A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and isolating (2S,3R,4S)-4-hydroxy-L-isoleucine is...http://www.google.com/patents/US8114651?utm_source=gb-gplus-sharePatent US8114651 - Method for producing 4-hydroxy-L-isoleucine