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A method and composition for inhibiting certain enzymes, where such inhibition results in various health benefits is provided. More particularly, a method and composition using one or more of the following: Noni Leaf Extract; Noni Leaf Juice; and/or Roast Leaf to inhibit the following: HMG-CoA Reductase; Phosphodiesterases (3 and 4) PDE3 and PDE4; 5-Lipoxygenase (LOX) and 15-LOX; Xanthine Oxidase (XO); Gamma Amino Butyric Acid (GABA) and the growth of the second most common human skin cancer cell line, is provided. Moreover, the foregoing enzymatic inhibitions result in: alleviating pain and inflammation; treating prostate cancers; lowering cholesterol levels; counteracting Diabetes Type II; maintaining the highest possible integrity of cellular interactions in the brain resulting in an undisturbed neural function, (i.e., neuroprotection); ameliorating the effects of asthma and allergies; improving energy; improving insulin secretion; decreasing kidney stone accumulation; alleviatin...

Claims

1. A method of treating disease in, comprising the steps of: administering

a compound containing an extract from Morinda citrifolia leaves; and

inhibiting an enzyme selected from a list consisting of: 5-Lipoxygenase, 15-Lipoxygenase, HMG-CoA Reductase, PDE3, PDE4, XO, and GABA.

2. The method of claim 1, wherein said inhibition of 5-Lipoxygenase and 15-Lipoxygenase results in an effect selected from a list consisting of: treatment of pain, treatment of inflammation, inhibition of 5-Lipoxygenase and 15-Lipoxygenase provides neuroprotection.

3. The method of claim 1, wherein said inhibition results in a physiological effect selected from a list consisting of: treats prostate cancer, lowers cholesterol, treats diseases associated with Type II Diabetes, improves memory, increases insulin, treats for asthma, treats allergies, treats Gout, decreases kidney stone accumulation, improves cardiovascular health, reduce seizures, minimizes convulsant activity, offers therapeutic effects for a mammal suffering from drug addiction and, reducing skin cancer.

4. The method of claim 1 wherein said compound contains Isoflavones.

5. The method of claim 1, wherein said compound contains sterols.

6. A composition comprising a processed Morinda citrifolia component in an amount between 0.01 and 100% by weight selected from a group consisting of: Morinda citrifolia leaf juice, Morinda citrifolia leaf extract, extracts from Morinda citrifolia seeds, Morinda citrifolia seeds, and defatted pulverized Morinda citrifolia seed powder.

7. The composition of claim 6, wherein the composition inhibits the synthesis of leukotrienes from arachidonic acid involving the inhibition of one or more Lipoxygenase enzymes, selected from a list consisting of 5-Lipoxygenase and 15-Lipoxygenase.

8. The composition of claim 6, wherein the composition inhibits the oxygenation of arachidonic acid into its intermediate constituents.

9. The composition of claim 6 further comprising:

processed Morinda citrifolia fruit juice present in an amount by weight between about 0.1-80%;

processed Morinda citrifolia oil present in an amount by weight between about 0.1-20%; and

a carrier medium present in an amount by weight between about 20-90%.

10. A method for inhibiting a Lipoxygenase enzyme comprising the steps of:

adding a processed Morinda citrifolia component to an alcohol-based solution;

isolating and extracting an active ingredient of said processed Morinda citrifolia component from said solution to obtain a fraction;

introducing said extracted active ingredient into said mammal, wherein said extracted active ingredient inhibits oxygenation of arachidonic acid into its intermediate constituents.

11. The method claim of 10, wherein inhibiting the oxygenation of arachidonic acid is affected by inhibiting a lipoxygenase enzyme selected from a list consisting of 5-Lipoxygenase and 15-Lipoxygenase.

12. The method of claim 10, wherein Cyclooxygenase-2 is also selectively inhibited.

13. The method of claim 10, wherein inhibiting the oxygenation of arachidonic acid into its intermediate constituents is accomplished while maintaining gastric mucosal integrity.

14. The method of claim 10, wherein said Morinda citrifolia product is comprised of one or more of the following: Morinda citrifolia fruit juice, Morinda citrifolia oil extract, Morinda citrifolia dietary fiber, Morinda citrifolia puree juice, Morinda citrifolia puree, Morinda citrifolia fruit juice concentrate, Morinda citrifolia puree juice concentrate.

15. The method of claim 10, wherein said alcohol-based solution is selected from the group consisting essentially of methanol, ethanol, and ethyl acetate, and other alcohol-based derivatives.

16. The method of claim 10, wherein said active ingredient is a soluble alcohol supernatant fraction.

17. The method of claim 10, wherein said active ingredient is Quercetin.

18. The method of claim 10, wherein said Quercetin is present in an amount between 0.01 and 10% by weight.

19. The method of claim 10, wherein said active ingredient is Rutin.

20. The method of claim 10, wherein said Rutin is present in an amount between 0.01 and 10% by weight.