A composition comprising Transferrin binding proteins A and B is described (TbpA and TbpB). The composition is suitable for use in vaccines and for treatment of Gram negative bacterial infection, particularly meningococcal infection, demonstrating a broad spectrum of protection to a number of different...http://www.google.com/patents/US6821521?utm_source=gb-gplus-sharePatent US6821521 - Multicomponent meningococcal vaccine