The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure...http://www.google.com/patents/US6943000?utm_source=gb-gplus-sharePatent US6943000 - JNK3 modulators and methods of use
