A novel apparatus for generating temperature gradients is described. The apparatus includes a semiconductive wafer and electrical connectors attached to, preferably, one of the edges of the wafer. Methods for transferring the temperature gradients to strata are described. The temperature gradients on...http://www.google.com/patents/US6610470?utm_source=gb-gplus-sharePatent US6610470 - Apparatus for generating a temperature gradient and methods for using the gradient to characterize molecular interactions