WO2012075782A1

WO2012075782A1 - Automatic liquid preparation system for purifying blood and its usage method

Info

Publication number: WO2012075782A1
Application number: PCT/CN2011/074494
Authority: WO
Inventors: 李昔华; 梅长林; 高光勇
Original assignee: 重庆山外山科技有限公司
Priority date: 2010-12-08
Filing date: 2011-05-23
Publication date: 2012-06-14
Also published as: CN102008763B; CN102008763A

Abstract

An automatic liquid preparation system for purifying blood and its usage method. The system is provided with suction pumps (3,5). The suction pumps (3,5) suck concentrated liquid from a concentrated liquid container (7,8), and the concentrated liquid is transported into a liquid conduit (9) via a pipe to form mixed liquid with reverse osmosis water. The ion concentration of mixed liquid is detected by an ion concentration sensor (4,6), and the value of the ion concentration is compared with that of the target concentration parameter. If the concentration exceeds the standard value, an alarm is provided; if not, the rotation speeds of the suction pumps (3,5) are adjusted so as to control the suction flux of the concentrated liquid, and the rotation speed is compared with the alarm threshold simultaneously. If the rotation speed is abnormal, an alarm is provided; if not, the liquid circuit is detected continuously in real time. The invention has the advantages that the system has the function of ion concentration online detection and feedback control, can regulate the rotating speed of the fluid absorption pump in real time, effectively avoids safety risks of hemodialysis, avoids mechanical failures of a motor, and has high fluid preparation speed, accurate concentration proportion, high stability and high reliability.

Description

Description Automatic liquid dispensing system for blood purification and method of using the same

The invention belongs to an automatic liquid dispensing system for blood purification, and relates to a system for automatically preparing and safely monitoring dialysate for blood purification equipment and a using method thereof.

Background technique

During the blood purification process, the patient's blood flows out of the body and returns to the body through the extracorporeal circulation formed by the pipeline. In this circulation system, the blood path, the liquid path and the monitoring system are mainly included. The blood in the patient's body is taken out of the body, enters the extracorporeal tube such as dialyzer or filter, and is purified and then returned to the human body to form a blood circuit system. In the liquid system, the standard ion concentration dialysate enters the dialyzer and the dialyzer membrane opposite to the dialyzer. The patient's blood undergoes processes such as diffusion, convection, ultrafiltration, etc., and removes excess water from the patient at an appropriate rate. The monitoring system monitors the various components, parameters, indicators, etc. of the blood purification equipment and issues alarms and safety controls.

Under normal circumstances, the dialysate entering the dialyzer is a liquid containing a standard ion concentration and a formulation ratio, and a process of diffusion, convection, ultrafiltration, and the like in the dialyzer to achieve blood purification. The reverse osmosis water purified by the water treatment device enters the machine through the liquid pipeline, and is respectively sucked from the concentrate B and the second aspiration pump sucked from the concentrate A container by the first liquid suction pump. Concentrate B is mixed in proportion to prepare a dialysate. Improper formulation or failure of dialysate preparation will cause the ion concentration in the dialysate to deviate from the standard value range, so that the ion concentration monitor will give an alarm and the dialysate bypasses the waste liquid discharge channel to prevent the excess dialysate from entering the dialyzer or filtering. A safety incident has been triggered in the device.

The traditional dialysate preparation process is divided into two steps: The first is to select two kinds of dialysis powders of standard formula A and B, and then add reverse osmosis water through strict dilution ratio, and respectively use different containers; According to the user's parameter setting, under the control of the computer program, two liquid suction pumps with metering function are introduced into the equipment liquid path system according to their respective fixed set speeds. The medium is mixed with the heated reverse osmosis water to form a standard dialysate. In this process, the first sputum concentrate preparation process will introduce a certain concentration error due to human operation; the second 歩 metering aspiration pump speed flow error, wear or mechanical failure, etc. will also lead to dialysate The ion concentration exceeds the standard, causing an alarm of the monitoring device, interrupting the treatment or even causing a safety accident.

It can be seen that the conventional method for preparing a dialysate for blood purification has the disadvantage that it requires a strict proportional preparation and precise electromechanical control to meet the treatment requirements, and once the concentration fluctuation occurs, a relatively long adjustment time is required to perform normal. Treatment, its stability, safety and reliability are relatively poor.

Therefore, an on-line monitoring and feedback control function with ion concentration is needed, which can effectively avoid the safety risk caused by the concentration deviation of the concentrated liquid and the fixed speed ratio of the aspiration pump, and has the advantages of fast liquid dispensing speed, accurate concentration ratio, and reliability. Significant advantage of high sex.

Summary of the invention

In view of the above, an object of the present invention is to provide an automatic liquid dispensing system for blood purification and a method for using the same, which has an on-line monitoring and feedback control function for ion concentration, which can effectively avoid concentration concentration deviation and liquid suction pump fixing when used. The safety risk caused by the formulation of the speed ratio has the advantages of fast liquid dispensing speed, accurate concentration ratio and high reliability.

The automatic liquid dispensing system for blood purification of the present invention comprises a concentrate A addition system, a concentrate B addition system and a liquid pipeline, and an automatic control system, the automatic control system comprising:

a first ion concentration sensor disposed in the liquid conduit for detecting an ion concentration of the concentrate A after entering the liquid conduit;

a second ion concentration sensor is disposed in the liquid pipeline for detecting the ion concentration of the concentrated liquid B after being mixed with the concentrate A after entering the liquid pipeline;

The detection control circuit is configured to receive the data signals of the first ion concentration sensor and the second ion concentration sensor, and send an alarm signal or / and add the system to the concentrate A and the concentrate B to join the system to issue a control command signal.

Further, the concentrate A addition system includes a concentrate A container, and the concentrate A in the concentrate A container is input to the first liquid suction pump upstream of the liquid pipeline; the concentrated liquid B addition system includes a thick Liquid shrinkage B The container and the concentrated liquid B in the concentrated liquid B container are input to the second liquid suction pump downstream of the liquid pipeline; the command signal output end of the detection control circuit is respectively connected to the control circuit of the first liquid suction pump motor and the second Control circuit of the liquid suction pump motor;

The concentrate A container and the concentrate B container are respectively filled with a concentrate A and a concentrate B, which are a formulation component of the dialysate, and the positions of the concentrate A container and the concentrate B container can be exchange. Both the first aspiration pump and the second aspiration pump are liquid pumps having a metering function. The first aspiration pump (second aspiration pump) separately draws the concentrate A (concentrate B) from the concentrate A container (concentrate B container) and pipes it into the liquid pipe Mix with reverse osmosis water. The reverse osmosis water flows in upstream of the liquid pipe, flows through the upstream liquid inlet end of the liquid pipe, and is mixed with the concentrate A to form a first mixed liquid, and the first mixed liquid flows through the downstream liquid inlet end of the liquid pipe, and is concentrated. The liquid B is mixed to form a second mixed liquid, and the second mixed liquid flows out through the downstream of the liquid pipeline, and a dialysis reaction occurs with the human blood in the dialyzer;

Further, the detecting electrode of the first ion concentration sensor is located downstream of the liquid pipe concentrate A access point, and the detecting electrode of the second ion concentration sensor is located downstream of the liquid pipe concentrate B access point, a data transmission end group of an ion concentration sensor is connected to the first data transmission end group of the detection control circuit, and the first control end group of the detection control circuit is connected to the control signal input end group of the first liquid absorption pump; a data transmission end group of the ion concentration sensor is connected to the second data transmission end group of the detection control circuit, and a second control end group of the detection control circuit is connected to the control signal input end group of the second liquid absorption pump; The concentration sensor sends the detected ion concentration value of the first mixed liquid to the detection control circuit for analysis and comparison, and adjusts the motor rotation speed of the first liquid suction pump through the detection control circuit to realize the suction amount of the concentrated liquid A. The flow rate is controlled in real time to achieve real-time adjustment of the ion concentration of the first mixture; the second ion concentration sensor will detect the separation of the second mixture The concentration value is sent to the detection control circuit for analysis and comparison, and the motor speed of the second liquid suction pump is adjusted by the detection control circuit, realizing real-time control of the flow rate of the concentrated liquid B suction amount, reaching the second mixed liquid ion The real-time adjustment of the concentration; further, the automatic control system further includes an alarm circuit, the first data end of the detection control circuit is connected to the parameter output end of the parameter setting alarm circuit, and the second data end of the detection control circuit is connected This parameter sets the alarm control signal input end of the alarm circuit;

After the detection control circuit analyzes, if the ion concentration value or the motor speed is abnormal, the detection control circuit immediately controls the parameter setting alarm circuit to perform real-time alarm, and bypasses the dialysis circuit. The dialysate does not enter the dialyzer and human blood, directly Discharge from the waste port through the waste circuit to avoid harm to the patient's life.

Further, the detection control circuit is provided with a microcontroller IC1, an interface conversion module IC3, and the first data transmission end groups UART2-TX, UART2-RX of the microcontroller IC1 and the first ion concentration sensor respectively The data transmission end group TXD2 and RXD2 of the detection module CONDI are connected; the second data transmission end group UART3 - TX, UART3 - RX of the microcontroller IC1 and the data transmission end group of the detection module COND2 of the second ion concentration sensor, respectively The TXD3 and RXD3 are connected; the ion concentration sensor sends the detected ion concentration value of the mixed liquid to the detection control circuit for analysis and comparison, and determines whether the mixed liquid ion concentration exceeds the standard, and if it exceeds the standard, it will promptly report the alarm.

The first control terminal group PC0, PC1, PC2, PC3 of the microcontroller IC1 is respectively connected to the control signal input terminal group A+, A -, B+, B_ of the drive module DRIVER1 of the motor M1 of the first liquid suction pump. The second control terminal group PC6, PC7, PC8, PC9 of the microcontroller IC1 is respectively connected to the control signal input terminal groups A+, A-, B+, B_ of the drive module DRIVER2 of the motor M2 of the second liquid suction pump Through the detection control circuit, the rotation speed of the motor of the liquid suction pump is adjusted, real-time control of the suction flow rate of the concentrated liquid is realized, and the real-time adjustment of the ion concentration of the mixed liquid is achieved.

The parameter input terminal UART1_RX of the microcontroller IC1 is connected to the data transmitting end TXD1 of the interface conversion module IC3, and the alarm control terminal UART1_TX of the microcontroller IC1 is connected to the data receiving end RXD1 of the interface conversion module IC3. The transceiver control terminal PA8 of the microcontroller IC1 is connected to the transceiver control signal input terminal R/D of the interface conversion module IC3; the first data terminal A of the interface conversion module IC3 is connected to the parameter output terminal of the parameter setting alarm circuit, The second data terminal B of the interface conversion module IC3 is connected to the alarm control signal input terminal of the parameter setting alarm circuit.

The microcontroller IC1 transmits a "receive/transmit control signal" to the interface conversion module IC3 for controlling the data transmission direction of IC1 and IC3. When the interface conversion module IC3 receives the "send control signal", the interface is turned The module IC3 sends the target concentration of the parameter setting alarm circuit to the microcontroller IC1 for comparison and analysis with the ion concentration signal detected in real time to determine whether the ion concentration exceeds the standard; when the interface conversion module IC3 receives the "receive control signal" The interface conversion module IC3 outputs the alarm control signal sent by the microcontroller IC1 to the parameter setting alarm circuit, and the control parameter sets the alarm circuit alarm.

The invention also discloses a method for using an automatic liquid dispensing system for blood purification, wherein the detection control circuit works according to the following steps:

Obtaining the target concentration and the alarm threshold: Obtaining the first mixed liquid target concentration CondTl, the second mixed liquid target concentration CondT2, the first mixed liquid concentration exceeding the standard alarm threshold CondWK, and the second mixed liquid concentration exceeding the standard alarm threshold CondW2 from the parameter setting alarm circuit The first mixed liquid minimum speed alarm threshold value MWL1, the first mixed liquid maximum speed alarm threshold value MWH1, the second mixed liquid minimum speed alarm threshold value MWL2, and the second mixed liquid maximum speed alarm threshold value MWL2;

The user sets the target concentration in the alarm circuit according to the specific needs. The detection control circuit compares the target concentration with the real-time measurement parameters to analyze whether the dialysate ion concentration is within the safe range and avoid medical accidents.

Define the initial value of the number of detections i = i;

Determine the initial motor speed:

Determining an initial value of the rotational speed of the motor M1 of the first liquid suction pump Mvl i-l jlxCondTl, where jl is an initial rotational speed adjustment coefficient of the motor M1;

Determining an initial value of the rotational speed of the motor M2 of the second liquid suction pump Mv2 i-l)=j2xCondT2, where j2 is an initial rotational speed adjustment coefficient of the motor M2;

The initial value of the motor speed is obtained according to the target concentration value, which ensures that the dosing system strictly performs the dialysate concentration ratio according to the user's requirements to ensure the accuracy of the dosing.

Parameter initialization:

Defining the initial value of the rotational speed change amount of the motor M1 Vxl(i-1)=0, the rotational speed adjustment rate k1 of M1 _; defining the initial value of the rotational speed change amount of the motor M2 Vx2(i-1)=0, the rotational speed of M2 The adjustment rate k2 _; wherein, the rotation speed adjustment rate of the motor M1 is k1=2, and the rotation speed adjustment rate of the motor M2 is k2=3. Defining a real-time ion concentration initial value of the first mixed liquid C _O ndVl(il)=0, and a real-time ion concentration initial value CondV2 of the second mixed liquid (ii:>=0 _;

Control motor rotation:

Controlling the motor M1 of the first liquid suction pump to rotate according to the initial value of the rotational speed Mv i-Ι); controlling the motor M2 of the second liquid suction pump to rotate according to the initial value of the rotational speed Mv2(i-1); The initial value of the motor speed determined by the value can ensure that the motor rotates strictly according to the user's requirements, ensuring that the suction pump draws the flow rate of the concentrate and ensures the dialysate concentration.

Get the real-time ion concentration at the i-th test:

Reading the real-time ion concentration CondVl(i) of the first mixture obtained by the first ion concentration sensor;

Reading the real-time ion concentration CondV2(i) of the second mixture obtained by the second ion concentration sensor _;

The detection electrode on the ion concentration sensor can accurately measure the ion concentration in the mixture, ensuring the accuracy of subsequent parameter adjustment, ensuring accurate dialysate concentration, and high reliability.

Determine whether the real-time concentration at the time of the i-th detection exceeds the standard:

If CondVl(i)<CondWl, and CondV2(i)<CondW2, the real-time concentration does not exceed the standard, and the flow of determining the rotational speed adjustment amount at the i-th detection is entered;

Otherwise, the real-time concentration exceeds the standard, and the parameter setting alarm circuit alarm is controlled, and the process of obtaining the target concentration and the alarm threshold is returned;

If the ion concentration exceeds the standard, the real-time alarm is controlled, and the dialysis circuit is bypassed. The dialysate does not enter the dialyzer and the human blood, and is directly discharged from the waste liquid port through the waste liquid circuit, thereby avoiding harm to the patient's life and ensuring the safety of the treatment process. reliable.

The process of determining the rotational speed adjustment amount at the time of the i-th detection is:

Determining the rotational speed adjustment amount of the first mixed liquid Vxl(i)=klx[CondVl(i)- CondTl];

Determining the rotational speed adjustment amount of the second mixed liquid Vx2 (i) = k2x [CondV2 (i) - CondT2] _;

Determine the motor speed at the ith test: Determining the rotation speed of the motor M1 of the first liquid suction pump

Determining the rotation speed of the motor Μ2 of the second liquid suction pump

Adjust the speed of the aspirating pump according to the ion concentration of the mixed liquid, adjust the flow rate of the concentrated liquid entering the reverse osmosis water in real time, effectively control the concentration of the mixed liquid to meet the target set value range, and realize the automatic preparation of the dialysate.

Determine whether the motor speed at the i-th inspection is safe:

If MWL KMvl(i) < MWH 1, and MWL2 < Mv2(i) < MWL2, the motor speed is safe, i is incremented by 1, and the flow of controlling the motor rotation is returned;

Otherwise, the motor speed is unsafe, and the parameter setting alarm circuit alarm is controlled, and the process of obtaining the target concentration and the alarm threshold is returned;

If the motor speed exceeds the speed alarm threshold, it is easy to cause mechanical failure of the motor, and serious safety accidents may occur. In this case, the system should be controlled in real time to avoid a safety accident.

The remarkable effects of the invention are as follows: the on-line monitoring and feedback control function of the ion concentration is adopted, and the rotation speed of the liquid suction pump is adjusted in real time according to the ion concentration of the mixed liquid in the liquid circuit, thereby effectively avoiding the concentration deviation of the concentrated liquid and the fixed speed ratio of the liquid suction pump. The safety risk can also effectively avoid the mechanical failure and mechanical wear caused by the abnormal speed of the suction pump motor. It has the advantages of fast liquid distribution speed, accurate concentration ratio, good stability, safety and reliability.

DRAWINGS

The invention will now be further described in conjunction with the drawings and embodiments.

Figure 1 is a structural view of an automatic liquid dispensing system for blood purification;

2 is a circuit connection diagram of the present invention;

Figure 3 is a flow chart of the method of use of the present invention.

detailed description

1 is a structural view of an automatic liquid dispensing system for blood purification, FIG. 2 is a circuit connection diagram of the present invention, and FIG. 3 is a flow chart of a method of using the present invention, as shown in the drawing: Automatic liquid dispensing for blood purification of the present embodiment The system includes a concentrate A addition system, a concentrate B addition system and a liquid conduit, and an automatic control system, the automatic control system comprising: a first ion concentration sensor 4 disposed in the liquid pipeline for detecting the ion concentration of the concentrate A after entering the liquid pipeline;

The second ion concentration sensor 6 is disposed in the liquid pipeline for detecting the ion concentration of the concentrated liquid B after being mixed with the concentrate A after entering the liquid pipeline;

The detection control circuit 2 is configured to receive the data signals of the first ion concentration sensor 4 and the second ion concentration sensor 6, and issue an alarm signal or/and add the system to the concentrate A and the concentrate B to the system to issue a control command signal. .

In practice, the concentrate A container 7 and the concentrate B container 8 are respectively filled with the concentrate A and the concentrate B, which are a formulation component of the dialysate, and the concentrate A container 7 and the concentrate The position of the B container 8 can be interchanged. The first aspiration pump 3 and the second aspiration pump 5 are both liquid pumps having a metering function. The first aspiration pump (second aspiration pump) separately draws the concentrate A (concentrate B) from the concentrate A container (concentrate B container) and pipes it into the liquid pipe Mix with reverse osmosis water. The reverse osmosis water flows in upstream of the liquid pipe, flows through the upstream liquid inlet end of the liquid pipe, and is mixed with the concentrate A to form a first mixed liquid, and the first mixed liquid flows through the downstream liquid inlet end of the liquid pipe, and is concentrated. The liquid B is mixed to form a second mixed liquid, and the second mixed liquid flows out through the downstream of the liquid pipeline, and a dialysis reaction occurs with the human blood in the dialyzer.

In this embodiment, the concentrate A addition system includes a concentrate A container 7 and a first liquid suction pump 3 that feeds the concentrate A in the concentrate A container 7 upstream of the liquid line; The liquid B adding system includes a concentrated liquid B container 8 and a second liquid suction pump 5 for inputting the concentrated liquid B in the concentrated liquid B container 8 downstream of the liquid pipe; the command signal output ends of the detection control circuit 2 are respectively connected The control circuit of the motor of the first liquid suction pump 3 and the control circuit of the motor of the second liquid suction pump 5.

In this embodiment, the detecting electrode of the first ion concentration sensor 4 is located downstream of the liquid pipe 9 concentrated liquid A access point, and the detecting electrode of the second ion concentration sensor 6 is located at the liquid pipe 9 concentrated liquid B. Downstream of the in point, the data transmission end group of the first ion concentration sensor 4 is connected to the first data transmission end group of the detection control circuit 2, and the first control end group of the detection control circuit 2 is connected to the first liquid absorption pump a control signal input group of 3; a data transmission end group connection of the second ion concentration sensor 6 The second data transmission end group of the detection control circuit 2, the second control end group of the detection control circuit 2 is connected to the control signal input end group of the second liquid suction pump 5.

As shown in FIG. 1, the concentrate A container 7 is in communication with the upstream liquid inlet end of the liquid conduit 9, and the first liquid suction pump 3 is located in the liquid supply line of the concentrate A container 7; The concentrated liquid B container 8 is in communication with the downstream liquid inlet end of the liquid pipe 9, and the second liquid suction pump 5 is located in the liquid supply line of the concentrated liquid B container 8; the concentrated liquid A container 7 and concentrated The position of the liquid B container 8 can be interchanged.

The detection electrode of the first ion concentration sensor 4 detects the ion concentration at the upstream liquid inlet end of the liquid conduit 9, and the data transmission end group of the first ion concentration sensor 4 is connected to the first data transmission end of the detection control circuit 2. a first control terminal group of the detection control circuit 2 is connected to a control signal input terminal group of the first liquid suction pump 3; a detection electrode of the second ion concentration sensor 6 detects a downstream liquid inlet of the liquid conduit 9 The ion concentration at the end, the data transmission end group of the second ion concentration sensor 6 is connected to the second data transmission end group of the detection control circuit 2, and the second control end group of the detection control circuit 2 is connected to the second suction a control signal input end group of the liquid pump 5; a first data end of the detection control circuit 2 is connected to a parameter output end of the parameter setting alarm circuit 1, and a second data end of the detection control circuit 2 is connected to the parameter setting alarm circuit 1 alarm control signal input.

The first ion concentration sensor 4 sends the detected ion concentration value of the first mixed liquid to the detection control circuit 2 for analysis and comparison, and adjusts the motor rotation speed of the first liquid suction pump 3 through the detection control circuit 2, thereby realizing The flow rate of the suction amount of the concentrated liquid A is controlled in real time to achieve real-time adjustment of the ion concentration of the first mixed liquid; the second ion concentration sensor 6 sends the detected ion concentration value of the second mixed liquid to the detection control circuit 2 Analyze and compare, and adjust the motor rotation speed of the second liquid suction pump 5 through the detection control circuit 2, realizing real-time control of the flow rate of the concentrated liquid B suction amount, and realizing the real-time adjustment of the second mixed liquid ion concentration;

In this embodiment, the automatic control system further includes an alarm circuit 1, the first data end of the detection control circuit 2 is connected to the parameter output end of the parameter setting alarm circuit 1, and the second data end of the detection control circuit 2 is connected to the The parameter sets the alarm control signal input of alarm circuit 1. After the detection control circuit analyzes, if the ion concentration value or the motor speed is abnormal, the detection control circuit immediately controls the parameters. The alarm circuit is set to perform real-time alarm, and the dialysis circuit is bypassed. The dialysate does not enter the dialyzer and human blood, and is directly discharged from the waste liquid port through the waste liquid circuit to avoid harm to the patient's life.

As shown in FIG. 2, the detection control circuit 2 is provided with a microcontroller IC1, an interface conversion module IC3, and a first data transmission end group UART2_TX, UART2_RX of the microcontroller IC1 and the first The data transmission end groups TXD2 and RXD2 of the detection module CONDI of the ion concentration sensor 4 are connected; the second data transmission end groups UART3 - TX, UART3 - RX of the microcontroller IC1 and the detection module of the second ion concentration sensor 6 respectively The data transmission end groups TXD3 and RXD3 of the COND2 are connected; the control signals of the first control terminal group PC0, PC1, PC2, PC3 of the microcontroller IC1 and the drive module DRIVER1 of the motor M1 of the first liquid suction pump 3, respectively The input group A+, A -, B+, B- connection; the second control end group PC6, PC7, PC8, PC9 of the microcontroller ICl and the drive module DRIVER2 of the motor M2 of the second liquid suction pump 5, respectively Control signal input group A+, A-, B+, B- connection;

The parameter input terminal UART1_RX of the microcontroller IC1 is connected to the data transmitting end TXD1 of the interface conversion module IC3, and the alarm control terminal UART1-TX of the microcontroller IC1 is connected to the data receiving end RXD1 of the interface conversion module IC3. The transceiver control terminal PA8 of the microcontroller IC1 is connected to the transceiver control signal input terminal R/D of the interface conversion module IC3; the first data terminal A of the interface conversion module IC3 is connected to the parameter output terminal of the parameter setting alarm circuit 1, The second data terminal B of the interface conversion module IC3 is connected to the alarm control signal input terminal of the parameter setting alarm circuit 1.

As shown in Fig. 3, in the method of using the automatic liquid dispensing system for blood purification, the detection control circuit 2 operates in accordance with the following steps:

Obtaining the target concentration and the alarm threshold: obtaining the first mixed liquid target concentration CondT1, the second mixed liquid target concentration CondT2, the first mixed liquid concentration exceeding the standard alarm threshold CondWl, and the second mixed liquid concentration exceeding the standard alarm from the parameter setting alarm circuit 1 Threshold CondW2, first mixed liquid minimum speed alarm threshold value MWL1, first mixed liquid maximum speed alarm threshold value MWH1, second mixed liquid minimum speed alarm threshold value MWL2 and second mixed liquid maximum speed alarm threshold value MWL2; Determine the initial motor speed:

Determining a rotational speed initial value Mvl i-l jlxCondTl of the motor M1 of the first liquid suction pump 3, wherein j l is an initial rotational speed adjustment coefficient of the motor M1;

Determining the initial value of the rotational speed of the motor M2 of the second aspirating pump 5 Mv2 i-l)=j2xCondT2, where j2 is the initial rotational speed adjustment coefficient of the motor M2;

Parameter initialization:

The initial value of the rotational speed change of the motor M1 is defined as Vxl(i-1)=0, and the rotational speed adjustment rate of M1 is k1=2; the initial value of the rotational speed change of the motor M2 is defined as Vx2(i-1)=0, M2 The rotational speed adjustment rate k2=3; the initial value of the real-time ion concentration of the first mixed liquid is defined C _O ndVl(il)=0, and the real-time ion concentration initial value CondV2 of the second mixed liquid (ii:>=0 _;

Control motor rotation:

The motor M1 that controls the first liquid suction pump 3 rotates according to the initial value of the rotational speed Mv i-1); the motor M2 that controls the second liquid suction pump 5 rotates according to the initial value of the rotational speed Mv2 (i-1); Real-time ion concentration at the i-th test:

Reading the real-time ion concentration CondVl(i) of the first mixture obtained by the first ion concentration sensor 4;

Reading the real-time ion concentration CondV2(i) of the second mixture obtained by the second ion concentration sensor 6 _;

Otherwise, the real-time concentration exceeds the standard, and the parameter setting alarm circuit 1 is controlled to alarm, and the process of obtaining the target concentration and the alarm threshold is returned;

Determining the rotational speed adjustment amount of the second mixed liquid Vx2 (i) = k2x [CondV2 (i) - CondT2] _; Determine the motor speed at the ith test:

Determining the rotation speed of the motor M1 of the first liquid suction pump 3

Determining the rotation speed Mv2(i)=Mv2(ii:)+Vx2 of the motor Μ2 of the second liquid suction pump 5 (3⁄4 _;

Determine whether the motor speed at the i-th inspection is safe:

Otherwise, the motor speed is unsafe, and the parameter setting alarm circuit 1 is controlled to alarm, and the process of obtaining the target concentration and the alarm threshold is returned;

The working condition is as follows: The aspirating pump draws the concentrated liquid from the concentrated liquid container and pipes it into the liquid pipeline to mix with the reverse osmosis water to form a mixed liquid; the ion concentration sensor detects the ions of the mixed liquid in the liquid pipeline through the detecting electrode Concentration, and output the ion concentration signal to the detection control circuit for analysis; the detection control circuit compares the concentration target parameter value in the parameter setting alarm circuit with the real-time detection value of the mixed liquid, and if the mixed liquid ion concentration exceeds the standard, the control parameter setting The alarm circuit alarms, otherwise the motor speed of the liquid suction pump is adjusted to realize the control of the suction flow of the concentrated liquid to achieve real-time adjustment of the ion concentration of the mixed liquid; meanwhile, the detection control circuit will also adjust the speed and parameter setting in the alarm circuit. The speed alarm threshold is compared. If the motor speed is abnormal, the control parameter sets the alarm circuit and alarm, otherwise the real-time detection of the liquid circuit is continued.

The above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to be limiting, and the present invention will be described in detail with reference to the preferred embodiments. Modifications or equivalents are intended to be included within the scope of the appended claims.

Claims

Claim

An automatic liquid dispensing system for blood purification, comprising a concentrate A addition system, a concentrate B addition system and a liquid pipeline, characterized by: further comprising an automatic control system, the automatic control system comprising: a first ion a concentration sensor (4), disposed in the liquid pipeline for detecting the concentration of ions after the concentrate A enters the liquid pipeline;

The second ion concentration sensor (6) is disposed in the liquid pipeline for detecting the ion concentration after the concentrated liquid B is mixed with the concentrate A after entering the liquid pipe;

a detection control circuit (2) for receiving data signals of the first ion concentration sensor (4) and the second ion concentration sensor (6), and issuing an alarm signal or/and adding the system to the concentrate A and the concentrate B Join the system to issue a control command signal.

The automatic liquid dispensing system for blood purification according to claim 1, wherein the concentrated liquid A adding system comprises a concentrated liquid A container (7) and a concentrated liquid A container (7). Concentrate A is input to the first aspiration pump (3) upstream of the liquid line; the concentrate B addition system includes a concentrate B container (8) and a concentrate in the concentrate B container (8) B input second suction pump downstream of the liquid pipeline

(5); The command signal output end of the detection control circuit (2) is respectively connected to the control circuit of the first liquid suction pump (3) motor and the control circuit of the second liquid suction pump (5) motor.

The automatic liquid dispensing system for blood purification according to claim 2, wherein the detecting electrode of the first ion concentration sensor (4) is located downstream of the liquid pipe (9) concentrate A access point, The detection electrode of the second ion concentration sensor (6) is located downstream of the liquid pipe (9) concentrate B access point, and the data transmission end group of the first ion concentration sensor (4) is connected to the detection control circuit (2) a first data transmission end group, the first control end group of the detection control circuit (2) is connected to the control signal input end group of the first liquid suction pump (3); the data of the second ion concentration sensor (6) The transmission end group is connected to the second data transmission end group of the detection control circuit (2), and the second control end group of the detection control circuit (2) is connected to the control signal input end group of the second liquid absorption pump (5) .

The automatic liquid dispensing system for blood purification according to claim 3, characterized in that: automatic control The system further includes an alarm circuit (1), the first data end of the detection control circuit (2) is connected to a parameter output end of the parameter setting alarm circuit (1), and the second data end of the detection control circuit (2) Connect this parameter to set the alarm control signal input of the alarm circuit (1).

The automatic liquid dispensing system for blood purification according to claim 4, wherein the detection control circuit (2) is provided with a microcontroller IC1, an interface conversion module IC3, and the first of the microcontroller IC1 Data transmission end group UART2 - TX, UART2 - RX and the first ion concentration sensor respectively

(4) detection module CONDI data transmission end group TXD2, RXD2 connection; the second data transmission end group of the microcontroller IC1 UART3 - TX, UART3 - RX and the second ion concentration sensor respectively

(6) The detection module of the COND2 data transmission end group TXD3, RXD3 connection;

The first control terminal group PC0, PC1, PC2, PC3 of the microcontroller IC1 and the control signal input terminal group A+, A-, B+ of the drive module DRIVER1 of the motor M1 of the first liquid suction pump (3), respectively , B-connection; the second control terminal group PC6, PC7, PC8, PC9 of the microcontroller ICl and the control signal input terminal group A+ of the drive module DRIVER2 of the motor M2 of the second liquid suction pump (5), respectively A -, B+, B_ connection;

The parameter input terminal UART1_RX of the microcontroller IC1 is connected to the data transmitting end TXD1 of the interface conversion module IC3, and the alarm control terminal UART1-TX of the microcontroller IC1 is connected to the data receiving end RXD1 of the interface conversion module IC3. The transceiver control terminal PA8 of the microcontroller IC1 is connected to the transceiver control signal input terminal R/D of the interface conversion module IC3; the first data terminal A of the interface conversion module IC3 is connected to the parameter output of the parameter setting alarm circuit (1) The second data terminal B of the interface conversion module IC3 is connected to the alarm control signal input terminal of the parameter setting alarm circuit (1).

The method of using the automatic liquid dispensing system for blood purification according to any one of claims 1 to 5, wherein the detection control circuit (2) operates in accordance with the following steps:

Obtaining the target concentration and the alarm threshold: obtaining the first mixed liquid target concentration CondT1, the second mixed liquid target concentration CondT2, the first mixed liquid concentration exceeding the standard alarm threshold CondWl, and the second mixed liquid concentration from the parameter setting alarm circuit (1) Exceeded alarm threshold CondW2, first mixed liquid minimum speed alarm threshold value MWL1, first mixed liquid maximum speed alarm threshold value MWH1, second mixed liquid minimum speed alarm threshold value MWL2 and second mixed liquid maximum speed alarm threshold value MWL2; Define the initial value i = l of the number of detections i;

Determine the initial motor speed:

Determining a rotational speed initial value Mvl i-l jlxCondTl of the motor M1 of the first liquid suction pump (3), wherein j1 is an initial rotational speed adjustment coefficient of the motor M1;

Determining an initial value of the rotational speed of the motor M2 of the second liquid suction pump (5) Mv2(i-1)=j2xCondT2, where j2 is an initial rotational speed adjustment coefficient of the motor M2;

Parameter initialization:

Defining the initial value of the rotational speed change amount of the motor M1 Vxl(i-1)=0, the rotational speed adjustment rate kl of M1; defining the initial value of the rotational speed change amount of the motor M2 Vx2(i-1)=0, the rotational speed of M2 Adjusting rate k2 _; defining a real-time ion concentration initial value of the first mixed liquid C _O ndVl(il)=0, and a real-time ion concentration initial value CondV2 of the second mixed liquid (ii:>=0 _;

Control motor rotation:

The motor M1 controlling the first liquid suction pump (3) is rotated according to the initial speed value Mv i-Ι); the motor M2 controlling the second liquid suction pump (5) is initialized according to the initial value Mv2(i-1) Rotate; obtain the real-time ion concentration at the ith test:

Reading the real-time ion concentration CondVl(i) of the first mixed liquid obtained by the first ion concentration sensor (4);

Reading the real-time ion concentration CondV2(i) of the second mixture obtained by the second ion concentration sensor (6) _;

Otherwise, the real-time concentration exceeds the standard, and the parameter setting alarm circuit (1) is controlled to return to the process of obtaining the target concentration and the alarm threshold;

Determining the rotational speed adjustment amount of the second mixed liquid Vx2(i)=k2x [CondV2(i) - CondT2]; Determine the motor speed at the ith test:

Determining the rotation speed Mvl(i)=Mvl(il)+Vxl(i) of the motor M1 of the first liquid suction pump (3) _; determining the rotation speed Mv2 of the motor M2 of the second liquid suction pump (5) (i) )=Mv2(il)+Vx2(i) _; Determine whether the motor speed at the i-th detection is safe:

If MWL 1 < Mv 1 (i) < MWH 1, and MWL2 < Mv2(i) < MWL2, the motor speed is safe, i is incremented by 1, and the flow of controlling the motor rotation is returned;

Otherwise, the motor speed is unsafe, and the parameter setting alarm circuit (1) is controlled to alarm, and the process of obtaining the target concentration and the alarm threshold is returned;

The method of using the automatic liquid dispensing system for blood purification according to claim 3, characterized in that: the rotational speed adjustment rate of the motor M1 is k1 = 2, and the rotational speed adjustment rate of the motor M2 is k2 = 3.