The DNA encoding an antibody with an altered function, e.g. altered affinity for an effector ligand such as Fc receptor (FcR) on a cell or the Cl component of complement is produced by replacing the nucleic acid encoding at least one amino acid residue in the constant portion of the antibody with nucleic...http://www.google.com/patents/US5648260?utm_source=gb-gplus-sharePatent US5648260 - DNA encoding antibodies with altered effector functions
