The instant invention provides a method for producing RNA enzymatically in a semi-batch or continuous-flow bioreactor using a DNA template immobilized to a solid support through a linkage having a single-stranded overhang extending from a noncoding strand. The coding strand remains dissociable...http://www.google.com/patents/US5700667?utm_source=gb-gplus-sharePatent US5700667 - Strategy for the production of RNA from immobilized templates
