The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor (InK4a-p16) of the cyclin D-dependent kinases CDK4 and CDK6. InK4a-p16 can block these kinase from phosphorylating the retinoblastoma protein (pRb), preventing exit from the G1 phase of the cell cycle. Deletions and mutations involving the gene...http://www.google.com/patents/US6586203?utm_source=gb-gplus-sharePatent US6586203 - ARF-P19, a novel regulator of the mammalian cell cycle
