | 2001-06-18 | 2007-03-13 | Pdl Biopharma, Inc. | Methods of diagnosis of ovarian cancer, compositions and methods of screening for modulators of ovarian cancer |
US20050037388A1 (en) * | 2001-06-22 | 2005-02-17 | University Of Geneva | Method for detecting diseases caused by chromosomal imbalances |
US7381535B2 (en) | 2002-07-10 | 2008-06-03 | The Board Of Trustees Of The Leland Stanford Junior | Methods and compositions for detecting receptor-ligand interactions in single cells |
US6783928B2 (en) | 2001-07-17 | 2004-08-31 | Georgi Hvichia | Microstructures for cell proliferation assays and semen analysis |
US7993908B2 (en) | 2001-07-17 | 2011-08-09 | Parsortix, Inc. | Microstructure for particle and cell separation, identification, sorting, and manipulation |
DE60227678D1 (en) | 2001-08-23 | 2008-08-28 | Immunivest Corp | ANALYSIS OF CIRCULATING TUMOR CELLS, FRAGMENTS AND TRUMS |
US7863012B2 (en) | 2004-02-17 | 2011-01-04 | Veridex, Llc | Analysis of circulating tumor cells, fragments, and debris |
US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
AUPR749901A0 (en) | 2001-09-06 | 2001-09-27 | Monash University | Method of identifying chromosomal abnormalities and prenatal diagnosis |
ATE309393T1 (en) | 2001-09-06 | 2005-11-15 | Adnagen Ag | METHOD FOR THE QUALITATIVE AND/OR QUANTITATIVE DETECTION OF CELLS |
DE10143776A1 (en) * | 2001-09-06 | 2003-04-03 | Adnagen Ag | Selection and determination of specific cells, useful particularly for diagnosis and monitoring of tumors, by antibody-mediated selection then detecting specific mRNA |
EP1409745B1 (en) | 2001-09-06 | 2007-04-11 | Adnagen AG | Method and kit for the diagnosis or treatment control of intestinal carcinoma |
US20070042360A1 (en) * | 2001-09-17 | 2007-02-22 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
US7202045B2 (en) | 2001-09-19 | 2007-04-10 | Regents Of The University Of Michigan | Detection and treatment of cancers of the lung |
WO2003025543A2 (en) | 2001-09-21 | 2003-03-27 | The Regents Of The University Of California | Methods of cytodiagnostic staging of neoplasia and squamous cell carcinoma |
US7166443B2 (en) | 2001-10-11 | 2007-01-23 | Aviva Biosciences Corporation | Methods, compositions, and automated systems for separating rare cells from fluid samples |
US20030072682A1 (en) | 2001-10-11 | 2003-04-17 | Dan Kikinis | Method and apparatus for performing biochemical testing in a microenvironment |
CA2462914A1 (en) | 2001-10-11 | 2003-04-17 | Aviva Biosciences Corporation | Methods, compositions, and automated systems for separating rare cells from fluid samples |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
KR20040047971A (en) | 2001-10-26 | 2004-06-05 | 이뮤니베스트 코포레이션 | Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample |
US7262269B2 (en) | 2001-10-26 | 2007-08-28 | The Regents Of University Of California | Method for screening combinational bead library; ligands for cancer cells |
US20030232350A1 (en) | 2001-11-13 | 2003-12-18 | Eos Biotechnology, Inc. | Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer |
US20050244843A1 (en) | 2001-11-16 | 2005-11-03 | Wen-Tien Chen | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
DE60232013D1 (en) | 2001-11-20 | 2009-05-28 | Exact Sciences Corp | AUTOMATIC SAMPLE PREPARATION METHOD AND DEVICES |
AU2002219137A1 (en) | 2001-11-22 | 2003-06-10 | Adnagen Ag | Diagnosis kit, dna chip, and methods for diagnosing or supervising the treatment of testicular cancer |
JP4355210B2 (en) | 2001-11-30 | 2009-10-28 | フルイディグム コーポレイション | Microfluidic device and method of using microfluidic device |
US7691333B2 (en) * | 2001-11-30 | 2010-04-06 | Fluidigm Corporation | Microfluidic device and methods of using same |
EP1462800A4 (en) | 2001-12-11 | 2007-01-17 | Netech Inc | Blood cell separation system |
EP1466162A1 (en) | 2002-01-10 | 2004-10-13 | Board Of Regents The University Of Texas System | Flow sorting system and methods regarding same |
US7383134B2 (en) | 2002-01-15 | 2008-06-03 | Piper James R | Method and/or system for analyzing biological samples using a computer system |
AU2003216175A1 (en) | 2002-02-04 | 2003-09-02 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
WO2003068672A2 (en) * | 2002-02-12 | 2003-08-21 | Kionix, Inc. | Fabrication of ultra-shallow channels for microfluidic devices and systems |
US7764821B2 (en) | 2002-02-14 | 2010-07-27 | Veridex, Llc | Methods and algorithms for cell enumeration in a low-cost cytometer |
WO2003069421A2 (en) | 2002-02-14 | 2003-08-21 | Immunivest Corporation | Methods and algorithms for cell enumeration in a low-cost cytometer |
US7893248B2 (en) * | 2002-02-20 | 2011-02-22 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA) |
US6977162B2 (en) * | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
ES2685702T3 (en) | 2002-03-13 | 2018-10-10 | Genomic Health, Inc. | Obtaining gene expression profile in biopsied tumor tissues |
US7223371B2 (en) | 2002-03-14 | 2007-05-29 | Micronics, Inc. | Microfluidic channel network device |
US7214427B2 (en) | 2002-03-21 | 2007-05-08 | Aviva Biosciences Corporation | Composite beads comprising magnetizable substance and electro-conductive substance |
US7312085B2 (en) | 2002-04-01 | 2007-12-25 | Fluidigm Corporation | Microfluidic particle-analysis systems |
US20040241707A1 (en) | 2002-04-01 | 2004-12-02 | Gao Chun L. | Enhanced diagnostic potential of prostate-specific antigen expressing cells |
US7141369B2 (en) * | 2002-04-25 | 2006-11-28 | Semibio Technology, Inc. | Measuring cellular metabolism of immobilized cells |
CA2484730A1 (en) | 2002-05-03 | 2003-11-13 | Immunivest Corporation | Device and method for analytical cell imaging |
US20070178478A1 (en) | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
US7442506B2 (en) * | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
US7272252B2 (en) | 2002-06-12 | 2007-09-18 | Clarient, Inc. | Automated system for combining bright field and fluorescent microscopy |
US7229838B2 (en) | 2002-07-08 | 2007-06-12 | Innovative Micro Technology | MEMS actuator and method of manufacture for MEMS particle sorting device |
US7220594B2 (en) | 2002-07-08 | 2007-05-22 | Innovative Micro Technology | Method and apparatus for sorting particles with a MEMS device |
US6838056B2 (en) | 2002-07-08 | 2005-01-04 | Innovative Micro Technology | Method and apparatus for sorting biological cells with a MEMS device |
US7214348B2 (en) * | 2002-07-26 | 2007-05-08 | Applera Corporation | Microfluidic size-exclusion devices, systems, and methods |
US7150834B2 (en) * | 2003-07-31 | 2006-12-19 | Arryx, Inc. | Multiple laminar flow-based rate zonal or isopycnic separation with holographic optical trapping of blood cells and other static components |
US20060008807A1 (en) * | 2002-08-23 | 2006-01-12 | O'hara Shawn M | Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample |
US7106905B2 (en) * | 2002-08-23 | 2006-09-12 | Hewlett-Packard Development Company, L.P. | Systems and methods for processing text-based electronic documents |
US7252976B2 (en) | 2002-08-28 | 2007-08-07 | Board Of Regents The University Of Texas System | Quantitative RT-PCR to AC133 to diagnose cancer and monitor angiogenic activity in a cell sample |
US20040043506A1 (en) * | 2002-08-30 | 2004-03-04 | Horst Haussecker | Cascaded hydrodynamic focusing in microfluidic channels |
AU2002951346A0 (en) * | 2002-09-05 | 2002-09-26 | Garvan Institute Of Medical Research | Diagnosis of ovarian cancer |
EP2359689B1 (en) | 2002-09-27 | 2015-08-26 | The General Hospital Corporation | Microfluidic device for cell separation and use thereof |
CN1684977A (en) | 2002-09-27 | 2005-10-19 | 奥里迪斯生物医学研究及开发有限责任公司 | Polypeptides and nucleic acids encoding these and their use for the prevention, diagnosis or treatment of liver disorders and epithelial cancer |
ES2341103T3 (en) | 2002-10-23 | 2010-06-15 | The Trustees Of Princeton University | CONTINUOUS SEPARATION PROCEDURE OF PARTICLES USING RETICULATES OF ASYMETRICALLY ALIGNED OBSTACLES REGARDING FIELDS. |
WO2004042019A2 (en) * | 2002-10-30 | 2004-05-21 | Pointilliste, Inc. | Systems for capture and analysis of biological particles and methods using the systems |
US6811385B2 (en) | 2002-10-31 | 2004-11-02 | Hewlett-Packard Development Company, L.P. | Acoustic micro-pump |
AU2002952696A0 (en) | 2002-11-14 | 2002-11-28 | Genomics Research Partners Pty Ltd | Status determination |
US7704687B2 (en) | 2002-11-15 | 2010-04-27 | The Johns Hopkins University | Digital karyotyping |
JPWO2004051231A1 (en) * | 2002-11-29 | 2006-04-06 | 日本電気株式会社 | Separation apparatus and separation method |
DE10259703A1 (en) | 2002-12-19 | 2004-07-08 | Ivonex Gmbh | separation process |
CN101260429B (en) * | 2003-01-17 | 2011-03-30 | 香港中文大学 | Circulating mRNA as diagnostic markers of pregnancy related disorders |
US6746503B1 (en) | 2003-01-30 | 2004-06-08 | The Regents Of The University Of California | Precision gap particle separator |
EP1604184A4 (en) | 2003-02-27 | 2010-10-27 | Stephen A Lesko | Standardized evaluation of therapeutic efficacy based on cellular biomarkers |
JP4593557B2 (en) | 2003-02-27 | 2010-12-08 | ベリデックス・リミテッド・ライアビリティ・カンパニー | Circulating tumor cells (CTC): early assessment of time to progression, survival and response to therapy in patients with metastatic cancer |
AU2004217872B2 (en) | 2003-03-05 | 2010-03-25 | Genetic Technologies Limited | Identification of fetal DNA and fetal cell markers in maternal plasma or serum |
EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
DE10313201A1 (en) | 2003-03-21 | 2004-10-07 | Steag Microparts Gmbh | Microstructured separator and microfluidic process for separating liquid components from a liquid containing particles |
AU2004224448A1 (en) * | 2003-03-24 | 2004-10-07 | Corixa Corporation | Detection and monitoring of lung cancer |
AU2003901671A0 (en) | 2003-04-02 | 2003-05-01 | The University Of Adelaide | Comparative genomic hybridization |
US20050145496A1 (en) * | 2003-04-03 | 2005-07-07 | Federico Goodsaid | Thermal reaction device and method for using the same |
US7476363B2 (en) * | 2003-04-03 | 2009-01-13 | Fluidigm Corporation | Microfluidic devices and methods of using same |
AU2004226167A1 (en) | 2003-04-03 | 2004-10-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Antibodies with enhanced ability to immunomodulate cell functions |
US7604965B2 (en) * | 2003-04-03 | 2009-10-20 | Fluidigm Corporation | Thermal reaction device and method for using the same |
JP5419248B2 (en) * | 2003-04-03 | 2014-02-19 | フルイディグム コーポレイション | Microfluidic device and method of use thereof |
WO2004101762A2 (en) | 2003-05-12 | 2004-11-25 | The Regents Of The University Of Michigan | Detection and treatment of cancers of the colon |
US20070105105A1 (en) | 2003-05-23 | 2007-05-10 | Mount Sinai School Of Medicine Of New York University | Surrogate cell gene expression signatures for evaluating the physical state of a subject |
JP2007503597A (en) | 2003-06-13 | 2007-02-22 | ザ ジェネラル ホスピタル コーポレーション | Microfluidic system for removing red blood cells and platelets from blood based on size |
US8043846B2 (en) | 2003-06-13 | 2011-10-25 | The General Hospital Corporation | Device and method for contacting picoliter volumes of fluid |
US20070092881A1 (en) | 2003-07-10 | 2007-04-26 | Central Institute For Experimental Animals | Gene markers of tumor metastasis |
US7461048B2 (en) | 2003-07-21 | 2008-12-02 | Aureon Laboratories, Inc. | Systems and methods for treating, diagnosing and predicting the occurrence of a medical condition |
WO2005014792A2 (en) * | 2003-08-08 | 2005-02-17 | The General Hospital Corporation D/B/A Massachusetts General Hospital | Preservation of biomaterials with transported preservation agents |
WO2005017493A2 (en) | 2003-08-15 | 2005-02-24 | Smithkline Beecham Corporation | Biomarkers in cancer |
CA2536360C (en) | 2003-08-28 | 2013-08-06 | Celula, Inc. | Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network |
WO2005023091A2 (en) | 2003-09-05 | 2005-03-17 | The Trustees Of Boston University | Method for non-invasive prenatal diagnosis |
US20070178458A1 (en) | 2003-09-05 | 2007-08-02 | O'brien Philippa | Methods of diagnosis and prognosis of ovarian cancer II |
WO2005025518A2 (en) | 2003-09-11 | 2005-03-24 | The Uab Research Foundation | Inhibition of inward sodium currents in cancer |
JP4629675B2 (en) | 2003-09-18 | 2011-02-09 | ベリデックス・リミテッド・ライアビリティ・カンパニー | Programmable sample preparation and analysis system without operator |
US20070202109A1 (en) | 2003-09-24 | 2007-08-30 | Oncotherapy Science, Inc. | Method Of Diagnosing Breast Cancer |
WO2005035725A2 (en) * | 2003-10-08 | 2005-04-21 | The Trustees Of Boston University | Methods for prenatal diagnosis of chromosomal abnormalities |
DE60328193D1 (en) | 2003-10-16 | 2009-08-13 | Sequenom Inc | Non-invasive detection of fetal genetic traits |
US8062849B2 (en) | 2003-10-28 | 2011-11-22 | The Johns Hopkins University | Quantitative multiplex methylation-specific PCR |
CA2544373A1 (en) | 2003-10-31 | 2005-05-12 | Vitatex, Inc. | Blood test prototypes and methods for the detection of circulating tumor and endothelial cells |
WO2005047532A1 (en) | 2003-11-17 | 2005-05-26 | Gribbles Molecular Science Pty Ltd | Improved method of performing genetic analyses on reproductive tract cell samples |
WO2005049168A2 (en) | 2003-11-17 | 2005-06-02 | Immunivest Corporation | Method and apparatus for pre-enrichment and recovery of cells from densified whole blood |
JP3845416B2 (en) * | 2003-12-01 | 2006-11-15 | 株式会社ポストゲノム研究所 | Gene tag acquisition method |
WO2005056838A1 (en) | 2003-12-08 | 2005-06-23 | The Clinic For Special Children | Association of tspyl polymorphisms with siddt syndrome |
ES2616337T3 (en) | 2003-12-12 | 2017-06-12 | Government Of The United States Of America, As Repr. By The Secr. Of The Dept. Of Health And Human Services And His Successors | A human cytotoxic T lymphocyte epitope and its agonist epitope of the non-variable number of MUC-1 tandem repeat sequences |
US20050147977A1 (en) | 2003-12-29 | 2005-07-07 | Tae-Woong Koo | Methods and compositions for nucleic acid detection and sequence analysis |
EP1561507A1 (en) | 2004-01-27 | 2005-08-10 | Future Diagnostics B.V. | System for characterising a fluid, microfluidic device for characterising or analysing concentration components, a method of characterising or analysing such concentrations and a measurement device |
US7910353B2 (en) | 2004-02-13 | 2011-03-22 | Signature Genomic Laboratories | Methods and apparatuses for achieving precision genetic diagnoses |
US20050181353A1 (en) | 2004-02-17 | 2005-08-18 | Rao Galla C. | Stabilization of cells and biological specimens for analysis |
US20060046258A1 (en) * | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
US20050191636A1 (en) | 2004-03-01 | 2005-09-01 | Biocept, Inc. | Detection of STRP, such as fragile X syndrome |
US20070077578A1 (en) | 2004-03-02 | 2007-04-05 | Primagen Holding B.V. | Diagnosis of (a risk of ) disease and monitoring of therapy |
US20060121624A1 (en) | 2004-03-03 | 2006-06-08 | Huang Lotien R | Methods and systems for fluid delivery |
US20050282293A1 (en) | 2004-03-03 | 2005-12-22 | Cosman Maury D | System for delivering a diluted solution |
WO2005085861A2 (en) | 2004-03-03 | 2005-09-15 | Oridis Biomed Forschungs- Und Entwicklungs Gmbh | Nucleic acids and encoded polypeptides for use in liver disorders and epithelial cancer |
CA2557819A1 (en) | 2004-03-03 | 2005-09-15 | The General Hospital Corporation | Magnetic device for isolation of cells and biomolecules in a microfluidic environment |
US20070207351A1 (en) | 2004-03-23 | 2007-09-06 | Amminex A/S | Use Of An Ammonia Storage Device In Production Of Energy |
US7390388B2 (en) | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells on a biodevice |
WO2005098046A2 (en) | 2004-04-01 | 2005-10-20 | Immunivest Corporation | Methods for the determination of cell specific biomarkers |
WO2005098034A1 (en) | 2004-04-08 | 2005-10-20 | Hiltrud Brauch | Ercc2 polymorphisms |
WO2005108621A1 (en) | 2004-04-30 | 2005-11-17 | Yale University | Methods and compositions for cancer diagnosis |
JP2008500611A (en) | 2004-05-03 | 2008-01-10 | サイジーン ラボラトリーズ インク. | Method and system for providing anonymous testing and reporting based on a comprehensive knowledge database and selective access to testing results and reports |
US7468249B2 (en) | 2004-05-05 | 2008-12-23 | Biocept, Inc. | Detection of chromosomal disorders |
US20050287611A1 (en) | 2004-05-07 | 2005-12-29 | Nugent C T Iv | MHC bridging system for detecting CTL-mediated lysis of antigen presenting cells |
US7622281B2 (en) * | 2004-05-20 | 2009-11-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for clonal amplification of nucleic acid |
WO2005116264A2 (en) | 2004-05-24 | 2005-12-08 | Immunivest Corporation | A blood test to monitor the genetic changes of progressive cancer using immunomagnetic enrichment and fluorescence in situ hybridization (fish) |
US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
EP1607485A1 (en) | 2004-06-14 | 2005-12-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method for quantifying VEGF121 isoform in a biological sample |
DE102004036285A1 (en) | 2004-07-27 | 2006-02-16 | Advalytix Ag | Method for determining the frequency of sequences of a sample |
US7820382B2 (en) | 2004-08-03 | 2010-10-26 | Bauer A Robert | Method for the early detection of breast cancer, lung cancer, pancreatic cancer and colon polyps, growths and cancers as well as other gastrointestinal disease conditions and the preoperative and postoperative monitoring of transplanted organs from the donor and in the recipient and their associated conditions related and unrelated to the organ transplantation |
JP2008509387A (en) | 2004-08-04 | 2008-03-27 | スピンエックス インコーポレイテッド | Apparatus and method for connecting a microfluidic device to a fluid treatment device |
WO2006023563A2 (en) | 2004-08-17 | 2006-03-02 | Immunivest Corporation | A diagnostic imaging device for the analysis of circulating rare cells |
US20060051265A1 (en) * | 2004-09-08 | 2006-03-09 | Health Research, Inc. | Apparatus and method for sorting microstructures in a fluid medium |
WO2006041453A1 (en) | 2004-09-30 | 2006-04-20 | Immunivest Corporation | Circulating tumor cells (ctc’s): apoptotic assessment in prostate cancer patients |
ES2301268B1 (en) | 2004-10-25 | 2009-05-01 | Centro De Investigacion Biomolecular Aplicada Salamanca, S.L. | USE OF GEN SLUG, OR ITS REPLICATION, TRANSCRIPTION OR EXPRESSION PRODUCTS, IN THE IDENTIFICATION, DIAGNOSIS, PREVENTION OR TREATMENT OF CANCER DISSEMINATION AND / OR METASTASIS DEVELOPMENT. |
US20060094109A1 (en) | 2004-11-02 | 2006-05-04 | Immunivest Corporation | Device and method for analytical cell imaging |
WO2006076567A2 (en) | 2005-01-13 | 2006-07-20 | Micronics, Inc. | Microfluidic rare cell detection device |
US8158410B2 (en) | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
KR20070116585A (en) | 2005-01-18 | 2007-12-10 | 바이오셉트 인코포레이티드 | Cell separation using microchannel having patterned posts |
US20060252087A1 (en) | 2005-01-18 | 2006-11-09 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
US20060205057A1 (en) | 2005-02-18 | 2006-09-14 | Wayner Danial D M | Microfluidic microarray with high surface area active regions |
WO2007024264A2 (en) | 2005-02-23 | 2007-03-01 | Bioimagene, Inc. | Method and system for digital image based tissue independent simultaneous nucleus, cytoplasm and membrane quantitation |
US8383357B2 (en) | 2005-03-16 | 2013-02-26 | OSI Pharmaceuticals, LLC | Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors |
CA2894337C (en) * | 2005-03-18 | 2018-08-28 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis of trisomy 18 |
US7645576B2 (en) * | 2005-03-18 | 2010-01-12 | The Chinese University Of Hong Kong | Method for the detection of chromosomal aneuploidies |
JP5702909B2 (en) * | 2005-03-23 | 2015-04-15 | ヴェロシス インコーポレイテッド | Surface functional structure in microprocess technology |
FR2883488B1 (en) | 2005-03-24 | 2010-12-10 | Inst Nat Sante Rech Med | METHOD AND DEVICE FOR SEPARATING BY VERTICAL FILTRATION BIOLOGICAL PARTICLES CONTAINED IN A LIQUID |
US20070196820A1 (en) * | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
US20070026414A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026415A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20060223178A1 (en) | 2005-04-05 | 2006-10-05 | Tom Barber | Devices and methods for magnetic enrichment of cells and other particles |
US20070026418A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026413A1 (en) * | 2005-07-29 | 2007-02-01 | Mehmet Toner | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
EP1874920A4 (en) | 2005-04-05 | 2009-11-04 | Cellpoint Diagnostics | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
GB0509500D0 (en) | 2005-05-10 | 2005-06-15 | Revealcyte | Method of fetal cell enrichment |
US20070054287A1 (en) * | 2005-05-31 | 2007-03-08 | Applera Corporation | Method for identifying medically important cell populations using micro rna as tissue specific biomarkers |
US20070037173A1 (en) * | 2005-08-12 | 2007-02-15 | Allard Jeffrey W | Circulating tumor cells (CTC's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients |
EP2703499A1 (en) | 2005-06-02 | 2014-03-05 | Fluidigm Corporation | Analysis using microfluidic partitioning devices to generate single cell samples |
US20090215042A1 (en) * | 2005-06-08 | 2009-08-27 | Compugen Ltd. | Novel nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis |
US20070105133A1 (en) | 2005-06-13 | 2007-05-10 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
US8921102B2 (en) * | 2005-07-29 | 2014-12-30 | Gpb Scientific, Llc | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070059680A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for cell enrichment |
US20070026416A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US20070026419A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
US8173413B2 (en) * | 2005-08-11 | 2012-05-08 | University Of Washington | Separation and concentration of biological cells and biological particles using a one-dimensional channel |
US7901950B2 (en) | 2005-08-12 | 2011-03-08 | Veridex, Llc | Method for assessing disease states by profile analysis of isolated circulating endothelial cells |
AU2006281569A1 (en) | 2005-08-17 | 2007-02-22 | Medexis S.A. | Composition and method for determination of CK19 expression |
EP1758193A1 (en) * | 2005-08-22 | 2007-02-28 | LG Electronics Inc. | Fuel cell with water-cooled power converter |
JP2009506777A (en) | 2005-09-01 | 2009-02-19 | プレシジョン セラピューティクス,インコーポレイテッド | Chemotherapy sensitivity assay using tumor cells with resistant phenotypic characteristics |
US7507534B2 (en) * | 2005-09-01 | 2009-03-24 | National Health Research Institutes | Rapid efficacy assessment method for lung cancer therapy |
WO2007033167A2 (en) | 2005-09-12 | 2007-03-22 | The Regents Of The University Of Michigan | Compositions and methods for detecting and treating cancer |
EP1924710B1 (en) | 2005-09-15 | 2011-03-30 | Val-Chum, S.E.C. | Methods of diagnosing ovarian cancer |
US20070059719A1 (en) * | 2005-09-15 | 2007-03-15 | Michael Grisham | Business methods for prenatal Diagnosis |
US20070059718A1 (en) * | 2005-09-15 | 2007-03-15 | Mehmet Toner | Systems and methods for enrichment of analytes |
US20070059683A1 (en) * | 2005-09-15 | 2007-03-15 | Tom Barber | Veterinary diagnostic system |
US20070059716A1 (en) * | 2005-09-15 | 2007-03-15 | Ulysses Balis | Methods for detecting fetal abnormality |
US20070059781A1 (en) | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
US20070059774A1 (en) | 2005-09-15 | 2007-03-15 | Michael Grisham | Kits for Prenatal Testing |
DK1926996T3 (en) | 2005-09-20 | 2012-01-23 | Osi Pharmaceuticals Llc | Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors |
US20070071762A1 (en) | 2005-09-21 | 2007-03-29 | Ccc Diagnostics, Llc | Comprehensive diagnostic testing procedures for personalized anticancer chemotherapy (pac) |
US20110059069A1 (en) | 2005-09-22 | 2011-03-10 | Biogen Idec Ma Inc | Gapr-1 Methods |
GB0519405D0 (en) | 2005-09-23 | 2005-11-02 | Univ Aberdeen | Cancer therapy prognosis and target |
WO2007036025A1 (en) | 2005-09-27 | 2007-04-05 | University Of Saskatchewan | Use of n-myristoyltransferase on non-tumor tissue for cancer diagnosls |
EP1770171A1 (en) | 2005-09-29 | 2007-04-04 | Universität Zu Köln | DNA microarray for rapid identification of Candida albicans in blood cultures. |
US8158107B2 (en) | 2005-09-30 | 2012-04-17 | National Jewish Health | Genes and proteins associated with angiogenesis and uses thereof |
US20070202106A1 (en) | 2005-10-06 | 2007-08-30 | Baylor Research Institute | Compositions and methods for the treatment of cancer |
WO2007044690A2 (en) | 2005-10-07 | 2007-04-19 | The General Hospital Corporation | Devices and methods for cell manipulation |
US20090176218A1 (en) | 2005-10-21 | 2009-07-09 | The General Hospital Corporation | Method for the Diagnosis and Prognosis of Cancer |
US20110052570A1 (en) | 2005-10-26 | 2011-03-03 | Children's Medical Center Corporation | Method to prognose response to anti-egfr therapeutics |
EP1945754B1 (en) | 2005-10-31 | 2014-07-23 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
WO2007053142A1 (en) | 2005-11-03 | 2007-05-10 | Immunivest Corporation | Agr2 and tff3 regulation in the diagnosis and treatment of cancer |
EP1945794A2 (en) | 2005-11-09 | 2008-07-23 | Chemimage Corporation | System and method for cytological analysis by raman spectroscopic imaging |
US20070122856A1 (en) | 2005-11-10 | 2007-05-31 | Aurelium Biopharma Inc. | Tissue diagnostics for ovarian cancer |
ATE492651T1 (en) | 2005-11-10 | 2011-01-15 | Bristol Myers Squibb Pharma Co | MOESIN, CAVEOLIN 1 AND YES-ASSOCIATED PROTEIN 1 AS PREDICTIVE MARKERS OF RESPONSE TO DASATINIB IN BREAST CANCER |
US8642278B2 (en) | 2005-11-22 | 2014-02-04 | University Of South Florida | Inhibition of cell proliferation |
US20070238094A1 (en) | 2005-12-09 | 2007-10-11 | Baylor Research Institute | Diagnosis, prognosis and monitoring of disease progression of systemic lupus erythematosus through blood leukocyte microarray analysis |
US7566573B2 (en) | 2005-12-19 | 2009-07-28 | Idexx Laboratories, Inc. | Dual standard curve immunoassay |
CA2634591A1 (en) | 2005-12-22 | 2007-07-05 | Memorial Sloan-Kettering Cancer Center | Method for detection of cancer cells using virus |
WO2007079229A2 (en) | 2005-12-29 | 2007-07-12 | Cellpoint Diagnostics, Inc. | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
EP1803822A1 (en) | 2005-12-30 | 2007-07-04 | Adnagen AG | Method for the individual characterization of therapeutic target molecules and use thereof |
US20090215084A1 (en) | 2006-01-05 | 2009-08-27 | Mayo Foundation For Medical Education And Research | B7-h1 and b7-h4 in cancer |
US20100015642A1 (en) | 2006-01-05 | 2010-01-21 | Kwon Eugene D | B7-h1 and survivin in cancer |
US20070160974A1 (en) | 2006-01-10 | 2007-07-12 | South Eastern Sydney And Illawarra Area Health Service | Human embryonic stem cell clones |
US9133506B2 (en) | 2006-01-10 | 2015-09-15 | Applied Spectral Imaging Ltd. | Methods and systems for analyzing biological samples |
US7842465B2 (en) | 2006-01-17 | 2010-11-30 | Palo Alto Research Center Incorporated | Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection |
US7548145B2 (en) | 2006-01-19 | 2009-06-16 | Innovative Micro Technology | Hysteretic MEMS thermal device and method of manufacture |
WO2007082379A2 (en) | 2006-01-20 | 2007-07-26 | Mcgill University | Method to identify cd40-sensitive cells using gene expression |
US20070218480A1 (en) | 2006-01-25 | 2007-09-20 | The Board Of Regents Of The University Of Texas System | Detection and diagnosis of smoking related cancers |
EP1984030B1 (en) | 2006-01-30 | 2013-05-08 | The Scripps Research Institute | Methods for detection of circulating tumor cells and methods of diagnosis of cancer in a mammalian subject |
WO2007089880A2 (en) | 2006-01-31 | 2007-08-09 | Georgetown University | Method to detect breast cancer cells |
WO2007092713A2 (en) | 2006-02-02 | 2007-08-16 | Trustees Of The University Of Pennsylvania | Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease |
EP1981539B1 (en) | 2006-02-09 | 2014-07-23 | Amgen Research (Munich) GmbH | Treatment of metastatic breast cancer |
EP1818413A1 (en) | 2006-02-10 | 2007-08-15 | Fundacion para la Investigacion Clinica y Molecular del Cancer de Pulmon | Method of determining outcome of non small-cell lung cancer according to XRCC3 polymorphism |
CA2642854A1 (en) | 2006-02-18 | 2007-08-30 | Michael Strathmann | Massively multiplexed sequencing |
WO2007098484A2 (en) | 2006-02-21 | 2007-08-30 | The Trustees Of Princeton University | High-yield activation of polymer surfaces for covalent attachment of molecules |
EP1986675A2 (en) | 2006-02-24 | 2008-11-05 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Extracellular matrix/metastasis modifer genes for the prevention or inhibition of metastasis or growth of tumor and for characterization of tumor |
DE602007014335D1 (en) * | 2006-02-28 | 2011-06-16 | Univ Louisville Res Found | DETECTION OF CHROMOSOME ABNORMALITIES IN FATUS USING TANDEM INDIVIDUAL LIQUID POLYMORPHISMS |
EP1832661A1 (en) | 2006-03-09 | 2007-09-12 | Adnagen AG | Method for the individual staging of tumor diseases |
US8337755B2 (en) | 2006-03-13 | 2012-12-25 | Veridex, Llc | Operator independent programmable sample preparation and analysis system |
WO2007112418A2 (en) * | 2006-03-28 | 2007-10-04 | Baylor College Of Medicine | Screening for down syndrome |
US20090181358A1 (en) | 2006-03-30 | 2009-07-16 | Gross Susan J | Marker for Chromosomal Abnormalities |
US7754428B2 (en) | 2006-05-03 | 2010-07-13 | The Chinese University Of Hong Kong | Fetal methylation markers |
US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
US7735652B2 (en) * | 2006-06-01 | 2010-06-15 | The Trustees Of Princeton University | Apparatus and method for continuous particle separation |
EP2589668A1 (en) * | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
US8137912B2 (en) * | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
WO2009035447A1 (en) * | 2006-06-14 | 2009-03-19 | Living Microsystems, Inc. | Diagnosis of fetal abnormalities by comparative genomic hybridization analysis |
US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
WO2008111990A1 (en) | 2006-06-14 | 2008-09-18 | Cellpoint Diagnostics, Inc. | Rare cell analysis using sample splitting and dna tags |
US20080070792A1 (en) * | 2006-06-14 | 2008-03-20 | Roland Stoughton | Use of highly parallel snp genotyping for fetal diagnosis |
EP2038426A2 (en) | 2006-06-16 | 2009-03-25 | Sequenom, Inc. | Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample |
GB0616045D0 (en) | 2006-08-11 | 2006-09-20 | Univ Bristol | Blood cell separation |
AU2008213634B2 (en) | 2007-02-08 | 2013-09-05 | Sequenom, Inc. | Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification |
US20100112590A1 (en) * | 2007-07-23 | 2010-05-06 | The Chinese University Of Hong Kong | Diagnosing Fetal Chromosomal Aneuploidy Using Genomic Sequencing With Enrichment |
CA3176319A1 (en) | 2007-07-23 | 2009-01-29 | The Chinese University Of Hong Kong | Analyzing tumor dna in a cell-free sample |
US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
EP2227780A4 (en) * | 2008-03-19 | 2011-08-03 | Existence Genetics Llc | Genetic analysis |
SI2334812T1 (en) | 2008-09-20 | 2017-05-31 | The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Building 170 | Noninvasive diagnosis of fetal aneuploidy by sequencing |
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2009
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Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050221341A1 (en) * | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
US20070212689A1 (en) * | 2003-10-30 | 2007-09-13 | Bianchi Diana W | Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid |
US20080213775A1 (en) * | 2005-06-16 | 2008-09-04 | Government Of The United States Of America, Represented By The Secretary, Dept. Of Health And | Methods and materials for identifying polymorphic variants, diagnosing susceptibilities, and treating disease |
US20070202525A1 (en) * | 2006-02-02 | 2007-08-30 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
US20070238105A1 (en) * | 2006-04-07 | 2007-10-11 | Agilent Technologies, Inc. | High resolution chromosomal mapping |
Non-Patent Citations (3)
Title |
---|
"Leutwyler. Mapping Chromosome 21.", SCIENTIFIC AMERICAN, 15 May 2000 (2000-05-15), XP008145905, Retrieved from the Internet <URL:http://www.scientificamertcan.com/article.cfm?id=mapping-chromosome-21>> [retrieved on 20100304] * |
TETTELIN ET AL.: "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.", NATURE, vol. 387, no. 6632S, 1997, pages 81 - 84, XP008067802 * |
ZAVALA ET AL.: "Genomic GC content prediction in prokaryotes from a sample of genes.", GENE, vol. 357, no. 2, 2005, pages 137 - 143, XP005073557 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8318430B2 (en) | 2010-01-23 | 2012-11-27 | Verinata Health, Inc. | Methods of fetal abnormality detection |
US9493831B2 (en) | 2010-01-23 | 2016-11-15 | Verinata Health, Inc. | Methods of fetal abnormality detection |
CN103525939A (en) * | 2013-10-28 | 2014-01-22 | 广州爱健生物技术有限公司 | Method and system for noninvasive detection of fetus chromosome aneuploid |
CN103525939B (en) * | 2013-10-28 | 2015-12-02 | 博奥生物集团有限公司 | The method and system of Non-invasive detection foetal chromosome aneuploidy |
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