Antibodies are disclosed which specifically bind to native PrP.sup.Sc in situ. Preferred antibodies bind only to the native PrP.sup.Sc of a particular species e.g., human, cow, sheep, pig, etc. Particularly preferred antibodies bind specifically to a particular isoform of human PrP.sup.Sc. Preferred...http://www.google.com/patents/US6290954?utm_source=gb-gplus-sharePatent US6290954 - Antibodies specific for native PrPSc
