Altered and native immunoglobulins, including constant-variable region chimeras, are prepared in recombinant cell culture. The immunoglobulins contain variable regions which are immunologically capable of binding predetermined antigens. Methods are provided for refolding directly expressed immunoglobulins...http://www.google.com/patents/US4816567?utm_source=gb-gplus-sharePatent US4816567 - Recombinant immunoglobin preparations
