The invention relates to the use of mass labelled probes to characterize nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid in a sample, using a circularizing probe in which a mass tag is present in the probe. Further methods of...http://www.google.com/patents/US7618780?utm_source=gb-gplus-sharePatent US7618780 - Use of mass labelled probes to detect target nucleic acids using mass spectrometry