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Methods and devices for extracting thermal energy from the core body of a mammal are provided. In practicing the subject methods, a portion of the mammal, e.g. a limb or portion thereof, is placed in a sealed enclosure to produce an enclosed portion of the mammal. A surface of the enclosed portion of the mammal is then contacted with a low temperature medium under negative pressure conditions for a period of time sufficient to provide for the desired core body thermal energy extraction. The subject methods and devices find use in a variety of applications, e.g. providing relief from temperature sensitive disorders, such as multiple sclerosis, and the treatment of hyperthermia, among other treatments. The subject methods and devices are particularly suited for use in enhancing the physical ability of a mammal.

InventorsDennis A. Grahn, H. Craig Heller
Original AssigneeThe Board of Trustees of the Leland Stanford Junior University
Primary Examiner: Harold Joyce
Attorneys: Bret Field, Frank P. Becking, Bozicevic, Field & Francis LLP
Current U.S. Classification607/104
International Classification: A61H/3300

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Citations

Cited PatentFiling dateIssue dateOriginal AssigneeTitle
US4376437Jul 19, 1979Mar 15, 1983Topical environmental device
US5358467Mar 31, 1993Oct 25, 1994Method for vacuum mechanothermal stimulation of the body surface
US5683438Mar 10, 1995Nov 4, 1997Stanford UniversityApparatus and method for core body warming of mammals experiencing hypothermia
US5688225Jul 31, 1995Nov 18, 1997Therapeutic footwear
US6149674Nov 6, 1998Nov 21, 2000Hill-Rom, Inc.Patient thermal regulation system

Referenced by

Citing PatentFiling dateIssue dateOriginal AssigneeTitle
US7052509Nov 12, 2003May 30, 2006MedCool, Inc.Method and device for rapidly inducing and then maintaining hypothermia
US7056282Jul 31, 2003Jun 6, 2006Medtronic Emergency Response Systems, Inc.Coolant control for rapid induction of mild hypothermia
US7087075Sep 30, 2002Aug 8, 2006Medtronic Emergency Response Systems, Inc.Feedback system for rapid induction of mild hypothermia
US7160316Sep 23, 2004Jan 9, 2007Dynatherm Medical, Inc.Methods and apparatus for adjusting body core temperature
US7179279Sep 30, 2002Feb 20, 2007MedTronic Physio Control Corp.Rapid induction of mild hypothermia
US7377935Sep 24, 2004May 27, 2008Life Recovery Systems HD, LLCApparatus for altering the body temperature of a patient
US7507250Oct 11, 2005Mar 24, 2009MedCool, Inc.Method and device for rapidly inducing hypothermia
US7547320Aug 24, 2006Jun 16, 2009Life Recovery System HD, LLCApparatus for altering the body temperature of a patient
US7621945Nov 21, 2005Nov 24, 2009MedCool, Inc.Method and apparatus for reducing body temperature of a subject
US7666213Sep 24, 2004Feb 23, 2010Life Recovery Systems HD, LLCApparatus for altering the body temperature of a patient
US7731739Aug 24, 2006Jun 8, 2010Life-Recovery Systems HD, LLCApparatus for altering the body temperature of a patient
US7771461Aug 24, 2006Aug 10, 2010Life Recovery Systems HD, LLCApparatus for altering the body temperature of a patient
US7833179Dec 30, 2003Nov 16, 2010Otivio ASDevice for applying a pulsating pressure to a local region of the body and applications thereof
US7833180Oct 9, 2008Nov 16, 2010Otivio ASDevice for applying a pulsating pressure to a local region of the body and the applications thereof
US7892271Aug 24, 2006Feb 22, 2011Life Recovery Systems HD, LLCApparatus for altering the body temperature of a patient
US7972287Oct 27, 2006Jul 5, 2011Gaymar Industries, Inc.Heat transfer cuff
US8021314Oct 11, 2010Sep 20, 2011Otivio ASDevice for applying a pulsating pressure to a local region of the body and the applications thereof
US8052624Oct 29, 2008Nov 8, 2011Stryker CorporationNegative pressure, thermal energy transfer device that also provides positive pressure to the patient
US8066752Dec 4, 2006Nov 29, 2011Dynatherm Medical, Inc.Methods and apparatus for adjusting body core temperature
US8166734Oct 19, 2009May 1, 2012Equine cold therapy apparatus and method
US8177826Oct 6, 2005May 15, 2012The Board of Trustees of the Leland Stanford Junior UniversityMethods and devices for extracting thermal energy from the body core of a mammal
US8182520Dec 7, 2007May 22, 2012Life Recovery Systems HD, LLCApparatus for altering the body temperature of a patient
US8182521Jul 30, 2007May 22, 2012Dynatherm Medical Inc.Methods and apparatus for increasing blood circulation

Claims

1. A method for extracting thermal energy from the core body of a mammal, said method comprising:

(a) enclosing a portion of said mammal in a scaled enclosure to produce an enclosed portion of said mammal;
(b) contacting a surface of said enclosed portion with a low temperature medium under negative pressure conditions for a period of time sufficient to extract thermal energy from the core body of said mammal, wherein said low temperature medium has a temperature below said mammal's normal physiologic temperature but above a temperature that results in localized vasoconstriction at said surface.

2. The method according to claim 1, wherein said portion of said mammal is a limb or a portion thereof.

3. The method according to claim 2, wherein said limb is selected from the group consisting of an arm and a leg.

4. The method according to claim 3, wherein said portion is a heat exchange surface.

5. The method according to claim 4, wherein said heat exchange surface is selected from the group consisting of a sole and a palm.

6. The method according to claim 2, wherein said sealed enclosure under said negative pressure conditions has a pressure ranging from about 20 to about 80 mm Hg.

7. The method according to claim 2, wherein said low temperature medium has a temperature ranging from about 15 to about 35 C.

8. The method according to claim 2, wherein said period of time ranges from about 0.5 min to about 24 hrs.

9. The method according to claim 1, wherein said mammal is a human.

10. A method for enhancing the ability of a mammal to perform a physical procedure, said method comprising:

(a) enclosing a portion of said mammal in a sealed enclosure to produce an enclosed portion of said mammal;
(b) contacting a surface of said enclosed portion with a low temperature medium under negative pressure conditions at least once during said physical procedure for a period of time sufficient to enhance the ability of said mammal to perform said physical procedure, wherein said low temperature medium has a temperature below said mammal's normal physiologic temperature but above a temperature that results in localized vasoconstriction at said surface.

11. The method according to claim 10, wherein said portion of said mammal is a limb or a portion thereof.

12. The method according to claim 11, wherein said limb is selected from the group consisting of an arm and a leg.

13. The method according to claim 11, wherein said portion is a heat exchange surface.

14. The method according to claim 13, wherein said heat exchange surface is a palm or a sole.

15. The method according to claim 10, wherein said sealed enclosure under said negative pressure conditions has a pressure ranging from about 20 to about 80 mm Hg.

16. The method according to claim 10, wherein said low temperature medium has a temperature ranging from about 15 to about 35 C.

17. The method according to claim 10, wherein said period of time ranges from about 0.5 to about 600 min.

18. The method according to claim 10, wherein said mammal is a human.

19. The method according to claim 10, wherein said physical procedure is an athletic procedure.

20. The method according to claim 10, wherein thermal energy is extracted to effect rapid recovery from a heated condition.

21. The method according to claim 20, wherein said heated condition occurs in a hot environment.

22. The method according to claim 21, wherein said mammal is an athlete.

23. The method according to claim 22, wherein said physical procedure is a sporting event or practice session.

24. A method for enhancing the ability of a mammal to perform an athletic procedure, said method comprising:

extracting thermal energy from the body core of said mammal at least once during said athletic procedure for a period of time sufficient to enhance the ability of said mammal to perform said athletic procedure, wherein said core body thermal energy is extracted by the method comprising:
(a) enclosing a portion of said mammal in a sealed enclosure to produce an enclosed portion of said mammal;
(b) contacting a surface of said enclosed portion with a low temperature medium under negative pressure conditions for a period of time sufficient to extract said core body thermal energy, wherein said low temperature medium has a temperature below said mammal's normal physiologic temperature but above a temperature that results in localized vasoconstriction at said surface.

25. A device for extracting thermal energy from the core body of a mammal, said device comprising:

(a) a sealable enclosure having dimensions sufficient to produce an enclosed portion of a mammal;
(b) a negative pressure producing element that produces negative pressure conditions in said sealable enclosure; and
(c) a cooling element for producing a reduced temperature medium in said sealable enclosure;
(d) wherein said devices is adapted to avoid localized vasoconstriction on the surface of an enclosed portion of a mammal.

26. A device for extracting thermal energy from the core body of a mammal, said device comprising:

(a) a sealable enclosure having dimensions sufficient to produce an enclosed portion of a mammal;
(b) a negative pressure producing element that produces negative pressure conditions in said sealable enclosure; and
(c) a cooling element for producing a reduced temperature medium in said sealable enclosure, wherein said reduced temperature medium is at a temperature to avoid localized vasoconstriction on the surface of an enclosed portion of a mammal.

27. A device for enhancing the ability of a mammal to perform a physical procedure, said device comprising:

(a) a sealable enclosure having dimensions sufficient to produce an enclosed portion of a mammal;
(b) a negative pressure producing element that produces negative pressure conditions in said sealable enclosure; and
(c) a cooling element for producing a reduced temperature medium in said sealable enclosure;
(d) wherein said devices is adapted to avoid localized vasoconstriction on the surface of an enclosed portion of a mammal.

28. A device for enhancing the ability of a mammal to perform a physical procedure, said device comprising:

(a) a sealable enclosure having dimensions sufficient to produce an enclosed portion of a mammal;
(b) a negative pressure producing element that produces negative pressure conditions in said sealable enclosure; and
(c) a cooling element for producing a reduced temperature medium in said sealable enclosure, wherein said reduced temperature medium is at a temperature to avoid localized vasoconstriction on the surface of an enclosed portion of a mammal.