Inhibition of angiogenesis and destruction of angiogenic vessels with ...

1. A method of ameliorating or preventing angiogenesis in a mammal, said method comprising administering to the mammal a therapeutically effective amount of Noni juice, or of an alcohol precipitate of Noni juice.

2. The method of claim 1, wherein the angiogenesis is associated with a disease selected from the group consisting of diabetic retinopathy, macular degeneration, sickle cell anemia, sarcoid, syphilis, pseudoxanthoma elasticum, Crohn's disease, Pagets disease, vein occlusion, artery occlusion, carotid obstructive disease, chronic uveitis/vitritis, mycobacterial infections, Lyme disease, systemic lupus erythematosis, psoriasis, Kaposis sarcoma, rheumatoid arthritis, uveitis, retinopathy of prematurity, Eales disease, Bechets disease, infections causing retinitis or choroiditis, presumed ocular histoplasmosis, Bests disease, myopia, optic pits, Stargarts disease, pars planitis, chronic retinal detachment, hyperviscosity syndrome, toxoplasmosis, trauma, tumors, and post-laser surgery complications.

3. The method of claim 2, wherein the disease is psoriasis.

4. The method of claim 3, wherein said administration is topical.

5. The method of claim 4, wherein Noni juice is administered in a mixture or an emulsion in a concentration from about 10% to about 20% weight/volume.

6. The method of claim 1, wherein the disease is non-malignant disease.

7. The method of claim 1, wherein said administration is by injection.

8. The method of claim 1, wherein said mammal is a human.

9. A method of decreasing the growth of a malignant mammalian tumor greater than 2 mm in diameter, whereas the growth of the tumor depends on angiogenesis, said method comprising administering to the mammal a therapeutically effective amount of Noni juice or an alcohol precipitate of Noni juice.

10. The method of claim 9, wherein the tumor is a breast cancer tumor.

11. The method of claim 9, wherein said administration is by injection.

12. The method of claim 9, wherein said mammal is a human.

13. A method of inhibiting the growth of a malignant mammalian tumor greater than 2 mm in diameter, whereas the growth of the tumor depends on angiogenesis, said method comprising administering to the mammal a therapeutically effective amount of Noni juice or an alcohol precipitate of Noni juice.

14. The method of claim 13, wherein the tumor is a breast cancer tumor.

15. The method of claim 13, wherein said administration is by injection.

16. The method of claim 13, wherein said mammal is a human.

17. A method of decreasing the size of a existing capillary network in a mammal, wherein the growth of the network depends on angiogenesis, said method comprising administering to the mammal a therapeutically effective amount of Noni juice or an alcohol precipitate of Noni juice.

18. The method of claim 17, wherein the angiogenesis is associated with a disease selected from the group consisting of diabetic retinopathy, macular degeneration, sickle cell anemia, sarcoid, syphilis, pseudoxanthoma elasticum, Crohn's disease, Pagets disease, vein occlusion, artery occlusion, carotid obstructive disease, chronic uveitis/vitritis, mycobacterial infections, Lyme disease, systemic lupus erythematosis, psoriasis, Kaposis sarcoma, rheumatoid arthritis, uveitis, retinopathy of prematurity, Eales disease, Bechets disease, infections causing retinitis or choroiditis, presumed ocular histoplasmosis, Bests disease, myopia, optic pits, Stargarts disease, pars planitis, chronic retinal detachment, hyperviscosity syndrome, toxoplasmosis, trauma, tumors, and post-laser surgery complications.

19. The method of claim 18, wherein the disease is psoriasis.

20. The method of claim 19, wherein said administration is topical.

21. The method of claim 20, wherein Noni juice is administered in a mixture or an emulsion in a concentration from about 10% to about 20% weight/volume.

22. The method of claim 17, wherein the disease is non-malignant disease.

23. The method of claim 17, wherein said administration is intraperitoneal injection.

24. The method of claim 17, wherein said mammal is a human.

25. A compound that inhibits angiogenesis, wherein said compound is a carbohydrate; has a molecular weight less than about 6000 daltons as determined by size exclusion chromatography; is a natural component of Noni juice; appears in an ethanol precipitate from Noni juice; appears in an n-butanol extract from Noni juice; partitions in the ethanol phase of an ethanol/choroform extraction from Noni juice; and comprises by molar percent from about 65% to about 80% galacturonic acid and glucose residues.