WO2010036441A3 - Laesi for atmospheric pressure, in vivo and imaging mass spectrometry - Google Patents

Laesi for atmospheric pressure, in vivo and imaging mass spectrometry Download PDF

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Publication number
WO2010036441A3
WO2010036441A3 PCT/US2009/051157 US2009051157W WO2010036441A3 WO 2010036441 A3 WO2010036441 A3 WO 2010036441A3 US 2009051157 W US2009051157 W US 2009051157W WO 2010036441 A3 WO2010036441 A3 WO 2010036441A3
Authority
WO
WIPO (PCT)
Prior art keywords
atmospheric pressure
mass spectrometry
laesi
vivo
imaging mass
Prior art date
Application number
PCT/US2009/051157
Other languages
French (fr)
Other versions
WO2010036441A2 (en
WO2010036441A9 (en
Inventor
Akos Vertes
Peter Nemes
Original Assignee
The George Washington University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The George Washington University filed Critical The George Washington University
Publication of WO2010036441A2 publication Critical patent/WO2010036441A2/en
Publication of WO2010036441A9 publication Critical patent/WO2010036441A9/en
Publication of WO2010036441A3 publication Critical patent/WO2010036441A3/en

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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0459—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for solid samples
    • H01J49/0463—Desorption by laser or particle beam, followed by ionisation as a separate step
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/165—Electrospray ionisation

Abstract

The field of the invention is atmospheric pressure mass spectrometry (MS), and more specifically a process and apparatus which combine infrared laser ablation (LA) with electrospray ionization (ESI).
PCT/US2009/051157 2008-07-18 2009-07-20 Laesi for atmospheric pressure, in vivo and imaging mass spectrometry WO2010036441A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/176,324 2008-07-18
US12/176,324 US8067730B2 (en) 2007-07-20 2008-07-18 Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry

Publications (3)

Publication Number Publication Date
WO2010036441A2 WO2010036441A2 (en) 2010-04-01
WO2010036441A9 WO2010036441A9 (en) 2010-05-20
WO2010036441A3 true WO2010036441A3 (en) 2010-07-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/051157 WO2010036441A2 (en) 2008-07-18 2009-07-20 Laesi for atmospheric pressure, in vivo and imaging mass spectrometry

Country Status (2)

Country Link
US (3) US8067730B2 (en)
WO (1) WO2010036441A2 (en)

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WO2019013464A1 (en) * 2017-07-10 2019-01-17 재단법인대구경북과학기술원 Method for treating biological tissue, laser treatment device and atmospheric pressure mass spectrometry imaging system
KR102086716B1 (en) * 2017-07-10 2020-03-09 재단법인대구경북과학기술원 High resolution ambient mass spectrometric imaging system for analysis of living biomaterials
KR101955187B1 (en) * 2017-12-19 2019-03-07 재단법인대구경북과학기술원 High resolution ambient mass spectrometric imaging system for analysis of living biomaterials
KR102015504B1 (en) * 2017-11-09 2019-08-28 재단법인대구경북과학기술원 A method for treating biological tissue, a laser processing apparatus, and an atmospheric pressure mass spectrometry imaging system
WO2019092750A1 (en) * 2017-11-13 2019-05-16 INDIAN INSTITUTE OF TECHNOLOGY MADRAS (IIT Madras) Method of field induced photoionization of molecules using low power pointer laser in laser assisted paper spray ionization mass spectrometry (lapsi ms)
CN108010829B (en) * 2017-11-14 2019-12-03 大连民族大学 The mass spectrometer of plumage brightness particulate in a kind of laser welding
CN107907586A (en) * 2017-12-27 2018-04-13 常州英诺激光科技有限公司 A kind of portable laser mass spectrograph that can be worked under atmospheric environment
KR102209996B1 (en) * 2019-02-20 2021-02-01 주식회사 아스타 Mass spectrometer
CN111983006B (en) * 2020-07-31 2021-09-28 河海大学 Method for detecting water loss law of foam warm-mixed asphalt
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Also Published As

Publication number Publication date
US8487244B2 (en) 2013-07-16
WO2010036441A2 (en) 2010-04-01
US8809774B2 (en) 2014-08-19
US20090272892A1 (en) 2009-11-05
US20130214150A1 (en) 2013-08-22
US8067730B2 (en) 2011-11-29
US20120025069A1 (en) 2012-02-02
WO2010036441A9 (en) 2010-05-20

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