Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberWO2012170851 A3
Publication typeApplication
Application numberPCT/US2012/041608
Publication dateFeb 28, 2013
Filing dateJun 8, 2012
Priority dateJun 9, 2011
Also published asCA2838591A1, EP2718711A2, EP2718711A4, US8691520, US20120315659, US20140220608, WO2012170851A2
Publication numberPCT/2012/41608, PCT/US/12/041608, PCT/US/12/41608, PCT/US/2012/041608, PCT/US/2012/41608, PCT/US12/041608, PCT/US12/41608, PCT/US12041608, PCT/US1241608, PCT/US2012/041608, PCT/US2012/41608, PCT/US2012041608, PCT/US201241608, WO 2012/170851 A3, WO 2012170851 A3, WO 2012170851A3, WO-A3-2012170851, WO2012/170851A3, WO2012170851 A3, WO2012170851A3
InventorsEmanuela Silvana ANDREESEU, Maryna ORNATSKA, Cristina R. ISPAS, Daniel Andreescu
ApplicantClarkson University
Export CitationBiBTeX, EndNote, RefMan
External Links: Patentscope, Espacenet
Reagentless ceria-based colorimetric sensor
WO 2012170851 A3
Abstract
A colorimetric reagent in the form of nanoparticles, composite nanoparticles, and nanoparticle coatings, including methods of use, methods of preparation, deposition, and assembly of related devices and specific applications. The colorimetric reagent comprises cerium oxide nanoparticles which are used in solution or immobilized on a solid support, either alone or in conjunction with oxidase enzymes, to form an active colorimetric component that reacts with an analyte to form a colored complex. The rate of color change and the intensity of the color are proportional to the amount of analyte present in the sample. Also described is the use of ceria and doped ceria nanoparticles as an oxygen storage/delivery vehicle for oxidase enzymes and applications in biocatalytic processes in anaerobic conditions of interest in biomedicine and bioanalysis. Further described are a variety of related applications of the disclosed technology including clinical diagnosis, in vivo implantable devices, food safety, and fermentation control.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US7504356 *Feb 20, 2007Mar 17, 2009University Of Central Florida Research Foundation, Inc.Nanoparticles of cerium oxide having superoxide dismutase activity
US20090071848 *May 26, 2006Mar 19, 2009University Of Central FloridaCerium oxide nanoparticle regenerative free radical sensor
Non-Patent Citations
Reference
1 *ORNATSKA, M. ET AL.: 'Paper bioassay based on ceria nanoparticles as colorimetric probes' ANALYTICAL CHEMISTRY vol. 83, no. 11, 28 April 2011, USA, pages 4273 - 4280, XP055138602
2 *PATIL, S. D. FUNDAMENTAL ASPECTS OF REGENERATIVE CERIUM OXIDE NANOPARTICLES AND THEIR APPLICATIONS IN NANOBIOTECHNOLOGY (PH.D. THESIS) 2006, USA: UNIVERSITY OF CENTRAL FLORIDA ORLANDO, XP055138601
3 *See also references of EP2718711A2
Classifications
International ClassificationG01N21/77, G01N21/78, G01N31/22
Cooperative ClassificationY10T436/206664, G01N31/228, G01N21/8483, G01N21/78, G01N33/587, C12Q1/54, C12Q1/26, C12Q1/60
Legal Events
DateCodeEventDescription
Feb 13, 2013121Ep: the epo has been informed by wipo that ep was designated in this application
Ref document number: 12796633
Country of ref document: EP
Kind code of ref document: A2
Dec 5, 2013ENPEntry into the national phase in:
Ref document number: 2838591
Country of ref document: CA
Dec 9, 2013NENPNon-entry into the national phase in:
Ref country code: DE