The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal...http://www.google.com/patents/US6103479?utm_source=gb-gplus-sharePatent US6103479 - Miniaturized cell array methods and apparatus for cell-based screening
