WO2014141292A3 - Endoxifen citrate polymorph and process for preparing the same - Google Patents

Endoxifen citrate polymorph and process for preparing the same Download PDF

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Publication number
WO2014141292A3
WO2014141292A3 PCT/IN2014/000136 IN2014000136W WO2014141292A3 WO 2014141292 A3 WO2014141292 A3 WO 2014141292A3 IN 2014000136 W IN2014000136 W IN 2014000136W WO 2014141292 A3 WO2014141292 A3 WO 2014141292A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorph
preparing
same
endoxifen
endoxifen citrate
Prior art date
Application number
PCT/IN2014/000136
Other languages
French (fr)
Other versions
WO2014141292A2 (en
Inventor
Sanjay Jagdish Desai
Brijesh Dinkarrai DESAI
Jayesh Viththal GUNA
Sunil Chandulal PATEL
Original Assignee
Intas Pharmaceuticals Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intas Pharmaceuticals Limited filed Critical Intas Pharmaceuticals Limited
Publication of WO2014141292A2 publication Critical patent/WO2014141292A2/en
Publication of WO2014141292A3 publication Critical patent/WO2014141292A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

The present invention provides a novel crystal line form of Endoxifen citrate and process for preparation thereof.
PCT/IN2014/000136 2013-03-04 2014-03-03 Endoxifen citrate polymorph and process for preparing the same WO2014141292A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN646/MUM/2013 2013-03-04
IN646MU2013 IN2013MU00646A (en) 2013-03-04 2014-03-03

Publications (2)

Publication Number Publication Date
WO2014141292A2 WO2014141292A2 (en) 2014-09-18
WO2014141292A3 true WO2014141292A3 (en) 2014-12-24

Family

ID=51538243

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2014/000136 WO2014141292A2 (en) 2013-03-04 2014-03-03 Endoxifen citrate polymorph and process for preparing the same

Country Status (2)

Country Link
IN (1) IN2013MU00646A (en)
WO (1) WO2014141292A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018521988A (en) 2015-06-16 2018-08-09 ジエンス ヘンルイ メデイシンカンパニー リミテッドＪｉａｎｇｓｕ Ｈｅｎｇｒｕｉ Ｍｅｄｉｃｉｎｅ Ｃｏ．，Ｌｔｄ． Piperidine derivatives, production method thereof and pharmaceutical use
CN107428721B (en) 2015-12-22 2020-07-28 江苏恒瑞医药股份有限公司 Benzopiperidine derivative, preparation method and medical application thereof
AU2018329202B2 (en) * 2017-09-11 2022-10-27 Atossa Therapeutics, Inc. Methods for making and using endoxifen
ES2912740T3 (en) 2017-11-14 2022-05-27 Kind Pharmaceutical Heterocyclic compound and its application in medicine
CA3164166A1 (en) 2020-01-10 2021-07-15 Jiangsu Hengrui Medicine Co., Ltd. Tricyclic tetrahydroisoquinoline derivative, preparation method therefor and application thereof in medicine
CA3177266A1 (en) * 2020-04-10 2021-10-14 Jina Pharmaceuticals, Inc. Endoxifen for the treatment of bipolar i disorder
CN115484941A (en) 2020-04-10 2022-12-16 金纳药业公司 Use of idoxifene for treatment of bipolar I disorder
KR20240035515A (en) 2021-07-09 2024-03-15 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Salt form of triple ring tetrahydroisoquinoline derivative
TW202340135A (en) 2022-01-12 2023-10-16 美商阿托薩醫療公司 Compositions of (z)-endoxifen and methods of enrichment thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576645B1 (en) * 1999-11-16 2003-06-10 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
WO2009120999A2 (en) * 2008-03-28 2009-10-01 Olema Pharmaceuticals, Inc. Use of an endoxifen prodrug for treatment of breast cancer
WO2010135703A2 (en) * 2009-05-21 2010-11-25 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of mammalian diseases
WO2012050263A1 (en) * 2010-10-15 2012-04-19 Cj Cheiljedang Corp. Novel method of preparing endoxifen

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576645B1 (en) * 1999-11-16 2003-06-10 Hormos Medical Oy Ltd Triphenylalkene derivatives and their use as selective estrogen receptor modulators
WO2009120999A2 (en) * 2008-03-28 2009-10-01 Olema Pharmaceuticals, Inc. Use of an endoxifen prodrug for treatment of breast cancer
WO2010135703A2 (en) * 2009-05-21 2010-11-25 Jina Pharmaceuticals, Inc. Endoxifen methods and compositions in the treatment of mammalian diseases
WO2012050263A1 (en) * 2010-10-15 2012-04-19 Cj Cheiljedang Corp. Novel method of preparing endoxifen

Also Published As

Publication number Publication date
IN2013MU00646A (en) 2015-06-26
WO2014141292A2 (en) 2014-09-18

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