WO2010149578A3 - Novel biphenyl and phenyl-pyridine amides - Google Patents

Novel biphenyl and phenyl-pyridine amides Download PDF

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Publication number
WO2010149578A3
WO2010149578A3 PCT/EP2010/058611 EP2010058611W WO2010149578A3 WO 2010149578 A3 WO2010149578 A3 WO 2010149578A3 EP 2010058611 W EP2010058611 W EP 2010058611W WO 2010149578 A3 WO2010149578 A3 WO 2010149578A3
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WIPO (PCT)
Prior art keywords
phenyl
novel biphenyl
pyridine amides
compounds
amides
Prior art date
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PCT/EP2010/058611
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French (fr)
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WO2010149578A2 (en
Inventor
Chris Allen Broka
Ronald Charles Hawley
Original Assignee
F. Hoffmann-La Roche Ag
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Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Priority to ES10725188.6T priority Critical patent/ES2450891T3/en
Priority to SG2011094877A priority patent/SG177308A1/en
Priority to JP2012516659A priority patent/JP5476467B2/en
Priority to CA2764956A priority patent/CA2764956A1/en
Priority to CN201080027808.9A priority patent/CN102574778B/en
Priority to EP10725188.6A priority patent/EP2445868B1/en
Publication of WO2010149578A2 publication Critical patent/WO2010149578A2/en
Publication of WO2010149578A3 publication Critical patent/WO2010149578A3/en
Priority to HK12113110.4A priority patent/HK1172320A1/en

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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Abstract

Compounds of the formula (I) or a pharmaceutically acceptable salt thereof, wherein, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.
PCT/EP2010/058611 2009-06-22 2010-06-18 Novel biphenyl and phenyl-pyridine amides WO2010149578A2 (en)

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ES10725188.6T ES2450891T3 (en) 2009-06-22 2010-06-18 Biphenylamides useful as modulators of P2X3 and / or P2X2 / 3 receptors
SG2011094877A SG177308A1 (en) 2009-06-22 2010-06-18 Novel biphenyl and phenyl-pyridine amides
JP2012516659A JP5476467B2 (en) 2009-06-22 2010-06-18 Novel biphenylpyridine amide and phenylpyridine amide
CA2764956A CA2764956A1 (en) 2009-06-22 2010-06-18 Novel biphenyl and phenyl-pyridine amides
CN201080027808.9A CN102574778B (en) 2009-06-22 2010-06-18 Novel biphenyl and phenyl-pyridine amides
EP10725188.6A EP2445868B1 (en) 2009-06-22 2010-06-18 Biphenyl amides useful as p2x3 and/or p2x2/3 receptors modulators
HK12113110.4A HK1172320A1 (en) 2009-06-22 2012-12-19 Novel biphenyl and phenyl pyridine amides

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US8283383B2 (en) 2012-10-09
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US20130165443A1 (en) 2013-06-27
US8895589B2 (en) 2014-11-25
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US20150080408A1 (en) 2015-03-19
US9505726B2 (en) 2016-11-29
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