A method of improving specific immune responses to small immunogens, haptens, has been developed by changing the linkage between the hapten and carrier being used for immunization. Antibodies to a glycated protein have been developed, utilizing an immunogen which is composed of a glycated peptide mimic...http://www.google.com/patents/US7335516?utm_source=gb-gplus-sharePatent US7335516 - Methods to improve immunogenicity of antigens and specificity of antibodies