WO2010077867A3 - Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus - Google Patents

Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus Download PDF

Info

Publication number
WO2010077867A3
WO2010077867A3 PCT/US2009/068062 US2009068062W WO2010077867A3 WO 2010077867 A3 WO2010077867 A3 WO 2010077867A3 US 2009068062 W US2009068062 W US 2009068062W WO 2010077867 A3 WO2010077867 A3 WO 2010077867A3
Authority
WO
WIPO (PCT)
Prior art keywords
extracts
compositions
astragalus membranaceus
thrombocytopenic purpura
idiopathic thrombocytopenic
Prior art date
Application number
PCT/US2009/068062
Other languages
French (fr)
Other versions
WO2010077867A2 (en
Inventor
Jinhua An
John M. Fidler
John H. Musser
Original Assignee
Ecopharm, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ecopharm, Llc filed Critical Ecopharm, Llc
Priority to JP2011540971A priority Critical patent/JP5732604B2/en
Priority to SG2011041787A priority patent/SG172029A1/en
Priority to CN200980155742.9A priority patent/CN102300576B/en
Priority to EP09836839.2A priority patent/EP2376096B1/en
Priority to KR1020117016274A priority patent/KR101780074B1/en
Publication of WO2010077867A2 publication Critical patent/WO2010077867A2/en
Publication of WO2010077867A3 publication Critical patent/WO2010077867A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/202—IL-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The teachings provided herein generally relate to the preparation and uses of compositions comprising extracts of Astragalus membranaceus. The extracts are prepared from Astragalus membranaceus and can comprise, for example, an acid-modified arabinogalactan protein composition having an arabinose:galactose ratio ranging from about 3.5:1 to about 5.0: 1, from about 5% to about 10% rhamnose, from about 15% to about 20% galactose, and from about 10% to about 15% glucose. The compositions can be used in the treatment of idiopathic thrombocytopenic purpura and the formulation of medicaments for such treatments.
PCT/US2009/068062 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus WO2010077867A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2011540971A JP5732604B2 (en) 2008-12-15 2009-12-15 Treatment of idiopathic thrombocytopenic purpura with a composition containing Echinacea extract
SG2011041787A SG172029A1 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus
CN200980155742.9A CN102300576B (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus
EP09836839.2A EP2376096B1 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus
KR1020117016274A KR101780074B1 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12258608P 2008-12-15 2008-12-15
US61/122,586 2008-12-15

Publications (2)

Publication Number Publication Date
WO2010077867A2 WO2010077867A2 (en) 2010-07-08
WO2010077867A3 true WO2010077867A3 (en) 2010-11-25

Family

ID=42266446

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/068062 WO2010077867A2 (en) 2008-12-15 2009-12-15 Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus

Country Status (9)

Country Link
US (2) US8137710B2 (en)
EP (1) EP2376096B1 (en)
JP (1) JP5732604B2 (en)
KR (1) KR101780074B1 (en)
CN (1) CN102300576B (en)
MY (1) MY159317A (en)
SG (1) SG172029A1 (en)
TW (1) TWI507201B (en)
WO (1) WO2010077867A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103142726A (en) * 2013-02-21 2013-06-12 上海浦东高星生物技术研究所 Ulcer hemorrhage stopping powder
WO2016028714A1 (en) * 2014-08-18 2016-02-25 Pharmagenesis, Inc. Polygalacturonan rhamnogalacturonan1 (pgrg1) composition
CN104173563A (en) * 2014-08-22 2014-12-03 上海中医药大学附属岳阳中西医结合医院 Traditional Chinese medicine composition for treating idiopathic thrombocytopenic purpura
CN104740405B (en) * 2015-04-14 2018-09-04 日照市中医医院 A kind of Chinese medicine preparation and preparation method for treating anaphylactoid purpura renal damage
CN104784419A (en) * 2015-04-24 2015-07-22 陕西郝其军制药股份有限公司 Traditional Chinese medicine composition for treating immune thrombocytopenic purpura and preparation method of traditional Chinese medicine composition
CN108066354A (en) * 2016-11-10 2018-05-25 怀特生技新药股份有限公司 Purposes of the astragalus polyose extract in the drug for enhancing immunotherapy for cancer effect is prepared
CN109199907A (en) * 2017-07-07 2019-01-15 怀特生技新药股份有限公司 Radix Astragali extract is preparing the application in the composition for inhibiting melanin production

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100195884B1 (en) * 1996-02-12 1999-06-15 김박광 Blood glucose lowering composition containing extract of astragali radix and process for preparing extract of astragali radix
KR20020089817A (en) * 2001-05-24 2002-11-30 한국원자력연구소 Extract of herb mixture for heamatopoiesis augmentation and protection from radiation
KR20030091921A (en) * 2003-11-17 2003-12-03 한국원자력연구소 Extract of herb mixture for heamatopoiesis augmentation and protection from radiation
KR100526404B1 (en) * 2003-07-31 2005-11-08 학교법인 한림대학교 Composition for preventing neuronal cell death caused by cerebral ischemia continiaing extract from astragali radix root
KR100697212B1 (en) * 2005-01-29 2007-03-22 서울향료(주) Hematopoietic enhancer comprising herbal mixture extract of Astragali Radix and Angelicae Gigantis Radix for treating side-effect caused by administrating anticancer agent
KR100760384B1 (en) * 2006-02-22 2007-09-19 경희대학교 산학협력단 Composition comprising the extract of Astragalus membranaceus BGE. showing angiogenesis promoting activity and bone healing activity for preventing and treating fracture

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795742A (en) * 1985-09-24 1989-01-03 Yaguang Liu Therapeutic composition from plant extracts
US4708949A (en) * 1985-09-24 1987-11-24 Yaguang Liu Therapeutic composition from plant extracts
US5554386A (en) * 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US5589591A (en) * 1986-07-03 1996-12-31 Advanced Magnetics, Inc. Endotoxin-free polysaccharides
US5478576A (en) * 1986-07-03 1995-12-26 Advanced Magnetics, Inc. Arabinogalactan derivatives and uses thereof
US5336506A (en) * 1986-07-03 1994-08-09 Advanced Magnetics Inc. Targeting of therapeutic agents using polysaccharides
US5679323A (en) * 1986-07-03 1997-10-21 Advanced Magnetics, Inc. Hepatocyte-specific receptor-mediated endocytosis-type compositions
US4843067A (en) * 1986-11-19 1989-06-27 Yaguang Liu Polysaccharide containing pharmaceutical composition for increasing the immune function
US4944946A (en) * 1987-01-27 1990-07-31 Yaguang Liu Pharmaceutical composition for inhibiting viruses and increasing immune function (PII)
US5268467A (en) * 1988-05-23 1993-12-07 Verbiscar Anthony J Immunomodulatory polysaccharide fractions from Astragalus plants
CN1027168C (en) 1989-05-13 1994-12-28 储大同 Bioregulator made from Inter leukin-2
US4950751A (en) * 1989-06-02 1990-08-21 The Nanci Corporation International Method of isolating arabinogalactan from larch
IT1238685B (en) 1990-02-09 1993-09-01 Indena Spa IMMUNOMODULATING ACTION POLYSACCHARIDES FROM ASTRAGALUS MEMBRANACEOUS AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US5116969B1 (en) * 1990-04-26 1997-04-01 Larex International Inc Ultrarefined arabinogalactan product
CN1025590C (en) 1990-07-20 1994-08-10 邓恺 Preparation of injection for anal fistula
ES2049561B1 (en) 1991-04-27 1994-12-16 Andromaco Lab PROCEDURE FOR OBTAINING POLYMERS WITH ACTIVITY ON THE HEMATOPOYETIC SYSTEM.
US5547997A (en) 1991-10-01 1996-08-20 Chemisches Laboratorium Dr. Kurt Richter Gmbh Plant-derived cosmetic composition and method of treatment of skin
US5646029A (en) * 1993-12-03 1997-07-08 Cooperative Research Centre For Industrial Plant Biopolymers Plant arabinogalactan protein (AGP) genes
US5756098A (en) * 1995-12-12 1998-05-26 The University Of Montana Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent
US5770217A (en) * 1997-07-02 1998-06-23 Atlatl, Inc. Dietary supplement for hematological, immune and appetite enhancement
CN1179979C (en) * 1999-06-30 2004-12-15 法蒙金希公司 Hematopoietic arabinogalactan composition
JP2004502703A (en) * 2000-06-29 2004-01-29 ファーマジェネシス，　インコーポレイテッド Acid-modified arabinogalactan protein composition
JP2006070217A (en) * 2004-09-03 2006-03-16 Kitasato Inst:The Polysaccharide and biophylactic activation agent originated from aboveground part of astragalus mongholicus bunge

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100195884B1 (en) * 1996-02-12 1999-06-15 김박광 Blood glucose lowering composition containing extract of astragali radix and process for preparing extract of astragali radix
KR20020089817A (en) * 2001-05-24 2002-11-30 한국원자력연구소 Extract of herb mixture for heamatopoiesis augmentation and protection from radiation
KR100526404B1 (en) * 2003-07-31 2005-11-08 학교법인 한림대학교 Composition for preventing neuronal cell death caused by cerebral ischemia continiaing extract from astragali radix root
KR20030091921A (en) * 2003-11-17 2003-12-03 한국원자력연구소 Extract of herb mixture for heamatopoiesis augmentation and protection from radiation
KR100697212B1 (en) * 2005-01-29 2007-03-22 서울향료(주) Hematopoietic enhancer comprising herbal mixture extract of Astragali Radix and Angelicae Gigantis Radix for treating side-effect caused by administrating anticancer agent
KR100760384B1 (en) * 2006-02-22 2007-09-19 경희대학교 산학협력단 Composition comprising the extract of Astragalus membranaceus BGE. showing angiogenesis promoting activity and bone healing activity for preventing and treating fracture

Also Published As

Publication number Publication date
JP2012512176A (en) 2012-05-31
SG172029A1 (en) 2011-07-28
CN102300576A (en) 2011-12-28
US20100158861A1 (en) 2010-06-24
EP2376096A2 (en) 2011-10-19
US8137710B2 (en) 2012-03-20
KR101780074B1 (en) 2017-09-19
KR20110094343A (en) 2011-08-23
EP2376096A4 (en) 2013-10-02
CN102300576B (en) 2014-03-05
TWI507201B (en) 2015-11-11
WO2010077867A2 (en) 2010-07-08
TW201026318A (en) 2010-07-16
EP2376096B1 (en) 2019-07-24
JP5732604B2 (en) 2015-06-10
US8728543B2 (en) 2014-05-20
MY159317A (en) 2016-12-30
US20120141412A1 (en) 2012-06-07

Similar Documents

Publication Publication Date Title
WO2010077867A3 (en) Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus
WO2008030567A3 (en) Dry powder compound formulations and uses thereof
WO2013122932A3 (en) Topical use of a skin-commensal prebiotic agent and compositions containing the same
WO2007113222A3 (en) Immunogenic composition
NZ600118A (en) Lipopeptide compositions and related methods
WO2008036932A3 (en) Compositions and methods comprising boswellia species
WO2009109927A3 (en) Glp-1 receptor agonists and related active pharmaceutical ingredients for treatment of cancer
WO2007127273A3 (en) Methods and compositions for altering cell function
WO2009007328A3 (en) Use of homo- and copolymers for stabilizing active ingredient formulations
WO2010087964A3 (en) Compositions for treatment and prevention of acne, methods of making the compositions, and methods of use thereof
MX2010007011A (en) Composition for human and/or animal nutrition, uses thereof and yeasts.
WO2011035335A3 (en) Stabilized liquid and lyophilized adamts13 formulations
WO2010000877A3 (en) Formulation with irritation reducing action comprising bisabolol and [6]-paradol
MY143795A (en) Tetrahydropyridoindole derivatives
WO2010094009A3 (en) Methods and compositions for the treatment of ras associated disorders
MX2010005159A (en) Water dispersible enteric coating formulation for nutraceutical and pharmaceutical dosage forms.
WO2009055568A3 (en) Liposomal vancomycin formulations
WO2008119943A3 (en) Enteric pharmaceutical capsules
WO2011154905A3 (en) Colored aqueous cosmetic compositions
WO2005094554A3 (en) Therapeutic agents, methods, and treatments
MX2010005516A (en) Compositions containing at least one naphthoic acid derivative, benzoyl peroxide and at least one film-forming agent, methods for preparing same and uses thereof.
WO2011163467A3 (en) Low-irritating, clear cleansing compositions with relatively low ph
WO2008113912A3 (en) Novel cosmetic and/or pharmaceutical compositions and applications thereof
WO2007067519A3 (en) The use of neurotransmitters and neuropeptides for the treatment of dry eye diseases and related conditions
MY179559A (en) Cocoa powder compositions

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980155742.9

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09836839

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2011540971

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 20117016274

Country of ref document: KR

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2009836839

Country of ref document: EP