Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form more...http://www.google.com/patents/US5631135?utm_source=gb-gplus-sharePatent US5631135 - Oligonucleotide N3'.fwdarw.P5' phosphoramidates: hybridization and nuclease resistance properties
