WO2011098819A1 - Dietary supplement composition - Google Patents
Dietary supplement composition Download PDFInfo
- Publication number
- WO2011098819A1 WO2011098819A1 PCT/GB2011/050248 GB2011050248W WO2011098819A1 WO 2011098819 A1 WO2011098819 A1 WO 2011098819A1 GB 2011050248 W GB2011050248 W GB 2011050248W WO 2011098819 A1 WO2011098819 A1 WO 2011098819A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dietary supplement
- supplement composition
- weight
- curcumin
- piperine
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 30
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 28
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims abstract description 40
- 244000179886 Moringa oleifera Species 0.000 claims abstract description 23
- 235000011347 Moringa oleifera Nutrition 0.000 claims abstract description 22
- 235000012754 curcumin Nutrition 0.000 claims abstract description 20
- 229940109262 curcumin Drugs 0.000 claims abstract description 20
- 239000004148 curcumin Substances 0.000 claims abstract description 20
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019100 piperine Nutrition 0.000 claims abstract description 19
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 claims abstract description 19
- 229940075559 piperine Drugs 0.000 claims abstract description 19
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 claims abstract description 19
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 12
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 7
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 7
- 229960002216 methylparaben Drugs 0.000 claims description 7
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 6
- 229960003415 propylparaben Drugs 0.000 claims description 6
- 239000003381 stabilizer Substances 0.000 claims description 3
- 239000000284 extract Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 208000002720 Malnutrition Diseases 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000003556 assay Methods 0.000 description 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 244000163122 Curcuma domestica Species 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 108060003951 Immunoglobulin Proteins 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 235000019510 Long pepper Nutrition 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 240000003455 Piper longum Species 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 235000003373 curcuma longa Nutrition 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- 102000018358 immunoglobulin Human genes 0.000 description 2
- 230000001071 malnutrition Effects 0.000 description 2
- 235000000824 malnutrition Nutrition 0.000 description 2
- 208000004235 neutropenia Diseases 0.000 description 2
- 210000000440 neutrophil Anatomy 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 208000015380 nutritional deficiency disease Diseases 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 240000000572 Blumea balsamifera Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 241000220214 Moringaceae Species 0.000 description 1
- 244000136948 Ocimum sanctum Species 0.000 description 1
- 235000004072 Ocimum sanctum Nutrition 0.000 description 1
- 241000606856 Pasteurella multocida Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 230000024932 T cell mediated immunity Effects 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000287 crude extract Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 239000003797 essential amino acid Substances 0.000 description 1
- 235000020776 essential amino acid Nutrition 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000035931 haemagglutination Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 231100000225 lethality Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 235000000112 undernutrition Nutrition 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- This invention relates to a dietary supplement composition for the human or animal body, and in particular to a dietary supplement composition comprising Moringa oleifera, Curcumin, and Piperine.
- Moringa oleifera is instrumental in the fight against global malnutrition. It is a complete multivitamin vegetable. It is rich in Vitamin A, C, Calcium, Protein, Potassium, Iron, Essential Amino Acids and Phytonutrients which aid the immune system. It provides nourishment to the eyes and brain, strengthens the cell structure of the body, and delivers powerful nutrition.
- Moringa oleifera is an edible tree found worldwide in the dry tropics, and is increasingly being used for nutritional supplementation. Its nutrient-dense leaves are high in protein quality, leading to its widespread use by doctors, healers, nutritionists and community leaders, to treat under-nutrition and a variety of illnesses. The adoption of M. oleifera continues to increase.
- MEMO 250 and 750 mg/kg, po
- Ocimum sanctum 100 mg/kg, po
- MEMO produced significant increase in adhesion of neutrophils, attenuation of cyclophosphamide-induced neutropenia and an increase in phagocytic index in carbon clearance assay. From the above results, it can be concluded that MEMO stimulate both cellular and humoral immune response. However, low dose of MEMO was found to be more effective than the high dose.
- Moringa oleifera Lam (Moringaceae) are also used by the Indians in their herbal medicine as a hypocholesterolennic agent in obese patients.
- the scientific basis for their use in hypercholesterolemia was therefore examined. It was found (Ghasi et al Journal of Ethnopharmacology. 2000 Jan;69(1):21-5) that administration of the crude leaf extract of Moringa oleifera along with high-fat diet decreased the high-fat diet-induced increases in serum, liver, and kidney cholesterol levels by 14.35% (1 15-103.2 mg/100 ml of serum), 6.40% (9.4-8.8 mg/g wet weight) and 1 1 .09% (1 .09-0.97 mg/g wet weight) respectively.
- Piperine extract of Piper longum
- 1 Milligram of Piperine increases the body's ability to absorb curcumin and some other nutrients by over 100% (Shoba et al Planta Medica. 1998 May; 64(4):353-6 or Atal et al J Pharmacology and Experimental Therapeutics. 1985 Jan;232(1 ):258-62).
- a dietary supplement composition comprising Moringa oleifera, Curcumin and Piperine.
- the proportion of the ingredients that make up the dietary supplement composition of the present invention may be as follows:
- the proportion of the ingredients that make up the dietary supplement composition of the present invention may also be as follows:
- the dietary supplement composition may further comprise a stabiliser.
- the preservative may comprise about 2% by weight of Methyl Paraben and/or about 2% by weight of Proply Paraben.
- a dietary supplement composition comprising:
- the dietary supplement composition may further comprise a stabiliser.
- a stabiliser This may comprise at least Methyl Paraben, which may be about 10mg in weight and/or Propyl Paraben, which may be about 10mg in weight.
- the dietary supplement composition may comprise 250mg Moringa oleifera, 240mg Curcumin, 10mg Piperine, 10mg Methyl Paraben and 10mg Propyl Paraben.
- a tablet or capsule containing the dietary supplement composition according to this aspect of the present invention may have a weight that does not exceed about 700mg.
- the fornnulation may be adjusted to increase the potency and effect of certain ingredients, depending on the desired effect.
- the Piperine, Curcumin and Moringa oleifera help fight malnutrition, keep the body in its optimum form, while retaining all the medical benefits of a combination of PiCur, which is a food supplement with an ORAC (Oxygen Radical Absorbance Capacity) value of 159,000 and is available from The GlobaLeader Inc, Philippines.
- ORAC Oxygen Radical Absorbance Capacity
- Curcumin extract of Curcuma longa
- Curcumin and Piperine dry extracts are processed separately using known pulverization, extraction, evaporation, and crystallization techniques.
- Blumea balsamifera and Lagerstoemia speciosa dry extracts are processed separately using known pulverization and extraction techniques.
- the resulting powder extracts are then blended in the designated proportion and encapsulated using known techniques.
Abstract
A dietary supplement composition comprising Moringa oleifera, Curcumin and Piperine. In one aspect of the invention the dietary supplement composition comprises between about 48%to about 58%by weight of Moringa oleifera, between about 37%to about 47%by weight of Curcumin, and between about 2% to about 4%by weight of Piperine. According to a another aspect of the invention the dietary supplement composition comprises between about 250mg to about 375mg Moringa oleifera, between about 200mg to about 250mg of Curcumin, and between about 10mg to about 20mg of Piperine.
Description
DIETARY SUPPLEMENT COMPOSITION
[0001] This invention relates to a dietary supplement composition for the human or animal body, and in particular to a dietary supplement composition comprising Moringa oleifera, Curcumin, and Piperine.
[0002] Moringa oleifera is instrumental in the fight against global malnutrition. It is a complete multivitamin vegetable. It is rich in Vitamin A, C, Calcium, Protein, Potassium, Iron, Essential Amino Acids and Phytonutrients which aid the immune system. It provides nourishment to the eyes and brain, strengthens the cell structure of the body, and delivers powerful nutrition.
[0003] Moringa oleifera is an edible tree found worldwide in the dry tropics, and is increasingly being used for nutritional supplementation. Its nutrient-dense leaves are high in protein quality, leading to its widespread use by doctors, healers, nutritionists and community leaders, to treat under-nutrition and a variety of illnesses. The adoption of M. oleifera continues to increase.
[0004]A study was conducted to investigate the immunomodulatory action of methanol ic extract of Moringa oleifera (MEMO) in an experimental model of immunity (Sudha et al Indian Journal of Physiology and Pharmacology. 2010 Apr- Jun;54(2):133-40). The cellular immunity was evaluated using neutrophil adhesion test, cyclophosphamide induced neutropenia and carbon clearance assay, whereas, humoral immunity was tested by mice lethality test, serum immunoglobulin estimation and indirect haemagglutination assay in animals. Administration of MEMO (250 and 750 mg/kg, po) and Ocimum sanctum (100 mg/kg, po) significantly increased the levels of serum immunoglobulins and also prevented the mortality induced by bovine Pasteurella multocida in mice. They also increased significantly the circulating antibody titre in indirect haemagglunation test. Moreover, MEMO produced significant increase in adhesion of neutrophils, attenuation of cyclophosphamide-induced neutropenia and an increase in phagocytic index in carbon clearance assay. From the above
results, it can be concluded that MEMO stimulate both cellular and humoral immune response. However, low dose of MEMO was found to be more effective than the high dose. [0005] The leaves of Moringa oleifera Lam (Moringaceae) are also used by the Indians in their herbal medicine as a hypocholesterolennic agent in obese patients. The scientific basis for their use in hypercholesterolemia was therefore examined. It was found (Ghasi et al Journal of Ethnopharmacology. 2000 Jan;69(1):21-5) that administration of the crude leaf extract of Moringa oleifera along with high-fat diet decreased the high-fat diet-induced increases in serum, liver, and kidney cholesterol levels by 14.35% (1 15-103.2 mg/100 ml of serum), 6.40% (9.4-8.8 mg/g wet weight) and 1 1 .09% (1 .09-0.97 mg/g wet weight) respectively. The effect on the serum cholesterol was statistically significant. No significant effect on serum total protein was observed. However, the crude extract increased serum albumin by 15.22% (46-53 g/l). This value was also found to be statistically significant. It was concluded that the leaves of Moringa oleifera have definite hypocholesterolennic activity and that there is valid pharmacological basis for employing them for this purpose. [0006]Curcumin (extract of Curcuma longa) is backed by over 3,000 clinical studies conducted worldwide (for example the review article Aggarwal et al in Advances in Experimental Medicine and Biology 2007;595:1 -75). Curcumin is beneficial in over 100 medical conditions. [0007] Piperine (extract of Piper longum) is a bio-availability enhancer. 1 Milligram of Piperine increases the body's ability to absorb curcumin and some other nutrients by over 100% (Shoba et al Planta Medica. 1998 May; 64(4):353-6 or Atal et al J Pharmacology and Experimental Therapeutics. 1985 Jan;232(1 ):258-62).
[0008] Therefore, according to the present invention there is provided a dietary supplement composition comprising Moringa oleifera, Curcumin and Piperine.
[0009]The proportion of the ingredients that make up the dietary supplement composition of the present invention may be as follows:
- between about 48% to about 58% by weight of Moringa oleifera;
- between about 37% to about 47% by weight of Curcumin; and
- between about 2% to about 4% by weight of Piperine.
[0010]The proportion of the ingredients that make up the dietary supplement composition of the present invention may also be as follows:
- about 48% by weight of Moringa oleifera;
- about 46% by weight of Curcumin; and
- about 2% by weight of Piperine.
[0011]The dietary supplement composition may further comprise a stabiliser. The preservative may comprise about 2% by weight of Methyl Paraben and/or about 2% by weight of Proply Paraben.
[0012] According to a further aspect of the present invention there is provided a dietary supplement composition comprising:
- between about 250mg to about 375mg Moringa oleifera;
- between about 200mg to about 250mg of Curcumin; and
- between about 10mg and about 20mg of Piperine.
[0013]The dietary supplement composition may further comprise a stabiliser. This may comprise at least Methyl Paraben, which may be about 10mg in weight and/or Propyl Paraben, which may be about 10mg in weight.
[0014]The dietary supplement composition may comprise 250mg Moringa oleifera, 240mg Curcumin, 10mg Piperine, 10mg Methyl Paraben and 10mg Propyl Paraben.
[0015] A tablet or capsule containing the dietary supplement composition according to this aspect of the present invention may have a weight that does not exceed about 700mg.
[0016] The fornnulation may be adjusted to increase the potency and effect of certain ingredients, depending on the desired effect. [0017] In combination, the Piperine, Curcumin and Moringa oleifera help fight malnutrition, keep the body in its optimum form, while retaining all the medical benefits of a combination of PiCur, which is a food supplement with an ORAC (Oxygen Radical Absorbance Capacity) value of 159,000 and is available from The GlobaLeader Inc, Philippines.
[0018] At least one example of the present invention will now be described, by way of example only.
[0019] Example 1
Composition - Weight
Moringa oleifera
Curcumin (extract of Curcuma longa)
Piperine (extract of Piper longum)
Methyl Paraben
Propyl Paraben
Method
Curcumin and Piperine dry extracts are processed separately using known pulverization, extraction, evaporation, and crystallization techniques.
Blumea balsamifera and Lagerstoemia speciosa dry extracts are processed separately using known pulverization and extraction techniques.
The resulting powder extracts are then blended in the designated proportion and encapsulated using known techniques.
Claims
1 . A dietary supplement composition comprising Moringa oleifera, Curcumin and Piperine.
2. A dietary supplement composition according to Claim 1 comprising:
- between about 48% to about 58% by weight of Moringa oleifera;
- between about 37% to about 47% by weight of Curcumin; and
- between about 2% to about 4% by weight of Piperine.
3. A dietary supplement composition according to Claim 1 or Claim 2, comprising:
- about 48% by weight of Moringa oleifera;
- about 46% by weight of Curcumin; and
- about 2% by weight of Piperine.
4. A dietary supplement composition as claimed in any of Claims 1 to 3, further comprising a stabiliser.
5. A dietary supplement composition as claimed in Claim 4, wherein the preservative comprises about 2% by weight of Methyl Paraben.
6. A dietary supplement composition as claimed in Claim 4 or Claim 5, wherein the preservative comprises about 2% by weight of Propyl Paraben.
7. A dietary supplement composition as claimed in Claim 1 comprising:
- between about 250mg to about 375mg Moringa oleifera;
- between about 200mg to about 250mg of Curcumin; and
- between about 10mg to about 20mg of Piperine.
8. A dietary supplement composition as claimed in Claim 7, further comprising a preservative.
9. A dietary supplement composition as claimed in Claim 8, wherein the preservative comprises about 10mg of Methyl Paraben.
10. A dietary supplement composition as claimed in Claim 8 or Claim 9, wherein the preservative comprises about 10mg of Propyl Paraben.
1 1 . A dietary supplement composition as claimed in any of Claims 7 to 10, wherein the composition comprises 250mg of Moringa oleifera, 240mg of Curcumin, 10mg of Piperine, 10mg of Methyl Paraben and 10mg of Propyl Paraben.
12. A dietary supplement composition as claimed in any of Claims 5 to 9, wherein the total weight of the composition does not exceed about 700mg.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1002318.2A GB201002318D0 (en) | 2010-02-11 | 2010-02-11 | Dietary supplement composition |
| GB1002318.2 | 2010-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2011098819A1 true WO2011098819A1 (en) | 2011-08-18 |
Family
ID=42110562
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/GB2011/050248 WO2011098819A1 (en) | 2010-02-11 | 2011-02-10 | Dietary supplement composition |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB201002318D0 (en) |
| WO (1) | WO2011098819A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2654868C1 (en) * | 2017-03-10 | 2018-05-23 | Сергей Иванович Корнилов | Nutritional composition |
| KR20180089258A (en) * | 2017-01-31 | 2018-08-08 | 순천제일대학산학협력단 | Its Manufacturing method and Manufacturing for Pill using Moringa(Moringa oleifera) by Fermentation |
| CN110897157A (en) * | 2019-11-26 | 2020-03-24 | 纳图纽万达尼曼拉股份有限公司 | Health-care preparation, preparation process and application |
| WO2021053518A1 (en) * | 2019-09-17 | 2021-03-25 | Basilianus Basuki Nugroho Edward | A method of snake fish extraction |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180089258A (en) * | 2017-01-31 | 2018-08-08 | 순천제일대학산학협력단 | Its Manufacturing method and Manufacturing for Pill using Moringa(Moringa oleifera) by Fermentation |
| KR102228199B1 (en) | 2017-01-31 | 2021-03-16 | 순천제일대학산학협력단 | Its Manufacturing method and Manufacturing for Pill using Moringa(Moringa oleifera) by Fermentation |
| RU2654868C1 (en) * | 2017-03-10 | 2018-05-23 | Сергей Иванович Корнилов | Nutritional composition |
| WO2021053518A1 (en) * | 2019-09-17 | 2021-03-25 | Basilianus Basuki Nugroho Edward | A method of snake fish extraction |
| CN110897157A (en) * | 2019-11-26 | 2020-03-24 | 纳图纽万达尼曼拉股份有限公司 | Health-care preparation, preparation process and application |
Also Published As
| Publication number | Publication date |
|---|---|
| GB201002318D0 (en) | 2010-03-31 |
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